公开(公告)号：US20120045916A1

公开(公告)日：2012-02-23

申请号：US13289919

申请日：2011-11-04

Applicant: Ken Kan ,  Jeff Chen ,  Michael Chang

Inventor： Ken Kan ,  Jeff Chen ,  Michael Chang

IPC: H01R29/00

CPC classification number: H01R31/06 ,  H01R13/501 ,  H01R2201/06

Abstract: Systems and methods electrically connect a first electronic device or electrical component, having a external electrical connector, to a circuit board of a second electronic device. A low-cost, user-installable connection system isolates mechanical stresses imposed on the external electrical connector to within the user-installable connection system, thereby preventing the mechanical stresses from reaching the circuit board in the second electronic device. If the connection becomes faulty, only the low-cost, user-installable connection system must be replaced.

公开(公告)号：US08096837B2

公开(公告)日：2012-01-17

申请号：US12758696

申请日：2010-04-12

Applicant: Ken Kan ,  Jeff Chen ,  Michael Chang

Inventor： Ken Kan ,  Jeff Chen ,  Michael Chang

IPC: H01R24/00

CPC classification number: H01R31/06 ,  H01R13/501 ,  H01R2201/06

Abstract: Systems and methods electrically connect a first electronic device or electrical component, having a external electrical connector, to a circuit board of a second electronic device. A low-cost, user-installable connection system isolates mechanical stresses imposed on the external electrical connector to within the user-installable connection system, thereby preventing the mechanical stresses from reaching the circuit board in the second electronic device. If the connection becomes faulty, only the low-cost, user-installable connection system must be replaced.

Abstract translation: 系统和方法将具有外部电连接器的第一电子设备或电气部件电连接到第二电子设备的电路板。 低成本，用户可安装的连接系统将施加在外部电连接器上的机械应力隔离在用户可安装的连接系统内，从而防止机械应力到达第二电子设备中的电路板。 如果连接发生故障，则只能更换低成本，用户可安装的连接系统。

公开(公告)号：US08088767B2

公开(公告)日：2012-01-03

申请号：US12443103

申请日：2007-09-28

Applicant: Adam Antoni Galan ,  Jeff Chen ,  Hongwang Du ,  Timothy Forsyth ,  Tai Phat Huynh ,  Henry William Beecroft Johnson ,  Patrick Kearney ,  James W. Leahy ,  Matthew Sangyup Lee ,  Grace Mann ,  Brian Hugh Ridgway ,  Craig Stacy Takeuchi ,  Peiwen Zhou

Inventor： Adam Antoni Galan ,  Jeff Chen ,  Hongwang Du ,  Timothy Forsyth ,  Tai Phat Huynh ,  Henry William Beecroft Johnson ,  Patrick Kearney ,  James W. Leahy ,  Matthew Sangyup Lee ,  Grace Mann ,  Brian Hugh Ridgway ,  Craig Stacy Takeuchi ,  Peiwen Zhou

IPC: A61K31/5377 ,  A61K31/4439 ,  A61K31/4184 ,  C07D413/14 ,  C07D401/14 ,  C07D403/12

CPC classification number: C07D405/14 ,  C07D233/90 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.

Abstract translation: 本发明涉及蛋白酪氨酸激酶及其抑制剂的领域。 特别地，本发明涉及JAK-2抑制剂，用于抑制JAK-2的化合物的药物组合物，抑制细胞中JAK-2的方法，包括使需要JAK-2抑制的细胞与化合物 或包含根据本发明的化合物的药物组合物。 还包括治疗涉及JAK-2的疾病或病症的方法，包括向患者施用包含本发明化合物的药物组合物。

公开(公告)号：US20090298830A1

公开(公告)日：2009-12-03

申请号：US11992224

申请日：2007-01-30

Applicant: Grace Mann ,  Naing Aay ,  Arlyn Arcalas ,  S. David Brown ,  Wai Ki Vicky Chan ,  Jeff Chen ,  Hongwang Du ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Adam A. Galan ,  Tai Phat Huynh ,  Mohamed Abdulkader Ibrahim ,  Henry William Beecroft Johnson ,  Brian Kane ,  Patrick Kearney ,  Byung Gyu Kim ,  Elena S. Koltun ,  James W. Leahy ,  Matthew Sangyup Lee ,  Gary L. Lewis ,  Lisa E. Meyr ,  Robin Tammie Noguchi ,  Michael Pack ,  Brian Hugh Ridgway ,  Xian Shi ,  John Woolfrey ,  Peiwen Zhou

Inventor： Grace Mann ,  Naing Aay ,  Arlyn Arcalas ,  S. David Brown ,  Wai Ki Vicky Chan ,  Jeff Chen ,  Hongwang Du ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Adam A. Galan ,  Tai Phat Huynh ,  Mohamed Abdulkader Ibrahim ,  Henry William Beecroft Johnson ,  Brian Kane ,  Patrick Kearney ,  Byung Gyu Kim ,  Elena S. Koltun ,  James W. Leahy ,  Matthew Sangyup Lee ,  Gary L. Lewis ,  Lisa E. Meyr ,  Robin Tammie Noguchi ,  Michael Pack ,  Brian Hugh Ridgway ,  Xian Shi ,  John Woolfrey ,  Peiwen Zhou

IPC: A61K31/5377 ,  C07D413/14 ,  A61P7/00

CPC classification number: C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D453/02 ,  C07D487/04

Abstract: This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.

Abstract translation: 本发明涉及具有式（I）的JAK-2的某些嘧啶衍生物抑制剂：其中D，E，L，Z，R 1，R 2，R 25和n 1如说明书中所定义，其药学上可接受的盐，药物组合物 及其使用方法。

公开(公告)号：US20090000342A1

公开(公告)日：2009-01-01

申请号：US11819973

申请日：2007-06-29

Applicant: Jeff Chen

Inventor： Jeff Chen

IPC: E05B55/00 ,  E05B13/10

CPC classification number: E05B63/16 ,  E05B55/005 ,  E05B65/1086 ,  Y10T70/5416 ,  Y10T70/5832 ,  Y10T292/57

Abstract: A door lock has an outside doorknob assembly having an outside doorknob and a lock core, an inside doorknob assembly having an inside doorknob and a latch button, an arresting assembly and a latch assembly. The arresting assembly has a retaining blade connecting the lock core and the latch button, a driving tube mounted rotatably around the retaining blade, a recessed arrestor slidably and non-rotatably mounted on the retaining blade and a protruding arrestor slidably mounted rotatably on the retaining blade and selectively engaging with the recessed arrestor. The latch assembly has a driving element interacting with the driving tube and a latch bolt connected to the driving element. A person can turn the latch button to rotate the retaining blade to drive the recessed arrestor to smoothly engage with or detach from the protruding arrestor to selectively lock or unlock the door lock.

Abstract translation: 门锁具有外部门把手组件，其具有外部门把手和锁芯，内部门把手组件具有内部门把手和闩锁按钮，止动组件和闩锁组件。 止动组件具有连接锁芯和闩锁按钮的保持刀片，围绕保持刀片可旋转地安装的驱动管，可滑动和不可旋转地安装在保持刀片上的凹陷避雷器和可滑动地安装在保持刀片上的突出式止动器 并且选择性地与凹陷的避雷器接合。 闩锁组件具有与驱动管相互作用的驱动元件和连接到驱动元件的闩锁螺栓。 一个人可以转动闩锁按钮来旋转固定刀片，以驱动凹陷的避雷器，以与突出的避雷器平滑地接合或分离，以选择性地锁定或解锁门锁。

公开(公告)号：US20080249079A1

公开(公告)日：2008-10-09

申请号：US11722719

申请日：2005-12-28

Applicant: Jeff Chen ,  Lisa Esther Dalrymple Meyr ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Mohamed Abdulkader Ibrahim ,  James W. Leahy ,  Gary Lee Lewis ,  Grace Mann ,  Larry W. Mann ,  Robin Tammie Noguchi ,  Brian Hugh Ridgway ,  Joan Cruz Sangalang ,  Kevin Luke Schnepp ,  Xian Shi ,  Craig Stacy Takeuchi ,  Matthew Alan Williams ,  John Nuss ,  Atwood K. Cheung

Inventor： Jeff Chen ,  Lisa Esther Dalrymple Meyr ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Mohamed Abdulkader Ibrahim ,  James W. Leahy ,  Gary Lee Lewis ,  Grace Mann ,  Larry W. Mann ,  Robin Tammie Noguchi ,  Brian Hugh Ridgway ,  Joan Cruz Sangalang ,  Kevin Luke Schnepp ,  Xian Shi ,  Craig Stacy Takeuchi ,  Matthew Alan Williams ,  John Nuss ,  Atwood K. Cheung

IPC: A61K31/506 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/519 ,  A61P35/00 ,  C07D403/14 ,  C07D403/12

CPC classification number: C07D413/14 ,  C07D239/48 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/12 ,  C07D417/14 ,  C07D487/04

Abstract: The invention provides compounds and methods for inhibition of kinases, more specifically IGF 1 R kinases. The invention also provides compounds and methods for inhibition of wildtype Abl. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, wherein, V is NR1R1a, or O—R1, wherein X is H, halo, C1-C6 alkyl, NO2, mono-, di-, or tri-halo substituted methyl, NR13R,14. C(O)O—C1-C6 alkyl, or N(R13)—C(O)—C1-C6 alkyl; Y is H, halo, OH, C1-C6 alkyl, C0-C6alkyl-NR,15R16, NR15R,6, C1-C6 alkoxy, —N(R13)—(CH2)n-NR15R16, —C(O)O—C1-C6 alkyl, —O—(CH2)n—NR15R16, —C(O)—C1-C6 alkyl, —C0-C6-alkyl-R21, —O—R21, —C(O)—R21, —O—(CH2)n—R21, —C(O)—NR13R14, —C(O)—N(R13)-aryl, —C(O)—N(R13)(CH2)n—NR15R16, —C(O)—N(R13)—(CH2)n-aryl —C(O)—N(R13)—(CH2)n-heterocyclyl; or X and Y together with the atoms to which they are attached form a 4-7 membered heterocyclyl or heteroaryl group containing one or two heteroatoms independently selected from O, N, and S. Z is H, NR2R3, —S—R2a, or —O—R2a

公开(公告)号：US20080234270A1

公开(公告)日：2008-09-25

申请号：US11572962

申请日：2005-07-30

Applicant: Lynne Canne Bannen ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Brenton T. Flatt ,  Timothy Patrick Forsyth ,  Xiao-Hui Gu ,  Morrison B. Mac ,  Larry W. Mann ,  Grace Mann ,  Richard Martin ,  Raju Mohan ,  Brett Murphy ,  Michael Charles Nyman ,  William C. Stevens ,  Tie-Lin Wang ,  Yong Wang ,  Jason H. Wu

Inventor： Lynne Canne Bannen ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Brenton T. Flatt ,  Timothy Patrick Forsyth ,  Xiao-Hui Gu ,  Morrison B. Mac ,  Larry W. Mann ,  Grace Mann ,  Richard Martin ,  Raju Mohan ,  Brett Murphy ,  Michael Charles Nyman ,  William C. Stevens ,  Tie-Lin Wang ,  Yong Wang ,  Jason H. Wu

IPC: A61K31/40 ,  C07D207/34 ,  C07D403/02 ,  C07D413/02 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/506

CPC classification number: C07D207/416 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.

Abstract translation: 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。

公开(公告)号：US20070244116A1

公开(公告)日：2007-10-18

申请号：US11753503

申请日：2007-05-24

Applicant: LYNNE BANNEN ,  Diva Chan ,  Jeff Chen ,  Lisa Dalrymple ,  Timothy Forsyth ,  Tai Huynh ,  Vasu Jammalamadaka ,  Richard Khoury ,  James Leahy ,  Morrison Mac ,  Grace Mann ,  Larry Mann ,  John Nuss ,  Jason Parks ,  Craig Takeuchi ,  Yong Wang ,  Wei Xu

Inventor： LYNNE BANNEN ,  Diva Chan ,  Jeff Chen ,  Lisa Dalrymple ,  Timothy Forsyth ,  Tai Huynh ,  Vasu Jammalamadaka ,  Richard Khoury ,  James Leahy ,  Morrison Mac ,  Grace Mann ,  Larry Mann ,  John Nuss ,  Jason Parks ,  Craig Takeuchi ,  Yong Wang ,  Wei Xu

IPC: A61K31/47 ,  A61K31/16 ,  A61K31/517 ,  C07C229/40 ,  C07D215/22 ,  C07D239/94 ,  C07D413/12 ,  C07D239/88 ,  C07C233/59 ,  A61K31/5355 ,  A61K31/196

CPC classification number: C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/22 ,  C07D215/36 ,  C07D215/38 ,  C07D215/46 ,  C07D239/88 ,  C07D239/94 ,  C07D295/15 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C12Q1/485 ,  G01N2500/04 ,  Y02A50/393

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract translation: 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。

公开(公告)号：US06993945B1

公开(公告)日：2006-02-07

申请号：US10980666

申请日：2004-11-03

Applicant: Jeff Chen

Inventor： Jeff Chen

IPC: E05B13/10

CPC classification number: E05B13/101 ,  Y10S292/27 ,  Y10T70/5416 ,  Y10T70/5496 ,  Y10T70/5823 ,  Y10T70/5832

Abstract: The doorknob with a lock has a bolt assembly, a lock activating assembly, an outer doorknob assembly and an inner doorknob assembly. The bolt assembly is mounted in a door and has a bolt head and a rotatable plug. The lock activating assembly has a base, a head, an outer clutch plate and an inner clutch plate. The base and the head respectively have an annular longitudinal protrusion, and the base is covered by the annular longitudinal protrusion. Each annular longitudinal protrusion has two opposite gaps. The outer and inner clutch plates respectively have a long protruding end, a short end, a longitudinal slot and a transverse slot. The ends of the clutch plates are slidably mounted in the gaps in the annular longitudinal protrusion, and the long protruding ends selectively engage the gaps in the annular longitudinal protrusion to lock and unlock the door.

Abstract translation: 具有锁的门把手具有螺栓组件，锁定启动组件，外部门把手组件和内部门把手组件。 螺栓组件安装在门中，并具有螺栓头和可旋转塞。 锁定启动组件具有基座，头部，外部离合器板和内部离合器板。 基座和头部分别具有环形纵向突起，基部被环形纵向突起覆盖。 每个环形纵向突起具有两个相对的间隙。 外离合器片和内离合器片分别具有长的突出端，短端，纵向槽和横向槽。 离合器板的端部可滑动地安装在环形纵向突起中的间隙中，并且长突出端选择性地接合环形纵向突起中的间隙以锁定和解锁门。

公开(公告)号：US6071604A

公开(公告)日：2000-06-06

申请号：US26646

申请日：1998-02-20

Applicant: Jeff Chen ,  Honda Cheng

Inventor： Jeff Chen ,  Honda Cheng

IPC: B05D5/06 ,  B62K19/00 ,  B32B5/16

CPC classification number: B62K19/00 ,  Y10T29/49622 ,  Y10T428/25

Abstract: A process for making a light-reflective bicycle frame and a light-reflective bicycle frame made therefrom are provided. The process includes: preparing a bicycle frame, providing a transparent adhesive layer on the bicycle frame, spreading uniformly light-reflective particles on the transparent adhesive layer to form a light-reflective particle layer which is substantially free of any superimposed or overlapping particles, and providing a transparent protective layer on the light-reflective particle layer.

Abstract translation: 提供了制造反光自行车车架和由其制成的反光自行车车架的方法。 该方法包括：制备自行车车架，在自行车车架上提供透明粘合剂层，将透明粘合剂层上的光反射颗粒均匀铺展，以形成基本上没有任何叠加或重叠的颗粒的光反射颗粒层，以及 在光反射性粒子层上设置透明保护层。