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11.发明授权Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin 有权用40-O-（2-羟基）乙基雷帕霉素的释放聚合物涂覆支架的方法公开(公告)号：US08961588B2
公开(公告)日：2015-02-24
申请号：US11527971
申请日：2006-09-26
申请人： Syed F. A. Hossainy , Gordon Stewart , Mark A. Williams , Jeff Royal , Paul M. Consigny , Dorie M. Happ , Kurt Scheinpflug , Ty Hu
发明人： Syed F. A. Hossainy , Gordon Stewart , Mark A. Williams , Jeff Royal , Paul M. Consigny , Dorie M. Happ , Kurt Scheinpflug , Ty Hu
CPC分类号： A61F2/844 , A61F2250/0067 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606
摘要： A method of coating a stent is presented such that less than 50% of the total amount of 40-O-(2-hydroxyl)ethyl-rapamycin, or an analog or derivative thereof, is released in vivo in a 24 hour period, wherein the method comprises exposing the coating to sufficient temperature to modify the structure of the polymer.
摘要翻译： 提出了一种涂覆支架的方法，使得在24小时内体内释放40-O-（2-羟基）乙基雷帕霉素或其类似物或衍生物的总量的少于50％，其中 该方法包括将涂层暴露于足够的温度以改变聚合物的结构。
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公开(公告)号：US07396539B1
公开(公告)日：2008-07-08
申请号：US10177154
申请日：2002-06-21
申请人： Syed F A. Hossainy , Gordon Stewart
发明人： Syed F A. Hossainy , Gordon Stewart
IPC分类号： A61F2/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2420/08 , C08L33/10
摘要： Coatings and methods of forming coatings for implantable medical devices, such as stents, are described. The coatings are used for the sustained release of a therapeutic agent or drug.
摘要翻译： 描述了用于可植入医疗装置（例如支架）的成膜涂层和方法。 涂层用于治疗剂或药物的持续释放。
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公开(公告)号：US20120231049A1
公开(公告)日：2012-09-13
申请号：US13481515
申请日：2012-05-25
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2300/608 , A61L2420/02
摘要： Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.
摘要翻译： 公开了用于控制活性剂从包含聚合物基质和一种或多种活性剂的医疗装置的涂层的形态和释放速率的方法。 所述方法包括将湿或干涂层暴露于冻融循环。 涂层可用于控制递送活性剂或活性剂的组合。
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14.发明申请公开(公告)号：US20060002968A1
公开(公告)日：2006-01-05
申请号：US10882506
申请日：2004-06-30
申请人： Gordon Stewart , Gina Zhang , Nancy Kristen , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Syed Hossainy
发明人： Gordon Stewart , Gina Zhang , Nancy Kristen , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Syed Hossainy
IPC分类号： A61K31/4745 , A61F2/00
CPC分类号： A61K31/4745 , A61F2250/0067 , A61K31/436 , A61K31/573 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61K2300/00
摘要： Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.
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15.发明授权公开(公告)号：US08017140B2
公开(公告)日：2011-09-13
申请号：US11804997
申请日：2007-05-21
申请人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译： 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。
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16.发明申请公开(公告)号：US20060105019A1
公开(公告)日：2006-05-18
申请号：US11322282
申请日：2005-12-29
申请人： Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Sayed Hossainy
发明人： Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Sayed Hossainy
IPC分类号： A61K31/4745 , A61F2/00
CPC分类号： A61K31/4745 , A61F2250/0067 , A61K31/436 , A61K31/573 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61K2300/00
摘要： Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.
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公开(公告)号：US08936780B2
公开(公告)日：2015-01-20
申请号：US11468721
申请日：2006-08-30
申请人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
发明人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61K31/785 , A61F2/00 , A61K9/00 , A61L24/00 , A61L24/04
CPC分类号： A61K47/48207 , A61K9/0019 , A61K31/436 , A61K47/595 , A61L24/001 , A61L24/046 , A61L2430/36 , C08G69/44 , Y10S977/906 , C08L77/12
摘要： A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.
摘要翻译： 一种包含适于引入血管的溶液的组合物，其包含包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括将输送装置引入血管的方法; 并且将溶液引入血管中，所述溶液包括包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括处理剂和可调谐刺激响应性聚合物的组合的方法; 以及形成适于通过血管输送的组合颗粒。
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18.发明授权公开(公告)号：US08586069B2
公开(公告)日：2013-11-19
申请号：US11322282
申请日：2005-12-29
申请人： Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Syed Faiyaz Ahmed Hossainy
发明人： Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Syed Faiyaz Ahmed Hossainy
CPC分类号： A61K31/4745 , A61F2250/0067 , A61K31/436 , A61K31/573 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61K2300/00
摘要： Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.
摘要翻译： 提供了药物递送系统，例如具有抗增殖剂如依维莫司的药物递送支架和抗炎剂如氯倍他索。 还公开了治疗血管损伤如再狭窄或易损斑块的方法。
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19.发明申请公开(公告)号：US20050287184A1
公开(公告)日：2005-12-29
申请号：US10881540
申请日：2004-06-29
申请人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
IPC分类号： A61K31/4745 , A61K31/56 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译： 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。
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20.发明申请公开(公告)号：US20090286761A1
公开(公告)日：2009-11-19
申请号：US12191209
申请日：2008-08-13
申请人： Jin Cheng , Stephen Dugan , Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Christopher Feezor , Gene Park , Wouter Roorda , Syed F.A. Hossainy
发明人： Jin Cheng , Stephen Dugan , Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Christopher Feezor , Gene Park , Wouter Roorda , Syed F.A. Hossainy
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0067 , A61F2250/0068 , A61K31/4745 , A61K31/56 , A61K31/573 , A61L31/10 , A61L31/148 , A61L2300/222 , A61L2300/416 , A61L2300/45 , A61K2300/00
摘要： A drug-delivery system is provided including at least 100 μg of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 μg, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).
摘要翻译： 提供了一种药物递送系统，其包括至少100杯依维莫司和氯倍他索，使得依维莫司与氯倍他索的比例至少为10：1（w / w），依维莫司的重量比为至少10倍 氯倍他索 该系统可以是支架。 还提供了治疗血管的再狭窄或易损斑块的方法，所述方法包括向患者局部施用选自雷帕霉素（西罗莫司），Biolimus A9，deforolimus，AP23572，他克莫司，替西罗莫司，吡美莫司， 40-（2-羟基）乙基雷帕霉素（依维莫司），40-O-（3-羟基）丙基雷帕霉素，40-O- [2-（2-羟基）乙氧基]乙基雷帕霉素，40- O-四唑基雷帕霉素和40-表 - （N1-四唑基）雷帕霉素，并且对患者局部施用由氯倍他索组成的第二药物，其中局部施用的第一药物的最小量为100杯，其中 第二种药物的第一种药物例如为10：1〜100：1（w / w）。
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