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1.发明申请公开(公告)号：US20050287184A1
公开(公告)日：2005-12-29
申请号：US10881540
申请日：2004-06-29
申请人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
IPC分类号： A61K31/4745 , A61K31/56 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译： 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。
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2.发明申请公开(公告)号：US20070269484A1
公开(公告)日：2007-11-22
申请号：US11804997
申请日：2007-05-21
申请人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译： 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。
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3.发明授权公开(公告)号：US08017140B2
公开(公告)日：2011-09-13
申请号：US11804997
申请日：2007-05-21
申请人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译： 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。
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4.发明申请公开(公告)号：US20060093842A1
公开(公告)日：2006-05-04
申请号：US10976551
申请日：2004-10-29
申请人： Jessica DesNoyer , Stephen Pacetti , Syed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
发明人： Jessica DesNoyer , Stephen Pacetti , Syed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC分类号： C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
摘要： Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
摘要翻译： 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。 PEA聚合物共混物由PEA聚合物和能够与PEA氢键合的材料形成。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。
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公开(公告)号：US20080113207A1
公开(公告)日：2008-05-15
申请号：US12016811
申请日：2008-01-18
申请人： Stephen Pacetti , Syed Hossainy , Yiwen Tang , Andrew Tung , Thierry Glauser
发明人： Stephen Pacetti , Syed Hossainy , Yiwen Tang , Andrew Tung , Thierry Glauser
CPC分类号： A61L31/10 , A61F2250/0067 , A61L2420/08 , Y10T428/24942 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31565 , Y10T428/31573 , Y10T428/31576 , Y10T428/31786 , Y10T428/31797 , Y10T428/31855 , Y10T428/31909 , Y10T428/31928 , Y10T428/31935
摘要： A coating for an implantable medical device is provided comprising a first layer including a first polymer and a second layer including a second polymer. The second layer is disposed over at least a portion of the first layer. The second polymer has a lower degree of hydration than the first polymer.
摘要翻译： 提供了一种用于可植入医疗装置的涂层，包括包含第一聚合物的第一层和包含第二聚合物的第二层。 第二层设置在第一层的至少一部分上。 第二聚合物的水合度比第一聚合物低。
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6.发明申请公开(公告)号：US20070098758A1
公开(公告)日：2007-05-03
申请号：US11641250
申请日：2006-12-18
申请人： Syed Hossainy , Eugene Michal , Yiwen Tang
发明人： Syed Hossainy , Eugene Michal , Yiwen Tang
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/114 , A61L2300/606 , C08L67/04 , C08L71/02
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer.
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公开(公告)号：US20050196422A1
公开(公告)日：2005-09-08
申请号：US11064530
申请日：2005-02-22
申请人： Syed Hossainy , Yiwen Tang , Andrew Tung , Stephen Pacetti
发明人： Syed Hossainy , Yiwen Tang , Andrew Tung , Stephen Pacetti
CPC分类号： A61F2/82 , A61F2250/0056 , A61F2250/0067 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , Y10T428/24942
摘要： Methods for fabricating coatings for implantable medical devices are disclosed. The coatings include hydrophilic and hydrophobic components. The methods provide for treatment of the coatings to cause enrichment a region close to, at or on the outer surface of the coating with the hydrophilic component.
摘要翻译： 公开了用于制造可植入医疗装置的涂层的方法。 涂层包括亲水和疏水组分。 该方法提供了处理涂层以使亲水组分在涂层的外表面附近或附近的区域富集。
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公开(公告)号：US20050233062A1
公开(公告)日：2005-10-20
申请号：US10856984
申请日：2004-05-27
申请人： Syed Hossainy , Yiwen Tang , Manish Gada
发明人： Syed Hossainy , Yiwen Tang , Manish Gada
CPC分类号： A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2420/02 , B29C71/02 , C08L67/04
摘要： A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device.
摘要翻译： 公开了一种制造可植入医疗装置的方法，例如药物洗脱支架。 该方法包括使包含聚合物的可植入医疗装置经受热条件。 加热条件可导致活性剂从植入装置之后的装置释放速率降低，和/或改善装置上的聚合物涂层的机械性能。
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9.发明申请Biologically absorbable coatings for implantable devices and methods for fabricating the same 有权用于可植入装置的生物可吸收涂层及其制造方法公开(公告)号：US20050025799A1
公开(公告)日：2005-02-03
申请号：US10630261
申请日：2003-07-30
申请人： Syed Hossainy , Eugene Michal , Yiwen Tang
发明人： Syed Hossainy , Eugene Michal , Yiwen Tang
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/114 , A61L2300/606 , C08L67/04 , C08L71/02
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer.
摘要翻译： 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含生物可降解，生物可侵蚀和/或生物可再吸收的ABA或AB嵌段共聚物。 生物活性剂可以与嵌段共聚物缀合。
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公开(公告)号：US20050214339A1
公开(公告)日：2005-09-29
申请号：US10812780
申请日：2004-03-29
申请人： Yiwen Tang , Syed Hossainy , Andrew Tung , Stephen Pacetti
发明人： Yiwen Tang , Syed Hossainy , Andrew Tung , Stephen Pacetti
CPC分类号： A61L31/10 , A61L27/34 , A61L31/148 , A61L2420/06 , C08L67/04
摘要： A medical article is disclosed, comprising a biologically degradable AB block copolymer and a biologically degradable polymer that is capable, at equilibrium and at room temperature, of absorbing less than about 5 mass % water.
摘要翻译： 公开了一种医疗用品，其包含生物降解性AB嵌段共聚物和生物可降解聚合物，其能够在平衡和室温下吸收小于约5质量％的水。
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