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1.发明申请公开(公告)号：US20050287184A1
公开(公告)日：2005-12-29
申请号：US10881540
申请日：2004-06-29
申请人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
IPC分类号： A61K31/4745 , A61K31/56 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译： 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。
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2.发明申请公开(公告)号：US20070269484A1
公开(公告)日：2007-11-22
申请号：US11804997
申请日：2007-05-21
申请人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译： 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。
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3.发明授权公开(公告)号：US08017140B2
公开(公告)日：2011-09-13
申请号：US11804997
申请日：2007-05-21
申请人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译： 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。
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公开(公告)号：US20060135943A1
公开(公告)日：2006-06-22
申请号：US11283032
申请日：2005-11-17
IPC分类号： A61M31/00
CPC分类号： A61M25/0084 , A61B2017/22081 , A61M25/0026 , A61M25/1006 , A61M2025/0096
摘要： An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.
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公开(公告)号：US07008411B1
公开(公告)日：2006-03-07
申请号：US10262151
申请日：2002-09-30
CPC分类号： A61M25/0084 , A61B2017/22081 , A61M25/0026 , A61M25/1006 , A61M2025/0096
摘要： An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.
摘要翻译： 一种治疗易损斑块的装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送生物活性剂以稳定易损斑块。
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公开(公告)号：US20060265043A1
公开(公告)日：2006-11-23
申请号：US11388355
申请日：2006-03-24
申请人： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy , Jessica Chiu , Mina Chow , Eugene Michal , Charles Claude , William Webler
发明人： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy , Jessica Chiu , Mina Chow , Eugene Michal , Charles Claude , William Webler
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B5/02007 , A61B2017/22077 , A61F2/82 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/077 , A61F2220/0058 , A61F2250/0067 , A61M1/3613 , A61M25/104 , A61M2025/105 , A61M2025/1056 , A61M2025/107 , A61M2025/1086 , A61M2025/1095
摘要： Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.
摘要翻译： 描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。 在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。 另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。
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公开(公告)号：US20060129041A1
公开(公告)日：2006-06-15
申请号：US11346771
申请日：2006-02-03
CPC分类号： A61B5/14542 , A61B5/14552 , A61B5/1459 , A61B5/6851
摘要： A guidewire with a sensor which can detect NO and/or superoxide levels is disclosed. This invention can be useful for in vivo analysis of vascular health.
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公开(公告)号：US07329223B1
公开(公告)日：2008-02-12
申请号：US09872310
申请日：2001-05-31
IPC分类号： A61B5/00
CPC分类号： A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/02154 , A61B5/1459 , A61B5/6853 , A61B2017/22001
摘要： An apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment, the apparatus includes an intravascular device to perform a therapeutic treatment and at least one optical fiber disposed through the intravascular device. The optical fiber is configured to provide diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.
摘要翻译： 通过使用其中设置有光纤的血管内装置来对患者的脉管系统进行治疗处理和诊断的装置和方法。 在一个实施例中，该装置包括执行治疗性处理的血管内装置和通过血管内装置设置的至少一个光纤。 光纤被配置为在治疗之前，期间和之后提供诊断信息。 在一个实施方案中，诊断信息包括血管和血液特征，例如血液动力学特征，与血液和血液成分有关的血液学参数，以及脉管系统的热参数。
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公开(公告)号：US07326238B1
公开(公告)日：2008-02-05
申请号：US10262149
申请日：2002-09-30
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B17/22 , A61B2017/22077 , A61B2017/22082 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/075 , A61F2250/0067 , A61L27/3808 , A61L27/3843 , A61L31/16 , A61M25/0084 , A61M29/02 , A61M2025/0086
摘要： An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.
摘要翻译： 一种治疗易损斑块的装置和方法。 在一个实施方案中，该装置具有治疗闭塞性斑块的医疗装置，并且还适于释放生物活性剂以治疗位于封闭斑块下游的易损斑块。 在替代实施例中，该装置具有连接到支架的内表面的可扩张管和接种在可扩张管的内表面上的内皮细胞层。 可扩张管屏蔽易损斑块与体腔。
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公开(公告)号：US20050222584A1
公开(公告)日：2005-10-06
申请号：US11140240
申请日：2005-05-26
CPC分类号： A61F2/958 , A61B2017/22081
摘要： A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.
摘要翻译： 一种治疗易损斑块的方法，包括使用从无翅未膨胀直径膨胀至有限扩张直径的无翼气球故意破坏或破裂易损斑块。 该过程在损伤或破裂部位产生ECM合成的显着增加。 因此，该方法可加强易损斑块，同时最大限度地减少或避免对体腔周围壁的损害或损坏被认为是易损斑块的稳定斑块。 本发明的方法特别可用于治疗纤维腺瘤型易损斑块。 在一个实施例中，气囊是自限制性的，使得其在初始充气压力下顺应地膨胀，并且在额定压力之上，其膨胀不顺利。 在替代实施例中，使用直径限制装置（例如限制气囊中的充气压力或膨胀流体的体积的装置）使球囊膨胀。
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