公开(公告)号：US06951735B2

公开(公告)日：2005-10-04

申请号：US09314889

申请日：1999-05-19

申请人： Guo-Liang Yu ,  Jian Ni ,  Vishva Dixit ,  Reiner L. Gentz ,  Patrick J. Dillon

发明人： Guo-Liang Yu ,  Jian Ni ,  Vishva Dixit ,  Reiner L. Gentz ,  Patrick J. Dillon

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H21/04 ,  C07K14/705 ,  C07K14/715 ,  C12N1/21 ,  C12N5/00 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12R1/19 ,  C12R1/91 ,  C12N15/63

CPC分类号： C07K14/70578 ,  A61K38/00

摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。 特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。 还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

公开(公告)号：US06667390B2

公开(公告)日：2003-12-23

申请号：US09756854

申请日：2001-01-10

申请人： Jian Ni ,  Guo-Liang Yu ,  Ping Fan ,  Reiner L. Gentz

发明人： Jian Ni ,  Guo-Liang Yu ,  Ping Fan ,  Reiner L. Gentz

IPC分类号： C07K14715

CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K14/4747 ,  C07K14/7151 ,  C12N2799/026

摘要： The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.

公开(公告)号：US06448044B2

公开(公告)日：2002-09-10

申请号：US08832488

申请日：1997-04-03

申请人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

发明人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

IPC分类号： C12P2102

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/52

摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

公开(公告)号：US06329169B1

公开(公告)日：2001-12-11

申请号：US09043646

申请日：1998-09-09

申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

IPC分类号： C12P2102

CPC分类号： G01N33/57415 ,  A61K38/00 ,  C07K14/475

摘要： The invention relates to cytostatin II growth modulatory peptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications which are related, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及细胞抑制素II生长调节肽，编码多肽的多核苷酸，特别是通过表达多核苷酸产生多肽的方法，多肽的激动剂和拮抗剂。 本发明还涉及利用这些多核苷酸，多肽，激动剂和拮抗剂用于部分与研究，诊断和临床领域有关的应用的方法。

公开(公告)号：US5919658A

公开(公告)日：1999-07-06

申请号：US832535

申请日：1997-04-03

申请人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

发明人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

IPC分类号： A61K38/00 ,  C07K14/81 ,  C12P21/06 ,  C07H21/04 ,  C12N5/00 ,  C12N15/00

CPC分类号： C07K14/8139 ,  A61K38/00 ,  C07K2319/00

摘要： The invention relates to cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及半胱氨酸蛋白酶抑制剂F多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

公开(公告)号：US06759513B2

公开(公告)日：2004-07-06

申请号：US09333966

申请日：1999-06-16

申请人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

发明人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

IPC分类号： C07K14705

CPC分类号： C07K14/70578 ,  A61K38/00

摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

公开(公告)号：US06541224B2

公开(公告)日：2003-04-01

申请号：US09879919

申请日：2001-06-14

申请人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

发明人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

IPC分类号： C12N1500

CPC分类号： A61K49/0004 ,  A61K47/6849 ,  A61K2039/505 ,  C07K14/52 ,  C07K14/70575 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/74 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/525

摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

公开(公告)号：US06482922B2

公开(公告)日：2002-11-19

申请号：US09263811

申请日：1999-03-08

申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

IPC分类号： C07K100

CPC分类号： C07K14/82 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026 ,  C12Q1/6886 ,  C12Q2600/136

摘要： A human mammary transforming protein and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for inhibiting such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

摘要翻译： 公开了一种编码这种多肽的人类乳腺转化蛋白和DNA（RNA），以及通过重组技术产生这种多肽的方法。 还公开了抑制这种多肽以预防和/或治疗瘤形成的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

公开(公告)号：US20100266533A1

公开(公告)日：2010-10-21

申请号：US12771910

申请日：2010-04-30

申请人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

发明人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

IPC分类号： A61K39/395 ,  C07K16/18 ,  A61K38/20 ,  A61K38/21 ,  C07K14/435 ,  A61K38/17 ,  A61P35/00 ,  A61P37/00 ,  A61P37/06 ,  A61P29/00

CPC分类号： C07K14/4747 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/70578 ,  C07K16/2878 ,  C07K2317/21 ,  C12N2799/026

摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。 特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。 还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还提供了结合本发明多肽的抗体及其片段。 本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07709218B2

公开(公告)日：2010-05-04

申请号：US12463301

申请日：2009-05-08

申请人： Reiner L. Gentz ,  Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jian Ni ,  Ping Feng

发明人： Reiner L. Gentz ,  Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jian Ni ,  Ping Feng

IPC分类号： G01N33/53 ,  G01N33/563 ,  G01N33/577 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28

CPC分类号： A61K48/005 ,  A61K38/00 ,  A61K48/0058 ,  C07K14/4703 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/00 ,  C07K2319/30 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides and antibodies that bind TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α＆-6＆bgr的分离的核酸分子; 蛋白质。 TNFR-6α＆-6＆bgr; 结合TNFR-6α＆-6＆bgr的多肽和抗体; 还提供多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定TNFR-6α和-6β的激动剂和拮抗剂的筛选方法。 活动。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。