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    METHOD FOR INHIBITING ADHESION FORMATION
    11.
    发明申请
    METHOD FOR INHIBITING ADHESION FORMATION 有权
    抑制粘连形成的方法

    公开(公告)号：US20120294909A1

    公开(公告)日：2012-11-22

    申请号：US13569138

    申请日：2012-08-07

    申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

    发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

    IPC分类号： A61K9/00 ,  A61K35/12

    CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

    摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

    摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，表现为结合牙龈上皮细胞的细胞粘附生物活性因子，其遍及基底膜的上部。

    PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME
    12.
    发明申请
    PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME 有权
    特殊组织和改进的制备和使用方法

    公开(公告)号：US20120078378A1

    公开(公告)日：2012-03-29

    申请号：US12206508

    申请日：2008-09-08

    申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

    发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

    IPC分类号： A61F2/02

    CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

    摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

    摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，表现为结合牙龈上皮细胞的细胞粘附生物活性因子，其遍及基底膜的上部。

    TISSUE GRAFTS MODIFIED WITH A CROSS-LINKING AGENT AND METHOD OF MAKING AND USING THE SAME
    15.
    发明申请
    TISSUE GRAFTS MODIFIED WITH A CROSS-LINKING AGENT AND METHOD OF MAKING AND USING THE SAME 审中-公开
    用交联剂修饰的组织接头及其制造和使用方法

    公开(公告)号：US20140205646A1

    公开(公告)日：2014-07-24

    申请号：US13984842

    申请日：2012-02-13

    申请人： Brenda S. Morse ,  Somaly Sith ,  Randall Spencer ,  John Daniel

    发明人： Brenda S. Morse ,  Somaly Sith ,  Randall Spencer ,  John Daniel

    IPC分类号： A61L27/38 ,  A61K35/50

    CPC分类号： A61L27/3891 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3687 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3878 ,  A61L27/3882 ,  A61L2400/18 ,  A61L2430/12 ,  A61L2430/16 ,  A61L2430/22 ,  A61L2430/32 ,  A61L2430/40

    摘要： Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of amnion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. Also described herein are methods for making and using the tissue grafts.

    摘要翻译： 本文描述了衍生自胎盘的组织移植物，其具有对生物组织的良好粘附性并且可用于治愈应用。 在一个方面，组织移植物包括（1）两层或更多层羊膜，其中至少一层羊膜交联，（2）两层或多层绒毛膜，其中至少一层羊膜是交叉的， 连接或（3）一层或多层羊膜和绒毛膜，其中至少一层羊膜和/或绒毛膜交联。 另一方面，移植物由彼此交联的羊膜和绒毛膜组成。 在另一方面，移植物具有夹在羊膜和绒毛膜之间的一层或多层。 羊膜和/或绒毛膜在形成移植物之前用交联剂处理。 本文还描述了用于制造和使用组织移植物的方法。

    PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME
    16.
    发明申请
    PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME 有权
    特殊组织和改进的制备和使用方法

    公开(公告)号：US20130224159A1

    公开(公告)日：2013-08-29

    申请号：US13861305

    申请日：2013-04-11

    申请人： John Daniel ,  Randall Spencer

    发明人： John Daniel ,  Randall Spencer

    IPC分类号： A61K35/12

    CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

    摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

    摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，细胞粘附生物活性因子显示结合牙龈上皮细胞，遍及基底膜的上部。