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11.发明申请公开(公告)号：US20100298343A1
公开(公告)日：2010-11-25
申请号：US12681636
申请日：2008-09-12
申请人： John Howard Hutchinson , Thomas Jon Seiders , Jeannie M. Arruda , Nicholas Simon Stock , Jeffrey Roger Roppe , Bowei Wang
发明人： John Howard Hutchinson , Thomas Jon Seiders , Jeannie M. Arruda , Nicholas Simon Stock , Jeffrey Roger Roppe , Bowei Wang
IPC分类号： A61K31/506 , C07D401/12 , A61K31/4439 , A61P29/00 , A61P11/06 , C07D401/14 , A61K31/444 , A61K31/4709 , C07D403/14 , A61K31/497
CPC分类号： C07D401/12 , C07D401/14 , C07D403/14
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
摘要翻译： 本文描述了含有调节5-脂氧合酶活化蛋白（FLAP）的活性的化合物的化合物和药物组合物。 本文还描述了使用这样的FLAP调节剂单独和与其它化合物组合用于治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。
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公开(公告)号：US08426449B2
公开(公告)日：2013-04-23
申请号：US12935253
申请日：2009-03-25
IPC分类号： A01N43/40 , C07D213/62 , C07D229/00
CPC分类号： C07C233/62 , C07C217/58 , C07C233/18 , C07C233/43 , C07C233/73 , C07C271/16 , C07C271/20 , C07C271/24 , C07C311/08 , C07C311/17 , C07C311/29 , C07C311/40 , C07C317/14 , C07C2601/02 , C07C2602/08
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US08247602B2
公开(公告)日：2012-08-21
申请号：US13246688
申请日：2011-09-27
IPC分类号： C07C323/57 , C07C321/20 , C07C229/18 , A61K31/167 , A61K31/10
CPC分类号： C07C323/42 , A61K31/235 , C07C317/28 , C07C323/41 , C07C323/44 , C07C323/49 , C07C2601/02
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US20110301211A1
公开(公告)日：2011-12-08
申请号：US13139260
申请日：2009-12-15
申请人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
发明人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
IPC分类号： A61K31/42 , C07D413/10 , A61K31/422 , A61P1/16 , A61P17/00 , A61P35/00 , A61P9/00 , A61P11/00 , A61P29/00 , A61P1/00 , A61P13/12 , A61P13/02 , A61P13/00 , A61P1/18 , A61P9/10 , A61P7/04 , A61P11/06 , A61P35/02 , A61P35/04 , A61P27/02 , C07D261/14
CPC分类号： C07D261/14 , C07D413/10
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
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公开(公告)号：US20110144160A1
公开(公告)日：2011-06-16
申请号：US12999617
申请日：2009-07-02
申请人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Brian Andrew Stearns
发明人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Brian Andrew Stearns
IPC分类号： A61K31/445 , A61K31/44 , A61K31/433 , A61K31/42 , A61K31/4166 , A61K31/195 , C07D211/06 , C07D211/72 , C07D285/12 , C07D263/00 , C07D233/70 , C07C321/16 , C07C317/06
CPC分类号： C07C323/42 , A61K31/235 , C07C317/28 , C07C323/41 , C07C323/44 , C07C323/49 , C07C2601/02
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US08524748B2
公开(公告)日：2013-09-03
申请号：US13123196
申请日：2009-10-07
IPC分类号： A61K31/433 , A61K31/192 , A61K31/216 , C07D285/08
CPC分类号： C07D285/12 , A61K31/41 , A61K31/433 , A61K45/06 , C07C59/68 , C07C317/46 , C07C323/56 , A61K2300/00
摘要： Described herein are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是PGD 2受体的拮抗剂。 还描述了包括本文所述化合物的药物组合物和药物，以及使用PGD2受体单独和与其它化合物组合的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症的方法 或疾病。
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公开(公告)号：US08273780B2
公开(公告)日：2012-09-25
申请号：US13246746
申请日：2011-09-27
申请人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
发明人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
IPC分类号： A61K31/42
CPC分类号： A61K31/42 , C07D261/14
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号：US20110301142A1
公开(公告)日：2011-12-08
申请号：US13139271
申请日：2009-12-15
申请人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr , Lucy Zhao
发明人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr , Lucy Zhao
IPC分类号： A61K31/444 , C07D261/14 , C07D413/12 , C07D413/04 , C07D417/10 , A61P35/00 , C07D413/14 , A61K31/422 , A61K31/42 , A61K31/4439 , A61K31/427 , C07D413/10 , C07D417/04
CPC分类号： C07D261/14 , C07D413/10
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号：US08048902B2
公开(公告)日：2011-11-01
申请号：US12638702
申请日：2009-12-15
申请人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
发明人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
IPC分类号： A61K31/42 , C07D261/14
CPC分类号： C07D261/14 , C07D413/10
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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20.发明申请公开(公告)号：US20110245303A1
公开(公告)日：2011-10-06
申请号：US13123196
申请日：2009-10-07
IPC分类号： A61K31/433 , C07C53/23 , A61K31/192 , C07C69/712 , A61K31/216 , C07D285/08 , A61P11/06 , A61P11/00 , A61P9/00 , A61P17/06 , A61P1/00 , A61P35/00 , A61P17/02
CPC分类号： C07D285/12 , A61K31/41 , A61K31/433 , A61K45/06 , C07C59/68 , C07C317/46 , C07C323/56 , A61K2300/00
摘要： Described herein are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是PGD 2受体的拮抗剂。 还描述了包括本文所述化合物的药物组合物和药物，以及使用PGD2受体单独和与其它化合物组合的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症的方法 或疾病。
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