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公开(公告)号：US20140135317A1
公开(公告)日：2014-05-15
申请号：US14038646
申请日：2013-09-26
申请人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Rubin Martinez , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
发明人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Rubin Martinez , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
IPC分类号： C07D243/14 , C07D403/06
CPC分类号： C07D413/06 , A61K31/5513 , A61K31/553 , C07B59/002 , C07B2200/05 , C07D243/14 , C07D243/24 , C07D267/08 , C07D267/14 , C07D291/08 , C07D403/06 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D419/06 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Z1, Z2, Z3, Z4, X, Y, R2, R3 and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
摘要翻译： 本公开涉及作为钠通道抑制剂的化合物及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的用途。 在具体实施方案中，化合物的结构由式I给出：其中Z 1，Z 2，Z 3，Z 4，X，Y，R 2，R 3和R 4如本文所述，用于制备和使用该化合物的方法， 含有该组合物的药物组合物。
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公开(公告)号：US08552196B2
公开(公告)日：2013-10-08
申请号：US13615259
申请日：2012-09-13
IPC分类号： A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P1/16 , A61P25/28 , A61P29/00 , A61P37/06 , A61P13/12 , A61P9/00 , A61P3/10 , A61P11/00
CPC分类号： A61K31/444 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/585 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048
摘要： The present invention relates to compounds of Formula (I): wherein X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
摘要翻译： 本发明涉及式（I）的化合物：其中X 1，X 2，X 3，X 4，X 5，X 6，X 7，X 8，R 1，R 2，R 3如上所定义。 该化合物具有凋亡信号调节激酶（“ASK1”）抑制活性，因此可用于治疗ASK1介导的病症，包括自身免疫性疾病，炎性疾病，心血管疾病和神经变性疾病。 本发明还涉及包含一种或多种式（I）化合物的药物组合物和制备式（I）化合物的方法。
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公开(公告)号：US20130005706A1
公开(公告)日：2013-01-03
申请号：US13538307
申请日：2012-06-29
申请人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
发明人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
IPC分类号： A61K31/553 , C07D413/04 , C07D267/14 , C07D413/12 , C07D413/14 , A61P25/06 , A61P25/08 , A61P25/00 , A61P3/10 , A61P9/10 , A61P9/00 , A61P9/06 , A61P9/04 , A61P9/12 , C07D498/04
CPC分类号： C07D498/04 , C07D267/14 , C07D413/04 , C07D413/12 , C07D413/14
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Y, Z, n, R1 and R3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
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公开(公告)号：US20130005689A1
公开(公告)日：2013-01-03
申请号：US13537536
申请日：2012-06-29
申请人： Carina E. Cannizzaro , Michael Graupe , Juan A. Guerrero , Yafan Lu , Robert G. Strickley , Chandrasekar Venkataramani , Jeff Zablocki
发明人： Carina E. Cannizzaro , Michael Graupe , Juan A. Guerrero , Yafan Lu , Robert G. Strickley , Chandrasekar Venkataramani , Jeff Zablocki
IPC分类号： A61K31/675 , C07F9/06 , C07D213/64 , A61P3/04 , A61P25/36 , A61P25/34 , A61P25/32 , A61K31/4412 , A61P25/30
CPC分类号： A61K31/675 , A61K31/4418 , C07D213/64 , C07F9/58
摘要： Disclosed are novel compounds having the structure of Formula (I): which are useful for treating mammals for dependence upon substances of addiction, for example addiction to a dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and/or alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of a compound of Formula (I) and methods of using the compounds of Formula (I) in the treatment of addiction to a dopamine-producing agent.
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公开(公告)号：US08344018B2
公开(公告)日：2013-01-01
申请号：US12997487
申请日：2009-07-14
CPC分类号： C07D209/34 , C07D407/10 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04
摘要： A compound of general Formula (I) having histone deacetylase (HDAC) and/or CDK inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound. (Formula should be inserted here) Formula (I)
摘要翻译： 具有组蛋白脱乙酰酶（HDAC）和/或CDK抑制活性的通式（I）的化合物，包含该化合物的药物组合物和可用于使用该化合物治疗疾病的方法。 （公式应在此插入）公式（I）
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公开(公告)号：US20120157404A1
公开(公告)日：2012-06-21
申请号：US13291977
申请日：2011-11-08
申请人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
发明人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
IPC分类号： A61K31/4184 , A61K31/501 , A61K31/439 , A61K31/7056 , A61K31/7068 , A61K31/496 , A61P31/14
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US08198299B2
公开(公告)日：2012-06-12
申请号：US13284559
申请日：2011-10-28
IPC分类号： A61K31/437 , A61K31/4433 , A61K31/4196 , C07D513/04 , C07D405/04 , C07D249/08
CPC分类号： C07D471/04 , C07D213/56 , C07D277/24 , C07D277/30 , C07D277/56 , C07D277/60 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
摘要翻译： 本发明提供具有组蛋白脱乙酰酶（HDAC）抑制活性的通式（I）的化合物，包含该化合物的药物组合物和可用于使用该化合物治疗疾病的方法。
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公开(公告)号：US08124764B2
公开(公告)日：2012-02-28
申请号：US12502967
申请日：2009-07-14
IPC分类号： C07D401/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) and/or Cyclin-dependent kinase (CDK) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
摘要翻译： 本发明提供具有组蛋白脱乙酰酶（HDAC）和/或细胞周期蛋白依赖性激酶（CDK）抑制活性的通式（I）的化合物，包含该化合物的药物组合物和可用于治疗使用该化合物的疾病的方法。
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公开(公告)号：US20100029638A1
公开(公告)日：2010-02-04
申请号：US12502967
申请日：2009-07-14
IPC分类号： A61K31/506 , C07D471/04 , C07D487/04 , C07D413/14 , A61K31/5025 , A61K31/5377 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) and/or Cyclin-dependent kinase (CDK) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
摘要翻译： 本发明提供具有组蛋白脱乙酰酶（HDAC）和/或细胞周期蛋白依赖性激酶（CDK）抑制活性的通式（I）的化合物，包含该化合物的药物组合物和可用于治疗使用该化合物的疾病的方法。
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公开(公告)号：US20100022543A1
公开(公告)日：2010-01-28
申请号：US12510809
申请日：2009-07-28
IPC分类号： A61K31/5377 , C07D405/04 , A61K31/4178 , C07D405/14 , A61K31/4965 , C07D417/14 , A61K31/497
CPC分类号： C07D471/04 , C07D213/56 , C07D277/24 , C07D277/30 , C07D277/56 , C07D277/60 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
摘要翻译： 本发明提供具有组蛋白脱乙酰酶（HDAC）抑制活性的通式（I）的化合物，包含该化合物的药物组合物和可用于使用该化合物治疗疾病的方法。
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