公开(公告)号：US20080249623A1

公开(公告)日：2008-10-09

申请号：US11963745

申请日：2007-12-21

Applicant: Qi-Bin Bao ,  Brian P. Janowski ,  Thomas S. Kilpela ,  John Sullivan ,  Jeffrey L. Trudeau

Inventor： Qi-Bin Bao ,  Brian P. Janowski ,  Thomas S. Kilpela ,  John Sullivan ,  Jeffrey L. Trudeau

IPC: A61F2/44

CPC classification number: A61F2/442 ,  A61F2002/30092 ,  A61F2002/30383 ,  A61F2002/30448 ,  A61F2002/30462 ,  A61F2002/30471 ,  A61F2002/30565 ,  A61F2002/30579 ,  A61F2002/30604 ,  A61F2002/30672 ,  A61F2002/444 ,  A61F2210/0014 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2220/0091

Abstract: An implant retention device is provided to assist in restraining movement of a nuclear implant and to assist in preventing expulsion of the nuclear implant through an incision portal or defect in the annular wall. In general, the implant retention device blocks or obstructs at least a portion of an opening in the annular wall, thereby keeping the implant from exiting the nuclear space through the annular opening. In one form, the implant retention device comprises an expulsion prevention member positioned adjacent the nuclear implant and configured to transition between a compressed position and an expanded position. In another form, the implant retention device may comprise a mounting portion to be positioned adjacent one of the vertebral bodies, a blocking portion for at least partially obstructing the annular opening, and an end projection at a terminal end of the blocking portion to resist expulsion of the implant through the annular opening. In yet another form, the implant retention device may include an elongate blocking member having annulus connector portions extending from each side of the blocking member for engaging with an annular wall.

Abstract translation: 提供植入物保持装置以帮助限制核植入物的运动，并且有助于防止核植入物通过切口入口或环形壁中的缺陷的排出。 通常，植入物保持装置阻挡或阻挡环形壁中的开口的至少一部分，从而保持植入物不通过环形开口离开核空间。 在一种形式中，所述植入物保持装置包括与所述核植入物相邻定位并且构造成在压缩位置和扩张位置之间转变的防止排出构件。 在另一种形式中，植入物保持装置可以包括邻近一个椎体定位的安装部分，用于至少部分地阻挡环形开口的阻挡部分，以及阻挡部分末端的端部突出部以抵抗排出 的植入物通过环形开口。 在另一种形式中，植入物保持装置可以包括细长的阻挡构件，其具有从阻挡构件的每一侧延伸的环形连接器部分，用于与环形壁接合。

公开(公告)号：US20080040445A1

公开(公告)日：2008-02-14

申请号：US11598113

申请日：2006-11-08

Applicant: John Sullivan ,  David Sinclair Ferguson ,  Jarrod Lowe

Inventor： John Sullivan ,  David Sinclair Ferguson ,  Jarrod Lowe

IPC: G06F15/16 ,  G06F15/173

CPC classification number: H04L67/104 ,  H04L67/108 ,  H04L67/28 ,  H04L67/2842

Abstract: A network (10), such as a computer network, is disclosed. The network (10) has a plurality of nodes (20; 120) and includes a first node (30, 130) for storing pieces of a digital object and having a storage (40, 50; 140, 150). A plurality of connections are present between the first node (30, 130) and the plurality of nodes (20; 120). The first node (30, 130) has a requester for requesting one or more pieces of the digital object, a transmitter for transferring one or more pieces of the digital object to at least one further node among the plurality of nodes (20; 120), a receiver for receiving content availability messages from at least some of the plurality of nodes, and a sender for sending a limited content availability message to at least one further node (20; 120) among the plurality of nodes (20, 120). The limited content availability message indicates a subset but not all of the pieces of the digital object available through the first node (30; 130).

Abstract translation: 公开了诸如计算机网络的网络（10）。 网络（10）具有多个节点（20; 120），并且包括用于存储数字对象的部分并具有存储器（40,50; 140,150）的第一节点（30,130）。 在第一节点（30,130）和多个节点（20; 120）之间存在多个连接。 第一节点（30,130）具有用于请求一个或多个数字对象的请求者，用于将一个或多个数字对象传送到多个节点（20; 120）中的至少一个另外节点的发射机， ，用于从所述多个节点中的至少一些节点接收内容可用性消息的接收器，以及用于向所述多个节点（20,120）中的至少一个另外的节点（20; 120）发送有限内容可用性消息的发送器。 有限内容可用性消息指示通过第一节点（30; 130）可用的​​数字对象的子集，但不是全部。

公开(公告)号：US20070107982A1

公开(公告)日：2007-05-17

申请号：US11280174

申请日：2005-11-17

Applicant: John Sullivan

Inventor： John Sullivan

IPC: F01N1/02

CPC classification number: H01L35/30 ,  F01N1/06 ,  F01N3/02 ,  F01N5/025 ,  F01N2470/24 ,  Y02T10/16

Abstract: A sound-cancelling flow-through muffler includes a linear first inner passage, and a curved or zig-zagged second outer passage that wraps around or surrounds the inner passage and that is situated between the linear first inner passage and an exterior wall of the muffler. The outer passage has a length that is equal to, or a multiple of, one-half the wavelength of sound to be cancelled by the muffler such that sound exiting the inner and outer passages destructively interferes or cancels in a sound cancellation or conversion chamber. In addition, the walls of the outer passage serve as a heat sink to extract heat from the exhaust stream and conduct the heat to the outside of the housing. Alternatively, the outer passage may have a closed such that reflects sound back toward the inner passage for cancellation, the walls of the outer passage continuing to serve as a heat sink to extract heat from the exhaust stream and conduct the heat to the outside of the housing.

Abstract translation: 声音消除流通消音器包括线性第一内部通道，以及包围或围绕内部通道并且位于消声器的线性第一内部通道和外部壁之间的弯曲或锯齿形的第二外部通道 。 外部通道的长度等于或消除由消声器消除的声音的一半的倍数，使得离开内部和外部通道的声音在声音消除或转换室中破坏或消除。 此外，外通道的壁用作散热器以从排气流中提取热量并将热量传导到壳体的外部。 或者，外部通道可以具有闭合的，以将声音反射回内部通道用于抵消，外部通道的壁继续用作散热器以从排气流提取热量并将热量传导到 住房。

公开(公告)号：US20070071764A1

公开(公告)日：2007-03-29

申请号：US11406454

申请日：2006-04-17

Applicant: John Sullivan ,  Joseph McGivern ,  Leslie Miranda ,  Hung Nguyen ,  Kenneth Walker ,  Shaw-Fen Hu ,  Colin Gegg ,  Stefan McDonough

Inventor： John Sullivan ,  Joseph McGivern ,  Leslie Miranda ,  Hung Nguyen ,  Kenneth Walker ,  Shaw-Fen Hu ,  Colin Gegg ,  Stefan McDonough

IPC: A61K39/395 ,  C07K16/46

CPC classification number: A61K47/48215 ,  A61K38/00 ,  A61K47/60 ,  C07K14/43504 ,  C07K2319/30 ,  C07K2319/55

Abstract: Disclosed is a composition of matter of the formula (X1)a—(F1)d—(X2)b—(F2)e—(X3)c  (I) and multimers thereof, in which F1 and F2 are half-life extending moieties, and d and e are each independently 0 or 1, provided that at least one of d and e is 1; X1, X2, and X3 are each independently -(L)f-P-(L)g-, and f and g are each independently 0 or 1; P is a toxin peptide of no more than about 80 amino acid residues in length, comprising at least two intrapeptide disulfide bonds; L is an optional linker; and a, b, and c are each independently 0 or 1, provided that at least one of a, b and c is 1. Linkage to the half-life extending moiety or moieties increases the in vivo half-life of the toxin peptide, which otherwise would be quickly degraded. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are a DNA encoding the inventive composition of matter, an expression vector comprising the DNA, and a host cell comprising the expression vector. Methods of treating an autoimmune disorder, such as, but not limited to, multiple sclerosis, type 1 diabetes, psoriasis, inflammatory bowel disease, contact-mediated dermatitis, rheumatoid arthritis, psoriatic arthritis, asthma, allergy, restinosis, systemic sclerosis, fibrosis, scleroderma, glomerulonephritis, Sjogren syndrome, inflammatory bone resorption, transplant rejection, graft-versus-host disease, and lupus and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.

公开(公告)号：US5980251A

公开(公告)日：1999-11-09

申请号：US906575

申请日：1997-08-05

Applicant: John Sullivan ,  Steven Abdelqader

Inventor： John Sullivan ,  Steven Abdelqader

IPC: A61C17/20 ,  H01L41/06 ,  H01L41/12 ,  H01L41/20 ,  A61C1/07 ,  H02N10/00

CPC classification number: H01L41/12 ,  H01L41/06 ,  A61C17/20

Abstract: A magnetostrictive transducer including a plurality of magnetostrictive laminates each having a first end and a second end. The first and second ends of the laminates include openings. The laminates are arranged in a stacked configuration and bonded together by solder at the first and second ends. At the first and second ends the solder extends through the openings of the laminates forming a solder bar therein. The solder bars bond the laminates together with increased mechanical strength and also provide increased electrical contact between the laminates.

Abstract translation: 磁致伸缩换能器包括多个具有第一端和第二端的磁致伸缩层压板。 层压板的第一和第二端包括开口。 层叠体以堆叠的形式布置，并在第一和第二端通过焊料粘合在一起。 在第一和第二端，焊料延伸穿过层压板的开口，在其中形成焊条。 焊料棒以增加的机械强度将层压体结合在一起，并且还提供层压体之间增加的电接触。

公开(公告)号：US09381044B2

公开(公告)日：2016-07-05

申请号：US13608366

申请日：2012-09-10

Applicant: Daniel Rae Robinson ,  Matthew P. Gephart ,  John Sullivan

Inventor： Daniel Rae Robinson ,  Matthew P. Gephart ,  John Sullivan

IPC: A61B17/70 ,  A61B17/86

CPC classification number: A61B17/7059 ,  A61B17/705 ,  A61B17/7052 ,  A61B17/7055 ,  A61B17/8685 ,  A61B17/8695

Abstract: A device for connecting two spinal rods is provided. In one form, the device includes two clamping devices for receiving and locking to spinal rods and a central bridge or plate member that couples the clamping devices. In one aspect, the clamping devices are unitary members with deflectable jaw portions that snap-fit and then locked by operation of actuators. In another aspect, one or both of the clamping devices are adjustably coupled to the central bridge or plate member to allow at least translation and pivoting or rotation of the clamping devices relative to a central axis of the elongate bridge member. The clamping devices may be coupled to the bridge or plate member with the same locking actuator that causes clamping of the clamp device so that the positions of the clamp device and the spinal rod are locked into place by manipulation of only a single locking actuator.

Abstract translation: 提供了一种用于连接两个脊柱杆的装置。 在一种形式中，该装置包括用于接收和锁定到脊柱杆的两个夹持装置和联接夹紧装置的中心桥或板构件。 在一个方面，夹持装置是具有可偏转的钳口部分的整体构件，其通过致动器的操作卡扣配合然后锁定。 在另一方面，夹紧装置中的一个或两个可调节地联接到中心桥或板构件，以允许夹紧装置相对于细长桥构件的中心轴线至少平移和枢转或旋转。 夹紧装置可以通过相同的锁定致动器联接到桥或板构件，所述锁定致动器引起夹紧装置的夹紧，使得通过仅操纵单个锁定致动器来将夹紧装置和脊柱杆的位置锁定就位。

公开(公告)号：US20150132519A1

公开(公告)日：2015-05-14

申请号：US14076126

申请日：2013-11-08

Applicant: John Sullivan

Inventor： John Sullivan

IPC: C08L47/00 ,  B29C33/38

CPC classification number: C08K9/02 ,  Y10T428/1397 ,  Y10T428/31931 ,  Y10T442/3886 ,  C08L47/00

Abstract: Structural elements comprised of functionalized material in a rapidly setting resin. The structural elements are rapidly deployable and arranged as structures that provide ballistic and impact resistance. The structures are fabricated using specific molds that shape a specific rapid cure resin-filler mixture.

Abstract translation: 由快速固化树脂中的官能化材料组成的结构元件。 结构元件可快速展开并布置成提供弹道和抗冲击性的结构。 使用形成特定的快速固化树脂填料混合物的特定模具来制造结构。

公开(公告)号：US08573541B2

公开(公告)日：2013-11-05

申请号：US12807727

申请日：2010-09-13

Applicant: John Sullivan ,  Collin Robert Sullivan

Inventor： John Sullivan ,  Collin Robert Sullivan

IPC: B64C21/10

CPC classification number: F03D1/0633 ,  B64C3/10 ,  B64C3/14 ,  B64C3/16 ,  F03D3/061 ,  F05B2250/611 ,  F05B2260/96 ,  Y02E10/721 ,  Y02E10/74 ,  Y02T50/12

Abstract: This invention uses a novel shape of airfoil to achieve an improved lift to drag ratio and to improve performance at higher angles of attack. The airfoil has a three dimensional wave pattern that modifies the shape of a traditional airfoil to coordinate the airflow through channels on both the top and bottom sides. The uniquely shaped airfoil of this invention could have many uses including a wind turbine blade. This invention not only provides for a more efficient device by improving the effective angle of attack and lift/drag ratio, but also provides for a quiet airflow thus greatly reducing nuisance noise over conventional devices.

Abstract translation: 本发明使用翼型的新颖形状来获得改进的提升阻力比并且在较高的迎角下提高性能。 翼型件具有三维波纹，其改变传统翼型的形状，以通过顶部和底部两侧的通道来协调气流。 本发明的独特形状的翼型件可以具有许多用途，包括风力涡轮机叶片。 本发明不仅通过提高有效的迎角和提升/阻力比来提供更有效的装置，而且还提供了一种安静的气流，从而大大减少了传统装置的麻烦噪音。

公开(公告)号：US08470573B2

公开(公告)日：2013-06-25

申请号：US13165373

申请日：2011-06-21

Applicant: Yan Wang ,  John Sullivan

Inventor： Yan Wang ,  John Sullivan

IPC: C12N9/12 ,  C12N9/00 ,  C07K1/00

CPC classification number: C12N9/1252 ,  C07K2319/80

Abstract: The present invention provides DNA polymerases having increased efficiency of amplification of long amplicons. The present invention also provides for methods of amplifying target nucleic acid molecules with the DNA polymerases for increasing the efficiency of amplification of long amplicons.

Abstract translation: 本发明提供具有增加的长扩增子效率的DNA聚合酶。 本发明还提供了用DNA聚合酶扩增靶核酸分子以增加长扩增子扩增效率的方法。

公开(公告)号：US20120196793A1

公开(公告)日：2012-08-02

申请号：US13496042

申请日：2010-09-17

Applicant: Brant G. Firestone ,  Kymberly Levine ,  Dale A. Porter ,  John Sullivan ,  Leigh Zawel

Inventor： Brant G. Firestone ,  Kymberly Levine ,  Dale A. Porter ,  John Sullivan ,  Leigh Zawel

IPC: A61K38/05 ,  A61P31/12 ,  A61P35/00 ,  A61P9/00 ,  G01N33/53 ,  C07K5/078

CPC classification number: G01N33/6863 ,  A61K31/427 ,  A61K31/44 ,  A61K31/4439 ,  G01N2333/525 ,  G01N2333/5255 ,  G01N2333/70575

Abstract: A method to predict which patients will respond to a IAP inhibiting compound comprising administering an IAP inhibitor compound to a patient/and measuring IL1B, Lymphotoxin alpha (LTa), TWEAK, LIGHT, Fas, TNF alpha or TRAIL levels.

Abstract translation: 一种预测哪些患者将对IAP抑制化合物作出反应的方法，包括向患者施用IAP抑制剂化合物并测量IL1B，Lymphotoxinα（LTa），TWEAK，LIGHT，Fas，TNFα或TRAIL水平。