摘要:
Compounds of the general formula (I): wherein the variables are as defined in the specification are useful for the prophylaxis or treatment of serotonin-related, especially 5-HT2 receptor-related, diseases in human beings or animals, particularly diseases related to the 5-HT2c receptor, especially diseases such as eating disorders, memory disorders, schizophrenia, mood disorders, anxiety disorders, pain, sexual dysfunctionions, and urinary disorders.
摘要:
A method, in a base station subsystem (10), of allocating radio resources to mobile stations (20) in a wireless communication system (1) involves the base station subsystem (10) assigning a respective Temporary Block Flow (TBF) to each mobile station (20) in a cell (40) in the communication system (1), and then assigning to each TBF a Temporary Flow Identity (TFI), at least one Packet Data Channel (PDCH), and an Uplink State Flag (USF) if the TBF is an uplink TBF. The base station subsystem (10) then selects different training sequences from a plurality of available training sequences and assigns a respective different selected training sequence to two or more TBFs wherein these two or more TBFs share the same assigned Temporary Flow Identity (TFI), the same assigned Packet Data Channel (PDCH), and/or the same assigned Uplink State Flag (USF) if the TBF is an uplink TBF.
摘要:
There is provided a process for the preparation of a compound of formula I, wherein X, R1, R2a, R2b, R2c, R2d, R2e, R3a, R3b, R3c, R3d and R3e are as described in the description. Such compounds may, for example, be useful medicament (or intermediates for medicaments).
摘要:
Methods are provided for the prevention, treatment and diagnosis of Alzheimer's disease, based on the glycosylation pattern of amyloid-beta peptides in body fluids and tissues.
摘要:
There is provided a process for the preparation of a compound of formula I, wherein X, R1, R2a, R2b, R2c, R2d, R2e, R3a, R3b, R3c, R3d and R3e are as described in the description. Such compounds may, for example, be useful medicament (or intermediates for medicaments).
摘要:
The invention relates to compounds of the general formula (I): wherein Ar is optionally substituted aryl or heteroaryl; A is (i) —O—, —S—, —SO2—, —NH—, (ii) a C1-4-alkyl- or C1-6-acyl-substituted nitrogen atom or (iii) a C1-8-alkylene chain or a heteroalkylene chain having 2 to 8 chain atoms, which optionally contains at least one unsaturation, and which may be substituted and/or contain a bridge to form a saturated or partially or fully unsaturated ring having 3-8 ring members; B is —C(R4)(R5)—, —OC(R4)(R5)—, —N(R6)C(R4)(R5)—, —N(R6)—, —O—, —S— or —SO2—; R is optionally substituted C3-8-cycloalkyl, aryl or heteroaryl; R1 is (i) a saturated or unsaturated azacyclic or aminoazacyclic ring, or a saturated diazacyclic or aminodiazacyclic ring, which has 4 to 7 ring members, or a saturated aminoazabicyclic, azabicyclic or diazabicyclic ring which has 7 to 10 ring members, which rings optionally are substituted in one or more positions, or a group —[C(R4)(R5)]xN(R2a)(R3a)]; R2a, R3a, R4, R5, R6 and x are as defined in the claims, and n is 0 or 1; and pharmaceutically acceptable salts, hydrates and prodrug forms thereof. The compounds may be prepared by per se conventional methods and can be used for treating a human or animal subject suffering from a serotonin-related disorder, such as eating disorders, especially obesity, memory disorders, schizophrenia, mood disorders, anxiety disorders, pain, sexual dysfunctions, and urinary disorders The invention also relates to such use as well as to pharmaceutical compositions comprising a compound of formula (I).
摘要:
The present invention relates to compounds of the formula (I): including pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers, and N-oxides thereof, said compounds being useful as inhibitors of stearoyl-CoA desaturase (SCD). The invention further relates to the use of compounds of the formula (I) for treatment of medical conditions in which the modulation of SCD activity is beneficial, such as cardiovascular diseases, obesity, non-insulin-dependent diabetes mellitus, hypertension, neurological diseases, immune disorders, cancer, essential fatty acid deficiency, acne, psoriasis, rosacea or other skin conditions.
摘要:
A filling assembly for filling of a tube of packaging material having a seal starting at a first level, comprises a conduit arranged to lead liquid into the tube of packaging material below said first level and a passage arranged to eject gas through openings into the tube of packaging material below said first level. The filling assembly is characterized in that a gasket is arranged to provide a seal between said filling assembly and said tube of packaging material upstream said openings such that the overpressure P1 downstream the gasket may exceed an ambient pressure Pa upstream the gasket.
摘要:
A method, in a base station subsystem (10), of allocating radio resources to mobile stations (20) in a wireless communication system (1) involves the base station subsystem (10) assigning a respective Temporary Block Flow (TBF) to each mobile station (20) in a cell (40) in the communication system (1), and then assigning to each TBF a Temporary Flow Identity (TFI), at least one Packet Data Channel (PDCH), and an Uplink State Flag (USF) if the TBF is an uplink TBF. The base station subsystem (10) then selects different training sequences from a plurality of available training sequences and assigns a respective different selected training sequence to two or more TBFs wherein these two or more TBFs share the same assigned Temporary Flow Identity (TFI), the same assigned Packet Data Channel (PDCH), and/or the same assigned Uplink State Flag (USF) if the TBF is an uplink TBF.
摘要:
Methods are provided for the prevention, treatment and diagnosis of Alzheimer's disease, based on the glycosylation pattern of amyloid-beta peptides in body fluids and tissues.