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公开(公告)号：US5362475A
公开(公告)日：1994-11-08
申请号：US911800
申请日：1992-07-10
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28 , A61B5/055
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more Gadolinium ions and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译： 诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸和一种或多种钆离子的阴离子，以及任选的一种或多种无机和/或有机碱或氨基酸的生理学生物相容性阳离子或阳离子，任选地 具有常用于盖仑制剂中的添加剂，溶于或悬浮于水性介质中。
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12.发明授权DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production 失效DTPA单酰胺，含这些化合物的药剂，它们的用途和制备方法公开(公告)号：US06565830B1
公开(公告)日：2003-05-20
申请号：US09523310
申请日：2000-03-10
申请人： Heinz Gries , Erich Klieger , Bernd Radüchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jürgen Conrad
发明人： Heinz Gries , Erich Klieger , Bernd Radüchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jürgen Conrad
IPC分类号： A61B5055
CPC分类号： C07F5/003 , A61K49/06 , C07C237/04 , C07C237/12 , C07F15/025 , Y10S514/836
摘要： Compounds of formula I wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as susceptibility reagents for use in susceptibility imaging.
摘要翻译： 式Z1中Z 1，Z 2，X，R 2和R 3的化合物如本文所定义，适用于用于敏感性成像的易感性试剂。
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13.发明授权DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production 失效DTPA单酰胺，含这些化合物的药剂，它们的用途和制备方法
公开(公告)号：US5859214A
公开(公告)日：1999-01-12
申请号：US228524
申请日：1994-04-15
申请人： Heinz Gries , Erich Klieger , Bernd Raduchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jurgen Conrad
发明人： Heinz Gries , Erich Klieger , Bernd Raduchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jurgen Conrad
IPC分类号： A61K49/00 , A61K49/04 , A61K49/06 , C07C237/04 , C07C237/06 , C07C237/12 , C07C309/15 , C07C309/51 , C07C323/41 , C07C323/42 , C07D265/32 , C07F5/00 , C07F15/02 , C07F3/00 , A61B5/055 , A61K3/28
CPC分类号： C07F5/003 , A61K49/06 , C07C237/04 , C07C237/12 , C07F15/025 , Y10S514/836
摘要： Compounds of general formula I ##STR1## wherein Z.sup.1, Z.sup.2, X, R.sup.2 and R.sup.3 are as herein defined, are valuable pharmaceutical agents. In particular, the compounds are useful as contrast agents in NMR diagnosis.
摘要翻译： 其中Z1，Z2，X，R2和R3如本文所定义的通式I的化合物（I）是有价值的药剂。 特别地，该化合物可用作NMR诊断中的造影剂。
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公开(公告)号：US5843399A
公开(公告)日：1998-12-01
申请号：US484317
申请日：1995-06-07
申请人： Heinz Gries , Erich Klieger , Bernd Raduchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jurgen Conrad
发明人： Heinz Gries , Erich Klieger , Bernd Raduchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jurgen Conrad
IPC分类号： A61K49/06 , C07C237/04 , C07C237/12 , C07F5/00 , C07F15/02 , A61B5/055 , A61K49/04
CPC分类号： C07C237/04 , A61K49/06 , C07C237/12 , C07F15/025 , C07F5/003 , Y10S514/836
摘要： Chelate compounds of general formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and Z.sup.1, Z.sup.2, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein, as well as their salts with inorganic and/or organic bases, amino acids or amino acid amides, are valuable pharmaceutical agents, e.g., for NMR imaging.
摘要翻译： 通式I的螯合物化合物（I）其中X是原子序数21-29,31,32,37-40,42-44,49或57的元素的氢原子和/或金属离子当量 -83和Z1，Z2，R1，R2，R3和R4如本文所定义，以及它们与无机和/或有机碱，氨基酸或氨基酸酰胺的盐是有价值的药剂，例如用于NMR成像 。
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15.发明授权DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production 失效DTPA单酰胺，含这些化合物的药剂，它们的用途和制备方法公开(公告)号：US06287538B1
公开(公告)日：2001-09-11
申请号：US09066674
申请日：1998-04-28
申请人： Heinz Gries , Erich Klieger , Bernd Radüchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jürgen Conrad
发明人： Heinz Gries , Erich Klieger , Bernd Radüchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jürgen Conrad
IPC分类号： A61K4904
CPC分类号： C07F5/003 , A61K49/06 , C07C237/04 , C07C237/12 , C07F15/025 , Y10S514/836
摘要： Chelate compounds of general formula I wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and Z1, Z2, R1, R2, R3 and R4 are as defined herein, as well as their salts with inorganic and/or organic bases, amino acids or amino acid amides, are valuable pharmaceutical agents, e.g., for NMR imaging.
摘要翻译： 通式I的螯合物，其中X是氢原子和/或等价于原子序数21-29,31,32,37-40,42-44,49或57-83，Z1，Z2，R1的元素的金属离子 ，R2，R3和R4如本文所定义，以及它们与无机和/或有机碱，氨基酸或氨基酸酰胺的盐是有价值的药剂，例如用于NMR成像。
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公开(公告)号：US07083516B2
公开(公告)日：2006-08-01
申请号：US10890522
申请日：2004-07-14
IPC分类号： C07C51/255
CPC分类号： C07C51/285 , C07C63/38
摘要： A new process for the production of triiodotrimesic acid that is used as an intermediate product for the synthesis of x-ray contrast media is described.
摘要翻译： 描述了用作生产用于合成X射线造影剂的中间产物的三碘三次风酸的新方法。
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17.发明授权Nitroxyl compound and diagnostic media based thereon useful for enhancing NMR imaging 失效硝基化合物和基于其可用于增强NMR成像的诊断介质
公开(公告)号：US4845090A
公开(公告)日：1989-07-04
申请号：US779760
申请日：1985-09-24
IPC分类号： A61K49/00 , A61K49/20 , A61K51/00 , C07D207/16 , C07D207/22 , C07D207/46 , C07D211/94 , C07D405/12 , G01N33/532 , G01N33/60
CPC分类号： C07D405/12 , A61K49/20 , C07D207/16 , C07D207/22 , C07D207/46 , C07D211/94 , G01N33/532 , G01N33/60 , Y10T436/24
摘要： Diagnostic media suitable for NMR diagnoses contain compounds of Formula I ##STR1## wherein is a single bond or a double bond, X is the grouping --(CH.sub.2).sub.n -- or, if is a single bond, also the grouping --NHCO(CH.sub.2).sub.n -- wherein n means 0 to 4,m means the numbers 0, 1, or 2,R.sub.1 is an alkyl residue substituted by hydroxy groups, acyloxy groups and/or alkylidenedioxy groups,R.sub.2 has the same meanings as R.sub.1 or is a hydrogen atom or an alkyl residue,R.sub.3 and R.sub.4 are alkyl residues, andR.sub.5 and R.sub.6 are alkyl residues optionally substituted by hydroxy groups.
摘要翻译： 适用于NMR诊断的诊断介质含有式I化合物（I）其中单键或双键，X是分组 - （CH 2）n - ，或者如果是单键，也是分组-NHCO （CH2）n-，其中n表示0至4，m表示数字0,1或2，R1表示被羟基，酰氧基和/或亚烷基二氧基取代的烷基，R2表示与R1相同的含义或 氢原子或烷基残基，R 3和R 4是烷基，R 5和R 6是任选被羟基取代的烷基。
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18.发明授权
公开(公告)号：US4328202A
公开(公告)日：1982-05-04
申请号：US223634
申请日：1981-01-09
申请人： Heinz Gries , Heinrich Pfeiffer , Ulrich Speck , Wolfgang Muetzel
发明人： Heinz Gries , Heinrich Pfeiffer , Ulrich Speck , Wolfgang Muetzel
IPC分类号： C07C69/80 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/235 , A61K31/24 , A61K49/04 , C07C20060101 , C07C55/00 , C07C61/00 , C07C63/08 , C07C63/10 , C07C63/30 , C07C63/307 , C07C63/68 , C07C67/00 , C07C69/76 , C07C231/00 , C07C233/47 , C07C233/65 , C07C233/69 , C07C233/92 , C07C235/42 , C07C237/30 , C07C237/46 , C07F13/00
CPC分类号： C07C233/92 , C07C233/65 , C07C233/69 , C07C237/42 , Y10S430/168
摘要： Ionic compounds of the formula ##STR1## wherein X is --CONR.sub.1 R.sub.2, --CH.sub.2 NH.multidot.Acyl or --CH.sub.2 OH; Y is --NR.sub.3 R.sub.4, --NH.multidot.Acyl or OR.sub.5 ; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 can be identical or different, and each is hydrogen, C.sub.1-6 - alkyl or C.sub.2-8 -alkyl substituted by 1-5 OH groups and/or by one C.sub.1-3 -alkoxy group, R.sub.5 is C.sub.1-6 alkyl or C.sub.2-8 -alkyl substituted by 1-5 OH groups and/or by one C.sub.1-3 -alkoxy group, and Acyl, which can be the same or different in X and Y, is C.sub.2-6 -alkanoyl or C.sub.2-6 -alkanoyl substituted by 1-4 OH groups and/or by one C.sub.1-3 -alkoxy group, or a physiologically compatible salt thereof with an inorganic or organic base, have valuable properties as X-ray contrast agents.
摘要翻译： 式（I）的离子化合物，其中X是-CONR1R2，-CH2NHxAc或-CH2OH; Y是-NR 3 R 4，-NH x Acyl或OR 5; R 1，R 2，R 3和R 4可以相同或不同，各自为氢，被1-5个OH基团取代的C 1-6 - 烷基或C 2-8 - 烷基和/或被一个C 1-3 - 烷氧基取代，R 5是 C 1-6烷基或被1-5个OH基团和/或一个C 1-3 - 烷氧基取代的C 2-8 - 烷基，X和Y可以相同或不同的酰基是C 2-6 - 烷酰基 或被1-4个OH基团和/或一个C 1-3 - 烷氧基取代的C 2-6 - 烷酰基或其与无机或有机碱的生理上相容的盐具有作为X射线造影剂的有价值的性质。
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公开(公告)号：US5210290A
公开(公告)日：1993-05-11
申请号：US667309
申请日：1991-03-12
IPC分类号： A61K49/00 , A61K31/18 , C07C311/08 , C07C311/13 , C07C311/21
CPC分类号： C07C311/21 , C07C311/08 , C07C311/13
摘要： Fluorobenzenensulfonamides of Formula I ##STR1## wherein m means the number 0, 1, 2, 3, or 4,n means the number 0 or 1, andY means the residue of an aminocarboxylic or aminosulfonic acid,with the proviso that m and n are not to stand simultaneously for the number 0 and, if desired, the acid groups are present in the form of their amides or in the form of salts with organic or inorganic bases, are suitable for use as NMR diagnostic aids.
摘要翻译： 式I的氟苯磺酰胺其中m表示数0,1,2,3或4，n表示数字0或1，Y表示氨基羧酸或氨基磺酸的残基，条件是 m和n不能同时存在0号，如果需要，酸基以其酰胺的形式存在，或以有机或无机碱的盐形式存在，适合用作NMR诊断助剂。
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20.发明授权2-Amino-1-(1,2-dioxolan-4-yl)ethanol compounds, their preparation and use 失效2-氨基-1-（1,2-二氧戊环-4-基）乙醇化合物，其制备和用途
公开(公告)号：US4570007A
公开(公告)日：1986-02-11
申请号：US722088
申请日：1985-04-11
申请人： Ulrich Niedballa , Heinz Gries
发明人： Ulrich Niedballa , Heinz Gries
IPC分类号： C07C233/00 , C07C237/46 , C07D317/28 , C07D317/34 , C07D317/72 , C07D317/00
CPC分类号： C07C247/00 , C07D317/28 , C07D317/34
摘要： 2-Amino-1-(1,3-dioxolan-4-yl)ethanol compounds of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are identical or different and can be hydrogen or a lower alkyl group of 1-4 carbon atoms; or when R.sup.2 is an alkyl group of 1-4 carbon atoms, R.sup.1 can also be an alkoxy group of 1-4 carbon atoms; or R.sup.1 and R.sup.2 combined form an alkylene residue of 5 or 6 carbon atoms,are especially suited as intermediates in the production of opacifying compounds useful in X-ray contrast media.
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