公开(公告)号：US10881676B2

公开(公告)日：2021-01-05

申请号：US16396067

申请日：2019-04-26

Applicant: KALEIDO BIOSCIENCES, INC.

Inventor： Geoffrey A. von Maltzahn ,  Jared Silverman ,  Yvonne J. Yamanaka ,  John Miles Milwid ,  John M. Geremia

IPC: A61K31/702 ,  A61K35/741 ,  A61K31/7016 ,  A61K31/7004 ,  A23P10/00 ,  A23L33/10 ,  A61P1/00 ,  A61K31/733 ,  A61K31/716 ,  A61K45/06 ,  A61K31/09 ,  A61K31/11 ,  A61K31/12 ,  A61K31/165 ,  A61K31/34 ,  A61K31/353 ,  A61K31/365 ,  A61K31/366 ,  A61K31/7034 ,  A61K31/7048 ,  A61K31/706 ,  A61K31/715 ,  A61K35/00

Abstract: Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.

公开(公告)号：US09492473B2

公开(公告)日：2016-11-15

申请号：US15017396

申请日：2016-02-05

Applicant: KALEIDO BIOSCIENCES, INC.

Inventor： Geoffrey A. von Maltzahn ,  Jared Silverman ,  Yvonne J. Yamanaka ,  John Miles Milwid ,  John M. Geremia

IPC: A61K31/716 ,  A61K31/715 ,  A61K31/7048 ,  A61K31/12 ,  A61K31/7034 ,  A61K31/353 ,  A61K31/09 ,  A61K31/34 ,  A61K31/365 ,  A61K31/11 ,  A61K31/366 ,  A61K31/706 ,  A61K31/165 ,  A61K35/00

CPC classification number: A61K31/716 ,  A61K31/09 ,  A61K31/11 ,  A61K31/12 ,  A61K31/165 ,  A61K31/34 ,  A61K31/353 ,  A61K31/365 ,  A61K31/366 ,  A61K31/7034 ,  A61K31/7048 ,  A61K31/706 ,  A61K31/715 ,  A61K2035/115

Abstract: Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said glycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.

Abstract translation: 提供了聚糖治疗剂，其药物组合物和医药食品，任选地包含微量营养素，多酚，益生元，益生菌或其它药剂的制备方法及其制备方法。 还提供了使用所述聚糖治疗剂的方法，例如， 用于调节人类胃肠道微生物群并治疗生殖器发育不良。

公开(公告)号：US20220395521A1

公开(公告)日：2022-12-15

申请号：US17579067

申请日：2022-01-19

Applicant: Kaleido Biosciences, Inc.

Inventor： Geoffrey A. von Maltzahn ,  John M. Geremia

IPC: A61K31/7004 ,  A61K45/06 ,  A61K31/19 ,  A61K31/197 ,  A61K31/198 ,  A61K31/192 ,  A61K31/733 ,  A61K31/702 ,  A61K31/716 ,  A61K9/00 ,  A61K31/047 ,  A61K31/7016 ,  A61K35/741 ,  C12Q1/10

Abstract: Compositions comprising microbiome regulators are provided, as well as methods of using the same for the modulation of the human microbiota and to treat or prevent related diseases, disorders, or conditions.

公开(公告)号：US20210113596A1

公开(公告)日：2021-04-22

申请号：US16883107

申请日：2020-05-26

Applicant: KALEIDO BIOSCIENCES, INC.

Inventor： Geoffrey A. von Maltzahn ,  Jared Silverman ,  Yvonne J. Yamanaka ,  John Miles Milwid ,  John M. Geremia

IPC: A61K31/702 ,  A61K45/06 ,  A61K31/716 ,  A61K31/733 ,  A61P1/00 ,  A61K31/09 ,  A61K31/11 ,  A61K31/12 ,  A61K31/165 ,  A61K31/34 ,  A61K31/353 ,  A61K31/365 ,  A61K31/366 ,  A61K31/7034 ,  A61K31/7048 ,  A61K31/706 ,  A61K31/715 ,  A23L33/10 ,  A23P10/00 ,  A61K31/7004 ,  A61K31/7016 ,  A61K35/741

Abstract: Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.

公开(公告)号：US10314853B2

公开(公告)日：2019-06-11

申请号：US15624372

申请日：2017-06-15

Applicant: KALEIDO BIOSCIENCES, INC.

Inventor： Geoffrey A. von Maltzahn ,  Jared Silverman ,  Yvonne J. Yamanaka ,  John Miles Milwid ,  John M. Geremia

IPC: A61K31/702 ,  A61K31/716 ,  A23P10/00 ,  A61K45/06 ,  A61K35/741 ,  A23L33/10 ,  A61K31/7016 ,  A61K31/7004 ,  A61K31/733 ,  A61P1/00 ,  A61K35/00

Abstract: Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.

公开(公告)号：US20190091249A1

公开(公告)日：2019-03-28

申请号：US16140091

申请日：2018-09-24

Applicant: KALEIDO BIOSCIENCES, INC.

Inventor： Geoffrey A. von Maltzahn ,  Yvonne J. Yamanaka ,  Jared Silverman ,  John Miles Milwid ,  Jacob Rosenblum Rubens ,  John M. Geremia

IPC: A61K31/702 ,  A61K35/741 ,  A23L33/135 ,  A61P35/04 ,  A61P43/00 ,  A23L33/125 ,  A61P1/00 ,  A61K31/716 ,  A61K31/733 ,  A61P35/00 ,  A61K45/06 ,  A61P3/02

Abstract: Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said gycan therapeutics, e.g. in cancer therapy.

公开(公告)号：US20180296582A1

公开(公告)日：2018-10-18

申请号：US15568251

申请日：2016-04-23

Applicant: KALEIDO BIOSCIENCES, INC.

Inventor： Geoffrey A. von Maltzahn ,  John M. Geremia

IPC: A61K31/7004 ,  A61K9/00 ,  A61K35/741 ,  C12Q1/10 ,  A61K45/06 ,  A61K31/7016 ,  A61K31/047 ,  A61K31/19 ,  A61K31/198 ,  A61K31/197

Abstract: Compositions comprising microbiome regulators are provided, as well as methods of using the same for the modulation of the human microbiota and to treat or prevent related diseases, disorders, or conditions.

公开(公告)号：US20180147221A1

公开(公告)日：2018-05-31

申请号：US15568243

申请日：2016-04-23

Applicant: KALEIDO BIOSCIENCES, INC.

Inventor： Geoffrey A. von Maltzahn ,  Yvonne J. Yamanaka ,  Jared Silverman ,  Jack Milwid ,  Jacob R. Rubens ,  John M. Geremia

IPC: A61K31/702 ,  A61P43/00 ,  A61K35/741 ,  A61P35/00 ,  A61P1/00 ,  A61P3/02 ,  A61K45/06 ,  A61P35/04 ,  A23L33/125 ,  A23L33/135

CPC classification number: A61K31/702 ,  A23L33/125 ,  A23L33/135 ,  A23V2002/00 ,  A61K31/716 ,  A61K31/733 ,  A61K35/741 ,  A61K45/06 ,  A61P1/00 ,  A61P3/02 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00

Abstract: Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said gycan therapeutics, e.g. in cancer therapy.

公开(公告)号：US20210401861A1

公开(公告)日：2021-12-30

申请号：US17363597

申请日：2021-06-30

Applicant: Kaleido Biosciences, Inc.

Inventor： Geoffrey A. von Maltzahn ,  Yvonne J. Yamanaka ,  Jared Silverman ,  John Miles Milwid ,  Jacob Rosenblum Rubens ,  John M. Geremia

IPC: A61K31/702 ,  A61K45/06 ,  A61K31/716 ,  A61K31/733 ,  A23L33/125 ,  A23L33/135 ,  A61P3/02 ,  A61P43/00 ,  A61P1/00 ,  A61P35/04 ,  A61P35/00 ,  A61K35/741

Abstract: Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said glycan therapeutics, e.g. in cancer therapy.

公开(公告)号：US20210198302A1

公开(公告)日：2021-07-01

申请号：US17269721

申请日：2019-08-21

Applicant: Kaleido Biosciences, Inc.

Inventor： Christopher Matthew Liu ,  John M. Geremia ,  Anastasia Lioubomirov ,  Max Hecht

IPC: C07H3/06 ,  C08L5/00 ,  A61P3/00 ,  A23L33/21 ,  A23L33/125 ,  A23L33/00

Abstract: Aspects of the disclosure relate to oligosaccharide compositions and methods of making the same. Also provided are methods of using oligosaccharide compositions as microbiome metabolic therapies for reducing ammonia levels and for the treatment of hyperammonemia-related diseases (e.g., urea cycle disorders and hepatic encephalopathy).