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16 条记录 (耗时 0.021 秒)

    COMPOSITION CONTAINING 2-ACYL-LYSOPHOSPHATIDYLSERINE AND METHOD FOR PRODUCING THE SAME
    12.
    发明申请
    COMPOSITION CONTAINING 2-ACYL-LYSOPHOSPHATIDYLSERINE AND METHOD FOR PRODUCING THE SAME 有权
    含有2-乙酰基赖氨酸磷脂酰胆碱的组合物及其生产方法

    公开(公告)号：US20130281404A1

    公开(公告)日：2013-10-24

    申请号：US13824518

    申请日：2011-09-26

    申请人： Kazunaga Yazawa ,  Tomoyuki Susa ,  Shoji Gotoh ,  Yasuhito Tashiro ,  Junichi Kawashima ,  Shigeyuki Imamura

    发明人： Kazunaga Yazawa ,  Tomoyuki Susa ,  Shoji Gotoh ,  Yasuhito Tashiro ,  Junichi Kawashima ,  Shigeyuki Imamura

    IPC分类号： C12P13/06 ,  A61K31/685

    CPC分类号： C12P13/06 ,  A61K31/685 ,  C12P7/6481

    摘要： The present invention provides a method for producing a composition containing 2-acyl-lysophosphatidylserine, including (a) a step of obtaining a composition containing phosphatidylserine by allowing phospholipase D to act on a raw material containing phosphatidylcholine in the presence of serine and (b) a step of obtaining a composition containing 2-acyl-lysophosphatidylserine by allowing phospholipase A1 to act on the composition containing phosphatidylserine in the presence of one or more additives selected from the group consisting of the following (I), (II), and (III), in which (I) one or more salts selected from the group consisting of sulfate salts, phosphate salts, nitrate salts, citrate salts, and tartarate salts of monovalent cations, (II) a gum, and (III) an emulsifier.

    摘要翻译： 本发明提供一种含有2-酰基 - 溶血磷脂酰丝氨酸的组合物的制造方法，其包括（a）在丝氨酸存在下使磷脂酶D作用于含有磷脂酰胆碱的原料，得到含有磷脂酰丝氨酸的组合物的工序，（b） 在一种或多种选自以下（I），（II）和（III）中的添加剂的存在下，通过使磷脂酶A1作用于含有磷脂酰丝氨酸的组合物，获得含有2-酰基 - 溶血磷脂酰丝氨酸的组合物的步骤 ），其中（I）选自一价阳离子的硫酸盐，磷酸盐，硝酸盐，柠檬酸盐和酒石酸盐中的一种或多种盐，（II）树胶和（III）乳化剂。

    Hypocholesterolemically and/or hypotriglyceridemically active RNA fractions
    14.
    发明授权
    Hypocholesterolemically and/or hypotriglyceridemically active RNA fractions 失效
    低胆固醇血症和/或甘油三酯血症活性RNA级分

    公开(公告)号：US4833129A

    公开(公告)日：1989-05-23

    申请号：US877125

    申请日：1986-06-23

    申请人： Yasuo Kawai ,  Kazunaga Yazawa

    发明人： Yasuo Kawai ,  Kazunaga Yazawa

    IPC分类号： C07H21/02 ,  A61K31/70 ,  A61P3/06 ,  A61P9/10 ,  C12P19/34

    CPC分类号： A61K31/70 ,  C12P19/34

    摘要： Hypocholesterolemically and/or hypotriglyceridemically active RNA fractions having the following characteristics:(a) Molecular weight by gel filtration: 2,000.+-.1,000(b) Base composition ratio of nucleic acid: uracil: guanine: cytosine: adenine=13.0: 16.0: 16.0: 10.0(c) Infrared absorption sepctrum: shown in FIG. 2(d) Physiological characteristics: having a hypocholesterolemic and/or hypotriglyceridemic activity in mammals.These hypocholesterolemically and/or hypotriglyceridemically active RNA fractions can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypocholesterolemically and/or hypotriglyceridemically active RNA fractions from the cultured cells of the microorganism. These hypocholesterolemically and/or hypotriglyceridemically active RNA fractions can be used as an active ingredient of a hypocholesterolemic or hypotriglyceridemic pharmaceutical composition together with a pharmaceutically acceptable carrier therefor to form a hypocholesterolemic or hypotriglyceridemic pharmaceutical composition, which is suitable for oral administration to mammals.

    摘要翻译： 具有以下特征的低胆固醇血症和/或甘油三酯血症活性RNA级分：（a）通过凝胶过滤的分子量：2,000 +/- 1,000（b）核酸的基本组成比：尿嘧啶：鸟嘌呤：胞嘧啶：腺嘌呤= 13.0：16.0：16.0 ：10.0（c）红外吸收分隔值： 2（d）生理特征：哺乳动物具有低胆固醇血症和/或甘油三酯血症活性。 这些低胆固醇血症和/或甘油三酯血症活性RNA级分可以通过在适当的培养基中培养属于链球菌属的微生物来制备; 并从微生物的培养细胞中收集低胆固醇和/或低甘油三酯活性的RNA级分。 这些低胆固醇血症和/或低甘油三酯血症活性的RNA级分可以用作低胆固醇血症或低甘油三酯血症药物组合物的活性成分以及其药学上可接受的载体，以形成适合于向哺乳动物口服给药的低胆固醇血症或低甘油三酯血症药物组合物。

    Hypotriglyceridemically active polysaccharides
    15.
    发明授权
    Hypotriglyceridemically active polysaccharides 失效
    低甘油三酯活性多糖

    公开(公告)号：US4687764A

    公开(公告)日：1987-08-18

    申请号：US632844

    申请日：1984-07-20

    申请人： Yasuo Kawai ,  Kazunaga Yazawa

    发明人： Yasuo Kawai ,  Kazunaga Yazawa

    IPC分类号： C12P19/00 ,  A61K31/715 ,  A61K35/74 ,  A61P1/16 ,  A61P3/06 ,  A61P3/08 ,  A61P9/10 ,  A61P9/12 ,  C08B37/00 ,  C12P1/04 ,  C12P19/04 ,  C12R1/46 ,  A61K31/71 ,  C07H1/00

    CPC分类号： A61K31/715 ,  C08B37/00 ,  C12P19/04

    摘要： A hypotriglyceridemically active polysaccharide having the following characteristics:(a) Specific rotatory power:[.alpha.].sub.D.sup.29 =+190.1(1.8 w/v % solution)(b) Molecular weight by gel filtration:14,000.+-.3,000(c) Sugar composition (weight percent by gas chromatography)glucose: 70.3rhamnose: 13.7uronic acid: 16.0(d) Acid-base characteristic:neutral polysaccharides(e) Physiological characteristics:capable of reducing the blood triglyceride in mammals.This hypotriglyceridemically active polysaccharide can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypotriglyceridemically active polysaccharide from the cultured cells of the microorganism and/or the supernatant of the culture broth. The present hypotriglyceridemically active polysaccharide can be used as an active ingredient of a hypotriglyceridemic or antiatherosclerotic pharmaceutical composition together with a pharmaceutically acceptable carrier therefor to form a hypotriglyceridemic or antiatherosclerotic pharmaceutical composition, which is suitable for oral administration to mammals.

    摘要翻译： 具有以下特征的低甘油三酯活性多糖：（a）比旋光度：αD29 = + 190.1（1.8w / v％溶液）（b）通过凝胶过滤的分子量：14,000 +/- 3,000（c）糖组成 （气相色谱法的重量百分比）葡萄糖：70.3鼠李糖：13.7糖醛酸：16.0（d）酸碱特征：中性多糖（e）生理特征：能够减少哺乳动物中的血液甘油三酯。 这种甘油三酯活性多糖可以通过在适当的培养基中培养属于链球菌属的微生物来制备; 并从培养液的培养细胞和/或培养液的上清液中收集甘油三酯活性多糖。 本发明的甘油三酯活性多糖可以作为低甘油三酯血症或抗动脉粥样硬化药物组合物的活性成分与药学上可接受的载体一起使用，以形成适用于哺乳动物的口服给药的低血甘油三酯或抗动脉粥样硬化药物组合物。