Hypocholesterolemically and/or hypotriglyceridemically active RNA
fractions
    3.
    发明授权
    Hypocholesterolemically and/or hypotriglyceridemically active RNA fractions 失效
    低胆固醇血症和/或甘油三酯血症活性RNA级分

    公开(公告)号:US4833129A

    公开(公告)日:1989-05-23

    申请号:US877125

    申请日:1986-06-23

    CPC分类号: A61K31/70 C12P19/34

    摘要: Hypocholesterolemically and/or hypotriglyceridemically active RNA fractions having the following characteristics:(a) Molecular weight by gel filtration: 2,000.+-.1,000(b) Base composition ratio of nucleic acid: uracil: guanine: cytosine: adenine=13.0: 16.0: 16.0: 10.0(c) Infrared absorption sepctrum: shown in FIG. 2(d) Physiological characteristics: having a hypocholesterolemic and/or hypotriglyceridemic activity in mammals.These hypocholesterolemically and/or hypotriglyceridemically active RNA fractions can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypocholesterolemically and/or hypotriglyceridemically active RNA fractions from the cultured cells of the microorganism. These hypocholesterolemically and/or hypotriglyceridemically active RNA fractions can be used as an active ingredient of a hypocholesterolemic or hypotriglyceridemic pharmaceutical composition together with a pharmaceutically acceptable carrier therefor to form a hypocholesterolemic or hypotriglyceridemic pharmaceutical composition, which is suitable for oral administration to mammals.

    摘要翻译: 具有以下特征的低胆固醇血症和/或甘油三酯血症活性RNA级分:(a)通过凝胶过滤的分子量:2,000 +/- 1,000(b)核酸的基本组成比:尿嘧啶:鸟嘌呤:胞嘧啶:腺嘌呤= 13.0:16.0:16.0 :10.0(c)红外吸收分隔值: 2(d)生理特征:哺乳动物具有低胆固醇血症和/或甘油三酯血症活性。 这些低胆固醇血症和/或甘油三酯血症活性RNA级分可以通过在适当的培养基中培养属于链球菌属的微生物来制备; 并从微生物的培养细胞中收集低胆固醇和/或低甘油三酯活性的RNA级分。 这些低胆固醇血症和/或低甘油三酯血症活性的RNA级分可以用作低胆固醇血症或低甘油三酯血症药物组合物的活性成分以及其药学上可接受的载体,以形成适合于向哺乳动物口服给药的低胆固醇血症或低甘油三酯血症药物组合物。

    Intestinal microflora-improving agent
    4.
    发明授权
    Intestinal microflora-improving agent 失效
    肠道微生物群落改良剂

    公开(公告)号:US4710379A

    公开(公告)日:1987-12-01

    申请号:US938348

    申请日:1986-12-04

    IPC分类号: A61K35/74 A61K35/78

    CPC分类号: A61K35/744

    摘要: An intestinal microflora-improving agent containing, as an effective component, bacterial cells and/or the water-soluble extracts therefrom, obtained from microorganisms belonging to the genus Streptococcus.

    摘要翻译: 从属于链球菌属的微生物获得的含有作为有效成分的细菌细胞和/或其水溶性提取物的肠道微生物群落改良剂。

    Hypotriglyceridemically active polysaccharides
    5.
    发明授权
    Hypotriglyceridemically active polysaccharides 失效
    低甘油三酯活性多糖

    公开(公告)号:US4687764A

    公开(公告)日:1987-08-18

    申请号:US632844

    申请日:1984-07-20

    摘要: A hypotriglyceridemically active polysaccharide having the following characteristics:(a) Specific rotatory power:[.alpha.].sub.D.sup.29 =+190.1(1.8 w/v % solution)(b) Molecular weight by gel filtration:14,000.+-.3,000(c) Sugar composition (weight percent by gas chromatography)glucose: 70.3rhamnose: 13.7uronic acid: 16.0(d) Acid-base characteristic:neutral polysaccharides(e) Physiological characteristics:capable of reducing the blood triglyceride in mammals.This hypotriglyceridemically active polysaccharide can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypotriglyceridemically active polysaccharide from the cultured cells of the microorganism and/or the supernatant of the culture broth. The present hypotriglyceridemically active polysaccharide can be used as an active ingredient of a hypotriglyceridemic or antiatherosclerotic pharmaceutical composition together with a pharmaceutically acceptable carrier therefor to form a hypotriglyceridemic or antiatherosclerotic pharmaceutical composition, which is suitable for oral administration to mammals.

    摘要翻译: 具有以下特征的低甘油三酯活性多糖:(a)比旋光度:αD29 = + 190.1(1.8w / v%溶液)(b)通过凝胶过滤的分子量:14,000 +/- 3,000(c)糖组成 (气相色谱法的重量百分比)葡萄糖:70.3鼠李糖:13.7糖醛酸:16.0(d)酸碱特征:中性多糖(e)生理特征:能够减少哺乳动物中的血液甘油三酯。 这种甘油三酯活性多糖可以通过在适当的培养基中培养属于链球菌属的微生物来制备; 并从培养液的培养细胞和/或培养液的上清液中收集甘油三酯活性多糖。 本发明的甘油三酯活性多糖可以作为低甘油三酯血症或抗动脉粥样硬化药物组合物的活性成分与药学上可接受的载体一起使用,以形成适用于哺乳动物的口服给药的低血甘油三酯或抗动脉粥样硬化药物组合物。

    Separation method of goethite-containing red mud
    7.
    发明授权
    Separation method of goethite-containing red mud 有权
    含有针铁矿的红泥分离法

    公开(公告)号:US06669852B2

    公开(公告)日:2003-12-30

    申请号:US09984452

    申请日:2001-10-30

    IPC分类号: B01D2101

    摘要: In order to provide a method for effectively separating red mud generated during alumina-extraction treatment of an alumina ore containing goethite as an iron component, the alumina ore containing goethite as an iron component is treated with an alkaline solution at 110-160° C., to thereby take up alumina components through extraction, and a settling aid formed of a water-soluble polymer including, as an effective component, a copolymer containing, as a monomer component, a vinylhydroxamic acid compound or a salt thereof (A) and having an average molecular weight of at least 2,000 is added to the resultant extract, to thereby settle the red mud for separation thereof.

    摘要翻译: 为了提供一种有效分离作为铁成分的含有针铁矿的氧化铝矿石的氧化铝提取处理中产生的红泥的方法,将含有铁成分的铁精矿的氧化铝矿石用碱溶液在110-160℃下处理。 ,从而通过萃取吸收氧化铝组分,和由水溶性聚合物形成的沉淀助剂,其包括作为有效成分的含有作为单体组分的乙烯基异羟肟酸化合物或其盐(A)的共聚物,并且具有 向所得萃取液中加入至少2,000的平均分子量,由此沉淀红泥分离。

    Hypocholesterolemically active protein derived from streptococcus
    8.
    发明授权
    Hypocholesterolemically active protein derived from streptococcus 失效
    来自链球菌的低胆固醇血症活性蛋白

    公开(公告)号:US4812441A

    公开(公告)日:1989-03-14

    申请号:US827500

    申请日:1986-02-07

    摘要: A hypocholesterolemically active protein capable of reducing the blood cholesterol in mammals having the following characteristics:(a) Molecular weight by gel filtration: 30,000.+-.7,000(b) Isoelectric point: 7.9.+-.0.2(c) Amino acid composition (mole %):______________________________________ Glycine 25.23 Alanine 10.98 Glutamate 10.34 Asparaginate 8.20 Lysine 6.39 Leucine 5.58 Valine 5.41 Isoleucine 5.18 Threonine 4.23 Tyrosine 4.19 Serine 3.46 Proline 2.62 Arginine 2.60 Phenylalanine 2.51 Methionine 1.56 Histidine 1.30 Cysteine 0.16 ______________________________________ (d) Pattern of electrophoresis: a sharp band on the anode side on polyacrylamide gel electrophoresis. This hypocholesterolemically active protein is derived from a microorganism belonging to the genus Streptococcus.

    摘要翻译: 具有以下特征的能够降低哺乳动物血液胆固醇的降胆固醇活性蛋白质:(a)凝胶过滤分子量:30,000 +/- 7000(b)等电点:7.9 +/- 0.2(c)氨基酸组成 %): - 甘氨酸25.23丙氨酸10.98-谷氨酸盐10.34天冬酰胺酸盐8.20 -Lysine 6.39亮氨酸5.58-碱性5.41异亮氨酸5.18-苏氨酸4.23酪氨酸4.19-丝氨酸3.46脯氨酸2.62-精氨酸2.60苯丙氨酸2.51--乙硫醇1.56组氨酸1.30-半胱氨酸0.16 - (d) 电泳图案:在聚丙烯酰胺凝胶电泳上阳极侧的尖带。 该低胆固醇活性蛋白质来自属于链球菌属的微生物。

    X-ray exposure apparatus
    9.
    发明授权
    X-ray exposure apparatus 失效
    X射线曝光装置

    公开(公告)号:US5164974A

    公开(公告)日:1992-11-17

    申请号:US714353

    申请日:1991-06-12

    IPC分类号: G03F7/20

    CPC分类号: G03F7/70733 G03F7/70358

    摘要: An X-ray exposure apparatus wherein a member sensitive to X-ray is exposed to a pattern formed on a mask with the X-rays, includes an X-ray source for emitting X-rays, an irradiation chamber for accommodating the mask and the sensitive member and exposing them to the X-rays emitted by the X-ray source within the chamber and a vacuum pump for evacuating the chamber to effect the exposure operation in a vacuum.

    摘要翻译: 一种X射线曝光装置,其中对X射线敏感的部件暴露于用X射线形成在掩模上的图案,包括用于发射X射线的X射线源,用于容纳掩模的照射室和 将其暴露于室内由X射线源发射的X射线,以及真空泵,用于抽真空室以在真空中进行曝光操作。

    Aluminum hydroxide, process for preparation thereof and composition
    10.
    发明授权
    Aluminum hydroxide, process for preparation thereof and composition 失效
    氢氧化铝,其制备方法和组合物

    公开(公告)号:US5130113A

    公开(公告)日:1992-07-14

    申请号:US566474

    申请日:1990-08-22

    IPC分类号: C01F7/02 C04B14/30 C08K3/22

    摘要: Aluminum hydroxide having a particle size of 2 to 30 .mu.m and having small specific surface area and low resin filling viscosity can be prepared by using precipitated aluminum hydroxide composed of secondary agglomerated particles having a primary particle size almost equal to the desired average particle size of intended pulverized aluminum hydroxide as the starting material to be pulverized and pulverizing this starting aluminum hydroxide. This aluminum hydroxide has an average particle size of 2 to 30 .mu.m, a surface roughness coefficient Sr/Sc (in which Sr represents the specific surface area of particles measured by the nitrogen adsorption method and Sc represents the specific surface area calculated from the size of particles approximated to spheres while taking the particle size distribution of particles into consideration) smaller than 2.5 and a linseed oil absorption smaller than 30 cc/100 g as determined according to JIS K-5101.

    摘要翻译: PCT No.PCT / JP89 / 01123 Sec。 371日期1990年8月22日 102(e)日期1990年8月22日PCT提交1989年10月31日PCT公布。 出版物WO90 / 08737 日期为1990年8月9日。粒径为2〜30μm,比表面积小,树脂填充粘度低的氢氧化铝可以通过使用由初级粒径几乎相等的二次凝集粒子构成的沉淀氢氧化铝 达到期望的粉碎氢氧化铝的平均粒度,作为待粉碎的原料并粉碎该起始氢氧化铝。 该氢氧化铝的平均粒径为2〜30μm,表面粗糙度系数Sr / Sc(Sr表示通过氮吸附法测定的粒子的比表面积,Sc表示从尺寸计算出的比表面积 的颗粒接近球体,同时考虑到颗粒的粒度分布)小于2.5,亚麻子油吸收小于30cc / 100g,根据JIS K-5101测定。