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公开(公告)号：US5560933A
公开(公告)日：1996-10-01
申请号：US412726
申请日：1995-03-29
申请人： Patrick Soon-Shiong , Neil P. Desai , Mark W. Grinstaff , Paul A. Sandford , Kenneth S. Suslick
发明人： Patrick Soon-Shiong , Neil P. Desai , Mark W. Grinstaff , Paul A. Sandford , Kenneth S. Suslick
CPC分类号： A61K9/0026 , A23L33/40 , A61K47/48869 , A61K47/48876 , A61K49/0002 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug taxol) in which the pharmacologically active agent is delivered in a soluble form or in the form of suspended particles. In particular, the soluble form may comprise a solution of pharmacologically active agent in a biocompatible dispersing agent contained within a protein walled shell. Alternatively, the protein walled shell may contain particles of taxol. In another aspect, the suspended form comprises particles of pharmacologically active agent in a biocompatible aqueous liquid.
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公开(公告)号：US4010100A
公开(公告)日：1977-03-01
申请号：US619156
申请日：1975-10-03
申请人： Kenneth S. Suslick
发明人： Kenneth S. Suslick
摘要： An isotope separation method which comprises physically adsorbing an isotopically mixed molecular species on an adsorptive surface and irradiating the adsorbed molecules with radiation of a predetermined wavelength which will selectively excite a desired isotopic species. Sufficient energy is transferred to the excited molecules to desorb them from the surface and thereby separate them from the unexcited undesired isotopic species. The method is particularly applicable to the separation of hydrogen isotopes.
摘要翻译： 一种同位素分离方法，其包括在吸附表面上物理吸附同位素混合的分子物质，并用预定波长的辐射照射吸附的分子，该辐射将选择性地激发所需的同位素物质。 将足够的能量转移到激发的分子以将它们从表面解吸，从而将它们与未激发的不期望的同位素物质分离。 该方法特别适用于氢同位素的分离。
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公开(公告)号：US09880137B2
公开(公告)日：2018-01-30
申请号：US12552899
申请日：2009-09-02
CPC分类号： G01N31/22 , G01N21/253 , G01N21/78
摘要： A colorimetric array includes a substrate, a first spot on the substrate, and a second spot on the substrate. The first spot includes a first nanoporous pigment that includes a first nanoporous material and a first immobilized, chemoresponsive colorant. The second spot includes a second nanoporous pigment that includes a second nanoporous material and a second immobilized, chemoresponsive colorant. The first nanoporous pigment is different from the second nanoporous pigment.
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公开(公告)号：US20100166604A1
公开(公告)日：2010-07-01
申请号：US12552899
申请日：2009-09-02
CPC分类号： G01N31/22 , G01N21/253 , G01N21/78
摘要： A colorimetric array includes a substrate, a first spot on the substrate, and a second spot on the substrate. The first spot includes a first nanoporous pigment that includes a first nanoporous material and a first immobilized, chemoresponsive colorant. The second spot includes a second nanoporous pigment that includes a second nanoporous material and a second immobilized, chemoresponsive colorant. The first nanoporous pigment is different from the second nanoporous pigment.
摘要翻译： 比色阵列包括衬底，衬底上的第一点和衬底上的第二点。 第一点包括第一纳米多孔颜料，其包括第一纳米多孔材料和第一固定化学反应性着色剂。 第二点包括第二纳米多孔颜料，其包括第二纳米多孔材料和第二固定的化学响应着色剂。 第一纳米多孔颜料与第二纳米多孔颜料不同。
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公开(公告)号：US07217410B2
公开(公告)日：2007-05-15
申请号：US10463833
申请日：2003-06-17
CPC分类号： A61K49/001
摘要： A microparticle contains a cross-linked protein shell, and a surface coating.
摘要翻译： 微粒含有交联蛋白质壳和表面涂层。
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公开(公告)号：US07198777B2
公开(公告)日：2007-04-03
申请号：US10463835
申请日：2003-06-17
IPC分类号： A61K49/00
CPC分类号： A61K9/5089 , A61K9/1694 , A61K47/6925
摘要： A method of enhancing the contrast of an image of a sample, comprises forming an image of a mixture, by exposing the mixture to electromagnetic radiation. The mixture comprises the sample and microparticles. The enhancement is particularly suitable for optical coherence tomography.
摘要翻译： 提高样品图像的对比度的方法包括通过将混合物暴露于电磁辐射来形成混合物的图像。 混合物包含样品和微粒。 该增强特别适用于光学相干断层扫描。
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17.发明授权Polymeric shells for medical imaging prepared from synthetic polymers, and methods for the use thereof 失效由合成聚合物制备的用于医学成像的聚合物壳及其使用方法
公开(公告)号：US5512268A
公开(公告)日：1996-04-30
申请号：US486268
申请日：1995-06-06
申请人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
发明人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
IPC分类号： A61K9/00 , A61K9/50 , A61K9/51 , A61K47/48 , A61K49/18 , A61K49/22 , A61B5/055 , A61B8/13 , A61K49/04
CPC分类号： A61K49/223 , A61K47/48853 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1806 , A61K49/186 , A61K49/1863 , A61K49/1869 , A61K49/222 , Y10S436/806 , Y10T436/24
摘要： In accordance with the present invention, compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
摘要翻译： 根据本发明，提供了包含聚合物壳内的成像剂的组合物。 本发明组合物可用作例如磁共振成像（MRI），超声检查和X射线计算机断层摄影的造影剂。 聚合物外壳直径通常为约2微米。 因此，这些材料由于网状上游系统（RES）或单核吞噬细胞（MNP）系统在静脉注射后迅速清除而具有器官特异性。 此外，本发明的聚合物壳可用于测量和监测局部氧气和温度。 考虑用于本发明实践的示例性造影剂包括氟化合物。 氟化合物通常是疏水性的，因此具有有限的水溶性。 本发明方法允许以适于准备输送的生物相容形式制备这些化合物。
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18.发明授权Controlled chemical aerosol flow synthesis of nanometer-sized particles and other nanometer-sized products 失效纳米尺寸颗粒和其他纳米级产品的控制化学气溶胶流合成公开(公告)号：US07160489B2
公开(公告)日：2007-01-09
申请号：US10683948
申请日：2003-10-10
IPC分类号： B29B9/00
CPC分类号： C01B13/18 , B01J6/008 , B01J10/002 , B01J19/10 , B01J2219/00033 , B01J2219/0884 , B82Y30/00 , C01B17/20 , C01B19/007 , C01G11/02 , C01P2002/72 , C01P2002/84 , C01P2004/04 , C01P2004/10 , C01P2004/30 , C01P2004/64
摘要： A method and apparatus for producing nanometer-sized particles, the method including the steps of forming of mixture by mixing a first precursor reactant, a second precursor reactant, a surface-stabilizing surfactant, and a high boiling point liquid to form a mixture, forming a mist of droplets of the mixture, heating the droplets to cause a reaction between species of the first and second precursor reactants within the heated droplets, and collecting the nanometer-sized products.
摘要翻译： 一种制备纳米尺寸颗粒的方法和装置，所述方法包括以下步骤：通过混合第一前体反应物，第二前体反应物，表面稳定表面活性剂和高沸点液体形成混合物，形成混合物 混合物液滴的雾气，加热液滴以引起加热液滴内第一和第二前体反应物的种类之间的反应，并收集纳米级的产物。
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19.发明授权Colorimetric artificial nose having an array of dyes and method for artificial olfaction 有权比色仿真鼻具有一系列染料和人造嗅觉方法公开(公告)号：US06368558B1
公开(公告)日：2002-04-09
申请号：US09532125
申请日：2000-03-21
申请人： Kenneth S. Suslick , Neal A. Rakow
发明人： Kenneth S. Suslick , Neal A. Rakow
IPC分类号： G01N2100
CPC分类号： G01N21/272 , G01N21/78 , G01N31/22
摘要： The present invention involves an artificial nose having an array comprising at least a first dye and a second dye in combination and having a distinct spectral response to an analyte. In one embodiment, the first and second dyes are from the group comprising porphyrin, chlorin, chlorophyll, phthalocyanine, or salen. In a further embodiment, the first and second dyes are metalloporphyrins. The present invention is particularly useful in detecting metal ligating vapors. Further, the array of the present invention can be connected to a visual display device.
摘要翻译： 本发明涉及具有包含至少第一染料和第二染料并且对分析物具有不同光谱响应的阵列的人造鼻子。 在一个实施方案中，第一和第二染料来自包括卟啉，二氢卟酚，叶绿素，酞菁或salen的组。 在另一个实施方案中，第一和第二染料是金属卟啉。 本发明特别可用于检测金属结扎蒸汽。 此外，本发明的阵列可以连接到视觉显示装置。
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20.发明授权Methods for the preparation of pharmaceutically active agents for in vivo delivery 失效用于制备用于体内递送的药物活性剂的方法
公开(公告)号：US5665382A
公开(公告)日：1997-09-09
申请号：US485448
申请日：1995-06-07
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
CPC分类号： A61K47/48876 , A23L33/40 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/0026 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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