公开(公告)号：US10551293B2

公开(公告)日：2020-02-04

申请号：US15776584

申请日：2016-11-17

Applicant: Korea Advanced Institute of Science and Technology ,  The Wave Talk, Inc.

Inventor： YongKeun Park ,  JongHee Yoon ,  KyeoReh Lee ,  Young Dug Kim ,  Nam Kyun Kim

IPC: G01N15/06 ,  G01N33/483 ,  C12Q1/18 ,  G01N15/00

Abstract: Provided is a sample property detecting apparatus including: a wave source configured to irradiate a wave towards a sample; a detector configured to detect a laser speckle that is generated when the wave is multiple-scattered by the sample, at every time point that is set in advance; and a controller configured to obtain a temporal correlation that is a variation in the detected laser speckle according to time, and to detect properties of the sample in real-time based on the temporal correlation, wherein the detector detects the laser speckle between the sample and the detector or from a region in the detector.

公开(公告)号：US10036888B2

公开(公告)日：2018-07-31

申请号：US14579636

申请日：2014-12-22

Applicant: Korea Advanced Institute of Science and Technology

Inventor： YongKeun Park ,  Kyeo Reh Lee

IPC: G02B26/08 ,  G02F1/29 ,  H04B10/12 ,  G02B27/00 ,  G02B26/06 ,  H04B10/516 ,  H04B10/548 ,  H04B10/524 ,  H04B10/50 ,  G03H1/10 ,  H04B10/508 ,  G03H1/16

CPC classification number: G02B27/0012 ,  G02B26/06 ,  G02F2203/18 ,  G02F2203/50 ,  G03H1/10 ,  G03H1/16 ,  G03H2225/32 ,  H04B10/50577 ,  H04B10/508 ,  H04B10/516 ,  H04B10/524 ,  H04B10/548

Abstract: A single-channel phase conjugation apparatus includes a spatial light modulator and a single-channel optical sensing and generating unit. The spatial light modulator receives a light having a wavefront scattered by a scattering object. The single-channel optical sensing and generating unit senses a phase control wavefront of an output light focused by the spatial light modulator and outputs a light having a phase conjugation wavefront by changing a direction of the output light in a reverse direction depending on the phase control wavefront.

公开(公告)号：US20170357084A1

公开(公告)日：2017-12-14

申请号：US15243265

申请日：2016-08-22

Applicant: Korea Advanced Institute of Science and Technology ,  Tomocube, Inc.

Inventor： YongKeun Park ,  Seungwoo Shin ,  Gwang Sik Park

IPC: G02B21/36 ,  G01N21/64 ,  G03H1/00 ,  G01N21/41 ,  G02B21/16 ,  G02B27/46 ,  G02B26/08

CPC classification number: G02B21/367 ,  G01N21/4133 ,  G01N21/45 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/1787 ,  G01N2201/0635 ,  G02B21/16 ,  G02B26/0833 ,  G02B27/46 ,  G03H1/0005 ,  G03H2001/005

Abstract: An ultra-high-speed 3D refractive index tomography and structured illumination microscopy system using a wavefront shaper and a method using the same are provided. A method of using an ultra-high-speed 3D refractive index tomography and structured illumination microscopy system that utilizes a wavefront shaper includes adjusting an irradiation angle of a plane wave incident on a sample by using the wavefront shaper, measuring a 2D optical field, which passes through the sample, based on the irradiation angle of the plane wave, and obtaining a 3D refractive index image from information of the measured 2D optical field by using an optical diffraction tomography or a filtered back projection algorithm.

公开(公告)号：US11854142B2

公开(公告)日：2023-12-26

申请号：US17675370

申请日：2022-02-18

Applicant: Korea Advanced Institute of Science and Technology

Inventor： YongKeun Park ,  Moosung Lee ,  Herve Jerome Hugonnet

IPC: G06T15/20 ,  G16H30/40

CPC classification number: G06T15/205 ,  G16H30/40 ,  G06T2200/08 ,  G06T2207/10081

Abstract: Various example embodiments provide a computing device of an algorithm for reconstructing a three-dimensional (3D) image in consideration of multiple scattering and a method of the same. According to various example embodiments, the computing device may be configured to set a 3D refractive index based on a plurality of 2D images for a specimen and to reconstruct a 3D image for the specimen from the set refractive index using a modified Born expansion considering multiple scattering to converge a calculation result.

公开(公告)号：US20220156561A1

公开(公告)日：2022-05-19

申请号：US17431871

申请日：2019-09-27

Applicant: Tomocube, Inc. ,  Korea Advanced Institute of Science and Technology

Inventor： Kihyun Hong ,  Hyun-Seok Min ,  YongKeun Park ,  Geon Kim ,  Youngju Jo

IPC: G06N3/04 ,  G06T7/00

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for identifying the predicted type of one or more microorganisms. In one aspect, a system comprises a phase-contrast microscope and a microorganism classification system. The phase-contrast microscope is configured to generate a three-dimensional quantitative phase image of one or more microorganisms. The microorganism classification system is configured to process the three-dimensional quantitative phase image using a neural network to generate a neural network output characterizing the microorganisms, and thereafter identify the predicted type of the microorganisms using the neural network output.

公开(公告)号：US20200080936A1

公开(公告)日：2020-03-12

申请号：US16184677

申请日：2018-11-08

Applicant: THE WAVE TALK, INC. ,  Korea Advanced Institute of Science and Technology

Inventor： Hui Jun Park ,  Kyeo Reh Lee ,  Seung Woo Shin ,  YongKeun Park

IPC: G01N21/51 ,  G01N21/94

Abstract: An optical detection system includes a sample portion accommodating a sample, a wave source emitting waves to the sample portion, an optical portion provided on a path of an output wave output from the sample portion, and comprising a first spatial light modulator that modulates part of the output wave to a first wave and a second spatial light modulator that modulates part of the output wave to a second wave, a lens portion focusing the first wave and the second wave output from the optical portion, and a detection portion detecting a focused wave that is focused by the lens portion, in which the first spatial light modulator and the second spatial light modulator modulate the output wave such that the first wave and the second wave have destructive interference with respect to the sample under an already known condition.

公开(公告)号：US10215697B2

公开(公告)日：2019-02-26

申请号：US14981355

申请日：2015-12-28

Applicant: Korea Advanced Institute of Science and Technology

Inventor： YongKeun Park ,  Kyoohyun Kim ,  Seungwoo Shin

IPC: G01N21/45

Abstract: A method and apparatus for measuring 3D refractive-index tomograms using a wavefront shaper in ultra-high speed and high precision is provided. The method includes the steps of modifying at least one of an illumination angle and a wavefront pattern of an incident ray through the wavefront shaper and leading the modified incident ray to a sample, measuring a 2D optical field, which passes through the sample, through an interferometry along at least one or more of the incident rays, and obtaining 3D refractive-index tomograms through measured information of the 2D optical field.

公开(公告)号：US10082662B2

公开(公告)日：2018-09-25

申请号：US15243265

申请日：2016-08-22

Applicant: Korea Advanced Institute of Science and Technology ,  Tomocube, Inc.

Inventor： YongKeun Park ,  Seungwoo Shin ,  Gwang Sik Park

IPC: G02B21/36 ,  G01N21/41 ,  G01N21/64 ,  G02B21/16 ,  G02B26/08 ,  G02B27/46 ,  G03H1/00 ,  G01N21/45 ,  G01N21/17

CPC classification number: G02B21/367 ,  G01N21/4133 ,  G01N21/45 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/1787 ,  G01N2201/0635 ,  G02B21/16 ,  G02B26/0833 ,  G02B27/46 ,  G03H1/0005 ,  G03H2001/005

Abstract: An ultra-high-speed 3D refractive index tomography and structured illumination microscopy system using a wavefront shaper and a method using the same are provided. A method of using an ultra-high-speed 3D refractive index tomography and structured illumination microscopy system that utilizes a wavefront shaper includes adjusting an irradiation angle of a plane wave incident on a sample by using the wavefront shaper, measuring a 2D optical field, which passes through the sample, based on the irradiation angle of the plane wave, and obtaining a 3D refractive index image from information of the measured 2D optical field by using an optical diffraction tomography or a filtered back projection algorithm.

公开(公告)号：US09354605B2

公开(公告)日：2016-05-31

申请号：US14453448

申请日：2014-08-06

Applicant: Korea Advanced Institute of Science and Technology

Inventor： YongKeun Park ,  Hyeon Seung Yu

IPC: G03H1/08 ,  G03H1/22 ,  G03H1/00

CPC classification number: G03H1/0808 ,  G03H1/2205 ,  G03H1/2294 ,  G03H2001/0072 ,  G03H2210/30 ,  G03H2223/14

Abstract: A method for forming a three-dimensional holographic image includes identifying a transmission matrix of a scattering material, calculating an incident wave-front corresponding to wave-front information for forming a three-dimensional holographic image, using the identified transmission matrix, and forming the calculated incident wave-front by controlling a wave-front control to modulate a light projected from a light source and forming a three-dimensional holographic image.

Abstract translation: 用于形成三维全息图像的方法包括：使用所识别的传输矩阵来识别散射材料的传输矩阵，计算与用于形成三维全息图像的波前信息相对应的入射波前，并形成 通过控制波前控制来调制从光源投影的光并形成三维全息图像来计算入射波前。

公开(公告)号：US20140023255A1

公开(公告)日：2014-01-23

申请号：US13946833

申请日：2013-07-19

Applicant: Korea Advanced Institute of Science and Technology ,  Samsung Electronics Co., Ltd.

Inventor： Jae-guyn Lim ,  YongKeun Park ,  Jae-duck Jang ,  Seong-deok Lee ,  Woo-young Jang

IPC: G06T11/00

CPC classification number: G06T11/003 ,  G01B9/02091 ,  G06T11/005

Abstract: A method of generating a tomography image includes performing a depth scan on one spot on a surface of a subject using modulated light received from a spatial light modulator, obtaining depth scan data for each of a plurality of patterns of the spatial light modulator by repeating the depth scan on the spot for each of the plurality of patterns, forming a matrix R representing a vector space based on a correlation of signal values of the depth scan data for each of the plurality of patterns, performing a matrix decomposition on the matrix R, dividing the vector space into a noise subspace and a signal subspace based on a matrix obtained by the matrix decomposition, constructing a vector space based on either one or both of components of the signal subspace and components of the noise subspace, and generating a tomography image based on the reconstructed vector space.

Abstract translation: 生成断层摄影图像的方法包括使用从空间光调制器接收的调制光对被摄体的表面上的一个点进行深度扫描，通过重复所述空间光调制器的多个图案中的每一个来获得深度扫描数据 基于多个图案中的每一个的深度扫描数据的信号值的相关性，在矩阵R上执行矩阵分解，形成表示向量空间的矩阵R， 基于通过矩阵分解获得的矩阵将向量空间划分为噪声子空间和信号子空间，基于信号子空间的分量和噪声子空间的分量中的一个或两个构成向量空间，并生成断层图像 基于重构矢量空间。