公开(公告)号：US11026441B2

公开(公告)日：2021-06-08

申请号：US16117511

申请日：2018-08-30

Applicant: Laboratoires Expanscience

Inventor： Alex Saunois ,  Caroline Baudouin ,  Sophie Leclere-Bienfait ,  Sebastien Garnier ,  Philippe Msika

IPC: A61K36/54 ,  A23L19/00 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  A23L33/105 ,  A61K9/00 ,  A61K8/9789 ,  A61K8/9794 ,  A61K8/49 ,  A61K31/353 ,  A61K45/06 ,  A61Q5/12 ,  A61Q17/04

Abstract: The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which consists in administering such a composition or such an extract.

公开(公告)号：US10463593B2

公开(公告)日：2019-11-05

申请号：US15323347

申请日：2015-07-03

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Caroline Baudouin ,  Sophie Leclere-Bienfait ,  Philippe Msika ,  Stéphanie Bredif

IPC: A61K8/64 ,  A61Q19/06 ,  A61Q19/08 ,  A61K8/97

Abstract: The present invention relates to the use of a lupin peptide extract to prevent loss of skin firmness or to increase the firmness of skin. Advantageously, the lupin peptide extract can prevent the appearance of cellulite and/or reduce skin cellulite.

公开(公告)号：US10444226B2

公开(公告)日：2019-10-15

申请号：US14915702

申请日：2014-09-03

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Nadège Lachmann ,  Caroline Baudouin

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/50 ,  G01N33/68

Abstract: A method for determining whether the skin surface of a subject is mature/immature in its organization/function, by taking a skin sample and determining the corneodesmosome distribution within the stratum corneum of the sample by an immunoelectron microscopy method.

公开(公告)号：US10092495B2

公开(公告)日：2018-10-09

申请号：US14766602

申请日：2014-02-11

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Caroline Baudouin

IPC: A61K31/7024 ,  A61K8/60 ,  A61K31/22 ,  C07C69/02 ,  C07C69/52 ,  C07C69/533 ,  A61K31/232 ,  C07C69/587 ,  A61K31/23 ,  A61Q19/00 ,  A61Q19/08 ,  A61K45/06 ,  A61K31/7012 ,  A61K36/54 ,  A61K8/97 ,  A61Q5/02 ,  A61Q17/04 ,  A61Q19/10

Abstract: The invention concerns a use of C7 sugars and derivatives of formula (I), called avocado perseose, which have, inter alia, a protective activity to epidermal skin cells. These C7 sugars and derivatives are capable of maintaining the expression of markers of adult stem cells, in particular basal stem cells. Avocado perseose can also be used for preventing the deleterious effects of environmental damage. Avocado perseose has a beneficial effect on the conservation of the potential of epidermal stem cells and thus helps maintain skin homeostasis.

公开(公告)号：US11892447B2

公开(公告)日：2024-02-06

申请号：US16062488

申请日：2016-12-16

Applicant: Laboratoires Expanscience

Inventor： Stephanie Bredif ,  Caroline Baudouin

IPC: G01N33/50 ,  G01N33/68 ,  C12N5/071 ,  C12Q1/6883

CPC classification number: G01N33/5088 ,  C12N5/0698 ,  C12Q1/6883 ,  G01N33/6881 ,  C12Q2600/148 ,  C12Q2600/158

Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is dry. Such markers are particularly advantageous in that they allow the skin's response to dehydration to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of dehydration on children's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

公开(公告)号：US11604184B2

公开(公告)日：2023-03-14

申请号：US16311378

申请日：2017-06-23

Applicant: Laboratoires Expanscience

Inventor： Caroline Baudouin ,  Stephanie Bredif

IPC: C12Q1/68 ,  G01N33/50 ,  C12Q1/6883 ,  C12N5/00 ,  C12N5/071

Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is affected by atopic dermatitis. Such markers are particularly advantageous in that they allow the skin's response to atopic dermatitis to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of atopic dermatitis on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

公开(公告)号：US10175230B2

公开(公告)日：2019-01-08

申请号：US14785212

申请日：2014-04-22

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Caroline Baudouin ,  Stephanie Bredif

IPC: G01N33/50 ,  G01N33/68

Abstract: The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers and stratum granulosum regulation markers.

公开(公告)号：US09952201B2

公开(公告)日：2018-04-24

申请号：US15023882

申请日：2014-09-24

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Caroline Baudouin ,  Stephanie Bredif ,  Philippe Msika

IPC: G01N33/53 ,  G01N33/50 ,  G01N33/68

CPC classification number: G01N33/5023 ,  G01N33/5044 ,  G01N33/6881 ,  G01N2333/4721 ,  G01N2333/5421 ,  G01N2333/545 ,  G01N2333/96486

Abstract: The invention relates to in vitro methods for testing formulations or active ingredients for preventing the harmful effects of UV on children's skin, in particular children aged three or less. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the harmful effects of UV on the skin of children aged three or less, using a skin model specifically capable of reproducing the characteristics of the skin of children of this age.

公开(公告)号：US20160084822A1

公开(公告)日：2016-03-24

申请号：US14785212

申请日：2014-04-22

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Caroline Baudouin ,  Stephanie Bredif

IPC: G01N33/50

CPC classification number: G01N33/5023 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/6881

Abstract: The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers and stratum granulosum regulation markers.

Abstract translation: 本发明涉及一种用于评估选自C7鳄梨糖（也称为鳄梨坚果）用于预防或治疗皮肤屏障缺陷的活性成分的有效性的方法，所述方法包括测定表达水平和/或激活 的至少一种生物标志物，其中所述生物标志物选自表皮成熟标志物，脂质屏障标记物，水合调节标记物和颗粒颗粒调节标记物。