公开(公告)号：US20160040153A1

公开(公告)日：2016-02-11

申请号：US14821955

申请日：2015-08-10

Applicant: LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC

Inventor： Allan Froehlich ,  Brooks Henningsen ,  Sean Covalla

IPC: C12N9/92 ,  C12P7/06

CPC classification number: C12N9/92 ,  C07K14/395 ,  C12P7/06 ,  C12Y503/01005 ,  Y02E50/17

Abstract: There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.

Abstract translation: 提供了工程化的宿主细胞，其包含（a）编码与铁代谢相关的蛋白质的一个或多个内源基因中的一个或多个突变; 和（b）编码具有木糖异构酶活性的多肽的至少一个基因及其使用方法。

公开(公告)号：US20240191263A1

公开(公告)日：2024-06-13

申请号：US18537421

申请日：2023-12-12

Applicant: DANSTAR FERMENT AG ,  LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC

Inventor： Jeffery R. Broadbent ,  James L. Steele ,  Brooks Henningsen ,  Ekkarat Phrommao ,  Fernanda Cristina Firmino

IPC: C12P7/14 ,  C12N9/04 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52

CPC classification number: C12P7/14 ,  C12N9/0006 ,  C12N9/1205 ,  C12N9/88 ,  C12N15/52 ,  C12Y101/01001 ,  C12Y101/01006 ,  C12Y207/01121 ,  C12Y401/01001 ,  C12Y401/02009

Abstract: The present disclosure concerns a symbiotic combination of a bacterial host cell and a yeast host cell selected or engineered to utilize glycerol to reduce greenhouse gases during the production of ethanol from a biomass comprising hexoses.

公开(公告)号：US11034949B2

公开(公告)日：2021-06-15

申请号：US16785232

申请日：2020-02-07

Applicant: Lallemand Hungary Liquidity Management LLC

Inventor： Allan Froehlich ,  Brooks Henningsen

IPC: C12N9/90 ,  C12N15/62 ,  C12P7/06 ,  C12N9/92

Abstract: There is provided chimeric polypeptides capable of converting xylose to xylulose, engineered host cells that express the chimeric polypeptides, methods of creating chimeric polypeptides, and methods of fermenting cellulosic biomass to produce biofuels, including ethanol.

公开(公告)号：US10465181B2

公开(公告)日：2019-11-05

申请号：US15884449

申请日：2018-01-31

Applicant: LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC

Inventor： Allan Froehlich ,  Brooks Henningsen ,  Sean Covalla ,  Rintze M. Zelle

IPC: C12N9/92 ,  C07K14/395 ,  C12P7/06

Abstract: There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.

公开(公告)号：US09920312B2

公开(公告)日：2018-03-20

申请号：US14821955

申请日：2015-08-10

Applicant: LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC

Inventor： Allan Froehlich ,  Brooks Henningsen ,  Sean Covalla ,  Rintze M. Zelle

IPC: C12N9/92 ,  C12P7/06 ,  C07K14/395

CPC classification number: C12N9/92 ,  C07K14/395 ,  C12P7/06 ,  C12Y503/01005 ,  Y02E50/17

Abstract: There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.

公开(公告)号：US20240191262A1

公开(公告)日：2024-06-13

申请号：US18537410

申请日：2023-12-12

Applicant: DANSTAR FERMENT AG ,  LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC

Inventor： Jeffery R. Broadbent ,  James L. Steele ,  Brooks Henningsen ,  Ekkarat Phrommao ,  Fernanda Cristina Firmino

IPC: C12P7/14 ,  C12N9/04 ,  C12N9/88 ,  C12N15/52

CPC classification number: C12P7/14 ,  C12N9/0006 ,  C12N9/88 ,  C12N15/52 ,  C12Y101/01006 ,  C12Y101/01027 ,  C12Y401/01001 ,  C12Y401/02009

Abstract: The present disclosure concerns a symbiotic combination of a bacterial host cell and a yeast host cell selected or engineered to utilize glycerol to reduce greenhouse gases during the production of ethanol from a biomass comprising pentoses.

公开(公告)号：US11739338B2

公开(公告)日：2023-08-29

申请号：US16648625

申请日：2018-09-18

Applicant: Lallemand Hungary Liquidity Management LLC

Inventor： Brooks Henningsen ,  Sean Covalla ,  Rintze Zelle ,  Allan Froehlich

IPC: C12N15/81 ,  C07K14/395 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/90 ,  C12N9/92 ,  C12N9/00 ,  C12P7/06

CPC classification number: C12N15/81 ,  C07K14/395 ,  C12N9/0006 ,  C12N9/1022 ,  C12N9/12 ,  C12N9/1205 ,  C12N9/90 ,  C12N9/92 ,  C12N9/93 ,  C12P7/06 ,  C12Y101/01001 ,  C12Y202/01002 ,  C12Y207/01017 ,  C12Y207/11001 ,  C12Y501/03001 ,  C12Y503/01006 ,  C12Y602/01001

Abstract: Acetate is a potent microbial inhibitor which can affect the performance of yeast in ethanolic fermentation. The present disclosure provides a recombinant microbial host cell having (i) a first genetic modification for increasing the activity of one or more proteins that function in a first metabolic pathway to convert acetate into an alcohol in the microbial host cell; (ii) a second genetic modification for increasing the activity of one or more proteins that function in a second metabolic pathway to import glycerol in the recombinant microbial host cell (iii) a third genetic modification for increasing the activity of one or more proteins that function in a third metabolic pathway to convert a C5 carbohydrate into ethanol in the microbial host cell. The recombinant microbial host cell comprises and natively expresses native proteins that function in a fourth native metabolic pathway to produce glycerol in the microbial host cell.

公开(公告)号：US20220228176A1

公开(公告)日：2022-07-21

申请号：US17292358

申请日：2019-11-13

Applicant: Lallemand Hungary Liquidity Management LLC

Inventor： Jeffery R. Broadbent ,  Aaron Argyros ,  Brooks Henningsen ,  Fernanda Cristina Firmino ,  Ekkarat Phrommao ,  James L. Steele

IPC: C12P7/14 ,  C12P19/02 ,  C12P7/10 ,  C12P7/54 ,  C12N9/88

Abstract: The present disclosure concerns a symbiotic combination of host cells engineered to produce a first metabolic product, for example a carbohydrate, and to convert the second metabolic product into a second metabolic product, for example an alcohol.

公开(公告)号：US20220127564A1

公开(公告)日：2022-04-28

申请号：US16493595

申请日：2018-03-13

Applicant: Lallemand Hungary Liquidity Management LLC

Inventor： Aaron Argyros ,  Michelle Oeser ,  Erin Wiswall ,  Janet Fisher ,  Johannes Van Eijk ,  J. Kevin Kraus ,  Kevin Wenger ,  Brooks Henningsen ,  Ryan Skinner

IPC: C12N1/18 ,  C12P21/02 ,  C12N1/06 ,  C12N9/00

Abstract: The present disclosure concerns recombinant yeast host cells expressing cell-associated heterologous proteins which are expressed during the propagation phase of the recombinant yeast host cells and processes for propagating same. The recombinant yeast host cells can be 5 used to make a yeast composition or a yeast product enriched in the heterologous proteins.

公开(公告)号：US11306304B2

公开(公告)日：2022-04-19

申请号：US16575350

申请日：2019-09-18

Applicant: LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC

Inventor： Allan Froehlich ,  Brooks Henningsen ,  Sean Covalla ,  Rintze M. Zelle

IPC: C12N9/92 ,  C07K14/395 ,  C12P7/06

Abstract: There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.