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公开(公告)号：US11739338B2
公开(公告)日：2023-08-29
申请号：US16648625
申请日：2018-09-18
发明人： Brooks Henningsen , Sean Covalla , Rintze Zelle , Allan Froehlich
IPC分类号： C12N15/81 , C07K14/395 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/90 , C12N9/92 , C12N9/00 , C12P7/06
CPC分类号： C12N15/81 , C07K14/395 , C12N9/0006 , C12N9/1022 , C12N9/12 , C12N9/1205 , C12N9/90 , C12N9/92 , C12N9/93 , C12P7/06 , C12Y101/01001 , C12Y202/01002 , C12Y207/01017 , C12Y207/11001 , C12Y501/03001 , C12Y503/01006 , C12Y602/01001
摘要： Acetate is a potent microbial inhibitor which can affect the performance of yeast in ethanolic fermentation. The present disclosure provides a recombinant microbial host cell having (i) a first genetic modification for increasing the activity of one or more proteins that function in a first metabolic pathway to convert acetate into an alcohol in the microbial host cell; (ii) a second genetic modification for increasing the activity of one or more proteins that function in a second metabolic pathway to import glycerol in the recombinant microbial host cell (iii) a third genetic modification for increasing the activity of one or more proteins that function in a third metabolic pathway to convert a C5 carbohydrate into ethanol in the microbial host cell. The recombinant microbial host cell comprises and natively expresses native proteins that function in a fourth native metabolic pathway to produce glycerol in the microbial host cell.
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公开(公告)号：US09862975B2
公开(公告)日：2018-01-09
申请号：US14858571
申请日：2015-09-18
申请人： CARGILL INCORPORATED
发明人： Holly J. Jessen , Jian Yi , Joshua Lundorff , Hans Liao , Ana Negrete-Raymond , Pirkko Suominen , Aristos Aristidou
IPC分类号： C12N1/00 , C12N1/19 , C12N1/22 , C12P7/06 , C12N9/12 , C12N9/90 , C12P7/10 , C12N15/81 , C07K14/39 , C12N9/04 , C12N9/10 , C12N9/92 , C12P7/54
CPC分类号： C12P7/10 , C07K14/39 , C12N9/0006 , C12N9/1022 , C12N9/1205 , C12N9/90 , C12N9/92 , C12N15/815 , C12P7/06 , C12P7/54 , C12Y101/01 , C12Y101/01009 , C12Y101/0101 , C12Y202/01001 , C12Y202/01002 , C12Y207/01016 , C12Y207/01017 , C12Y501/03001 , C12Y501/03004 , C12Y503/01003 , C12Y503/01005 , C12Y503/01006 , Y02E50/16 , Y02E50/17
摘要： The present application discloses the identification of the novel K. marxianus xylose transporter genes KHT105 and RAG4, as well as the identification of a novel set of I. orientalis pentose phosphate pathway genes The present application further discloses a series of genetically modified yeast cells comprising various combinations of arabinose fermentation pathways, xylose fermentation pathways, pentose phosphate pathways, and/or xylose transporter genes, and methods of culturing these cells to produce ethanol in fermentation media containing xylose.
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公开(公告)号：US09181563B2
公开(公告)日：2015-11-10
申请号：US14111415
申请日：2012-04-11
申请人： Holly J. Jessen , Jian Yi , Joshua Lundorff , Hans Liao , Ana Negrete-Raymond , Pirkko Suominen , Aristos Aristidou
发明人： Holly J. Jessen , Jian Yi , Joshua Lundorff , Hans Liao , Ana Negrete-Raymond , Pirkko Suominen , Aristos Aristidou
IPC分类号： C12N1/00 , C12N1/19 , C12N1/22 , C12P7/06 , C07K14/39 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/90 , C12N9/92 , C12P7/10 , C12N15/81
CPC分类号： C12P7/10 , C07K14/39 , C12N9/0006 , C12N9/1022 , C12N9/1205 , C12N9/90 , C12N9/92 , C12N15/815 , C12P7/06 , C12P7/54 , C12Y101/01 , C12Y101/01009 , C12Y101/0101 , C12Y202/01001 , C12Y202/01002 , C12Y207/01016 , C12Y207/01017 , C12Y501/03001 , C12Y501/03004 , C12Y503/01003 , C12Y503/01005 , C12Y503/01006 , Y02E50/16 , Y02E50/17
摘要： The present application discloses the identification of the novel K. marxianus xylose transporter genes KHT105 and RAG4, as well as the identification of a novel set of I. orientalis pentose phosphate pathway genes The present application further discloses a series of genetically modified yeast cells comprising various combinations of arabinose fermentation pathways, xylose fermentation pathways, pentose phosphate pathways, and/or xylose transporter genes, and methods of culturing these cells to produce ethanol in fermentation media containing xylose.
摘要翻译： 本申请公开了新型马克斯黄连木糖转运蛋白基因KHT105和RAG4的鉴定，以及一种新型东方山羊戊糖磷酸途径基因的鉴定本申请还公开了一系列基因修饰的酵母细胞，其包含各种 阿拉伯糖发酵途径的组合，木糖发酵途径，戊糖磷酸途径和/或木糖转运蛋白基因，以及培养这些细胞以在含有木糖的发酵培养基中产生乙醇的方法。
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4.发明申请公开(公告)号：US20140038253A1
公开(公告)日：2014-02-06
申请号：US14111415
申请日：2012-04-11
申请人： Holly J. Jessen , Jian Yi , Joshua Lundorff , Hans Liao , Ana Negrete-Raymond , Pirkko Suominen , Aristos Aristidou
发明人： Holly J. Jessen , Jian Yi , Joshua Lundorff , Hans Liao , Ana Negrete-Raymond , Pirkko Suominen , Aristos Aristidou
CPC分类号： C12P7/10 , C07K14/39 , C12N9/0006 , C12N9/1022 , C12N9/1205 , C12N9/90 , C12N9/92 , C12N15/815 , C12P7/06 , C12P7/54 , C12Y101/01 , C12Y101/01009 , C12Y101/0101 , C12Y202/01001 , C12Y202/01002 , C12Y207/01016 , C12Y207/01017 , C12Y501/03001 , C12Y501/03004 , C12Y503/01003 , C12Y503/01005 , C12Y503/01006 , Y02E50/16 , Y02E50/17
摘要： The present application discloses the identification of the novel K. marxianus xylose transporter genes KHT105 and RAG4, as well as the identification of a novel set of I. orientalis pentose phosphate pathway genes The present application further discloses a series of genetically modified yeast cells comprising various combinations of arabinose fermentation pathways, xylose fermentation pathways, pentose phosphate pathways, and/or xylose transporter genes, and methods of culturing these cells to produce ethanol in fermentation media containing xylose.
摘要翻译： 本申请公开了新型马克斯黄连木糖转运蛋白基因KHT105和RAG4的鉴定，以及一种新型东方山羊戊糖磷酸途径基因的鉴定本申请还公开了一系列基因修饰的酵母细胞，其包含各种 阿拉伯糖发酵途径的组合，木糖发酵途径，戊糖磷酸途径和/或木糖转运蛋白基因，以及培养这些细胞以在含有木糖的发酵培养基中产生乙醇的方法。
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公开(公告)号：US20070298476A1
公开(公告)日：2007-12-27
申请号：US10901471
申请日：2004-07-29
CPC分类号： C12P7/08 , C12N9/1022 , C12N9/1205 , C12N9/92 , C12P7/065 , C12Y202/01001 , C12Y202/01002 , C12Y207/01017 , C12Y503/01005 , Y02E50/17
摘要： This invention provides transformed microorganisms which can produce ethanol from pentose, by introducing pentose metabolizing enzymes into microorganisms belonging to genus Zymobacter which cannot utilize pentose.
摘要翻译： 本发明提供了可以从戊糖产生乙醇的转化微生物，其通过将戊糖代谢酶引入不能利用戊糖的酵母属属的微生物中。
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公开(公告)号：US5879909A
公开(公告)日：1999-03-09
申请号：US57762
申请日：1998-04-09
申请人： Andras Perl
发明人： Andras Perl
CPC分类号： C12Y202/01002 , C12N9/1022
摘要： Transaldolase is an enzyme which acts as an autoantigen in immune-related neurodegenerative diseases, particularly multiple sclerosis. Human transaldolase, the DNA coding therefore, peptides derived therefrom, and DNA control elements associated therewith and anti-transaldolase antibodies are disclosed. These compositions are useful in methods such as immunoassays for detecting subjects making anti-transaldolase antibodies and diagnosing the neurodegenerative disease.
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公开(公告)号：US12049660B2
公开(公告)日：2024-07-30
申请号：US18052410
申请日：2022-11-03
发明人： Chris Todd Hittinger , Trey Sato , Sae-Byuk Lee
CPC分类号： C12P7/10 , C10L1/02 , C12N9/0093 , C12N9/1022 , C12N9/1205 , C12N9/92 , C12Y117/99 , C12Y202/01002 , C12Y207/01017 , C12Y503/01005 , C10L2200/0469
摘要： An engineered yeast strain capable of efficient fermentation of xylose to ethanol, and methods of making and using the strain, are provided.
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公开(公告)号：US20230227861A1
公开(公告)日：2023-07-20
申请号：US18052410
申请日：2022-11-03
发明人： Chris Todd Hittinger , Trey Sato , Sae-Byuk Lee
CPC分类号： C12P7/10 , C12N9/0093 , C12Y117/99 , C12N9/92 , C12Y503/01005 , C12N9/1205 , C12Y207/01017 , C12N9/1022 , C12Y202/01002 , C10L1/02 , C10L2200/0469
摘要： An engineered yeast strain capable of efficient fermentation of xylose to ethanol, and methods of making and using the strain, are provided
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公开(公告)号：US11655484B2
公开(公告)日：2023-05-23
申请号：US17098057
申请日：2020-11-13
IPC分类号： C12N9/88 , C12P7/06 , C12N9/04 , C12N9/02 , C12N9/10 , C12N9/12 , C12N15/52 , C12N1/16 , C12N9/16 , C12N9/90
CPC分类号： C12P7/06 , C12N1/16 , C12N9/0004 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/1029 , C12N9/1217 , C12N9/16 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y101/01001 , C12Y101/01008 , C12Y102/0101 , C12Y197/01004 , C12Y202/01001 , C12Y202/01002 , C12Y203/01008 , C12Y203/01054 , C12Y207/02012 , C12Y301/03021 , C12Y401/01001 , C12Y401/02009 , C12Y401/02022 , C12Y501/03001 , C12Y503/01006 , Y02E50/10
摘要： The present invention provides for a mechanism to completely replace the electron accepting function of glycerol formation with an alternative pathway to ethanol formation, thereby reducing glycerol production and increasing ethanol production. In some embodiments, the invention provides for a recombinant microorganism comprising a down-regulation in one or more native enzymes in the glycerol-production pathway. In some embodiments, the invention provides for a recombinant microorganism comprising an up-regulation in one or more enzymes in the ethanol-production pathway.
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公开(公告)号：US09594869B2
公开(公告)日：2017-03-14
申请号：US14001299
申请日：2012-03-01
申请人： Desmond Siu Men Lun
发明人： Desmond Siu Men Lun
IPC分类号： C12N1/21 , C12P7/64 , C12P5/02 , G06F19/12 , C12N9/02 , C12N9/10 , C12N9/90 , C12N1/20 , C10G3/00
CPC分类号： G06F19/12 , C10G3/50 , C12N1/20 , C12N9/001 , C12N9/1022 , C12N9/90 , C12P7/6409 , C12Y103/99003 , C12Y202/01002 , C12Y501/03001 , Y02P20/52 , Y02P30/20
摘要： This invention concerns methods of identifying genetic alterations with which a microbe can be used to produce fatty acids at a large amount for making biofuels. Also disclosed are microbes with such genetic alterations and uses thereof.
摘要翻译： 本发明涉及鉴定遗传变异的方法，通过该遗传改变微生物可用于大量生产用于制备生物燃料的脂肪酸。 还公开了具有这种遗传改变及其用途的微生物。
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