公开(公告)号：US20180334648A1

公开(公告)日：2018-11-22

申请号：US16046426

申请日：2018-07-26

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Nephi D. Jones ,  Christopher D. Brau

IPC: C12M1/00 ,  C12M1/36 ,  B01D5/00 ,  B01D53/26 ,  B01D46/44 ,  B01D46/00 ,  B01D19/00 ,  C12M1/34

Abstract: A method for filtering a gas includes delivering a gas into a compartment of a gas filter assembly; applying a partial vacuum to the gas filter assembly so that the partial vacuum assists in drawing the gas through a porous filter body of the gas filter assembly that is at least partially disposed within the compartment of the gas filter assembly; and regulating the application of the partial vacuum based on a pressure reading of the gas upstream of the gas filter assembly.

公开(公告)号：US09457306B2

公开(公告)日：2016-10-04

申请号：US14508824

申请日：2014-10-07

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Nephi D. Jones ,  Christopher D. Brau

IPC: B01D5/00 ,  C12M1/00 ,  B01D46/00 ,  B01D46/44 ,  B01D19/00

CPC classification number: C12M29/20 ,  B01D5/00 ,  B01D19/0005 ,  B01D19/0031 ,  B01D19/0036 ,  B01D46/0002 ,  B01D46/002 ,  B01D46/446 ,  B01D53/265 ,  C12M23/14 ,  C12M23/26 ,  C12M29/04 ,  C12M29/06 ,  C12M41/14 ,  C12M41/40 ,  C12M41/48

Abstract: A method for filtering a gas includes sparging a gas through a liquid within a compartment of a container. In one embodiment the container can comprise a flexible bag. The sparged gas is passed from the container through a gas filter of a filter assembly. A partial vacuum is applied to the gas filter so that the partial vacuum assists in drawing the gas through the gas filter.

Abstract translation: 用于过滤气体的方法包括通过容器的隔室内的液体喷射气体。 在一个实施例中，容器可以包括柔性袋。 喷射的气体从容器通过过滤器组件的气体过滤器。 部分真空被施加到气体过滤器，使得部分真空有助于通过气体过滤器抽吸气体。

公开(公告)号：US20220054954A1

公开(公告)日：2022-02-24

申请号：US17521445

申请日：2021-11-08

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Scott P. Collins ,  Christopher D. Brau ,  Nephi D. Jones

IPC: B01D11/04 ,  B01F11/00 ,  B01F13/10 ,  G01N1/34

Abstract: A sample purification system includes a mixing zone; a settling zone in fluid communication with the mixing zone; a mixer element disposed in the mixing zone, the mixer element being configured to mix immiscible liquids to form a mixture; and a first acoustic wave settler configured to emit an acoustic wave into the mixture.

公开(公告)号：US11162062B2

公开(公告)日：2021-11-02

申请号：US16715087

申请日：2019-12-16

Applicant: Life Technologies Corporation

Inventor： Christopher D. Brau ,  Nephi D. Jones ,  Benjamin R. Madsen ,  Michael E. Goodwin

IPC: C12N1/00 ,  C12M1/00 ,  B01F13/02 ,  B01F3/04 ,  C12M1/02 ,  C12M1/34 ,  B01F7/22 ,  B01F15/00 ,  C12M1/06 ,  B01F11/00

Abstract: A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A tube has a first end and an opposing second end, the first end of the tube being disposed within the compartment of the container. A nozzle is disposed within the compartment of the container and has at least one outlet, the nozzle being coupled with the tube so that a gas can be passed through the tube and out the at least one outlet of the nozzle. The nozzle is sufficiently buoyant so that when a fluid is disposed within the compartment of the container, the nozzle floats on the fluid.

公开(公告)号：US20210040432A1

公开(公告)日：2021-02-11

申请号：US17084083

申请日：2020-10-29

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Nephi D. Jones ,  Christopher D. Brau

IPC: C12M1/00 ,  B01D46/00 ,  B01D46/44 ,  B01D19/00 ,  B01D5/00 ,  B01D53/26 ,  C12M1/34 ,  C12M1/36

Abstract: A method for filtering a gas includes delivering a gas into a compartment of a gas filter assembly; applying a partial vacuum to the gas filter assembly so that the partial vacuum assists in drawing the gas through a porous filter body of the gas filter assembly that is at least partially disposed within the compartment of the gas filter assembly; and regulating the application of the partial vacuum based on a pressure reading of the gas upstream or downstream of the gas filter assembly.

公开(公告)号：US10519413B2

公开(公告)日：2019-12-31

申请号：US15916635

申请日：2018-03-09

Applicant: Life Technologies Corporation

Inventor： Christopher D. Brau ,  Nephi D. Jones ,  Benjamin R. Madsen ,  Michael E. Goodwin

IPC: C12M1/04 ,  C12M1/00 ,  B01F13/02 ,  B01F3/04 ,  C12M1/02 ,  C12M1/34 ,  B01F7/22 ,  B01F15/00 ,  C12M1/06 ,  B01F11/00

Abstract: A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A tube has a first end and an opposing second end, the first end of the tube being disposed within the compartment of the container. A nozzle is disposed within the compartment of the container and has at least one outlet, the nozzle being coupled with the tube so that a gas can be passed through the tube and out the at least one outlet of the nozzle. The nozzle is sufficiently buoyant so that when a fluid is disposed within the compartment of the container, the nozzle floats on the fluid.

公开(公告)号：US20190001237A1

公开(公告)日：2019-01-03

申请号：US16067509

申请日：2016-12-21

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Scott P. Collins ,  Federico Carlos Rodriguez Peralta ,  Nephi D. Jones ,  Christopher D. Brau

IPC: B01D11/04 ,  B01D15/36 ,  B01D15/38

Abstract: Sample purification systems include a particle extraction assembly having a mixing compartment and a settling compartment. A biological sample is mixed with two liquid phases formulated to effectuate transfer of a biological molecule into a first phase and particulate contaminants into a second phase. The first phase includes a solubilizing salt, the second phase includes an organic molecule, and the mixture can have little or no monoatomic salt or dextran. The molecule-containing first phase can be optionally concentrated without also concentrating the particulate contaminants and introduced into a multi-stage liquid-liquid extractor, by which the biological molecule or molecular contaminants are extracted from the first phase into a third phase, thereby purifying the molecule away from contaminants. The extracted sample can be further purified through a series of processing steps. The system can be run in continuously mode to maintain sterility of the sample.

公开(公告)号：US10059916B2

公开(公告)日：2018-08-28

申请号：US15249781

申请日：2016-08-29

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Nephi D. Jones ,  Christopher D. Brau

IPC: B01D5/00 ,  C12M1/00 ,  B01D46/00 ,  B01D46/44 ,  B01D19/00 ,  B01D53/26 ,  C12M1/34 ,  C12M1/36

CPC classification number: C12M29/20 ,  B01D5/00 ,  B01D19/0005 ,  B01D19/0031 ,  B01D19/0036 ,  B01D46/0002 ,  B01D46/002 ,  B01D46/446 ,  B01D53/265 ,  C12M23/14 ,  C12M23/26 ,  C12M29/04 ,  C12M29/06 ,  C12M41/14 ,  C12M41/40 ,  C12M41/48

Abstract: A method for filtering a gas includes delivering a gas into a compartment of a gas filter, the compartment being at least partially bounded by a casing comprised of a flexible sheet of polymeric film. A partial vacuum is applied to the gas filter so that the partial vacuum assists in drawing the gas through a porous filter body of the gas filter that is at least partially disposed within the compartment of the gas filter.

公开(公告)号：US09932553B2

公开(公告)日：2018-04-03

申请号：US15187258

申请日：2016-06-20

Applicant: Life Technologies Corporation

Inventor： Christopher D. Brau ,  Nephi D. Jones ,  Benjamin R. Madsen ,  Michael E. Goodwin

IPC: C12M1/00 ,  B01F13/02 ,  B01F3/04 ,  C12M1/02 ,  C12M1/34 ,  B01F7/22 ,  B01F15/00 ,  C12M1/06 ,  B01F11/00

CPC classification number: C12M29/06 ,  B01F3/04439 ,  B01F3/0446 ,  B01F3/04531 ,  B01F7/22 ,  B01F11/0002 ,  B01F11/0082 ,  B01F13/0205 ,  B01F13/0211 ,  B01F13/0272 ,  B01F15/0085 ,  B01F2003/04879 ,  B01F2003/04943 ,  B01F2215/0073 ,  C12M23/00 ,  C12M23/14 ,  C12M23/26 ,  C12M27/00 ,  C12M27/02 ,  C12M29/14 ,  C12M41/34

Abstract: A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A first opening is formed on the container so as to communicate with the compartment. A liquid is disposed within the compartment and having a top surface disposed below the first opening. A gas is blown through the first opening so that the gas passes over at least a portion of the top surface of the liquid, the gas producing turbulence on the top surface of the liquid that is sufficient to produce a mass transfer between the gas and the liquid. A mixing element is disposed within the compartment.

公开(公告)号：US20160298071A1

公开(公告)日：2016-10-13

申请号：US15187258

申请日：2016-06-20

Applicant: Life Technologies Corporation

Inventor： Christopher D. Brau ,  Nephi D. Jones ,  Benjamin R. Madsen ,  Michael E. Goodwin

IPC: C12M1/00 ,  B01F15/00 ,  B01F7/22 ,  B01F13/02 ,  C12M1/06 ,  B01F3/04

CPC classification number: C12M29/06 ,  B01F3/04439 ,  B01F3/0446 ,  B01F3/04531 ,  B01F7/22 ,  B01F11/0002 ,  B01F11/0082 ,  B01F13/0205 ,  B01F13/0211 ,  B01F13/0272 ,  B01F15/0085 ,  B01F2003/04879 ,  B01F2003/04943 ,  B01F2215/0073 ,  C12M23/00 ,  C12M23/14 ,  C12M23/26 ,  C12M27/00 ,  C12M27/02 ,  C12M29/14 ,  C12M41/34

Abstract: A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A first opening is formed on the container so as to communicate with the compartment. A liquid is disposed within the compartment and having a top surface disposed below the first opening. A gas is blown through the first opening so that the gas passes over at least a portion of the top surface of the liquid, the gas producing turbulence on the top surface of the liquid that is sufficient to produce a mass transfer between the gas and the liquid. A mixing element is disposed within the compartment.

Abstract translation: 用于进行气液传质的系统包括一个限定隔室的容器，并且具有顶壁，底壁和在其间延伸的环绕侧壁。 在容器上形成第一开口以与隔室连通。 液体设置在隔室内并且具有设置在第一开口下方的顶表面。 通过第一开口吹入气体，使得气体通过液体顶表面的至少一部分，气体在液体顶表面上产生湍流，足以产生气体与气体之间的传质 液体。 混合元件设置在隔间内。