公开(公告)号：US20150231636A1

公开(公告)日：2015-08-20

申请号：US14613496

申请日：2015-02-04

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Chee Kiong Lim ,  Way Xuang LEE ,  Wuh Ken LOH ,  Chee Wee CHING ,  Chin Yong KOO ,  Siew Ying KOH ,  Tiong Han TOH ,  Kuan Moon BOO ,  Soo Yong LAU

IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/68

CPC classification number: B01L7/52 ,  B01L2200/147 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1883 ,  C12Q1/6806

Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.

Abstract translation: 一方面，公开了一种包括样品块和热电装置的热循环仪系统。 在各种实施例中，样品块具有构造成容纳多个反应容器和相对的第二表面的第一表面。 在各种实施例中，热电装置可操作地耦合到样品块的第二表面。 在各种实施例中，提供了热控制单元。 在各种实施例中，热控制单元包括计算机处理单元。 在各种实施例中，热控制单元包括电流源。 在各种实施例中，热控制单元还包括被配置为通过电缆将热电装置与电流源连接的电接口部分。 在各种实施例中，热控制单元定向在与样品块和热电冷却器不同的平面中。

公开(公告)号：US20230221280A1

公开(公告)日：2023-07-13

申请号：US18084587

申请日：2022-12-20

Applicant: Life Technologies Holdings PTE Limited ,  Life Technologies Corporation

Inventor： Beng Heng LIM ,  Wuh Ken LOH ,  Hwee Siong KUAH ,  Jing Han WONG ,  Jefferson Cruz GANGCUANGCO ,  Jin Xin ONG ,  Soo Yong LAU ,  Yanping XU ,  Victor SHAPIRO ,  Zhi Da TEH ,  Chee Woei CHONG ,  Kuan Moon BOO

IPC: G01N27/447

CPC classification number: G01N27/44721

Abstract: A gel electrophoresis system includes a base module and a camera module. The base module includes a cassette slot for receiving a gel electrophoresis cassette, and a light element that functions to illuminate the gel electrophoresis cassette. The camera module is selectively attachable to and detachable from the base module. When attached to the base module, the camera module facilitates imaging of the gel electrophoresis cassette and provides additional imaging capabilities.

公开(公告)号：US20220412890A1

公开(公告)日：2022-12-29

申请号：US17825222

申请日：2022-05-26

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kevin MAHER ,  Mingsong CHEN ,  Jacob K. FREUDENTHAL ,  Kuan Moon BOO ,  Soo Yong LAU ,  David FORTESCUE ,  Ming SHEN ,  Woon Liang Terence SOH

IPC: G01N21/64

Abstract: An instrument for processing and/or measuring a biological process comprises a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.

公开(公告)号：US20190300936A1

公开(公告)日：2019-10-03

申请号：US16382294

申请日：2019-04-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jacob K. FREUDENTHAL ,  Geoffrey DAHLHOFF ,  Kevin MAHER ,  Ming Song CHEN ,  Gary LIM ,  Ronald DANEHY ,  David FORTESCUE ,  Ming SHEN ,  Woon Liang Soh ,  Francis T. CHENG ,  Ruoyun WU ,  Thiam Chye LEE ,  Gary A. CHAPPELL ,  Chee Kiong LIM ,  Jeff DERE ,  Ted E. STRAUB ,  Jorge FONSECA ,  Kuan Moon BOO ,  Soo Yong LAU

IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00

Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.

公开(公告)号：US20160228875A1

公开(公告)日：2016-08-11

申请号：US14778106

申请日：2014-02-14

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tiong Han Toh ,  Wuh Ken LOH ,  Kuan Moon BOO ,  Sandro David KLEIN ,  Daniel WELSH

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2300/043 ,  B01L2300/1822

Abstract: In one aspect, a thermal cycler system is disclosed. The thermal cycler can be comprised of a device housing and a cover that is operably connected to the device housing. The cover can include a handle portion, a device lid portion, a sample block platen and a link bar. The device lid portion is attached to the proximal side of the handle portion with a pin. The sample block platen is operably connected to the handle portion such that the sample block platen is positioned against the sample block when the handle portion is flush with the device lid portion and the cover is in a closed position. The link bar is operably connected to the device housing and the pin such that a distal side of the handle portion is elevated away from the device lid portion when the cover is moved to an open position.

Abstract translation: 一方面，公开了一种热循环仪系统。 热循环仪可以由装置壳体和可操作地连接到装置壳体的盖组成。 盖可以包括手柄部分，装置盖部分，样品块压板和连杆。 装置盖部分用销钉安装在把手部分的近侧。 样品块压板可操作地连接到手柄部分，使得当手柄部分与装置盖部分齐平并且盖处于关闭位置时，样品块压板位于样品块上。 连杆可操作地连接到装置壳体和销上，使得当盖移动到打开位置时把手部分的远端从装置盖部分升高。

公开(公告)号：US20160011115A1

公开(公告)日：2016-01-14

申请号：US14766725

申请日：2014-02-24

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Mingsong CHEN ,  Mauro AGUANNO ,  Kuan Moon BOO ,  Woon Liang Terence SOH ,  Jacob K. FREUDENTHAL ,  Jeffrey A. MARKS

IPC: G01N21/64 ,  G01N21/03

Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

Abstract translation: 用于处理和/或测量生物过程的仪器包括样品处理系统，激发源，激发光学系统，光学传感器和发射光学系统。 样品处理系统被配置为保持第一样品保持器和第二样品保持器，其中样品池的数量对于每个样品保持器是不同的，或者第一样品池的特征尺寸与第二样品保持器的特征尺寸不同。 仪器还包括激发源温度控制器，其包括耦合到激发源的温度传感器。 温度控制器被配置为当第一样本保持器被仪器保持时产生第一目标温度，并且当第二样本保持器被仪器保持时产生第二目标温度。