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11.发明授权Method for treating swine dysentery with the derivatives of the antibiotic A82810 失效用抗生素A82810衍生物治疗猪痢疾的方法
公开(公告)号：US5314875A
公开(公告)日：1994-05-24
申请号：US752816
申请日：1991-08-30
申请人： Robert L. Hamill , Raymond C. Yao
发明人： Robert L. Hamill , Raymond C. Yao
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P19/445 , C12P19/60 , C12R1/03
摘要： New polyether antibiotic A82810, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A82810 by culture of Actinomodura fibrosa sp. nov. NRRL 18348 and synergistic compositions of the A82810 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
摘要翻译： 新型聚醚抗菌素A82810，其酰基和烷基酯，酰基酯和氨基甲酸酯衍生物及其盐是有用的抗菌和抗球虫剂，并增加动物的饲料利用效率。 通过培养Actinomodura fibrosa sp。制备A82810的方法 nov。 还提供了NRRL 18348和A82810化合物与氨基脲，4,4'-二硝基苯甲酰胺，某些萘胺和苯胺化合物和二氯吲哚醇的协同组合物。
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公开(公告)号：US4876273A
公开(公告)日：1989-10-24
申请号：US220650
申请日：1988-07-18
申请人： Robert L. Hamill , Raymond C. Yao
发明人： Robert L. Hamill , Raymond C. Yao
IPC分类号： C07D407/14 , C12P17/16
CPC分类号： C07D407/14 , C12P17/16 , C12R1/03
摘要： New polyether antibiotic A80577, its acyl ester and alkyl ether derivatives, and salts thereof, are useful antibacterial agents and increase feed-utilization efficiency in animals. Methods of making A80577 by culture of Actinomadura verrucosospora, NRRL 18236, and compositions containing an A80577 compound also are provided.
摘要翻译： 新型聚醚抗菌素A80577，其酰基酯和烷基醚衍生物及其盐是有用的抗菌剂，并增加动物的饲料利用效率。 还提供了通过培养Actinomadura verrucosospora，NRRL 18236和含有A80577化合物的组合物制备A80577的方法。
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公开(公告)号：US4677071A
公开(公告)日：1987-06-30
申请号：US638189
申请日：1984-08-06
CPC分类号： C12P1/06 , Y10S435/886
摘要： This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus subspecies rubidus or a mutant thereof. The new antibiotics are active against a variety of microorganisms and are also useful in treating tuberculosis.
摘要翻译： 本发明涉及在微生物发酵过程中，在控制条件下，使用新的菌株Streptomyces coeruleorubidus subspecies rubidus，命名为LL-BO2964α，LL-BO2964β，LL-BO2964γ的新型多肽抗生素及其名称为LL-BO2964的混合物 或其突变体。 新的抗生素对各种微生物有活性，也可用于治疗结核病。
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公开(公告)号：US5391492A
公开(公告)日：1995-02-21
申请号：US66352
申请日：1993-05-21
申请人： Robert L. Hamill , Raymond C. Yao
发明人： Robert L. Hamill , Raymond C. Yao
摘要： New glycopeptide antibiotic A83850, comprising A83850A, and A83850B, is produced by Amycolatopsis albus strain NRRL 18532. A83850A and A83850B can be reduced to give new biologically active denatures. The A83850 antibiotics have activity against Gram-positive bacteria comparable to that of vancomycin.
摘要翻译： 包含A83850A和A83850B的新糖肽抗生素A83850由Amycolatopsis albus菌株NRRL 18532生产.A83850A和A83850B可以被还原以产生新的生物活性变性。 A83850抗生素具有与万古霉素相当的革兰氏阳性菌的活性。
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15.发明授权
公开(公告)号：US5278064A
公开(公告)日：1994-01-11
申请号：US878254
申请日：1992-05-04
申请人： Dennis R. Berry , Anne H. Dantzig , Manuel Debono , Robert Hamill , R. Michael Molloy , Raymond C. Yao
发明人： Dennis R. Berry , Anne H. Dantzig , Manuel Debono , Robert Hamill , R. Michael Molloy , Raymond C. Yao
IPC分类号： A61K20060101 , A61K35/74 , C12N20060101 , C12N1/20 , C12P20060101 , C12P1/06 , C12R20060101 , A61K35/00 , C12R1/01 , C12P1/04
CPC分类号： C12P1/06
摘要： Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C.sub.1-6 -alkyl ether and C.sub.1-6 -alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A.sub.2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A.sub.2 inhibitors that are also useful as antiinflammatory agents.
摘要翻译： 发酵产物A87689由选自NRRL 18815和NRRL 18851或其A87689产生突变体的Amycolatopsis地塞米松菌株产生。 A87689，其C1-6烷基醚和C1-6-烷酰基酯衍生物及其药学上可接受的盐是可用作抗炎剂的磷脂酶A2抑制剂。 被称为BU-3889V的发酵产物及其组分和药学上可接受的盐是也可用作抗炎剂的磷脂酶A2抑制剂。
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公开(公告)号：US5187082A
公开(公告)日：1993-02-16
申请号：US568578
申请日：1990-08-16
申请人： Robert L. Hamill , Raymond C. Yao
发明人： Robert L. Hamill , Raymond C. Yao
摘要： New glycopeptide antibiotic A83850, comprising A83850A, and A83850B, is produced by Amycolatopsis albus strain NRRL 18532. A83850A and A83850B can be reduced to give new biologically active derivatives. The A83850 antibiotics have activity against Gram-positive bacteria comparable to that of vancomycin.
摘要翻译： 包含A83850A和A83850B的新糖肽抗生素A83850由Amycolatopsis albus菌株NRRL 18532生产.A83850A和A83850B可以被还原以产生新的生物活性衍生物。 A83850抗生素具有与万古霉素相当的革兰氏阳性菌的活性。
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公开(公告)号：US4499075A
公开(公告)日：1985-02-12
申请号：US362002
申请日：1982-03-25
CPC分类号： C12P1/06
摘要： This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus subspecies rubidus or a mutant thereof. The new antibiotics are active against a variety of microorganisms and are also useful in treating tuberculosis.
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公开(公告)号：US5552386A
公开(公告)日：1996-09-03
申请号：US42343
申请日：1993-04-02
申请人： Robert L. Hamill , Raymond C. Yao
发明人： Robert L. Hamill , Raymond C. Yao
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P19/445 , C12P19/60 , C12R1/03
摘要： New polyether antibiotic A82810, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A82810 by culture of Actinomodura fibrosa sp. nov. NRRL 18348 and synergistic compositions of the A82810 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
摘要翻译： 新型聚醚抗菌素A82810，其酰基和烷基酯，酰基酯和氨基甲酸酯衍生物及其盐是有用的抗菌和抗球虫剂，并增加动物的饲料利用效率。 通过培养Actinomodura fibrosa sp。制备A82810的方法 nov。 还提供了NRRL 18348和A82810化合物与氨基脲，4,4'-二硝基苯甲酰胺，某些萘胺和苯胺化合物和二氯吲哚醇的协同组合物。
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19.发明授权Process for producing antibiotic A8210 which comprises cultivating Actinomadura Fibrosa sp nov. NRRL 18348, or an A82810-producing mutant thereof 失效生产抗生素A8210的方法，包括培养Actinomadura Fibrosa sp nov。 NRRL 18348或其产生A82810的突变体
公开(公告)号：US5098834A
公开(公告)日：1992-03-24
申请号：US335332
申请日：1989-04-10
申请人： Robert L. Hamill , Raymond C. Yao
发明人： Robert L. Hamill , Raymond C. Yao
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P19/445 , C12P19/60 , C12R1/03 , Y10S435/825
摘要： New Polyether antibiotic A82810, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A82810 by culture of Actinomodura fibrosa sp. nov. NRRL 18348 and synergistic compositions of the A82810 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
摘要翻译： 新的聚醚抗生素A82810，其酰基和烷基酯，酰基酯和氨基甲酸酯衍生物及其盐是有用的抗菌和抗球虫剂，并增加动物的饲料利用效率。 通过培养Actinomodura fibrosa sp。制备A82810的方法 nov。 还提供了NRRL 18348和A82810化合物与氨基脲，4,4'-二硝基苯甲酰胺，某些萘胺和苯胺化合物和二氯吲哚醇的协同组合物。
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公开(公告)号：US4830967A
公开(公告)日：1989-05-16
申请号：US738317
申请日：1985-05-28
申请人： Robert L. Hamill , Raymond C. Yao
发明人： Robert L. Hamill , Raymond C. Yao
IPC分类号： C07D493/10 , A23K20/195 , A61K31/35 , A61P3/00 , A61P31/04 , C07H19/01 , C12P17/18 , C12P19/44 , C12R1/465
CPC分类号： C07H19/01 , A23K20/195 , C12P17/181 , C12P19/44 , C12P19/445 , C12R1/465 , Y10S435/886
摘要： A new strain of Streptomyces pactum, NRRL 15970, and an improved fermentation process for producing the polyether antibiotic A80438 using this microorganism are provided.
摘要翻译： 提供了一种新的链霉菌菌株NRRL 15970，以及使用该微生物生产聚醚抗生素A80438的改进的发酵方法。
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