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1.发明授权7-(substituted)-8-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines 失效7-（取代的）-8-（取代的）-9 - [（取代的甘氨酰基）酰胺基] -6-脱甲基-6-脱氧四环素
公开(公告)号：US5457096A
公开(公告)日：1995-10-10
申请号：US312018
申请日：1994-09-26
Applicant: Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
IPC: C07D295/12 , A61K31/397 , A61K31/445 , A61K31/65 , A61P31/00 , A61P31/04 , C07C20060101 , C07C231/12 , C07C237/26 , C07C239/20 , C07C255/41 , C07C309/39 , C07C309/65 , C07C323/59 , C07D205/04 , C07D205/12 , C07D207/06 , C07D207/16 , C07D207/32 , C07D207/327 , C07D211/34 , C07D213/56 , C07D231/12 , C07D233/60 , C07D233/61 , C07D239/26 , C07D265/02 , C07D265/30 , C07D295/14 , C07D295/15 , C07D295/22 , C07D295/24 , C07D307/54 , C07D401/06 , C07D487/04 , C07D487/08 , C07D521/00
CPC classification number: C07D207/327 , C07C237/26 , C07D205/04 , C07D207/16 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/02 , C07D295/15 , C07D295/24 , C07D307/54 , C07D487/04 , C07C2101/02 , C07C2101/04 , C07C2103/46
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
Abstract translation: 本发明提供下式的化合物：其中R，R 3，R 4，X和W在说明书中定义。 这些化合物可用作抗生素。
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2.发明授权7-(substituted)-8-(substituted)-9-substituted amino)-6-demethyl-6-deoxytetracyclines 失效7-（取代的）-8-（取代的）-9-取代的氨基）-6-脱甲基-6-脱氧四环素
公开(公告)号：US5430162A
公开(公告)日：1995-07-04
申请号：US214992
申请日：1994-03-21
Applicant: Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
IPC: A61K31/65 , A61P31/00 , A61P31/04 , C07C20060101 , C07C237/26 , C07C239/18 , C07C243/20 , C07C245/20 , C07C247/18 , C07C255/41 , C07C271/24 , C07C271/60 , C07C309/39 , C07C309/65 , C07C317/28 , C07C323/59 , C07D205/04 , C07D207/16 , C07D209/52 , C07D221/22 , C07D231/14 , C07D233/61 , C07D233/96 , C07D241/12 , C07D249/04 , C07D249/08 , C07D249/10 , C07D249/16 , C07D257/04 , C07D261/08 , C07D265/30 , C07D265/36 , C07D279/12 , C07D295/08 , C07D295/14 , C07D295/20 , C07D295/22 , C07D307/18 , C07D333/06 , C07D333/36 , C07D453/06 , C07D471/08 , C07D487/08 , C07C233/64 , C07C235/32
CPC classification number: C07C237/26 , C07C243/20 , C07C245/20 , C07C247/18 , C07C271/24 , C07C271/60 , C07C309/65 , C07C2103/46
Abstract: The invention provides compounds of formula ##STR1## wherein X, R and R.sup.1 are defined in the specification. These compounds are useful as antibiotic agents.
Abstract translation: 本发明提供式I的化合物，其中X，R和R 1在本说明书中定义。 这些化合物可用作抗生素。
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3.发明授权7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines 失效7-（取代的）-8-（取代的）-9 - ]（取代的甘氨酰基）酰胺基] -6-脱甲基-6-脱氧四环素
公开(公告)号：US5420272A
公开(公告)日：1995-05-30
申请号：US928578
申请日：1992-08-13
Applicant: Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
IPC: C07D295/12 , A61K31/397 , A61K31/445 , A61K31/65 , A61P31/00 , A61P31/04 , C07C20060101 , C07C231/12 , C07C237/26 , C07C239/20 , C07C255/41 , C07C309/39 , C07C309/65 , C07C323/59 , C07D205/04 , C07D205/12 , C07D207/06 , C07D207/16 , C07D207/32 , C07D207/327 , C07D211/34 , C07D213/56 , C07D231/12 , C07D233/60 , C07D233/61 , C07D239/26 , C07D265/02 , C07D265/30 , C07D295/14 , C07D295/15 , C07D295/22 , C07D295/24 , C07D307/54 , C07D401/06 , C07D487/04 , C07D487/08 , C07D521/00 , C07C233/64
CPC classification number: C07D207/327 , C07C237/26 , C07D205/04 , C07D207/16 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/02 , C07D295/15 , C07D295/24 , C07D307/54 , C07D487/04 , C07C2101/02 , C07C2101/04 , C07C2103/46
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
Abstract translation: 本发明提供了在本说明书中所述的下式的化合物。 这些化合物可用作抗生素。
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公开(公告)号：US5380888A
公开(公告)日：1995-01-10
申请号：US205009
申请日：1994-03-02
Applicant: Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
IPC: A61K31/16 , A61K31/40 , A61K31/403 , A61K31/425 , A61K31/428 , A61K31/65 , A61P31/04 , C07C20060101 , C07C231/12 , C07C237/26 , C07C255/50 , C07C255/52 , C07C317/28 , C07D207/16 , C07D209/02 , C07D211/14 , C07D211/22 , C07D211/26 , C07D213/36 , C07D213/38 , C07D233/56 , C07D233/64 , C07D237/26 , C07D249/04 , C07D249/08 , C07D261/08 , C07D265/30 , C07D277/64 , C07D293/00 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/15 , C07D295/22 , C07D295/30 , C07D307/32 , C07C235/66
CPC classification number: C07D295/30 , C07C237/26 , C07D207/16 , C07D213/38 , C07D295/13 , C07D295/15 , C07C2101/02 , C07C2103/46
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
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公开(公告)号：US4078056A
公开(公告)日：1978-03-07
申请号：US654327
申请日：1976-02-02
Applicant: Marvin J. Weinstein , Gerald H. Wagman , Joseph A. Marquez , Raymond T. Testa
Inventor： Marvin J. Weinstein , Gerald H. Wagman , Joseph A. Marquez , Raymond T. Testa
CPC classification number: C07K4/04 , C07G11/00 , C12P17/185 , C12P21/02 , Y10S435/863
Abstract: Micromonospora arborensis produces a plurality of antibiotics named herein antibiotic 68-1147 complex, when cultivated under controlled aerobic conditions. Two of the antibiotics, antibiotic 68-1147 I and antibiotic 68-1147 II are described and shown to be effective antibacterial agents, especially against gram positive bacteria.
Abstract translation: 当在受控的有氧条件下栽培时，小单孢菌产生多种本文中称为抗生素68-1147复合物的抗生素。 描述了两种抗生素，抗生素68-1147 I和抗生素68-1147 II，并显示为有效的抗菌剂，特别是抗革兰氏阳性细菌。
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Patent Agency Ranking
公开(公告)号：US3959254A
公开(公告)日：1976-05-25
申请号：US414010
申请日：1973-11-08
Applicant: Marvin J. Weinstein , Gerald H. Wagman , Raymond T. Testa , Joseph A. Marquez
Inventor： Marvin J. Weinstein , Gerald H. Wagman , Raymond T. Testa , Joseph A. Marquez
CPC classification number: C07G11/00 , C07H15/22 , Y10S435/863
Abstract: A novel actinomycete herein designated Micromonospora rhodorangea elaborates a product having substantial antibacterial activity, said activity being due primarily to a novel antibiotic herein designated Antibiotic G-418. The disclosure sets forth methods for producing, isolating and using said antibiotic.
Abstract translation: 本文命名为小单孢菌（Rhodomonic）的新颖放线菌制备了具有显着抗菌活性的产品，所述活性主要是由于本文命名为抗生素G-418的新型抗生素。 本公开阐述了生产，分离和使用所述抗生素的方法。
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7.发明授权7-(substituted)-8-(substituted)-9-[(substituted glycyl) amido]-6-demethyl-6-deoxytetracyclines 失效7-（取代的）-8-（取代的）-9 - [（取代的甘氨酰基）酰胺基] -6-脱甲基-6-脱氧四环素
公开(公告)号：US5386041A
公开(公告)日：1995-01-31
申请号：US193828
申请日：1994-02-08
Applicant: Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
IPC: C07D295/12 , A61K31/397 , A61K31/445 , A61K31/65 , A61P31/00 , A61P31/04 , C07C20060101 , C07C231/12 , C07C237/26 , C07C239/20 , C07C255/41 , C07C309/39 , C07C309/65 , C07C323/59 , C07D205/04 , C07D205/12 , C07D207/06 , C07D207/16 , C07D207/32 , C07D207/327 , C07D211/34 , C07D213/56 , C07D231/12 , C07D233/60 , C07D233/61 , C07D239/26 , C07D265/02 , C07D265/30 , C07D295/14 , C07D295/15 , C07D295/22 , C07D295/24 , C07D307/54 , C07D401/06 , C07D487/04 , C07D487/08 , C07D521/00 , C07C235/66
CPC classification number: C07D207/327 , C07C237/26 , C07D205/04 , C07D207/16 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/02 , C07D295/15 , C07D295/24 , C07D307/54 , C07D487/04 , C07C2101/02 , C07C2101/04 , C07C2103/46
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
Abstract translation: 本发明提供下式的化合物：其中R，R 3，R 4，X和W在说明书中定义。 这些化合物可用作抗生素。
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公开(公告)号：US4774184A
公开(公告)日：1988-09-27
申请号：US765418
申请日：1985-08-14
Applicant: Taikwang M. Lee , Donald B. Borders , Joseph J. Goodman , Raymond T. Testa , William M. Maiese , David P. Labeda
Inventor： Taikwang M. Lee , Donald B. Borders , Joseph J. Goodman , Raymond T. Testa , William M. Maiese , David P. Labeda
IPC: A23K20/195 , C07D491/16 , C12P17/18 , C12P17/16 , C12N1/20 , C12R1/03
CPC classification number: C07D491/16 , A23K20/195 , C12P17/188 , C12R1/03 , Y10S435/825
Abstract: The invention is a process for the production by fermentation of the antibacterial and antiparasitic agents designated LL-D42067.alpha., to methods for its recovery and concentration from crude solutions and to processes for its purification. The invention includes within its scope the biologically pure culture of the antibiotic.
Abstract translation: 本发明是通过发酵生产名为LL-D42067α的抗细菌剂和抗寄生虫剂的方法，用于从粗溶液中回收和浓缩的方法及其纯化方法。 本发明在其范围内包括抗生素的生物学纯培养。
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公开(公告)号：US4705688A
公开(公告)日：1987-11-10
申请号：US880230
申请日：1986-06-30
Applicant: Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
Inventor： Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
CPC classification number: C12P1/06
Abstract: This invention relates to antibiotic LL-E19020.alpha. and LL-E19020.beta. derived from the microorganism Streptomyces lydicus subspecies tanzanius NRRL 18036, which are useful as an antibacterial agent.
Abstract translation: 本发明涉及衍生自微生物链霉菌属（Streptomyces lydicus subspecies tanzanius）NRRL 18036的抗生素LL-E19020α和LL-E19020ββ，其可用作抗菌剂。
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公开(公告)号：US4499075A
公开(公告)日：1985-02-12
申请号：US362002
申请日：1982-03-25
Applicant: May D. Lee , John H. Martin , Donald B. Borders , Raymond C. Yao , Raymond T. Testa
Inventor： May D. Lee , John H. Martin , Donald B. Borders , Raymond C. Yao , Raymond T. Testa
CPC classification number: C12P1/06
Abstract: This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus subspecies rubidus or a mutant thereof. The new antibiotics are active against a variety of microorganisms and are also useful in treating tuberculosis.
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