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22 条记录 (耗时 0.029 秒)

    Neutralizing Antibodies to Influenza Viruses
    12.
    发明申请
    Neutralizing Antibodies to Influenza Viruses 审中-公开
    中和抗体流感病毒

    公开(公告)号：US20080014205A1

    公开(公告)日：2008-01-17

    申请号：US11748980

    申请日：2007-05-15

    申请人： Lawrence Horowitz ,  Ramesh Bhatt ,  Arun Kashyap

    发明人： Lawrence Horowitz ,  Ramesh Bhatt ,  Arun Kashyap

    IPC分类号： A61K39/395 ,  C07K16/08 ,  C40B30/04 ,  C40B40/10

    CPC分类号： C07K16/1018 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76 ,  C12N15/1037

    摘要： The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the neutralizing antibodies produced. In particular, the invention concerns neutralizing antibodies against various influenza A virus subtypes, including neutralizing antibodies against two or more of H1, H2, H3, H5, H7 and H9, such as, for example all of H1, H2, H3, and H5 subtypes, and methods and means for making such antibodies. More specifically, the invention concerns antibodies capable of neutralizing more than one, preferably all, isolates of an influenza A virus subtype.

    摘要翻译： 本发明涉及用于鉴定，产生和设计中和甲型流感病毒抗体的方法和手段，以及产生的中和抗体。 特别地，本发明涉及针对各种甲型流感病毒亚型的中和抗体，包括针对H1，H2，H3，H5，H7和H9中的两种或多种的中和抗体，例如H1，H2，H3和H5全部 亚型，以及制备此类抗体的方法和手段。 更具体地，本发明涉及能够中和甲型流感病毒亚型的多于一种，优选全部的分离物的抗体。

    CHAIN REACTION CREATING OLIGOMERS FROM REPEAT UNITS OF BINDING MOLECULES
    16.
    发明申请
    CHAIN REACTION CREATING OLIGOMERS FROM REPEAT UNITS OF BINDING MOLECULES 审中-公开
    链条反应创建复合分子重复单元的寡聚体

    公开(公告)号：US20100233167A1

    公开(公告)日：2010-09-16

    申请号：US12597948

    申请日：2008-05-09

    申请人： Ramesh Bhatt ,  Lawrence Horowitz

    发明人： Ramesh Bhatt ,  Lawrence Horowitz

    IPC分类号： A61K39/395 ,  C07K16/46 ,  A61P35/00

    CPC分类号： C07K16/4208 ,  C07K16/00 ,  C07K16/283 ,  C07K16/32 ,  C07K16/42 ,  C07K2317/31 ,  C07K2317/32

    摘要： The present invention concerns a chain reaction of cross-linking antibodies or other binding molecules prior or subsequent to binding to a target, such as a target antigen. The invention further concerns oligomers comprising repeat units of binding molecules, such as antibodies, optionally bound to a target, such as a target antigen. The invention also relates to antibodies and other binding molecules with multiple specificities useful in the methods of the invention, as well as various uses of the oligomers and individual binding molecules present in the oligomers.

    摘要翻译： 本发明涉及在与靶标（例如靶抗原）结合之前或之后的交联抗体或其它结合分子的连锁反应。 本发明还涉及包含结合分子的重复单元的寡聚体，例如任选地与靶标结合的抗体，例如靶抗原。 本发明还涉及具有多种特异性的抗体和其它结合分子，其可用于本发明的方法，以及低聚物中存在的寡聚体和单独结合分子的各种用途。

    CONSTRUCTION OF DIVERSE SYNTHETIC PEPTIDE AND POLYPEPTIDE LIBRARIES
    19.
    发明申请
    CONSTRUCTION OF DIVERSE SYNTHETIC PEPTIDE AND POLYPEPTIDE LIBRARIES 有权
    多肽合成肽和多肽图谱的构建

    公开(公告)号：US20090082213A1

    公开(公告)日：2009-03-26

    申请号：US11864525

    申请日：2007-09-28

    申请人： Lawrence Horowitz ,  Ramesh Bhatt ,  Aaron L. Kurtzman

    发明人： Lawrence Horowitz ,  Ramesh Bhatt ,  Aaron L. Kurtzman

    IPC分类号： C40B30/02 ,  C40B50/02

    CPC分类号： G06F19/22 ,  C07K16/005 ,  C07K16/22 ,  C07K16/241 ,  C07K16/249 ,  C07K16/44 ,  C07K16/461 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/94 ,  C12N15/1058 ,  C40B50/02 ,  G06F19/28

    摘要： The present invention concerns the design and construction of diverse peptide and polypeptide libraries. In particular, the invention concerns methods of analytical database design for creating datasets using multiple relevant parameters as filters, and methods for generating sequence diversity by directed multisyntheses oligonucleotide synthesis. The present methods enable the reduction of large complex annotated databases to simpler datasets of related sequences, based upon relevant single or multiple key parameters that can be individually directly defined. The methods further enable the creation of diverse libraries based on this approach, using multisynthetic collections of discrete and degenerate oligonucleotides to capture the diverse collection of sequences, or portions thereof.

    摘要翻译： 本发明涉及不同肽和多肽文库的设计和构建。 特别地，本发明涉及使用多个相关参数作为滤波器创建数据集的分析数据库设计方法，以及通过定向多合成寡核苷酸合成生成序列多样性的方法。 基于可以单独直接定义的相关单个或多个关键参数，本方法使得能够将大型复杂注释数据库减少到相关序列的更简单的数据集。 该方法还使得能够基于这种方法创建多样化的文库，使用离散和简并寡核苷酸的多合成收集来捕获序列或其部分的不同集合。

    Facilitation of translocation of molecules through the gastrointestinal tract
    20.
    发明申请
    Facilitation of translocation of molecules through the gastrointestinal tract 审中-公开
    促进分子通过胃肠道易位

    公开(公告)号：US20070224627A1

    公开(公告)日：2007-09-27

    申请号：US11726902

    申请日：2007-03-23

    申请人： Lawrence Horowitz ,  Ramesh Bhatt ,  Aaron Kurtzman ,  Helena Yee

    发明人： Lawrence Horowitz ,  Ramesh Bhatt ,  Aaron Kurtzman ,  Helena Yee

    IPC分类号： C40B50/06 ,  C40B40/08 ,  C40B40/10 ,  C40B30/06

    CPC分类号： C07K16/00 ,  C07K2317/622 ,  G01N33/5082 ,  G01N33/5088

    摘要： The invention concerns methods and means for facilitating the translocation of molecules through the gastrointestinal tract of mammals. In particular, the invention concerns methods for identifying antibodies, including antibody fragments, capable of translocation from the lumenal side of gastrointestinal tissue into the blood stream or into the lymphatic circulation. The invention further concerns the identification of sequences within or associated with such antibodies facilitating translocation through the gastrointestinal tract. The invention additionally concerns the use of such antibodies and sequences, or other molecules or moieties identified by using such antibodies or sequences, for facilitating oral delivery and absorption of molecules, such as biomolecules (including proteins and nucleic acids), antibodies, peptides, and non-peptide small molecules.

    摘要翻译： 本发明涉及促进分子通过哺乳动物胃肠道易位的方法和手段。 特别地，本发明涉及用于鉴定抗体的方法，所述抗体包括抗体片段，其能够从胃肠组织的内腔侧移位到血流或淋巴循环中。 本发明还涉及确定促进易位通过胃肠道的此类抗体内或与之相关的序列。 本发明还涉及这样的抗体和序列或通过使用这些抗体或序列鉴定的其它分子或部分用于促进分子的口服递送和吸收（例如生物分子（包括蛋白质和核酸）），抗体，肽和 非肽小分子。