公开(公告)号：US08002753B2

公开(公告)日：2011-08-23

申请号：US12340920

申请日：2008-12-22

Applicant: John F. Krumme ,  Leslie A. Field

Inventor： John F. Krumme ,  Leslie A. Field

IPC: A61M5/00 ,  A61M5/178 ,  A61M37/00

CPC classification number: A61M5/2053 ,  A61M5/14244 ,  A61M5/14526 ,  A61M5/16881 ,  A61M5/20 ,  A61M2005/3128 ,  A61M2205/6081

Abstract: An apparatus includes a medicament container and an actuator assembly coupled to a proximal end portion of the medicament container. A distal end portion of the medicament container is configured to be coupled to a needle. A piston is movably disposed within the medicament container such that the medicament container is divided into a first internal portion and a second internal portion, the first internal portion containing a medicament. The actuator assembly has a pressurized fluid container, a regulator and a bias member. The pressurized fluid container is configured to move relative to the medicament container between a first position and a second position. The regulator is configured to fluidically couple the pressurized fluid container and the second internal portion of the medicament container when the pressurized fluid container is in the second position. The bias member is configured to bias the pressurized fluid container in the first position.

Abstract translation: 一种装置包括药物容器和联接到药物容器的近端部分的致动器组件。 药物容器的远端部分被配置为联接到针。 活塞可移动地设置在药物容器内，使得药物容器被分成第一内部部分和第二内部部分，第一内部部分包含药物。 致动器组件具有加压流体容器，调节器和偏置构件。 加压流体容器构造成在第一位置和第二位置之间相对于药物容器移动。 调节器构造成当加压流体容器处于第二位置时流体耦合加压流体容器和药物容器的第二内部部分。 偏置构件构造成在第一位置偏压加压流体容器。

公开(公告)号：US06398850B1

公开(公告)日：2002-06-04

申请号：US09892203

申请日：2001-06-25

Applicant: Leslie A. Field ,  David K. Donald ,  Phillip W. Barth ,  Jonathan Servaites ,  Storrs T. Hoen

Inventor： Leslie A. Field ,  David K. Donald ,  Phillip W. Barth ,  Jonathan Servaites ,  Storrs T. Hoen

IPC: B41J219

CPC classification number: B41J2/19

Abstract: A thermally-activated gas extraction device that comprises a bubble capture chamber, an exhaust manifold, a tapered extraction chamber and an extraction heater associated with the tapered extraction chamber. The tapered extraction chamber extends from the bubble capture chamber towards the exhaust manifold and has a cross-sectional area that increases towards the exhaust manifold. A gas removal method in which the gas extraction device is provided, a bubble of gas is accumulated in the bubble capture chamber, a portion of the liquid in the tapered extraction chamber heated to nucleate a bubble of vapor, and the bubble of vapor is heated to explosively expand the bubble of vapor into contact with the walls of the tapered extraction chamber and into contact with the bubble of gas to form a composite bubble. Contact with the walls of the tapered extraction moves the composite bubble towards the exhaust manifold. Finally, heating of the composite bubble is discontinued to condense the vapor in the composite bubble.

Abstract translation: 一种热活化气体提取装置，其包括气泡捕获室，排气歧管，锥形抽出室和与锥形抽出室相关联的抽出加热器。 锥形抽出室从气泡捕获室朝向排气歧管延伸并且具有朝向排气歧管增加的横截面面积。 一种气体去除方法，其中提供气体提取装置，气体的气泡积聚在气泡捕获室中，锥形抽出室中的一部分液体被加热以使蒸汽的气泡成核，并且蒸气的气泡被加热 以将爆炸性地膨胀蒸汽气泡与锥形抽出室的壁接触并与气泡接触以形成复合气泡。 与锥形提取物的壁接触将复合气泡朝向排气歧管移动。 最后，中止复合气泡的加热以冷凝复合气泡中的蒸汽。

公开(公告)号：US5882532A

公开(公告)日：1999-03-16

申请号：US656624

申请日：1996-05-31

Applicant: Leslie A. Field ,  Paul P. Merchant

Inventor： Leslie A. Field ,  Paul P. Merchant

IPC: B81B3/00 ,  B81C1/00 ,  B81C99/00 ,  H01L21/00

CPC classification number: B81C99/008

Abstract: A thin micromechanical device is fabricated in a way that is mechanically compatible with wafer handling for conventional-thickness wafers. A removable bonding layer bonds a fabrication wafer to a substantially conventional-thickness handle wafer to form a bonded wafer pair. The micromechanical device is formed in the fabrication wafer by subjecting the bonded wafer pair to processing including wafer handling for conventional-thickness wafers. The micromechanical device is formed to include part of the fabrication wafer. Finally, the bonding layer underlying the micromechanical device is removed to release the micromechanical device from the handle wafer.

Abstract translation: 以与常规厚度晶片的晶片处理机械相容的方式制造薄的微机械器件。 可移除的粘合层将制造晶片结合到基本上常规的厚度的处理晶片上以形成键合晶片对。 微机电器件通过使接合晶片对经受包括常规厚度晶片的晶片处理的处理而形成在制造晶片中。 微机械装置形成为包括制造晶片的一部分。 最后，去除微机械装置下面的粘合层，以从处理晶片释放微机械装置。

公开(公告)号：US5446811A

公开(公告)日：1995-08-29

申请号：US212543

申请日：1994-03-14

Applicant: Leslie A. Field ,  Richard C. Ruby

Inventor： Leslie A. Field ,  Richard C. Ruby

IPC: G02B26/08 ,  G02B6/35 ,  G02B6/26

CPC classification number: G02B6/3508 ,  G02B6/3576 ,  G02B6/3552 ,  G02B6/3584 ,  H01H2001/0068

Abstract: A micromachined device for selectively switching an optical fiber between a first and a second position includes a working leg that undergoes a greater degree of thermal expansion than a second leg with the conduction of an electrical current through the two legs. In a preferred embodiment, the working leg has a cross-sectional area that is less than that of the second leg, thereby presenting a greater electrical resistance to the current flow. The legs are each fixed to a substrate at first ends and are interconnected at second ends that are free to move relative to the substrate. The difference in electrical resistance provides a differential in thermal expansion, as the working leg lengthens to a greater degree than the second leg. The working leg deforms the second leg and the optical fiber is pressed into a second position until current flow is terminated. In another embodiment, the differential in thermal expansion is created by ensuring that the second leg has less thermal isolation from the substrate than the thermal isolation of the working leg from the substrate.

Abstract translation: 用于在第一位置和第二位置之间选择性地切换光纤的微机械加工装置包括经过两条腿的电流传导而经受比第二腿部更大程度的热膨胀的工作腿部。 在优选实施例中，工作腿的横截面积小于第二腿的横截面积，从而对电流呈现更大的电阻。 腿在第一端各自固定到基底，并且在相对于基底自由移动的第二端处互连。 电阻的差异提供了热膨胀的差异，因为工作腿比第二条腿更大程度地延长。 工作腿使第二腿变形，并将光纤压入第二位置，直到电流流动终止。 在另一个实施例中，热膨胀差异是通过确保第二支腿与工作支脚与基板的热隔离相比具有比基板更小的热隔离来产生的。

公开(公告)号：US20200072210A1

公开(公告)日：2020-03-05

申请号：US16556187

申请日：2019-08-29

Applicant: Phillip W. Barth ,  Leslie A. Field

Inventor： Phillip W. Barth ,  Leslie A. Field

IPC: F04B43/00 ,  F04B43/12

Abstract: A flow channel suitable for use with a peristaltic pump comprises: an upper wall having a bowed upward shape; a lower wall having one of a bowed downward shape and a flat shape; and one or more spacers between the upper wall and the lower wall disposed between lateral edges of the upper and lower walls, each spacer having a height. The upper wall, lower wall, and the one or more spacers define a lumen. When the upper wall is compressed toward the lower wall by compressing members, the one or more spacers limit vertical movement of the compressing members such that the lumen is maintained in an under-occluded condition. In some cases, the bowing of one of the upper and lower walls has a recurved shape.

公开(公告)号：US09072588B2

公开(公告)日：2015-07-07

申请号：US13251368

申请日：2011-10-03

Applicant: Sebastian Böhm ,  Leslie A. Field

Inventor： Sebastian Böhm ,  Leslie A. Field

IPC: A61F9/00 ,  A61F9/007

CPC classification number: A61F9/00781

Abstract: A selectable IOP valve for implantation in an eye of a patient controls IOP and/or bleb pressure. The valve includes a drainage tube configured to convey aqueous from an anterior chamber of an eye and includes a selectable flow control valve in fluid communication with the drainage tube and configured to control flow rates of the aqueous. The valve system includes a plurality of flow control pathways arranged to operate in parallel with each other, each of the flow control pathways being in communication with an entry port to the valve system. A flow control mechanism controls aqueous flow through the pathways. Methods and systems are also disclosed.

Abstract translation: 用于植入患者眼睛中的可选IOP阀控制IOP和/或气泡压力。 所述阀包括引流管，所述引流管构造成从眼睛的前房输送水分，并且包括与所述引流管流体连通并被配置为控制所述水的流速的可选择的流量控制阀。 阀系统包括多个流量控制通道，其布置成彼此并联操作，每个流量控制通路与阀系统的入口连通。 流量控制机构控制通过路径的水流。 还公开了方法和系统。

公开(公告)号：US20140311178A1

公开(公告)日：2014-10-23

申请号：US14259114

申请日：2014-04-22

Applicant: Leslie A. Field ,  Susan J. Strehlow ,  David G. Duff ,  Kimberly M. Wiefling

Inventor： Leslie A. Field ,  Susan J. Strehlow ,  David G. Duff ,  Kimberly M. Wiefling

IPC: F25C1/02

CPC classification number: F25C1/00

Abstract: Embodiments generally relate to methods and apparatuses for generating ice. In one embodiment, a material is introduced to water, and the temperature of the combination of the water and the material is lowered until ice forms, the formed ice having a higher albedo than it would have had if the step of lowering the temperature had been carried out on the water without first carrying out the step of introducing the material. In one embodiment, the material is selected such that an aqueous solution of the material is alkaline. In another embodiment, a material is introduced to water, and the temperature of the combination of the water and the material is lowered until ice forms, the ice forming at a faster rate than the rate at which it would have formed if the material had not been introduced to the water.

Abstract translation: 实施例通常涉及用于产生冰的方法和装置。 在一个实施方案中，将材料引入水中，并且水和材料的组合的温度降低直到形成冰，所形成的冰具有比如果降低温度的步骤已经具有更高的反照率 在水上进行，而不首先进行引入材料的步骤。 在一个实施方案中，选择材料使得材料的水溶液是碱性的。 在另一个实施方案中，将材料引入水中，并且降低水和材料的组合的温度，直到形成冰，形成冰的速度比材料未形成的速率更快 被引入水中。

公开(公告)号：US08864701B2

公开(公告)日：2014-10-21

申请号：US13584435

申请日：2012-08-13

Applicant: Cesario P. Dos Santos ,  Nicholas M. Gunn ,  Robert J. Sanchez, Jr. ,  Leslie A. Field ,  Chen Ning

Inventor： Cesario P. Dos Santos ,  Nicholas M. Gunn ,  Robert J. Sanchez, Jr. ,  Leslie A. Field ,  Chen Ning

IPC: A61M5/00

CPC classification number: A61F9/00781 ,  A61B3/16 ,  A61B2562/028 ,  A61F2210/0076

Abstract: An implantable MEMS package for the treatment of an ocular condition is provided. The MEMS package includes an outer portion; an active portion attached to the outer portion, the active portion including a fluid regulating element having a moving element; and a fluidic channel at an interface of the outer portion and the active portion. The fluidic channel is formed in at least one of the outer and active portions and permits fluid communication from the MEMS package to the fluid regulating element. A method for forming a MEMS package as above is also provided. An ocular implant for treating glaucoma including an inlet tube for receiving aqueous humor; a MEMS package as above, coupled to the inlet tube; a control system to control the MEMS package; and an outlet tube for draining aqueous humor at a drainage location, is provided.

Abstract translation: 提供了一种用于治疗眼睛病症的植入式MEMS封装。 MEMS封装包括外部部分; 活动部分附接到外部部分，活动部分包括具有移动元件的流体调节元件; 以及在外部部分和活动部分的界面处的流体通道。 流体通道形成在外部和活动部分中的至少一个中，并且允许从MEMS封装到流体调节元件的流体连通。 还提供了如上形成MEMS封装的方法。 一种用于治疗青光眼的眼部植入物，包括用于接收房水的入口管; 如上所述的MEMS封装，耦合到入口管; 控制系统来控制MEMS封装; 并且提供用于在排水位置排出房水的出口管。

公开(公告)号：US20130150776A1

公开(公告)日：2013-06-13

申请号：US13316717

申请日：2011-12-12

Applicant: Sebastian Böhm ,  Leslie A. Field ,  Matthew J.A. Rickard

Inventor： Sebastian Böhm ,  Leslie A. Field ,  Matthew J.A. Rickard

IPC: A61F9/00

CPC classification number: A61B3/16 ,  A61F9/00781

Abstract: Glaucoma drainage devices including vario-stable valves and associated systems and methods are disclosed. A glaucoma drainage device includes a drainage lumen and a valve system coupled to the drainage lumen to control the flow of fluid through the drainage lumen. The valve system includes an adjustable valve with a diaphragm that is in communication with the drainage lumen and is movable to occupy varying amounts of the drainage lumen. In some embodiments, the valve system is maintained in a desired position without the use of power such that power is only needed when changing a position of the adjustable valve.

公开(公告)号：US20090177158A1

公开(公告)日：2009-07-09

申请号：US12340920

申请日：2008-12-22

Applicant: John F. KRUMME ,  Leslie A. Field

Inventor： John F. KRUMME ,  Leslie A. Field

IPC: A61M5/155

CPC classification number: A61M5/2053 ,  A61M5/14244 ,  A61M5/14526 ,  A61M5/16881 ,  A61M5/20 ,  A61M2005/3128 ,  A61M2205/6081

Abstract: An apparatus includes a medicament container and an actuator assembly coupled to a proximal end portion of the medicament container. A distal end portion of the medicament container is configured to be coupled to a needle. A piston is movably disposed within the medicament container such that the medicament container is divided into a first internal portion and a second internal portion, the first internal portion containing a medicament. The actuator assembly has a pressurized fluid container, a regulator and a bias member. The pressurized fluid container is configured to move relative to the medicament container between a first position and a second position. The regulator is configured to fluidically couple the pressurized fluid container and the second internal portion of the medicament container when the pressurized fluid container is in the second position. The bias member is configured to bias the pressurized fluid container in the first position.

Abstract translation: 一种装置包括药物容器和联接到药物容器的近端部分的致动器组件。 药物容器的远端部分被配置为联接到针。 活塞可移动地设置在药物容器内，使得药物容器被分成第一内部部分和第二内部部分，第一内部部分包含药物。 致动器组件具有加压流体容器，调节器和偏置构件。 加压流体容器构造成在第一位置和第二位置之间相对于药物容器移动。 调节器构造成当加压流体容器处于第二位置时流体耦合加压流体容器和药物容器的第二内部部分。 偏置构件构造成在第一位置偏压加压流体容器。