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公开(公告)号：US11237108B2
公开(公告)日：2022-02-01
申请号：US16904784
申请日：2020-06-18
Inventor： Ming Song Chen , Chee Woei Chong , Wuh Ken Loh , Wern Yuh Foo , Kuan Moon Boo , Norbert Leclerc , Kristina Uhlendorf , Reiner Koellner , Torsten Fuchs , Stefan Breitfelder
IPC: G01N21/64
Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.
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公开(公告)号：US20240309441A1
公开(公告)日：2024-09-19
申请号：US18583747
申请日：2024-02-21
Applicant: Life Technologies Corporation
Inventor： Mingsong Chen , Soo Yong Lau , Kuan Moon Boo , Mauro Aguanno , Huei Yeo , Tiong Han Toh , Wei Fuh Teo
CPC classification number: C12Q1/686 , B01L7/52 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6458 , G02B21/244 , B01L2200/10 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/18 , G01N2021/6463
Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The instrument may further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.
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公开(公告)号：US12031916B2
公开(公告)日：2024-07-09
申请号：US17962123
申请日：2022-10-07
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Mingsong Chen , Mauro Aguanno , Kuan Moon Boo , Woon Liang Terence Soh , Jacob K. Freudenthal , Jeffrey A. Marks
CPC classification number: G01N21/6486 , G01N21/0332 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2201/061 , G01N2201/0624 , G01N2201/0627 , G01N2201/121
Abstract: An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.
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公开(公告)号：US11680905B2
公开(公告)日：2023-06-20
申请号：US17572926
申请日：2022-01-11
Inventor： Ming Song Chen , Chee Woei Chong , Wuh Ken Loh , Wern Yuh Foo , Kuan Moon Boo , Norbert Leclerc , Kristina Uhlendorf , Reiner Koellner , Torsten Fuchs , Stefan Breitfelder
IPC: G01N21/64
CPC classification number: G01N21/6452 , G01N21/6428 , G01N21/6458 , G01N2021/6478
Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.
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公开(公告)号：US11467092B2
公开(公告)日：2022-10-11
申请号：US16797561
申请日：2020-02-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Mingsong Chen , Mauro Aguanno , Kuan Moon Boo , Woon Liang Terence Soh , Jacob K. Freudenthal , Jeffrey A. Marks
Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.
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Patent Agency Ranking
公开(公告)号：USD822847S1
公开(公告)日：2018-07-10
申请号：US29585174
申请日：2016-11-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Designer： Kuan Moon Boo , Way Xuang Lee , Wuh Ken Loh , Zeqi Tan , Sandro Klein
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公开(公告)号：US20170072398A1
公开(公告)日：2017-03-16
申请号：US15266943
申请日：2016-09-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kuan Moon Boo , Wei Fuh Teo , Wuh Ken Loh , Zeqi Tan , Siew Yin Lee
CPC classification number: B01L7/52 , B01L2200/025 , B01L2200/04 , B01L2200/147 , B01L2300/0829 , B01L2300/1822 , F25B21/04 , F25B2321/0251
Abstract: A thermal block assembly for use in a biological analysis system includes a sample block, a heating and cooling element, a heat sink including a surface, the surface including a plurality of projections for engaging the heating and cooling element to hold the heating and cooling element on the heat sink. A thermal block assembly for use in a biological analysis system includes a heating and cooling element, a sample block including a lower surface configured to be thermally coupled to the heating and cooling element, one or more temperature sensors configured to extend through the one or more slots of the lower surface of the sample block, and one or more thermal pads between the one or more temperature sensors and heating and cooling element.
Abstract translation: 用于生物分析系统的热块组件包括样品块，加热和冷却元件，包括表面的散热器，所述表面包括多个突起，用于接合加热和冷却元件以保持加热和冷却元件 在散热片上 用于生物分析系统的热块组件包括加热和冷却元件，样品块，其包括配置成热耦合到加热和冷却元件的下表面，配置成延伸穿过所述一个或多个 样品块的下表面的槽，以及一个或多个温度传感器和加热和冷却元件之间的一个或多个热垫。
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公开(公告)号：US12140544B2
公开(公告)日：2024-11-12
申请号：US18308177
申请日：2023-04-27
Inventor： Ming Song Chen , Chee Woei Chong , Wuh Ken Loh , Wern Yuh Foo , Kuan Moon Boo , Norbert Leclerc , Kristina Uhlendorf , Reiner Koellner , Torsten Fuchs , Stefan Breitfelder
IPC: G01N21/64
Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.
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公开(公告)号：US11815460B2
公开(公告)日：2023-11-14
申请号：US17825222
申请日：2022-05-26
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kevin Maher , Mingsong Chen , Jacob K. Freudenthal , Kuan Moon Boo , Soo Yong Lau , David Fortescue , Ming Shen , Woon Liang Terence Soh
CPC classification number: G01N21/6486 , G01N21/6428 , G01N21/6452 , G01N2021/6471 , G01N2021/6478 , G01N2201/062
Abstract: A method of analyzing a plurality of biological sample volumes comprises emitting, along an excitation optical path toward a sample holder holding the plurality of biological sample volumes, electromagnetic radiation from a broadband LED, wherein the broadband LED emits the electromagnetic radiation across a range of wavelengths at a total output power of at least 5 watts and at a maximum intensity at a wavelength less than 600 nanometers and at an intensity less than 30 percent of the maximum intensity at a wavelength of 650 or 670 nanometers, and receiving, by a sensor, an electromagnetic emission transmitted from the sample holder along an emission optical path.
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公开(公告)号：US20230031117A1
公开(公告)日：2023-02-02
申请号：US17966364
申请日：2022-10-14
Inventor： Kuan Moon Boo , Wei Fuh Teo , Zeqi Tan , Soo Yong Lau , Ming Tiong Sia , Woon Liang Soh , Ching Yee Lam , Shan Hua Dong , Marc Haberstroh , Michael C. Pallas , Hardeep Sangha
Abstract: A system for biological analysis includes a housing, a block assembly within the housing having a sample block and a baseplate, a heated cover and a cover carrier. The sample block receives a sample holder comprising an RFID tag. A first drive mechanism generates relative movement between the sample block and the baseplate along a first axis. A second drive mechanism generates relative movement between the heated cover and the cover carrier along a second axis that is different from the first axis. Based on a first command the first drive mechanism releasably engages the sample block and operates the second drive mechanism to releasably engage the heated cover with the cover carrier. The system also includes first and second RFID antennas that receive RFID data from the sample holder RFID tag that is read by at least one RFID reader.
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