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公开(公告)号：US20240309441A1
公开(公告)日：2024-09-19
申请号：US18583747
申请日：2024-02-21
Applicant: Life Technologies Corporation
Inventor： Mingsong Chen , Soo Yong Lau , Kuan Moon Boo , Mauro Aguanno , Huei Yeo , Tiong Han Toh , Wei Fuh Teo
CPC classification number: C12Q1/686 , B01L7/52 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6458 , G02B21/244 , B01L2200/10 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/18 , G01N2021/6463
Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The instrument may further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.
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公开(公告)号：US11920191B2
公开(公告)日：2024-03-05
申请号：US17151657
申请日：2021-01-18
Applicant: Life TECHNOLOGIES CORPORATION
Inventor： Mingsong Chen , Kuan Moon Boo , Tiong Han Toh , Mauro Aguanno , Soo Yong Lau , Huei Yeo , Wei Fuh Teo
CPC classification number: C12Q1/686 , B01L7/52 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6458 , G02B21/244 , B01L2200/10 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/18 , G01N2021/6463
Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.
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公开(公告)号：US11339425B2
公开(公告)日：2022-05-24
申请号：US16382294
申请日：2019-04-12
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Ted Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.
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公开(公告)号：US10323274B2
公开(公告)日：2019-06-18
申请号：US14348504
申请日：2012-09-28
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jacob K. Freudenthal , Kevin Maher , Ming Song Chen , Theodore E. Straub , Kuan Moon Boo , Soo Yong Lau
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
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公开(公告)号：US20140213487A1
公开(公告)日：2014-07-31
申请号：US14348504
申请日：2012-09-28
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Theodore E. Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
CPC classification number: C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
Abstract translation: 提供生物分析系统。 该系统包括被配置为容纳多个样品保持器中的任何一个的可互换组件，每个样品保持器被配置为接收多个样品。 该系统还包括被配置为使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。
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Patent Agency Ranking
公开(公告)号：US20240295499A1
公开(公告)日：2024-09-05
申请号：US18662295
申请日：2024-05-13
Applicant: Life Technologies Corporation
Inventor： Kevin Maher , David Fortescue , Soo Yong Lau , Jacob K. Freudenthal , Woon Liang Terence SOH , Mingsong Chen , Ming Shen , Kuan Moon BOO
IPC: G01N21/64
CPC classification number: G01N21/6486 , G01N21/6428 , G01N21/6452 , G01N2021/6471 , G01N2021/6478 , G01N2201/062
Abstract: An instrument for processing and/or measuring a biological process comprises a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.
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公开(公告)号：US11815460B2
公开(公告)日：2023-11-14
申请号：US17825222
申请日：2022-05-26
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kevin Maher , Mingsong Chen , Jacob K. Freudenthal , Kuan Moon Boo , Soo Yong Lau , David Fortescue , Ming Shen , Woon Liang Terence Soh
CPC classification number: G01N21/6486 , G01N21/6428 , G01N21/6452 , G01N2021/6471 , G01N2021/6478 , G01N2201/062
Abstract: A method of analyzing a plurality of biological sample volumes comprises emitting, along an excitation optical path toward a sample holder holding the plurality of biological sample volumes, electromagnetic radiation from a broadband LED, wherein the broadband LED emits the electromagnetic radiation across a range of wavelengths at a total output power of at least 5 watts and at a maximum intensity at a wavelength less than 600 nanometers and at an intensity less than 30 percent of the maximum intensity at a wavelength of 650 or 670 nanometers, and receiving, by a sensor, an electromagnetic emission transmitted from the sample holder along an emission optical path.
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公开(公告)号：US20230031117A1
公开(公告)日：2023-02-02
申请号：US17966364
申请日：2022-10-14
Inventor： Kuan Moon Boo , Wei Fuh Teo , Zeqi Tan , Soo Yong Lau , Ming Tiong Sia , Woon Liang Soh , Ching Yee Lam , Shan Hua Dong , Marc Haberstroh , Michael C. Pallas , Hardeep Sangha
Abstract: A system for biological analysis includes a housing, a block assembly within the housing having a sample block and a baseplate, a heated cover and a cover carrier. The sample block receives a sample holder comprising an RFID tag. A first drive mechanism generates relative movement between the sample block and the baseplate along a first axis. A second drive mechanism generates relative movement between the heated cover and the cover carrier along a second axis that is different from the first axis. Based on a first command the first drive mechanism releasably engages the sample block and operates the second drive mechanism to releasably engage the heated cover with the cover carrier. The system also includes first and second RFID antennas that receive RFID data from the sample holder RFID tag that is read by at least one RFID reader.
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公开(公告)号：US11480584B2
公开(公告)日：2022-10-25
申请号：US16777820
申请日：2020-01-30
Inventor： Kuan Moon Boo , Wei Fuh Teo , Zeqi Tan , Soo Yong Lau , Ming Tiong Sia , Woon Liang Soh , Ching Yee Lam , Shan Hua Dong , Marc Haberstroh , Michael C. Pallas , Hardeep Sangha
Abstract: A system for biological analysis includes a housing, a block assembly within the housing having a sample block and a baseplate, a heated cover and a cover carrier. The sample block receives a sample holder comprising an RFID tag. A first drive mechanism generates relative movement between the sample block and the baseplate along a first axis. A second drive mechanism generates relative movement between the heated cover and the cover carrier along a second axis that is different from the first axis. Based on a first command the first drive mechanism releasably engages the sample block and operates the second drive mechanism to releasably engage the heated cover with the cover carrier. The system also includes first and second RFID antennas that receive RFID data from the sample holder RFID tag that is read by at least one RFID reader.
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10.发明授权公开(公告)号：US10471431B2
公开(公告)日：2019-11-12
申请号：US14613496
申请日：2015-02-04
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Chee Kiong Lim , Way Xuang Lee , Wuh Ken Loh , Chee Wee Ching , Chin Yong Koo , Siew Ying Koh , Tiong Han Toh , Kuan Moon Boo , Soo Yong Lau
IPC: B01L7/00 , C12Q1/6806
Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.
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