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    Optical Systems and Methods for Biological Analysis
    3.
    发明申请
    Optical Systems and Methods for Biological Analysis 有权

    公开(公告)号：US20250027881A1

    公开(公告)日：2025-01-23

    申请号：US18766173

    申请日：2024-07-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Mingsong Chen ,  Jeffrey A. Marks ,  Jacob K. Freudenthal ,  Mauro Aguanno ,  Woon Liang Terence Soh ,  Kuan Moon Boo

    IPC: G01N21/64 ,  G01N21/03 ,  G01N21/27

    Abstract: An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.

    Methods and Systems for Streamlining Optical Calibration
    4.
    发明申请
    Methods and Systems for Streamlining Optical Calibration 有权
    简化光学校准的方法和系统

    公开(公告)号：US20140294268A1

    公开(公告)日：2014-10-02

    申请号：US14348206

    申请日：2012-09-30

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jacob K. Freudenthal ,  Jeffrey A. Marks ,  Francis T. Cheng ,  Thomas Wessel

    IPC: G06T7/00

    CPC classification number: G06T7/0012 ,  G06T5/008 ,  G06T5/50 ,  G06T2207/10024 ,  G06T2207/10064 ,  G06T2207/10144 ,  G06T2207/20021 ,  G06T2207/20216 ,  G06T2207/30072

    Abstract: A method for calibrating a biological instrument is provided. The method comprises the steps of acquiring an image of at least one biological sample array, determining a first region of interest within the image, wherein the first region of interest comprises a first plurality of locations on the at least one biological array; and identifying within the first region of interest, a plurality of image elements associated with each of the first plurality of locations on the at least one biological array.

    Abstract translation: 提供了一种用于校准生物仪器的方法。 该方法包括以下步骤：获取至少一个生物样本阵列的图像，确定图像内的第一感兴趣区域，其中所述第一感兴趣区域包括所述至少一个生物阵列上的第一多个位置; 以及在所述第一感兴趣区域内识别与所述至少一个生物阵列上的所述第一多个位置中的每一个相关联的多个图像元素。

    Optical systems and methods for biological analysis
    6.
    发明授权
    Optical systems and methods for biological analysis 有权

    公开(公告)号：US11467092B2

    公开(公告)日：2022-10-11

    申请号：US16797561

    申请日：2020-02-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Mingsong Chen ,  Mauro Aguanno ,  Kuan Moon Boo ,  Woon Liang Terence Soh ,  Jacob K. Freudenthal ,  Jeffrey A. Marks

    IPC: G01N21/64 ,  G01N21/27 ,  G01N21/03

    Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

    Methods and Systems for a Digital PCR Experiment Designer
    8.
    发明申请
    Methods and Systems for a Digital PCR Experiment Designer 审中-公开
    数字PCR实验设计器的方法和系统

    公开(公告)号：US20150278437A1

    公开(公告)日：2015-10-01

    申请号：US14428312

    申请日：2013-09-13

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Nivedita Sumi Majumdar ,  Thomas Wessel ,  David C. Woo ,  Marcin Sikora ,  Gordon A. Janaway ,  Shweta Raizada ,  Joanna Lankester ,  Jeffrey A. Marks ,  Daniel Wessel

    IPC: G06F19/20 ,  C12Q1/68

    CPC classification number: G16B25/00 ,  C12Q1/686 ,  G16B40/00

    Abstract: A computer-implemented method for designing a digital PCR (dPCR) experiment is provided. The method includes receiving, from a user, a selection of optimization type. The optimization type may be maximizing the dynamic range, minimizing the number of substrates including reaction sites needed for the experiment, determining a dilution factor, or determining the lower limit of detection, for example. The method further includes receiving, from the user, a precision measure for an experiment, and a minimum concentration of a target in a reaction site for the experiment. The method also includes determining a set of dPCR experiment design factors for the experiment based on the optimization type. The set of dPCR experiment design factors is then displayed to the user.

    Abstract translation: 提供了一种用于设计数字PCR（dPCR）实验的计算机实现方法。 该方法包括从用户接收优化类型的选择。 优化类型可以使动态范围最大化，例如最小化包括实验所需的反应位点，确定稀释因子或确定检测下限的底物数量。 该方法还包括从用户接收实验的精确度量，以及用于实验的反应部位中靶的最小浓度。 该方法还包括基于优化类型确定实验的一组dPCR实验设计因子。 然后将该组dPCR实验设计因子显示给用户。

    Optical systems and methods for biological analysis
    10.
    发明授权
    Optical systems and methods for biological analysis 有权

    公开(公告)号：US10591416B2

    公开(公告)日：2020-03-17

    申请号：US14766725

    申请日：2014-02-24

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Mingsong Chen ,  Mauro Aguanno ,  Kuan Moon Boo ,  Woon Liang Terence Soh ,  Jacob K. Freudenthal ,  Jeffrey A. Marks

    IPC: G01N21/64 ,  G01N21/27 ,  G01N21/03

    Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

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