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公开(公告)号：US08193194B2
公开(公告)日：2012-06-05
申请号：US12124303
申请日：2008-05-21
申请人： Esther Martinborough , Tim Neubert , Tara Whitney , Danielle Lehsten , Tara Hampton , Nicole Zimmermann , Andreas P. Termin
发明人： Esther Martinborough , Tim Neubert , Tara Whitney , Danielle Lehsten , Tara Hampton , Nicole Zimmermann , Andreas P. Termin
IPC分类号： A61K31/497 , A61K31/405 , C07D401/12 , C07D209/04 , C07C311/02
CPC分类号： C07D209/08 , C07C311/51 , C07C311/53 , C07C2602/08 , C07D209/42 , C07D215/06 , C07D215/233 , C07D317/60 , C07D401/04 , C07D401/06 , C07D405/12
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的化合物。 现在已经发现，本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道的抑制剂。
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公开(公告)号：US08153655B2
公开(公告)日：2012-04-10
申请号：US12556845
申请日：2009-09-10
IPC分类号： A61K31/426 , A61K31/427 , A61K31/433 , A61K31/4375 , A61P23/00
CPC分类号： C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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13.发明授权Pyrrolidinone benzenesulfonamide derivatives as modulators of ion channels for the treatment of pain 有权吡咯烷酮苯磺酰胺衍生物作为离子通道的调节剂治疗疼痛公开(公告)号：US07994166B2
公开(公告)日：2011-08-09
申请号：US12269108
申请日：2008-11-12
申请人： Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Aarti Sameer Kawatkar
发明人： Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Aarti Sameer Kawatkar
IPC分类号： A61K31/5355 , C07D417/14
CPC分类号： C07D417/14
摘要： The present invention relates to pyrrolidinone benzenesulfonamide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的吡咯烷酮苯磺酰胺衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗疼痛的方法。
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公开(公告)号：US20090253682A1
公开(公告)日：2009-10-08
申请号：US12424883
申请日：2009-04-16
IPC分类号： A61K31/55 , C07D405/12 , C07D401/12 , C07D403/14 , C07D403/12 , A61K31/4525 , A61K31/454 , C07D491/113
CPC分类号： A61K31/405 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
摘要翻译： 杂环衍生物作为Ca通道拮抗剂。 该组合物可用于治疗或缓解Ca通道介导的病症。
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公开(公告)号：US20080293737A1
公开(公告)日：2008-11-27
申请号：US12124303
申请日：2008-05-21
申请人： Esther Martinborough , Tim Neubert , Tara Whitney , Danielle Lehsten , Tara Hampton , Nicole Zimmerman , Andreas P. Termin
发明人： Esther Martinborough , Tim Neubert , Tara Whitney , Danielle Lehsten , Tara Hampton , Nicole Zimmerman , Andreas P. Termin
IPC分类号： A61K31/496 , C07D401/06 , A61K31/404 , A61P25/00 , C07D209/04
CPC分类号： C07D209/08 , C07C311/51 , C07C311/53 , C07C2602/08 , C07D209/42 , C07D215/06 , C07D215/233 , C07D317/60 , C07D401/04 , C07D401/06 , C07D405/12
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的化合物。 现在已经发现，本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道的抑制剂。
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公开(公告)号：US20080027067A1
公开(公告)日：2008-01-31
申请号：US11643622
申请日：2006-12-21
申请人： Esther Martinborough , Lev Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Arati Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
发明人： Esther Martinborough , Lev Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Arati Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
IPC分类号： A61K31/495 , A61K31/426 , A61P29/00 , C07D401/00 , C07D403/00 , C07D277/02 , A61K31/445
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20060074076A1
公开(公告)日：2006-04-06
申请号：US11165254
申请日：2005-06-22
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/405 , A61K31/381 , A61K31/343
CPC分类号： A61K31/405 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
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公开(公告)号：US20050187217A1
公开(公告)日：2005-08-25
申请号：US10912912
申请日：2004-08-05
申请人： Dean Wilson , Andreas Termin , Timothy Neubert , Jian Wang , Yulian Zhang , Jesus Gonzalez , Esther Martinborough , Nicole Zimmerman
发明人： Dean Wilson , Andreas Termin , Timothy Neubert , Jian Wang , Yulian Zhang , Jesus Gonzalez , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/517 , A61K31/5377 , A61P25/00 , A61P29/00 , C07D239/70 , C07D239/91 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D413/02 , C07D471/04 , C07D495/04 , C07D43/02
CPC分类号： C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US08883766B2
公开(公告)日：2014-11-11
申请号：US13457855
申请日：2012-04-27
申请人： Esther Martinborough , Tim Neubert , Tara Whitney , Danielle Lehsten , Tara Hampton , Nicole Zimmermann , Andreas P. Termin
发明人： Esther Martinborough , Tim Neubert , Tara Whitney , Danielle Lehsten , Tara Hampton , Nicole Zimmermann , Andreas P. Termin
IPC分类号： A61K31/63 , A61K31/655 , C07D209/42 , C07D215/06 , C07D405/12 , C07D209/08 , C07D401/06 , C07D401/04 , C07D215/233 , C07D317/60 , C07C311/51 , C07C311/53
CPC分类号： C07D209/08 , C07C311/51 , C07C311/53 , C07C2602/08 , C07D209/42 , C07D215/06 , C07D215/233 , C07D317/60 , C07D401/04 , C07D401/06 , C07D405/12
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的化合物。 现在已经发现，本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道的抑制剂。
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20.发明授权公开(公告)号：US08357706B2
公开(公告)日：2013-01-22
申请号：US12946800
申请日：2010-11-15
申请人： Esther Martinborough , Marcus F. Boehm , Adam Richard Yeager , Junko Tamiya , Liming Huang , Enugurthi Brahmachary , Manisha Moorjani
发明人： Esther Martinborough , Marcus F. Boehm , Adam Richard Yeager , Junko Tamiya , Liming Huang , Enugurthi Brahmachary , Manisha Moorjani
IPC分类号： A61K31/4245 , A61K31/5377 , A61K31/454 , C07D271/06 , C07D413/12
CPC分类号： C07D271/06 , A61K31/4245 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D263/32 , C07D413/04 , C07D413/10 , C07D413/12
摘要： Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.
摘要翻译： 提供了选择性调节鞘氨醇1磷酸受体的化合物，包括调节S1P受体亚型1的化合物。 提供了这种化合物的手性合成方法。 本发明化合物的用途，治疗或预防方法以及制备本发明组合物的方法与治疗或预防医学上指示鞘氨醇1磷酸受体调节的疾病，病症和病症有关。
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