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公开(公告)号：US20080124721A1
公开(公告)日：2008-05-29
申请号：US11762750
申请日：2007-06-13
申请人： Martin Fuchs , Ravi Kapur , Mehmet Toner , Zihua Wang
发明人： Martin Fuchs , Ravi Kapur , Mehmet Toner , Zihua Wang
IPC分类号： C12Q1/68 , G01N33/574 , C12M1/34
CPC分类号： C12Q1/6886 , C12Q2600/156 , G01N1/405 , G01N33/5005 , G01N33/5091 , G01N33/57484 , G01N2015/1006 , G01N2015/1087 , G01N2800/385
摘要： The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g., epithelial cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject by analyzing a cellular sample from the subject.
摘要翻译： 本发明涉及用于检测，富集和分析存在于血液中的稀有细胞例如上皮细胞的方法。 本发明进一步具有分析稀有细胞以通过分析来自受试者的细胞样品来确定受试者中异常，疾病或病症的存在的方法。
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公开(公告)号：US20080113358A1
公开(公告)日：2008-05-15
申请号：US11830546
申请日：2007-07-30
申请人： Ravi Kapur , Mehmet Toner , Zihua Wang
发明人： Ravi Kapur , Mehmet Toner , Zihua Wang
IPC分类号： C12Q1/68
CPC分类号： G01N33/689
摘要： The present invention provides systems, apparatuses, and methods to isolate, select or detect the presence of a target cell (e.g., fetal cells) in a sample comprising mixed populations of cells that vastly outnumber the target cells. Target cells include fetal cells, such as nucleated red blood cells, and methods of selecting such cells include diagnosis of fetal abnormalities, i.e., aneuploidy. Furthermore, methods comprise utilizing fetal biomarkers to select fetal cells in a sample comprising fetal and adult cells.
摘要翻译： 本发明提供用于分离，选择或检测包含大量超过靶细胞数的混合细胞群的样品中靶细胞（例如胎儿细胞）的存在的系统，装置和方法。 靶细胞包括胎儿细胞，例如有核红细胞，以及选择这些细胞的方法包括胎儿异常的诊断，即非整倍体。 此外，方法包括利用胎儿生物标志物在包含胎儿和成体细胞的样品中选择胎儿细胞。
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公开(公告)号：US20100136529A1
公开(公告)日：2010-06-03
申请号：US12230628
申请日：2008-09-02
申请人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
发明人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常的系统，装置和方法，例如， 非整倍体 本发明涉及用不同的标记标记所述混合样品中每个细胞中的基因组DNA的区域，其中每个标记对每个细胞是特异性的，并且定量混合样品中每个细胞的基因组DNA的标记区域。 更具体地，本发明涉及从混合样品中的每个细胞定量标记的DNA多态性。
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公开(公告)号：US20160002737A1
公开(公告)日：2016-01-07
申请号：US14794488
申请日：2015-07-08
申请人： Martin Fuchs , Ravi Kapur , Mehmet Toner , Zihua Wang
发明人： Martin Fuchs , Ravi Kapur , Mehmet Toner , Zihua Wang
CPC分类号： C12Q1/6886 , C12Q2600/156 , G01N1/405 , G01N33/5005 , G01N33/5091 , G01N33/57484 , G01N2015/1006 , G01N2015/1087 , G01N2800/385
摘要： The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g., epithelial cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject by analyzing a cellular sample from the subject.
摘要翻译： 本发明涉及用于检测，富集和分析存在于血液中的稀有细胞例如上皮细胞的方法。 本发明进一步具有分析稀有细胞以通过分析来自受试者的细胞样品来确定受试者中异常，疾病或病症的存在的方法。
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公开(公告)号：US20120208186A1
公开(公告)日：2012-08-16
申请号：US13306520
申请日：2011-11-29
申请人： Ravi Kapur , Mehmet Toner , Zihua Wang , Martin Fuchs
发明人： Ravi Kapur , Mehmet Toner , Zihua Wang , Martin Fuchs
IPC分类号： G01N27/62
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N1/30 , G01N33/6893 , G01N2800/385
摘要： The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject.
摘要翻译： 本发明涉及用于检测，富集和分析存在于血液中的罕见细胞的方法，例如， 胎儿细胞。 本发明还涉及分析稀有细胞以确定受试者中异常，疾病或病症的存在的方法，例如， 通过分析来自受试者的细胞样品的胎儿。
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公开(公告)号：US20080220422A1
公开(公告)日：2008-09-11
申请号：US11763421
申请日：2007-06-14
申请人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
发明人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常的系统，装置和方法，例如， 非整倍体 本发明涉及用不同的标记标记所述混合样品中每个细胞中的基因组DNA的区域，其中每个标记对每个细胞是特异性的，并且定量混合样品中每个细胞的基因组DNA的标记区域。 更具体地，本发明涉及从混合样品中的每个细胞定量标记的DNA多态性。
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公开(公告)号：US20080090239A1
公开(公告)日：2008-04-17
申请号：US11762747
申请日：2007-06-13
申请人： DANIEL SHOEMAKER , Martin Fuchs , Neil Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
发明人： DANIEL SHOEMAKER , Martin Fuchs , Neil Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
CPC分类号： C12Q1/6886 , C12Q2600/156 , G01N1/405 , G01N33/5005 , G01N33/5091 , G01N33/57484 , G01N2015/1006 , G01N2015/1087 , G01N2800/385
摘要： Described herein are methods to diagnose or prognose cancer in a subject by enriching, detecting, and analyzing individual rare cells, e.g., epithelial cells, in a sample from the subject. Also described are methods for labeling regions of genomic DNA in individual cells in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the method includes detecting the presence of gene mutations in individual rare cells in a subsample.
摘要翻译： 本文描述的是通过在受试者的样品中富集，检测和分析个体稀有细胞（例如上皮细胞）来诊断或预测受试者的癌症的方法。 还描述了用于在具有不同标记的所述混合样品中标记个别细胞中基因组DNA区域的方法，其中每个标记对于每个细胞是特异性的，并且定量来自混合样品中每个细胞的基因组DNA的标记区域。 更具体地，该方法包括检测子样品中个体稀有细胞中基因突变的存在。
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公开(公告)号：US20130324418A1
公开(公告)日：2013-12-05
申请号：US13737730
申请日：2013-01-09
申请人： Martin Fuchs , Ravi Kapur , Mehmet Toner , Zihua Wang
发明人： Martin Fuchs , Ravi Kapur , Mehmet Toner , Zihua Wang
IPC分类号： G01N33/50
CPC分类号： C12Q1/6886 , C12Q2600/156 , G01N1/405 , G01N33/5005 , G01N33/5091 , G01N33/57484 , G01N2015/1006 , G01N2015/1087 , G01N2800/385
摘要： The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g., epithelial cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject by analyzing a cellular sample from the subject.
摘要翻译： 本发明涉及用于检测，富集和分析存在于血液中的稀有细胞例如上皮细胞的方法。 本发明进一步具有分析稀有细胞以通过分析来自受试者的细胞样品来确定受试者中异常，疾病或病症的存在的方法。
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公开(公告)号：US20080138809A1
公开(公告)日：2008-06-12
申请号：US11763245
申请日：2007-06-14
申请人： Ravi Kapur , Mehmet Toner , Zihua Wang , Martin Fuchs
发明人： Ravi Kapur , Mehmet Toner , Zihua Wang , Martin Fuchs
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N1/30 , G01N33/6893 , G01N2800/385
摘要： The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject.
摘要翻译： 本发明涉及用于检测，富集和分析存在于血液中的罕见细胞的方法，例如， 胎儿细胞。 本发明还涉及分析稀有细胞以确定受试者中异常，疾病或病症的存在的方法，例如， 通过分析来自受试者的细胞样品的胎儿。
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公开(公告)号：US20070059781A1
公开(公告)日：2007-03-15
申请号：US11229336
申请日：2005-09-15
申请人： Ravi Kapur , Mehmet Toner , Lotion Huang , Tom Barber , Bruce Carvalho , Darren Gray
发明人： Ravi Kapur , Mehmet Toner , Lotion Huang , Tom Barber , Bruce Carvalho , Darren Gray
IPC分类号： G01N33/567 , G06F19/00 , C12M3/00
CPC分类号： B01L3/502753 , B01L3/502746 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0409 , B01L2400/0472 , B01L2400/086 , B82Y15/00 , B82Y30/00 , G01N1/40 , G01N2035/00237
摘要： The invention relates to one or more size-based separation modules adapted to increase a concentration of a first analyte in a sample by at least 10,000 fold, wherein said first analyte has an initial concentration in said sample of less than 1×10−3 analytes/μL, and an analyzer for analyzing said first analytes in an enriched medium.
摘要翻译： 本发明涉及一种或多种基于尺寸的分离模块，其适于将样品中的第一分析物的浓度增加至少10,000倍，其中所述第一分析物在所述样品中的初始浓度小于1×10 -3 分析物/ muL，以及用于分析富集介质中的所述第一分析物的分析器。
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