公开(公告)号：US20080090239A1

公开(公告)日：2008-04-17

申请号：US11762747

申请日：2007-06-13

申请人： DANIEL SHOEMAKER ,  Martin Fuchs ,  Neil Krueger ,  Mehmet Toner ,  Darren Gray ,  Ravi Kapur ,  Zihua Wang

发明人： DANIEL SHOEMAKER ,  Martin Fuchs ,  Neil Krueger ,  Mehmet Toner ,  Darren Gray ,  Ravi Kapur ,  Zihua Wang

IPC分类号： C12Q1/20 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  G01N1/405 ,  G01N33/5005 ,  G01N33/5091 ,  G01N33/57484 ,  G01N2015/1006 ,  G01N2015/1087 ,  G01N2800/385

摘要： Described herein are methods to diagnose or prognose cancer in a subject by enriching, detecting, and analyzing individual rare cells, e.g., epithelial cells, in a sample from the subject. Also described are methods for labeling regions of genomic DNA in individual cells in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the method includes detecting the presence of gene mutations in individual rare cells in a subsample.

摘要翻译： 本文描述的是通过在受试者的样品中富集，检测和分析个体稀有细胞（例如上皮细胞）来诊断或预测受试者的癌症的方法。 还描述了用于在具有不同标记的所述混合样品中标记个别细胞中基因组DNA区域的方法，其中每个标记对于每个细胞是特异性的，并且定量来自混合样品中每个细胞的基因组DNA的标记区域。 更具体地，该方法包括检测子样品中个体稀有细胞中基因突变的存在。

公开(公告)号：US20070026418A1

公开(公告)日：2007-02-01

申请号：US11324041

申请日：2005-12-29

申请人： Martin Fuchs ,  Mehmet Toner ,  Ying-Xin Wang ,  Yi-Shuian Huang ,  Neil Krueger ,  Lotien Huang

发明人： Martin Fuchs ,  Mehmet Toner ,  Ying-Xin Wang ,  Yi-Shuian Huang ,  Neil Krueger ,  Lotien Huang

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/574 ,  C12M3/00

CPC分类号： G01N33/5005 ,  B01L3/502746 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/086 ,  B82Y5/00 ,  B82Y10/00 ,  G01N33/54366 ,  G01N33/57492 ,  G01N2800/52

摘要： The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.

公开(公告)号：US20070099207A1

公开(公告)日：2007-05-03

申请号：US11449161

申请日：2006-06-08

申请人： Martin Fuchs ,  Mehmet Toner ,  Yi-Shuian Huang ,  Neil Krueger ,  Daniel Haber

发明人： Martin Fuchs ,  Mehmet Toner ,  Yi-Shuian Huang ,  Neil Krueger ,  Daniel Haber

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/54366 ,  B01L3/502753 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0487 ,  B01L2400/086 ,  B82Y5/00 ,  B82Y10/00 ,  G01N33/574 ,  G01N2015/1006 ,  G01N2015/1087 ,  G01N2021/0346 ,  G01N2800/52

摘要： The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.

公开(公告)号：US20070026415A1

公开(公告)日：2007-02-01

申请号：US11323946

申请日：2005-12-29

申请人： Martin Fuchs ,  Mehmet Toner ,  Yi-Shuian Huang ,  Neil Krueger ,  Ying-Xin Wang

发明人： Martin Fuchs ,  Mehmet Toner ,  Yi-Shuian Huang ,  Neil Krueger ,  Ying-Xin Wang

IPC分类号： C12Q1/68 ,  G01N33/567 ,  C12M1/34

CPC分类号： B82Y10/00 ,  B01L3/502746 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0472 ,  B01L2400/0487 ,  B01L2400/086 ,  B82Y5/00 ,  C12Q1/6886 ,  C12Q2600/16 ,  C12Q2600/178 ,  G01N1/40 ,  G01N33/5005 ,  G01N33/5091 ,  G01N33/574 ,  G01N2035/00237 ,  G01N2800/52

摘要： The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.

公开(公告)号：US20070026469A1

公开(公告)日：2007-02-01

申请号：US11322791

申请日：2005-12-29

申请人： Martin Fuchs ,  Ying-Xin Wang ,  Yi-Shuian Huang ,  Neil Krueger

发明人： Martin Fuchs ,  Ying-Xin Wang ,  Yi-Shuian Huang ,  Neil Krueger

IPC分类号： G01N33/574 ,  C12M3/00

CPC分类号： G01N33/57484 ,  B01L3/502707 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/086 ,  B82Y5/00 ,  B82Y10/00 ,  G01N33/54366 ,  G01N33/56966 ,  G01N33/57492 ,  G01N2333/705 ,  G01N2333/70589 ,  G01N2333/71 ,  G01N2800/52

摘要： The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.

公开(公告)号：US4154033A

公开(公告)日：1979-05-15

申请号：US918281

申请日：1978-06-22

申请人： Neil Krueger ,  Donald L. Garofalo ,  John O. Kohl

发明人： Neil Krueger ,  Donald L. Garofalo ,  John O. Kohl

IPC分类号： E06B3/58 ,  E06B7/14

CPC分类号： E06B3/5821 ,  E06B7/14

摘要： A two-part glazing system for use on the lower rails of the upper and lower sashes of a double-hung window. The glazing system comprises a moisture impervious liner member which is snap fit onto the lower rail and underlies the lower edge of the windowpane. A glazing bead is snap fit onto the liner member and extends therefrom to the face of the windowpane. The glazing bead has a gasket for sealing against the windowpane and defining an enclosed drain tank. The gasket prevents substantial amounts of water from reaching the drain tank. Any moisture which does reach the drain tank is drained away through outlet holes in the liner member.

摘要翻译： 一个两部分的玻璃窗系统，用于双挂窗的上下窗玻璃的下轨道上。 玻璃窗系统包括防潮的衬里构件，其卡扣配合到下轨道并且在窗玻璃的下边缘的下方。 玻璃珠紧固在衬垫构件上并从其延伸到窗玻璃的表面。 玻璃珠具有用于密封窗玻璃并限定封闭的排水槽的垫圈。 垫圈可防止大量的水到达排水箱。 到达排水箱的任何水分都会通过衬套件中的出口孔排出。