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公开(公告)号：US10130630B2
公开(公告)日：2018-11-20
申请号：US15538976
申请日：2015-12-17
发明人： Jian Liu , Joseph A. Kozlowski , Abdul-Basit Alhassan , Rajan Anand , Sobhana Babu Boga , Deodial Guy Guiadeen , Wensheng Yu , Younong Yu , Shilan Liu , Hao Wu , Chundao Yang
IPC分类号： A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D519/00 , A61K45/06 , C07K16/28
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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12.发明授权Substituted benzamides and substituted pyridinecarboxamides as Btk inhibitors 有权取代的苯甲酰胺和取代的吡啶甲酰胺作为Btk抑制剂公开(公告)号：US09481682B2
公开(公告)日：2016-11-01
申请号：US14762954
申请日：2014-01-22
发明人： Ronald M. Kim , Jian Liu , Xiaolei Gao , Sobhana Babu Boga , Deodialsingh Guiadeen , Joseph A. Kozlowski , Wensheng Yu , Rajan Anand , Younong Yu , Oleg B. Selyutin , Ying-Duo Gao , Hao Wu , Shilan Liu , Chundao Yang , Hongjian Wang
IPC分类号： A61K31/4985 , A61K31/4427 , C07D241/38 , C07D213/81 , C07D491/048 , A61K31/497 , A61K31/519 , C07D487/04 , C07D519/00 , A61K31/506 , A61K31/5365 , A61K31/5383 , A61K45/06 , C07D455/02 , C07D471/04 , C07D498/04
CPC分类号： C07D491/048 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5365 , A61K31/5383 , A61K45/06 , C07D455/02 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00 , Y02A50/411 , Y02A50/463
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
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公开(公告)号：US20150246917A1
公开(公告)日：2015-09-03
申请号：US14711345
申请日：2015-05-13
发明人： Craig A. Coburn , Steven W. Ludmerer , Kun Liu , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4985 , C07D401/14 , A61K31/4439 , C07D403/14 , A61K31/4184 , C07D403/12 , C07D413/14 , A61K31/423 , C07D405/14 , A61K31/4025 , C07D405/12 , A61K31/404 , A61K31/506 , A61K31/5377 , C07D498/04 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K31/437
CPC分类号： C07D498/04 , A61K31/4025 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K38/05 , A61K38/06 , A61K45/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/10 , C07K5/06 , C07K5/08
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5A抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5A活性用于治疗或预防HCV感染的用途的式（I）化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。
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公开(公告)号：US20190127365A1
公开(公告)日：2019-05-02
申请号：US15800172
申请日：2017-11-01
发明人： Craig A. Coburn , Steven W. Ludmerer , Kun Liu , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4985 , A61K31/4439 , A61K31/4184 , A61K31/423 , A61K31/4025 , A61K31/519 , A61K31/404 , A61K31/506 , A61K31/5377 , A61K31/427 , A61K31/4245 , A61K31/475 , A61K31/536 , A61K31/4178 , A61K31/517 , A61K31/5386 , A61K31/553 , C07D487/04 , C07D401/14 , C07D403/14 , C07D403/12 , C07D413/14 , C07D405/14 , C07D405/12 , C07D417/14 , C07D409/14 , C07D407/14
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
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公开(公告)号：US10087188B2
公开(公告)日：2018-10-02
申请号：US15538902
申请日：2015-12-17
发明人： Jian Liu , Joseph A. Kozlowski , Abdul-Basit Alhassan , Sobhana Babu Boga , Xiaolei Gao , Deodial Guy Guiadeen , Jyhshing Wang , Wensheng Yu , Jiaqiang Cai , Shilan Liu , Dahai Wang , Hao Wu , Chundao Yang
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61K31/5377
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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16.发明申请SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开用于治疗阿尔茨海默病的螺旋罗哌啶β-分泌酶抑制剂公开(公告)号：US20150038490A1
公开(公告)日：2015-02-05
申请号：US14518825
申请日：2014-10-20
发明人： Kun Liu , Shawn J. Stachel , Craig A. Coburn , Thomas G. Steele , Richard Soll , Hao Wu , Xuanjin Peng , Yaxian Cai , Xiaoxiang Du , Jian Li
IPC分类号： C07D401/06 , C07D513/10 , C07D495/10 , C07D491/107 , C07D471/10
CPC分类号： C07D401/06 , C07D209/96 , C07D471/10 , C07D471/20 , C07D491/10 , C07D491/107 , C07D491/20 , C07D495/10 , C07D513/10 , C07D513/20
摘要： The present invention is directed to spiropyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并可用于治疗其中涉及β-分泌酶的疾病如阿尔茨海默氏病的式（I）的螺吡咯烷化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。
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17.发明申请TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权四环杂环化合物及其用于治疗病毒性疾病的方法公开(公告)号：US20140213571A1
公开(公告)日：2014-07-31
申请号：US14343450
申请日：2012-08-20
发明人： Nigel J. Liverton , Casey Cameron McComas , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Shuwen He , Xing Dai , Hong Liu , Zhong Lai , Clare London , Dong Xiao , Nicolas Zorn , Ravi Nargund
IPC分类号： A61K31/553 , A61K31/519 , A61K31/437 , A61K31/407 , C07D498/22 , C07D498/14 , C07D491/147 , C07D491/052 , A61K45/06 , A61K31/5365 , C07D498/04
CPC分类号： A61K31/553 , A61K31/407 , A61K31/437 , A61K31/519 , A61K31/5365 , A61K45/06 , C07D491/052 , C07D491/147 , C07D498/04 , C07D498/14 , C07D498/22 , Y02A50/387 , Y02A50/389 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物 并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。
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