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公开(公告)号：US10457958B2
公开(公告)日：2019-10-29
申请号：US16047187
申请日：2018-07-27
发明人： James A. Baum , Thomas Cerruti , Stanislaw Flasinski , Xiaoran Fu , Arlene R. Howe , Sara Ann Salvador
IPC分类号： C12N15/82 , C07K14/325 , A01N47/08 , A01N63/02
摘要： Engineered Cry1Da amino acid sequences are provided that exhibit improved Lepidopteran insecticidal activity and an enhanced Lepidopteran spectrum compared to the naturally occurring Cry1Da protein toxin. Polynucleotide sequences intended for use in expression of the improved proteins in plants are also provided. Particular embodiments provide compositions containing insect inhibitory amounts of the engineered proteins, as well as recombinant plants, plant parts, and seeds containing polynucleotide constructs encoding one or more of the improved engineered proteins.
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公开(公告)号：US10017549B2
公开(公告)日：2018-07-10
申请号：US13950439
申请日：2013-07-25
发明人： James A. Baum , Stanislaw Flasinski , Gregory R. Heck , Stephen R. Penn , Uma Rao Sukuru , Xiaohong Shi
IPC分类号： C07K14/325 , A01N63/00 , C12N15/82
CPC分类号： C07K14/325 , A01N63/00 , C12N15/8286 , Y02A40/162
摘要： A novel Bacillus thuringiensis crystal protein exhibiting insect inhibitory activity is disclosed. Growth of Lygus insects is significantly inhibited by providing the novel crystal protein in Lygus insect diet. Polynucleotides encoding the crystal protein, transgenic plants and microorganisms that contain the polynucleotides, isolated peptides derived from the crystal protein, and antibodies directed against the crystal protein are also provided. Methods of using the crystal protein and polynucleotides encoding the crystal protein to control Hemipteran insects are also disclosed.
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公开(公告)号：US20180127772A1
公开(公告)日：2018-05-10
申请号：US15848837
申请日：2017-12-20
发明人： James A. Baum , Thomas A. Cerruti , Crystal L. Dart , Leigh H. English , Stanislaw Flasinski , Xiaoran Fu , Victor M. Guzov , Arlene R. Howe , Jay P. Morgenstern , James K. Roberts , Sara A. Salvador , Jinling Wang
IPC分类号： C12N15/82
CPC分类号： C07K14/325 , A01N63/02 , C07K2319/00 , C12N15/62 , C12N15/8286 , Y02A40/162
摘要： Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.
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14.发明申请公开(公告)号：US20170114362A1
公开(公告)日：2017-04-27
申请号：US15348706
申请日：2016-11-10
发明人： James A. Baum , Claire A. CaJacob , Pascale Feldmann , Gregory R. Heck , Irene Maria Antonia Nooren , Geert Plaetinck , Wendy T. Maddelein , Ty T. Vaughn
IPC分类号： C12N15/82 , C07K14/435
CPC分类号： C12N15/8286 , C07H21/04 , C07K14/43536 , C07K14/43563 , C12N15/113 , C12N15/8218 , C12N15/8282 , C12N15/8285 , Y02A40/162 , Y02A40/164
摘要： The present invention relates to control of pest infestation by inhibiting one or more biological functions. The invention provides methods and compositions for such control, By feeding one or more recombinant double stranded RNA molecules provided by the invention to the pest, a reduction in pest infestation is obtained through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
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公开(公告)号：US09340797B2
公开(公告)日：2016-05-17
申请号：US13783125
申请日：2013-03-01
发明人： James A. Baum , Larry A. Gilbertson , David K. Kovalic , Thomas J. LaRosa , Maolong Lu , Tichafa R. I. Munyikwa , James K. Roberts , Wei Wu , Bei Zhang
CPC分类号： C12N15/8286 , A01N63/02 , C12N15/8275 , C12N15/8279 , C12N15/8285 , Y02A40/162 , Y02A40/164
摘要： The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention discloses methods and compositions for use in controlling pest infestation by feeding one or more different recombinant double stranded RNA molecules to the pest in order to achieve a reduction in pest infestation through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
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公开(公告)号：US12077770B2
公开(公告)日：2024-09-03
申请号：US17689613
申请日：2022-03-08
发明人： James A. Baum , Larry A. Gilbertson , David K. Kovalic , Thomas J. Larosa , Maolong Lu , Tichafa R. I. Munyikwa , James K. Roberts , Wei Wu , Bei Zhang
CPC分类号： C12N15/8286 , A01N63/50 , A01N63/60 , C12N15/8275 , C12N15/8279 , C12N15/8285 , Y02A40/146
摘要： The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention discloses methods and compositions for use in controlling pest infestation by feeding one or more different recombinant double stranded RNA molecules to the pest in order to achieve a reduction in pest infestation through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
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17.发明公开公开(公告)号：US20240117373A1
公开(公告)日：2024-04-11
申请号：US18490545
申请日：2023-10-19
发明人： James A. Baum , Claire A. CaJacob , Pascale Feldmann , Gregory R. Heck , Irene Maria Antonia Nooren , Geert Plaetinck , Wendy T. Maddelein , Ty T. Vaughn
IPC分类号： C12N15/82 , C07H21/04 , C07K14/435 , C12N15/113
CPC分类号： C12N15/8286 , C07H21/04 , C07K14/43536 , C07K14/43563 , C12N15/113 , C12N15/8218 , C12N15/8282 , C12N15/8285 , Y02A40/146
摘要： The present invention relates to control of pest infestation by inhibiting one or more biological functions. The invention provides methods and compositions for such control, By feeding one or more recombinant double stranded RNA molecules provided by the invention to the pest, a reduction in pest infestation is obtained through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
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公开(公告)号：US11685930B2
公开(公告)日：2023-06-27
申请号：US16988589
申请日：2020-08-07
发明人： James A. Baum , Larry A. Gilbertson , David K. Kovalic , Thomas J. LaRosa , Maolong Lu , Tichafa R. I. Munyikwa , James K. Roberts , Wei Wu , Bei Zhang
CPC分类号： C12N15/8286 , A01N63/50 , A01N63/60 , C12N15/8275 , C12N15/8279 , C12N15/8285 , Y02A40/146 , A01N63/50 , A01N63/23
摘要： The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention discloses methods and compositions for use in controlling pest infestation by feeding one or more different recombinant double stranded RNA molecules to the pest in order to achieve a reduction in pest infestation through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
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公开(公告)号：US20220315945A1
公开(公告)日：2022-10-06
申请号：US17729892
申请日：2022-04-26
发明人： James A. Baum , Claire A. CaJacob , Pascale Feldman , Gregory R. Heck , Irene Maria Antonia Nooren , Geert Plaetinck , Wendy T. Maddelein , Ty T. Vaughn
IPC分类号： C12N15/82 , C07H21/04 , C07K14/435 , C12N15/113
摘要： The present invention relates to control of pest infestation by inhibiting one or more biological functions. The invention provides methods and compositions for such control, By feeding one or more recombinant double stranded RNA molecules provided by the invention to the pest, a reduction in pest infestation is obtained through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
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公开(公告)号：US20220306703A1
公开(公告)日：2022-09-29
申请号：US17671011
申请日：2022-02-14
发明人： James A. Baum , Thomas A. Cerruti , Crystal L. Dart , Leigh H. English , Stanislaw Flasinski , Xiaoran Fu , Victor M. Guzov , Arlene R. Howe , Jay P. Morgenstern , James K. Roberts , Sara A. Salvador , Jinling Wang
IPC分类号： C07K14/325 , C12N15/82
摘要： Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.
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