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公开(公告)号:US20130218178A1
公开(公告)日:2013-08-22
申请号:US13821907
申请日:2011-09-12
申请人: Robin Shandas , Craig Joseph Lanning , Robyn Grace Yeon Glang , Bryan Andrew Rech , Naresh Mandava , Malik Kahook , Nageswara Rao Mandava
发明人: Robin Shandas , Craig Joseph Lanning , Robyn Grace Yeon Glang , Bryan Andrew Rech , Naresh Mandava , Malik Kahook , Nageswara Rao Mandava
IPC分类号: A61F2/00
CPC分类号: A61F2/0063 , C08J5/24 , C08J2300/12 , C08J2300/24
摘要: Formulations of shape memory polymer (SMP) are integrated with several existing clinically available medical fabrics. The SMP portion of a SMP-integrated fabric can be fabricated in varying thicknesses with the minimum thickness determined by the thickness of the underlying fabric and up to almost any thickness. A large variety of patterns may be formed in SMP-integrated fabrics based upon how the shape memory polymer is integrated into the base fabric. Integration of the SMP with the base fabrics does not alter the shape memory functionality of the SMP. The design tools for controlling activation rate for traditional SMP materials thus apply to SMP-integrated fabrics. SMP-integrated fabrics may also be steam sterilized without loss of shape memory functionality. By using multiple formulations of SMP on a single piece of fabric, a large combination of material properties may be provided within a single SMP-integrated fabric device.
摘要翻译: 形状记忆聚合物(SMP)的制剂与几种现有的临床医用织物相结合。 SMP集成织物的SMP部分可以以不同的厚度制造,最小厚度由下面的织物的厚度确定并且几乎达到任何厚度。 基于形状记忆聚合物如何整合到基底织物中,可以在SMP集成织物中形成各种图案。 SMP与基础结构的集成不会改变SMP的形状记忆功能。 用于控制传统SMP材料激活速率的设计工具因此适用于SMP集成的面料。 SMP集成的织物也可以进行蒸汽灭菌,而不会损失形状记忆功能。 通过在单个织物上使用多种配方的SMP,可以在单个SMP集成织物装置内提供大量材料性质的组合。
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公开(公告)号:US08911495B2
公开(公告)日:2014-12-16
申请号:US13257196
申请日:2010-03-16
申请人: Michael B. Lyons , Julie Marie Trommeter , Naresh Mandava , Malik Kahook , Robin Shandas , James Fogelberg , Jeffrey Paul Castleberry
发明人: Michael B. Lyons , Julie Marie Trommeter , Naresh Mandava , Malik Kahook , Robin Shandas , James Fogelberg , Jeffrey Paul Castleberry
IPC分类号: A61F2/14 , A61F9/007 , A61M31/00 , A61L27/50 , A61L27/14 , A61L27/04 , A61M25/01 , A61M25/04 , A61M25/00 , A61F9/00
CPC分类号: A61F9/00772 , A61F9/0017 , A61F2210/0014 , A61L27/04 , A61L27/14 , A61L27/50 , A61L2400/16 , A61L2430/16 , A61M25/00 , A61M25/01 , A61M25/04 , A61M31/002
摘要: An implantable ophthalmological device (10) in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device (10) may include an elongated body (25), an anchor (15) operably connected to the elongated body (25), a radially expanding occlusive feature disposed on an outer circumference of the elongated body (32), and a flange (30). The elongated body (25) may define a lumen (35) configured to receive a pharmacological treatment (55). The device (10) is made of a shape memory material such as a shape memory polymer.
摘要翻译: 鼻泪管或小管植入物形式的可植入眼科装置(10)被配置用于在鼻泪管排出系统处或附近使用。 在展开状态下,装置(10)可以包括细长主体(25),可操作地连接到细长主体(25)的锚固件(15),设置在细长主体(32)的外圆周上的径向扩张的闭塞特征 )和凸缘(30)。 细长主体(25)可以限定被配置为接受药物治疗(55)的管腔(35)。 装置(10)由诸如形状记忆聚合物的形状记忆材料制成。
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公开(公告)号:US20120116504A1
公开(公告)日:2012-05-10
申请号:US13257196
申请日:2010-03-16
申请人: Michael B. Lyons , Julie Marie Trommeter , Naresh Mandava , Malik Kahook , Robin Shandas , James Fogelberg , Jeffrey Paul Castleberry
发明人: Michael B. Lyons , Julie Marie Trommeter , Naresh Mandava , Malik Kahook , Robin Shandas , James Fogelberg , Jeffrey Paul Castleberry
IPC分类号: A61F2/14
CPC分类号: A61F9/00772 , A61F9/0017 , A61F2210/0014 , A61L27/04 , A61L27/14 , A61L27/50 , A61L2400/16 , A61L2430/16 , A61M25/00 , A61M25/01 , A61M25/04 , A61M31/002
摘要: An implantable ophthalmological device (10) in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device (10) may include an elongated body (25), an anchor (15) operably connected to the elongated body (25), a radially expanding occlusive feature disposed on an outer circumference of the elongated body (32), and a flange (30). The elongated body (25) may define a lumen (35) configured to receive a pharmacological treatment (55). The device (10) is made of a shape memory material such as a shape memory polymer.
摘要翻译: 鼻泪管或小管植入物形式的可植入眼科装置(10)被配置用于在鼻泪管排出系统处或附近使用。 在展开状态下,装置(10)可以包括细长主体(25),可操作地连接到细长主体(25)的锚固件(15),设置在细长主体(32)的外圆周上的径向扩张的闭塞特征 )和凸缘(30)。 细长主体(25)可以限定被配置为接受药物治疗(55)的管腔(35)。 装置(10)由诸如形状记忆聚合物的形状记忆材料制成。
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公开(公告)号:US08725266B2
公开(公告)日:2014-05-13
申请号:US12528832
申请日:2008-02-28
申请人: Jeffrey Olson , Naresh Mandava
发明人: Jeffrey Olson , Naresh Mandava
CPC分类号: A61K41/00 , A61K9/0009 , A61K9/0051 , A61K33/24 , A61K33/30 , A61K41/0004 , A61N1/0543 , A61N1/36046 , B82Y5/00 , Y10S977/774 , Y10S977/925
摘要: An improved method for stimulating electrical activity in an eye is provided. Provided is a technique for implanting small, nanometer-sized photoactive devices into an eye to improve electrical activity within an eye or mitigate degradation of electrical response in damaged eyes.
摘要翻译: 提供了用于刺激眼睛中电活动的改进方法。 提供了一种用于将小的纳米级光活性器件植入眼睛中以改善眼睛内的电活动或减轻受损眼睛的电响应降解的技术。
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公开(公告)号:US20130149734A1
公开(公告)日:2013-06-13
申请号:US13700682
申请日:2011-05-31
申请人: David Ammar , Malik Kahook , Tim Lei , Emily Gibson , Omid Masihzadeh , Naresh Mandava
发明人: David Ammar , Malik Kahook , Tim Lei , Emily Gibson , Omid Masihzadeh , Naresh Mandava
CPC分类号: A61B3/0008 , A61B3/18 , A61B5/0066 , A61B5/0068 , G01N21/64 , G01N21/6408 , G01N21/6486 , G01N21/65 , G01N2021/653 , G01N2021/655
摘要: A multimodal method for imaging tissue comprising: aligning an excitation light source with at least a portion of the tissue; selecting at least two modalities of image acquisition; imaging the tissue portion with each of the modalities of image acquisition; and constructing a dual mode image using images from each of the modalities of image acquisition. A multimodal system for imaging tissue comprising: an excitation light source or light sources; an optical and alignment system for directing the excitation beam or beams to a sample and receiving an emission beam from the sample; at least one detector for receiving the emission beam from the sample; and a spectral filtering or dispersing device for providing at least two imaging modalities at the at least one detector; and a processor for analyzing the detected emission beam and constructing a dual mode image using images from each of the modalities of image acquisition.
摘要翻译: 一种用于成像组织的多模式方法,包括:使激发光源与所述组织的至少一部分对准; 选择至少两种图像采集模式; 用图像采集的每种方式对组织部分进行成像; 以及使用来自每个图像采集模式的图像来构建双模式图像。 一种用于成像组织的多模式系统,包括:激发光源或光源; 光学和对准系统,用于将激发光束或光束引导到样品并接收来自样品的发射光束; 用于从样品接收发射光束的至少一个检测器; 以及用于在所述至少一个检测器处提供至少两个成像模态的光谱滤波或分散装置; 以及处理器,用于分析检测到的发射光束并使用来自图像采集的每种方式的图像构建双模式图像。
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