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    Multi-photon Tissue Imaging
    1.
    发明申请
    Multi-photon Tissue Imaging 审中-公开
    多光子组织成像

    公开(公告)号：US20130149734A1

    公开(公告)日：2013-06-13

    申请号：US13700682

    申请日：2011-05-31

    申请人： David Ammar ,  Malik Kahook ,  Tim Lei ,  Emily Gibson ,  Omid Masihzadeh ,  Naresh Mandava

    发明人： David Ammar ,  Malik Kahook ,  Tim Lei ,  Emily Gibson ,  Omid Masihzadeh ,  Naresh Mandava

    IPC分类号： A61B3/00 ,  G01N21/65 ,  G01N21/64

    CPC分类号： A61B3/0008 ,  A61B3/18 ,  A61B5/0066 ,  A61B5/0068 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6486 ,  G01N21/65 ,  G01N2021/653 ,  G01N2021/655

    摘要： A multimodal method for imaging tissue comprising: aligning an excitation light source with at least a portion of the tissue; selecting at least two modalities of image acquisition; imaging the tissue portion with each of the modalities of image acquisition; and constructing a dual mode image using images from each of the modalities of image acquisition. A multimodal system for imaging tissue comprising: an excitation light source or light sources; an optical and alignment system for directing the excitation beam or beams to a sample and receiving an emission beam from the sample; at least one detector for receiving the emission beam from the sample; and a spectral filtering or dispersing device for providing at least two imaging modalities at the at least one detector; and a processor for analyzing the detected emission beam and constructing a dual mode image using images from each of the modalities of image acquisition.

    摘要翻译： 一种用于成像组织的多模式方法，包括：使激发光源与所述组织的至少一部分对准; 选择至少两种图像采集模式; 用图像采集的每种方式对组织部分进行成像; 以及使用来自每个图像采集模式的图像来构建双模式图像。 一种用于成像组织的多模式系统，包括：激发光源或光源; 光学和对准系统，用于将激发光束或光束引导到样品并接收来自样品的发射光束; 用于从样品接收发射光束的至少一个检测器; 以及用于在所述至少一个检测器处提供至少两个成像模态的光谱滤波或分散装置; 以及处理器，用于分析检测到的发射光束并使用来自图像采集的每种方式的图像构建双模式图像。

    AQUEOUS HUMOR MICRO-BYPASS SHUNTS
    2.
    发明申请
    AQUEOUS HUMOR MICRO-BYPASS SHUNTS 审中-公开
    水疱OR OR。。。。。

    公开(公告)号：US20130267887A1

    公开(公告)日：2013-10-10

    申请号：US13825495

    申请日：2011-09-21

    申请人： Malik Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

    发明人： Malik Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

    IPC分类号： A61F9/007 ,  B29C53/02

    CPC分类号： A61F9/00781 ,  B29C53/02

    摘要： A small shunt can be placed within the eye to aid in drainage of aqueous humor from the anterior chamber of the eye to a pocket between the conjunctiva and the sclera to be absorbed, or to secrete through the cornea or the sclera external to the eye for glaucoma or ocular hypertension treatment. This drainage can decrease the pressure of the eye and potentially modify the course of advancing glaucomatous optic neuropathy as it relates to eye pressure. The shunt is formed of a shape memory polymer material and deformed into a smaller form factor to reduce trauma to the eye resulting from the insertion of the shunt through the sclera to the anterior chamber. Once in situ, the shunt deploys in response to body heat or other external stimulus and expands to its original, larger form factor to provide a secure friction fit of the shunt within the scleral tissue and to enlarge the lumen of the shunt to allow for aqueous flow.

    摘要翻译： 可以将小分流器放置在眼睛内以帮助房水从眼前房排出到结膜和巩膜之间的口袋中以被吸收，或通过眼睛外部的角膜或巩膜分泌 青光眼或高眼压症治疗。 这种引流可以降低眼睛的压力，并可能改变与眼压有关的青光眼性视神经病变进展。 分流器由形状记忆聚合物材料形成并变形成更小的形状因子，以减少由于将分流器穿过巩膜插入前房而引起的对眼睛的创伤。 一旦就地，分流器响应于身体热量或其他外部刺激部署，并扩展到其原始的更大的形状因子，以提供分流器在巩膜组织内的可靠的摩擦配合并且扩大分流器的内腔以允许水分 流。

    MEDICAL FABRIC WITH INTEGRATED SHAPE MEMORY POLYMER
    3.
    发明申请
    MEDICAL FABRIC WITH INTEGRATED SHAPE MEMORY POLYMER 审中-公开
    具有整体形状记忆聚合物的医用织物

    公开(公告)号：US20130218178A1

    公开(公告)日：2013-08-22

    申请号：US13821907

    申请日：2011-09-12

    申请人： Robin Shandas ,  Craig Joseph Lanning ,  Robyn Grace Yeon Glang ,  Bryan Andrew Rech ,  Naresh Mandava ,  Malik Kahook ,  Nageswara Rao Mandava

    发明人： Robin Shandas ,  Craig Joseph Lanning ,  Robyn Grace Yeon Glang ,  Bryan Andrew Rech ,  Naresh Mandava ,  Malik Kahook ,  Nageswara Rao Mandava

    IPC分类号： A61F2/00

    CPC分类号： A61F2/0063 ,  C08J5/24 ,  C08J2300/12 ,  C08J2300/24

    摘要： Formulations of shape memory polymer (SMP) are integrated with several existing clinically available medical fabrics. The SMP portion of a SMP-integrated fabric can be fabricated in varying thicknesses with the minimum thickness determined by the thickness of the underlying fabric and up to almost any thickness. A large variety of patterns may be formed in SMP-integrated fabrics based upon how the shape memory polymer is integrated into the base fabric. Integration of the SMP with the base fabrics does not alter the shape memory functionality of the SMP. The design tools for controlling activation rate for traditional SMP materials thus apply to SMP-integrated fabrics. SMP-integrated fabrics may also be steam sterilized without loss of shape memory functionality. By using multiple formulations of SMP on a single piece of fabric, a large combination of material properties may be provided within a single SMP-integrated fabric device.

    摘要翻译： 形状记忆聚合物（SMP）的制剂与几种现有的临床医用织物相结合。 SMP集成织物的SMP部分可以以不同的厚度制造，最小厚度由下面的织物的厚度确定并且几乎达到任何厚度。 基于形状记忆聚合物如何整合到基底织物中，可以在SMP集成织物中形成各种图案。 SMP与基础结构的集成不会改变SMP的形状记忆功能。 用于控制传统SMP材料激活速率的设计工具因此适用于SMP集成的面料。 SMP集成的织物也可以进行蒸汽灭菌，而不会损失形状记忆功能。 通过在单个织物上使用多种配方的SMP，可以在单个SMP集成织物装置内提供大量材料性质的组合。

    BIODEGRADABLE COPOLYMERS, SYSTEMS INCLUDING THE COPOLYMERS, AND METHODS OF FORMING AND USING SAME
    6.
    发明申请
    BIODEGRADABLE COPOLYMERS, SYSTEMS INCLUDING THE COPOLYMERS, AND METHODS OF FORMING AND USING SAME 有权
    可生物降解的共聚物，包括共聚物的体系及其形成和使用方法

    公开(公告)号：US20160051469A1

    公开(公告)日：2016-02-25

    申请号：US14888678

    申请日：2014-05-01

    申请人： Daewon Park ,  Malik Kahook ,  Amin Famili

    发明人： Daewon Park ,  Malik Kahook ,  Amin Famili

    IPC分类号： A61K9/107 ,  A61K47/34 ,  A61K9/00

    CPC分类号： A61K9/1075 ,  A61K9/0024 ,  A61K9/0051 ,  A61K47/34

    摘要： Therapeutic agent delivery systems, which include a thermally-sensitive copolymer and optionally a therapeutic agent, are disclosed. The copolymer is water soluble and biodegradable and, in accordance with exemplary embodiments, includes hydrophobic and hydrophilic portions. The systems may include supplemental compounds, such as polymeric nanoparticles, micelle compounds, or a combination thereof, to further provide sustained release of the therapeutic agent.

    摘要翻译： 公开了包括热敏共聚物和任选的治疗剂的治疗剂递送系统。 共聚物是水溶性的且可生物降解的，并且根据示例性实施方案，共聚物包括疏水和亲水部分。 该系统可以包括补充化合物，例如聚合物纳米颗粒，胶束化合物或其组合，以进一步提供治疗剂的持续释放。