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公开(公告)号：US08911495B2
公开(公告)日：2014-12-16
申请号：US13257196
申请日：2010-03-16
申请人： Michael B. Lyons , Julie Marie Trommeter , Naresh Mandava , Malik Kahook , Robin Shandas , James Fogelberg , Jeffrey Paul Castleberry
发明人： Michael B. Lyons , Julie Marie Trommeter , Naresh Mandava , Malik Kahook , Robin Shandas , James Fogelberg , Jeffrey Paul Castleberry
IPC分类号： A61F2/14 , A61F9/007 , A61M31/00 , A61L27/50 , A61L27/14 , A61L27/04 , A61M25/01 , A61M25/04 , A61M25/00 , A61F9/00
CPC分类号： A61F9/00772 , A61F9/0017 , A61F2210/0014 , A61L27/04 , A61L27/14 , A61L27/50 , A61L2400/16 , A61L2430/16 , A61M25/00 , A61M25/01 , A61M25/04 , A61M31/002
摘要： An implantable ophthalmological device (10) in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device (10) may include an elongated body (25), an anchor (15) operably connected to the elongated body (25), a radially expanding occlusive feature disposed on an outer circumference of the elongated body (32), and a flange (30). The elongated body (25) may define a lumen (35) configured to receive a pharmacological treatment (55). The device (10) is made of a shape memory material such as a shape memory polymer.
摘要翻译： 鼻泪管或小管植入物形式的可植入眼科装置（10）被配置用于在鼻泪管排出系统处或附近使用。 在展开状态下，装置（10）可以包括细长主体（25），可操作地连接到细长主体（25）的锚固件（15），设置在细长主体（32）的外圆周上的径向扩张的闭塞特征 ）和凸缘（30）。 细长主体（25）可以限定被配置为接受药物治疗（55）的管腔（35）。 装置（10）由诸如形状记忆聚合物的形状记忆材料制成。
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公开(公告)号：US20120116504A1
公开(公告)日：2012-05-10
申请号：US13257196
申请日：2010-03-16
申请人： Michael B. Lyons , Julie Marie Trommeter , Naresh Mandava , Malik Kahook , Robin Shandas , James Fogelberg , Jeffrey Paul Castleberry
发明人： Michael B. Lyons , Julie Marie Trommeter , Naresh Mandava , Malik Kahook , Robin Shandas , James Fogelberg , Jeffrey Paul Castleberry
IPC分类号： A61F2/14
CPC分类号： A61F9/00772 , A61F9/0017 , A61F2210/0014 , A61L27/04 , A61L27/14 , A61L27/50 , A61L2400/16 , A61L2430/16 , A61M25/00 , A61M25/01 , A61M25/04 , A61M31/002
摘要： An implantable ophthalmological device (10) in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device (10) may include an elongated body (25), an anchor (15) operably connected to the elongated body (25), a radially expanding occlusive feature disposed on an outer circumference of the elongated body (32), and a flange (30). The elongated body (25) may define a lumen (35) configured to receive a pharmacological treatment (55). The device (10) is made of a shape memory material such as a shape memory polymer.
摘要翻译： 鼻泪管或小管植入物形式的可植入眼科装置（10）被配置用于在鼻泪管排出系统处或附近使用。 在展开状态下，装置（10）可以包括细长主体（25），可操作地连接到细长主体（25）的锚固件（15），设置在细长主体（32）的外圆周上的径向扩张的闭塞特征 ）和凸缘（30）。 细长主体（25）可以限定被配置为接受药物治疗（55）的管腔（35）。 装置（10）由诸如形状记忆聚合物的形状记忆材料制成。
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公开(公告)号：US20120046687A1
公开(公告)日：2012-02-23
申请号：US13262546
申请日：2010-04-02
申请人： Julie Marie Trommeter , Michael B. Lyons , Jeffrey Paul Castleberry , Robin Shandas , James Fogelberg , Stephen Johnson
发明人： Julie Marie Trommeter , Michael B. Lyons , Jeffrey Paul Castleberry , Robin Shandas , James Fogelberg , Stephen Johnson
IPC分类号： A61F2/01
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B2017/00477 , A61B2017/00778 , A61B2017/00871 , A61B2017/00898 , A61B2017/12054 , A61L31/04 , A61L31/14 , A61L2400/16 , A61L2430/36
摘要： Shape memory materials (SMM) are formed as coil-shaped vascular occlusion devices upon deployment. Shape memory polymer (SMP) materials are tailored through formulation for specific mechanical behavior of the coils. Concurrent coil diameter changes enhance the relative change in stiffness along the length of the coil. Interconnecting structures (104a/b) are formed on ends of elongated members (102a) in the pre-deployment shape for multiple coil insertion capability within an introducer. Channels (206) are formed in pre-deployment shape, elongate members (202) that allow access for injection of imaging contrast agent or concurrent placement of instruments. A single SMM occlusive device (300) transforms into multiple, smaller diameter coils (302b) in the deployed state to generate a complex occlusive structure. A SMM occlusive device (400) has a collapsed fabric (404) component attached to and extending along a sidewall during storage and insertion, and then deploys as a coil (402b) to form a single- or multiple-layer occlusive fabric surface within a center of the coil (402b).
摘要翻译： 形状记忆材料（SMM）在部署时形成为线圈状血管闭塞装置。 形状记忆聚合物（SMP）材料通过配方为线圈的特定机械性能而定制。 并联线圈直径变化增强沿着线圈长度的刚度的相对变化。 互连结构（104a / b）形成在细长构件（102a）的端部中，用于在引导器内用于多个线圈插入能力的预展开形状。 通道（206）以预先展开形状形成，细长构件（202）允许进入成像造影剂的注入或仪器的同时放置。 单个SMM闭塞装置（300）在展开状态下变换成多个较小直径的线圈（302b），以产生复杂的闭塞结构。 SMM闭塞装置（400）具有在储存和插入期间附着并沿侧壁延伸的塌陷织物（404）部件，然后作为线圈（402b）展开以形成单层或多层闭塞织物表面 线圈（402b）的中心。
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公开(公告)号：US09808252B2
公开(公告)日：2017-11-07
申请号：US13262546
申请日：2010-04-02
申请人： Julie Marie Trommeter , Michael B. Lyons , Jeffrey Paul Castleberry , Robin Shandas , James Fogelberg , Stephen Johnson
发明人： Julie Marie Trommeter , Michael B. Lyons , Jeffrey Paul Castleberry , Robin Shandas , James Fogelberg , Stephen Johnson
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B2017/00477 , A61B2017/00778 , A61B2017/00871 , A61B2017/00898 , A61B2017/12054 , A61L31/04 , A61L31/14 , A61L2400/16 , A61L2430/36
摘要： Shape memory materials (SMM) are formed as coil-shaped vascular occlusion devices upon deployment. Shape memory polymer (SMP) materials are tailored through formulation for specific mechanical behavior of the coils. Concurrent coil diameter changes enhance the relative change in stiffness along the length of the coil. Interconnecting structures (104a/b) are formed on ends of elongated members (102a) in the pre-deployment shape for multiple coil insertion capability within an introducer. Channels (206) are formed in pre-deployment shape, elongate members (202) that allow access for injection of imaging contrast agent or concurrent placement of instruments. A single SMM occlusive device (300) transforms into multiple, smaller diameter coils (302b) in the deployed state to generate a complex occlusive structure. A SMM occlusive device (400) has a collapsed fabric (404) component attached to and extending along a sidewall during storage and insertion, and then deploys as a coil (402b) to form a single- or multiple-layer occlusive fabric surface within a center of the coil (402b).
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公开(公告)号：US09119714B2
公开(公告)日：2015-09-01
申请号：US12608714
申请日：2009-10-29
申请人： Robin Shandas , Avery Nelson , Bryan Rech , Devatha P. Nair , Michael B. Lyons , Jeffrey Paul Castleberry , Timothy Francis Scott
发明人： Robin Shandas , Avery Nelson , Bryan Rech , Devatha P. Nair , Michael B. Lyons , Jeffrey Paul Castleberry , Timothy Francis Scott
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/2469 , A61F2/2475 , A61F2/88 , A61F2230/0091 , B29C61/0608 , B29L2031/7534 , Y10T156/1031
摘要： A prosthetic medical device is formed by the combination of a biological tissue a shape memory polymer structure. The biological tissue provides an in-situ physiological function of the device. The shape memory polymer provides a capability for minimizing the device profile during insertion and then deploying after placement into a memory shape that achieves suitable mechanical structure and stability within an anatomical lumen or cavity. This configuration may be applied to form various prosthetic devices including aortic, mitral, and tricuspid valves in the heart; venous valves; anti-reflux valves for the lower esophageal sphincter; and other biological valve structures. Alternatively, an entirely non-biologic implementation using only shape memory polymer-based structures may be used as a prosthetic valve device.
摘要翻译： 假体医疗装置通过生物组织与形状记忆聚合物结构的组合形成。 生物组织提供了该装置的原位生理功能。 形状记忆聚合物提供了在插入期间最小化装置轮廓的能力，然后在放置到在解剖腔或腔内实现合适的机械结构和稳定性的记忆形状之前展开。 这种构造可以应用于形成心脏中的主动脉瓣，二尖瓣和三尖瓣的各种假体装置; 静脉瓣; 用于下食道括约肌的抗回流阀; 和其他生物瓣膜结构。 或者，仅使用形状记忆聚合物基结构的完全非生物学实施方式可以用作假体瓣膜装置。
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公开(公告)号：US20100152839A1
公开(公告)日：2010-06-17
申请号：US12608714
申请日：2009-10-29
申请人： Robin Shandas , Avery Nelson , Bryan Rech , Devatha P. Nair , Michael B. Lyons , Jeffrey Paul Castleberry , Timothy Francis Scott
发明人： Robin Shandas , Avery Nelson , Bryan Rech , Devatha P. Nair , Michael B. Lyons , Jeffrey Paul Castleberry , Timothy Francis Scott
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/2469 , A61F2/2475 , A61F2/88 , A61F2230/0091 , B29C61/0608 , B29L2031/7534 , Y10T156/1031
摘要： A prosthetic medical device is formed by the combination of a biological tissue a shape memory polymer structure. The biological tissue provides an in-situ physiological function of the device. The shape memory polymer provides a capability for minimizing the device profile during insertion and then deploying after placement into a memory shape that achieves suitable mechanical structure and stability within an anatomical lumen or cavity. This configuration may be applied to form various prosthetic devices including aortic, mitral, and tricuspid valves in the heart; venous valves; anti-reflux valves for the lower esophageal sphincter; and other biological valve structures. Alternatively, an entirely non-biologic implementation using only shape memory polymer-based structures may be used as a prosthetic valve device.
摘要翻译： 假体医疗装置通过生物组织与形状记忆聚合物结构的组合形成。 生物组织提供了该装置的原位生理功能。 形状记忆聚合物提供了在插入期间最小化装置轮廓的能力，然后在放置到在解剖腔或腔内实现合适的机械结构和稳定性的记忆形状之前展开。 这种构造可以应用于形成心脏中的主动脉瓣，二尖瓣和三尖瓣的各种假体装置; 静脉瓣; 用于下食道括约肌的抗回流阀; 和其他生物瓣膜结构。 或者，仅使用形状记忆聚合物基结构的完全非生物学实施方式可以用作假体瓣膜装置。
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公开(公告)号：US09062141B2
公开(公告)日：2015-06-23
申请号：US13814691
申请日：2011-08-05
IPC分类号： C08F214/16 , C08F222/20 , C08F263/02 , A61K49/04 , C08F222/10 , C08F222/12
CPC分类号： C08F222/20 , A61K49/0442 , C08F214/16 , C08F222/1006 , C08F222/12 , C08F263/02 , C08F2218/20 , C08G2280/00 , C08L2201/12
摘要： Radiopaque polymer compositions and methods for making the compositions are provided. These radiopaque polymer compositions include shape memory polymer compositions comprising a crosslinked polymer network, the network comprising a first repeating unit derived from a monofunctional iodinated monomer and a second repeating unit derived from a multifunctional non-iodinated monomer wherein neither of the two monomers is fluorinated. Devices formed from radiopaque polymer compositions are also provided.
摘要翻译： 提供不透射线的聚合物组合物和制备组合物的方法。 这些不透射线的聚合物组合物包括包含交联聚合物网络的形状记忆聚合物组合物，该网络包含衍生自单官能碘化单体的第一重复单元和衍生自多官能非碘化单体的第二重复单元，其中两种单体都不是氟化的。 还提供了由不透射线的聚合物组合物形成的装置。
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公开(公告)号：US20130225778A1
公开(公告)日：2013-08-29
申请号：US13814691
申请日：2011-08-05
IPC分类号： C08F222/20 , C08F222/12 , C08F222/10
CPC分类号： C08F222/20 , A61K49/0442 , C08F214/16 , C08F222/1006 , C08F222/12 , C08F263/02 , C08F2218/20 , C08G2280/00 , C08L2201/12
摘要： Radiopaque polymer compositions and methods for making the compositions are provided. These radiopaque polymer compositions include shape memory polymer compositions comprising a crosslinked polymer network, the network comprising a first repeating unit derived from a monofunctional iodinated monomer and a second repeating unit derived from a multifunctional non-iodinated monomer wherein neither of the two monomers is fluorinated. Devices formed from radiopaque polymer compositions are also provided.
摘要翻译： 提供不透射线的聚合物组合物和制备组合物的方法。 这些不透射线的聚合物组合物包括包含交联聚合物网络的形状记忆聚合物组合物，该网络包含衍生自单官能碘化单体的第一重复单元和衍生自多官能非碘化单体的第二重复单元，其中两种单体都不是氟化的。 还提供了由不透射线的聚合物组合物形成的装置。
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