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    Synthesis of chroman derivatives
    13.
    发明授权
    Synthesis of chroman derivatives 失效
    色氨酸衍生物的合成

    公开(公告)号：US5112972A

    公开(公告)日：1992-05-12

    申请号：US531490

    申请日：1990-05-31

    申请人： Rolf Gericke ,  Manfred Baumgarth ,  Ingeborg Lues ,  Rolf Bergmann ,  De Peyer

    发明人： Rolf Gericke ,  Manfred Baumgarth ,  Ingeborg Lues ,  Rolf Bergmann ,  De Peyer

    IPC分类号： A61K31/44 ,  A61K31/50 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/02 ,  C07D405/12

    CPC分类号： C07D405/12

    摘要： The invention relates to new chroman derivatives of the formula I ##STR1## in which R.sup.1 is A,R.sup.2 and R.sup.8 are each H or A,R.sup.1 and R.sup.2 together are also alkylene with 3-6 C atoms,R.sup.3 is OH, OA or OAc,R.sup.4 is H,R.sup.3 and R.sup.4 together are also a bond,R.sup.5 is Ar or C.sub.n H.sub.2n -R.sup.9,R.sup.9 is alkenyl or alkynyl with 2-4 C atoms in each case, OH, OA, CHO, CO-A, CS-A, COOH, COOA, COO-alkyl-Ar, CS-OA, NO.sub.2, NH.sub.2, NHA, NA.sub.2, CN, F, Cl, Br, I, CF.sub.3, SA, SO-A, SO.sub.2 -A or Ar,Ar is a phenyl group which is unsubstituted or substituted once or twice by R.sup.10, R.sup.6, R.sup.7 and R.sup.10 are each H, A, HO, AO, CHO, ACO, CF.sub.3 CO, ACS, HOOC, AOOC, AO-CS, ACOO, A-CS-O, hydroxy-alkyl, mercapto-alkyl, NO.sub.2, NH.sub.2, NHA, NA.sub.2, CN, F, Cl, Br, I, CF.sub.3, AS, ASO, ASO.sub.2, AO-SO, AO-SO.sub.2, AcNH, AO-CO-NH, H.sub.2 NSO, HANSO, A.sub.2 NSO, H.sub.2 NSO.sub.2, HANSO.sub.2, A.sub.2 NSO.sub.2, H.sub.2 NCO, HANCO, A.sub.2 NCO, H.sub.2 NCS, HANCS, A.sub.2 NCS, ASONH, ASO.sub.2 NH, AOSONH, AOSO.sub.2 NH, ACO-alkyl, nitro-alkyl, cyano-alkyl, A-C(.dbd.NOH), A-C(.dbd.NNH.sub.2), H.sub.2 PO.sub.3 or A.sub.2 PO.sub.3,n is 1, 2 or 3,A is alkyl with 1-6 C atoms,-alkyl is alkylene with 1-6 C atoms andAC is alkanoyl with 1-8 C atoms or aroyl with 7-11 C atoms,and the salts thereof which display effects on the cardiovascular system and can be used for the treatment or prophylaxis of heart failure, angina pectoris, high blood pressure, incontinence and alopecia.

    摘要翻译： 本发明涉及式Ⅰ的新的苯并二氢吡喃衍生物，其中R 1是A，R 2和R 8各自是H或A，R 1和R 2一起也是具有3-6个C原子的亚烷基，R 3是OH，OA或OAc R 4是H，R 3和R 4一起也是键，R 5是Ar或C n H 2n-R 9，R 9是每种情况下具有2-4个C原子的链烯基或炔基，OH，OA，CHO，CO-A，CS-A ，COOH，COOA，COO-烷基-Ar，CS-OA，NO2，NH2，NHA，NA2，CN，F，Cl，Br，I，CF3，SA，SO-A，SO2-A或Ar，Ar是 R 10，R 6，R 7和R 10未取代或取代一次或两次的苯基分别为H，A，HO，AO，CHO，ACO，CF 3 CO，ACS，HOOC，AOOC，AO-CS，ACOO，A-CS- O，羟基烷基，巯基烷基，NO2，NH2，NHA，NA2，CN，F，Cl，Br，I，CF3，AS，ASO，ASO2，AO-SO，AO-SO2，AcNH， NH，H2NSO，HANSO，A2NSO，H2NCO，HANCO2，A2NCO，H2NCS，HANCO，A2NCO，H2NCS，HANCS，A2NCS，ASONH，ASO2NH，AOSONH，AOSO2NH，ACO-烷基，硝基 - 烷基，氰基 - 烷基，AC（= NOH ），AC（= NNH 2），H 2 PO 3或A 2 PO 3，n为1,2或3，A为具有1-6个C原子的烷基， - 烷基为亚烷基 1-6个C原子，AC是具有1-8个C原子的烷酰基或7-11个C原子的芳酰基及其对心血管系统有影响的盐，可用于治疗或预防心力衰竭，心绞痛 ，高血压，失禁和脱发。