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公开(公告)号:US20130084263A1
公开(公告)日:2013-04-04
申请号:US13506865
申请日:2012-05-21
IPC分类号: A61K48/00 , A61K38/46 , A61K31/7068
CPC分类号: A61K48/0058 , A61K31/7068 , A61K35/761 , A61K38/465 , A61K2300/00
摘要: This invention is related to the field of cancer treatment, more specifically to gene therapy in combination with a suitable chemotherapeutic agent. The present invention is related to a new oncolytic virus, which is able to inhibit the growth of malignant tumors or is a treatment of hyperproliferative mammalian cells, or is a treatment of cancer. The oncolytic virus works in combination with a suitable chemotherapeutic agent. More specifically, the present invention provides a pharmaceutical kit comprising an oncolytic adenovirus and a chemotherapeutic agent, and a method for the treatment of cancer.
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公开(公告)号:US07598053B2
公开(公告)日:2009-10-06
申请号:US12317039
申请日:2008-12-18
申请人: Manuel Gidekel , Ana Gutierrez , Claudia Rabert , Gustavo Gabrera , Jaime Sanchez , Leon Bravo
发明人: Manuel Gidekel , Ana Gutierrez , Claudia Rabert , Gustavo Gabrera , Jaime Sanchez , Leon Bravo
IPC分类号: C12Q1/44
摘要: A novel gene isolated from Deschampsia antarctica coding for a lipase like protein is disclosed. A system for production of recombinant enzyme is also disclosed as well as uses for the enzyme.
摘要翻译: 公开了从编码脂肪酶类蛋白质的南极洲南极洲分离的新基因。 还公开了用于生产重组酶的系统以及该酶的用途。
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公开(公告)号:US07485445B2
公开(公告)日:2009-02-03
申请号:US11787383
申请日:2007-04-16
申请人: Manuel Gidekel , Ana Gutierrez , Claudia Rabert , Gustavo Gabrera , Jaime Sanchez , Leon Bravo
发明人: Manuel Gidekel , Ana Gutierrez , Claudia Rabert , Gustavo Gabrera , Jaime Sanchez , Leon Bravo
摘要: A novel gene isolated from Deschampsia antarctica coding for a lipase like protein is disclosed. A system for production of recombinant enzyme is also disclosed as well as uses for the enzyme.
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公开(公告)号:US10190181B2
公开(公告)日:2019-01-29
申请号:US15289103
申请日:2016-10-07
申请人: Manuel Gidekel
发明人: Manuel Gidekel
IPC分类号: A61K36/00 , C12R1/02 , A01N63/02 , C12N1/20 , C12R1/01 , B27K3/00 , A01N63/00 , C12R1/00 , A01N25/00
摘要: The present invention provides for a bio-nematocide for repairing damage to wood and related cellulosic products caused by nematodes.
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公开(公告)号:US20160174568A1
公开(公告)日:2016-06-23
申请号:US14120777
申请日:2014-06-26
申请人: Manuel Gidekel
发明人: Manuel Gidekel
摘要: The present invention provides for the first time a biological system which provides the dual function of killing termites and other wood damaging insects while also producing a by-product substance having the capability of repairing damage by termites and other insects to wood and related cellulosic products.The present invention, a biological system, toxic to termites, is provided which produces a means by which damage caused by termites is repaired, said means comprising a by-product produced by a modification of the bacteria of the genus Gluconacetobacter. Preferably, the biological system is in the form of toxic bait.
摘要翻译: 本发明首次提供了提供杀死白蚁和其他木材损伤昆虫的双重功能的生物系统,同时还生产具有修复白蚁和其他昆虫对木材和相关纤维素产品的损害能力的副产物物质。 提供了本发明的对白蚁有毒的生物系统,其产生了由白蚁引起的损伤被修复的手段,所述装置包括通过葡糖乙酸杆菌属细菌的修饰产生的副产物。 优选地,生物系统是有毒诱饵的形式。
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公开(公告)号:US20140328944A1
公开(公告)日:2014-11-06
申请号:US13986437
申请日:2013-05-02
IPC分类号: C12N15/113 , A61K33/24 , A61K31/704 , A61K31/7072
CPC分类号: C12N15/113 , A61K31/513 , A61K31/704 , A61K33/24 , C12N2310/14 , C12N2320/31 , A61K2300/00
摘要: This invention encompasses a novel composition comprising silenced CTBP-1 combined with a compound selected from among 5-FU, Cisplatin and Epirubicin. The invention further relates to a method of treating gastric cancer with a combination of siRNA silenced CTBP-1 and a compound selected from among 5-FU, Cisplatin and Epirubicin.
摘要翻译: 本发明包括一种包含沉默的CTBP-1与选自5-FU,顺铂和表柔比星的化合物的组合物。 本发明还涉及一种用siRNA沉默的CTBP-1和选自5-FU,顺铂和表柔比星的化合物组合治疗胃癌的方法。
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公开(公告)号:US20140235466A1
公开(公告)日:2014-08-21
申请号:US13815320
申请日:2013-02-21
申请人: Manuel Gidekel
发明人: Manuel Gidekel
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6886 , C12Q2600/158 , G01N33/57438
摘要: This invention pertains generally to the fields of molecular biology and medical diagnosis. More particularly this invention provides novel biomarkers for the detection of pancreatic cancer comprising at least one messenger RNA and/or up-regulated peptide in pancreatic cancer. The present invention provides biomarkers capable of discriminating between non-neoplastic pancreatic tissues and ductal adenocarcinoma tissues and can be correlated with a probable diagnosis of pancreatic cancer as well as assessing the efficacy of ongoing therapies for this disease.
摘要翻译: 本发明一般涉及分子生物学和医学诊断领域。 更具体地,本发明提供了用于胰腺癌检测的新型生物标志物,其包括胰腺癌中的至少一种信使RNA和/或上调肽。 本发明提供能够区分非肿瘤性胰腺组织和导管腺癌组织的生物标志物,并且可以与胰腺癌的可能诊断相关,并且评估正在进行的该疾病疗法的功效。
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公开(公告)号:US08357407B2
公开(公告)日:2013-01-22
申请号:US12736727
申请日:2009-01-30
申请人: Manuel Gidekel , Ramon Lucas Molina Carlevarino , Gustavo Cabrera Barjas , Carlos Sunkel Letelier , Ana Gutierrez Moraga , Juan Pablo Pivel Ranieri , Juan Manuel Ferrer Cuesta , Maria Teresa Sanz Berzosa
发明人: Manuel Gidekel , Ramon Lucas Molina Carlevarino , Gustavo Cabrera Barjas , Carlos Sunkel Letelier , Ana Gutierrez Moraga , Juan Pablo Pivel Ranieri , Juan Manuel Ferrer Cuesta , Maria Teresa Sanz Berzosa
IPC分类号: A61K36/899 , A61K36/00 , A61K8/00 , A61K8/18 , A61Q17/04
CPC分类号: A61Q17/04 , A61K8/97 , A61K36/899
摘要: This invention describes an agent for cutaneous photoprotection against UVA (I and II) and UVB radiation that contains an aqueous extract obtained from a plant in the Gramineae family from the Antarctic Continent (Deschampsia Antarctica), which presents both antioxidant and dissipation of excess UV radiation properties.
摘要翻译: 本发明描述了针对UVA(I和II)和UVB辐射的皮肤光保护剂,其含有从南极大陆(Deschampsia Antarctica)的禾本科家族中的植物获得的含水提取物,其呈现过量UV辐射的抗氧化和消散 属性。
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公开(公告)号:US20110195034A1
公开(公告)日:2011-08-11
申请号:US12736727
申请日:2009-01-30
申请人: Manuel Gidekel , Ramon Lucas Molina Carlevarino , Gustavo Cabrera Barjas , Carlos Sunkel Letelier , Ana Gutierrez Moraga , Juan Pablo Pivel Ranieri , Juan Manuel Ferrer Cuesta , Maria Teresa Sanz Berzosa
发明人: Manuel Gidekel , Ramon Lucas Molina Carlevarino , Gustavo Cabrera Barjas , Carlos Sunkel Letelier , Ana Gutierrez Moraga , Juan Pablo Pivel Ranieri , Juan Manuel Ferrer Cuesta , Maria Teresa Sanz Berzosa
CPC分类号: A61Q17/04 , A61K8/97 , A61K36/899
摘要: This invention describes a new agent for cutaneous photoprotection against UVA (I and II) and UVB radiation that contains an aqueous extract obtained from a plant in the Gramineae family from the Antarctic Continent (Deschampsia Antarctica), which presents both antioxidant and dissipation of excess UV radiation properties.
摘要翻译: 本发明描述了一种用于针对UVA(I和II)和UVB辐射的皮肤光保护的新试剂,其包含从南极大陆(Deschampsia Antarctica)的禾本科家族中的植物获得的含水提取物,其提供过量UV的抗氧化和耗散 辐射性能。
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公开(公告)号:US20070118922A1
公开(公告)日:2007-05-24
申请号:US11639474
申请日:2006-12-15
申请人: Manuel Gidekel , Ana Gutierrez , Luis Destefano-Beltran , Pamela Leal , Jorge Dinamarca , Emilio Guerra
发明人: Manuel Gidekel , Ana Gutierrez , Luis Destefano-Beltran , Pamela Leal , Jorge Dinamarca , Emilio Guerra
CPC分类号: C12N15/8237 , C07K14/415 , C12N15/8273
摘要: This disclosure provides gene sequence of a novel gene DaRub1 of Deschampsia antarctica expressed at low temperatures. The promoter sequence of this gene is identified and characterized. The promoter is inducible at low temperature, upon wounding and after auxin-treatment. Additionally this disclosure shows improved low temperature tolerance of transgenic Eucalyptus plants expressing DaRub1 gene.
摘要翻译: 本公开提供了在低温下表达的南极洲南极Des a新基因DaRub1的基因序列。 鉴定和表征该基因的启动子序列。 启动子可在低温,伤口和生长素处理后诱导。 此外,该公开内容显示了表达DaRub1基因的转基因桉树植物的低温耐受性的改善。
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