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    Systems and methods for providing neural stimulation transitions
    13.
    发明授权
    Systems and methods for providing neural stimulation transitions 有权
    用于提供神经刺激过渡的系统和方法

    公开(公告)号：US08630716B2

    公开(公告)日：2014-01-14

    申请号：US13587654

    申请日：2012-08-16

    申请人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfayesus

    发明人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfayesus

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36114 ,  A61N1/36117

    摘要： A method embodiment comprises generating a neural stimulation signal for a neural stimulation therapy. The signal is generated during a duty cycle of a stimulation period to provide the neural stimulation therapy with an intensity at a therapy level for a portion of the duty cycle. In various embodiments, a ramp up protocol is implemented to begin the duty cycle, a ramp down protocol is implemented to end the duty cycle, or both the ramp up protocol and the ramp down protocol are implemented. The ramp up protocol includes ramping up the intensity from a non-zero first subthreshold level for the neural stimulation therapy at the beginning of the duty cycle to the therapy level. The ramp down protocol includes ramping down the intensity from the therapy intensity level to a non-zero second subthreshold level for the neural stimulation therapy at the end of the duty cycle.

    摘要翻译： 方法实施例包括产生用于神经刺激治疗的神经刺激信号。 在刺激期的占空比期间产生信号，以在占空比的一部分的治疗水平上提供具有强度的神经刺激治疗。 在各种实施例中，实现斜坡上升协议以开始占空比，实现斜降协议以结束占空比，或者实现了升温协议和斜降协议两者。 加速协议包括在占空比开始时到神经刺激治疗的非零第一亚阈值水平上升到治疗水平。 斜坡协议包括在占空比结束时将神经刺激治疗的强度从治疗强度水平向下降至非零秒次阈值水平。

    Sensing rate of change of pressure in the left ventricle with an implanted device
    15.
    发明授权
    Sensing rate of change of pressure in the left ventricle with an implanted device 有权
    用植入装置感测左心室压力变化率

    公开(公告)号：US08277389B2

    公开(公告)日：2012-10-02

    申请号：US13178945

    申请日：2011-07-08

    申请人： Gerrard M. Carlson ,  Krzysztof Z. Siejko ,  Ramesh Wariar ,  Marina V. Brockway

    发明人： Gerrard M. Carlson ,  Krzysztof Z. Siejko ,  Ramesh Wariar ,  Marina V. Brockway

    IPC分类号： A61B5/02

    CPC分类号： A61B5/021 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/375

    摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.

    摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。

    SYSTEMS AND METHODS FOR PROVIDING NEURAL STIMULATION TRANSITIONS
    19.
    发明申请
    SYSTEMS AND METHODS FOR PROVIDING NEURAL STIMULATION TRANSITIONS 有权
    用于提供神经刺激转换的系统和方法

    公开(公告)号：US20120310304A1

    公开(公告)日：2012-12-06

    申请号：US13587654

    申请日：2012-08-16

    申请人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfayesus

    发明人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfayesus

    IPC分类号： A61N1/08

    CPC分类号： A61N1/36114 ,  A61N1/36117

    摘要： A method embodiment comprises generating a neural stimulation signal for a neural stimulation therapy. The signal is generated during a duty cycle of a stimulation period to provide the neural stimulation therapy with an intensity at a therapy level for a portion of the duty cycle. In various embodiments, a ramp up protocol is implemented to begin the duty cycle, a ramp down protocol is implemented to end the duty cycle, or both the ramp up protocol and the ramp down protocol are implemented. The ramp up protocol includes ramping up the intensity from a non-zero first subthreshold level for the neural stimulation therapy at the beginning of the duty cycle to the therapy level. The ramp down protocol includes ramping down the intensity from the therapy intensity level to a non-zero second subthreshold level for the neural stimulation therapy at the end of the duty cycle.

    摘要翻译： 方法实施例包括产生用于神经刺激治疗的神经刺激信号。 在刺激期的占空比期间产生信号，以在占空比的一部分的治疗水平上提供具有强度的神经刺激治疗。 在各种实施例中，实现斜坡上升协议以开始占空比，实现斜降协议以结束占空比，或者实现升温协议和斜降协议两者。 加速协议包括在占空比开始时到神经刺激治疗的非零第一亚阈值水平上升到治疗水平。 斜坡协议包括在占空比结束时将神经刺激治疗的强度从治疗强度水平向下降至非零秒次阈值水平。

    Cardiac rhythm management device
    20.
    发明授权
    Cardiac rhythm management device 有权
    心律管理装置

    公开(公告)号：US08321036B2

    公开(公告)日：2012-11-27

    申请号：US13087997

    申请日：2011-04-15

    申请人： Brian Brockway ,  Marina V. Brockway

    发明人： Brian Brockway ,  Marina V. Brockway

    IPC分类号： A61N1/362

    CPC分类号： A61N1/365 ,  A61N1/39

    摘要： A medical device is disclosed for implantation on an epicardial surface of the heart. The device has a transmural member providing optimal electrode locations for various therapies. The hemodynamically optimal therapy is guided by sensed left ventricular pressure and electrical activity. The device may be used alone or with a companion implanted cardiac rhythm management device.

    摘要翻译： 公开了用于植入在心脏的心外膜表面上的医疗装置。 该装置具有提供用于各种疗法的最佳电极位置的透壁构件。 血液动力学最佳治疗由感测到的左心室压力和电活动指导。 该装置可以单独使用或与伴随植入的心律管理装置一起使用。