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    SYSTEMS AND METHODS FOR PROVIDING NEURAL STIMULATION TRANSITIONS
    1.
    发明申请
    SYSTEMS AND METHODS FOR PROVIDING NEURAL STIMULATION TRANSITIONS 有权
    用于提供神经刺激转换的系统和方法

    公开(公告)号：US20090024186A1

    公开(公告)日：2009-01-22

    申请号：US11779764

    申请日：2007-07-18

    申请人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfayesus

    发明人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfayesus

    IPC分类号： A61N1/05

    CPC分类号： A61N1/36114 ,  A61N1/36117

    摘要： A method embodiment comprises generating a neural stimulation signal for a neural stimulation therapy. The signal is generated during a duty cycle of a stimulation period to provide the neural stimulation therapy with an intensity at a therapy level for a portion of the duty cycle. In various embodiments, a ramp up protocol is implemented to begin the duty cycle, a ramp down protocol is implemented to end the duty cycle, or both the ramp up protocol and the ramp down protocol are implemented. The ramp up protocol includes ramping up the intensity from a non-zero first subthreshold level for the neural stimulation therapy at the beginning of the duty cycle to the therapy level. The ramp down protocol includes ramping down the intensity from the therapy intensity level to a non-zero second subthreshold level for the neural stimulation therapy at the end of the duty cycle.

    摘要翻译： 方法实施例包括产生用于神经刺激治疗的神经刺激信号。 在刺激期的占空比期间产生信号，以在占空比的一部分的治疗水平上提供具有强度的神经刺激治疗。 在各种实施例中，实现斜坡上升协议以开始占空比，实现斜降协议以结束占空比，或者实现升温协议和斜降协议两者。 加速协议包括在占空比开始时到神经刺激治疗的非零第一亚阈值水平上升到治疗水平。 斜坡协议包括在占空比结束时将神经刺激治疗的强度从治疗强度水平向下降至非零秒次阈值水平。

    Systems and methods for providing neural stimulation transitions
    2.
    发明授权
    Systems and methods for providing neural stimulation transitions 有权
    用于提供神经刺激过渡的系统和方法

    公开(公告)号：US08630716B2

    公开(公告)日：2014-01-14

    申请号：US13587654

    申请日：2012-08-16

    申请人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfayesus

    发明人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfayesus

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36114 ,  A61N1/36117

    摘要： A method embodiment comprises generating a neural stimulation signal for a neural stimulation therapy. The signal is generated during a duty cycle of a stimulation period to provide the neural stimulation therapy with an intensity at a therapy level for a portion of the duty cycle. In various embodiments, a ramp up protocol is implemented to begin the duty cycle, a ramp down protocol is implemented to end the duty cycle, or both the ramp up protocol and the ramp down protocol are implemented. The ramp up protocol includes ramping up the intensity from a non-zero first subthreshold level for the neural stimulation therapy at the beginning of the duty cycle to the therapy level. The ramp down protocol includes ramping down the intensity from the therapy intensity level to a non-zero second subthreshold level for the neural stimulation therapy at the end of the duty cycle.

    摘要翻译： 方法实施例包括产生用于神经刺激治疗的神经刺激信号。 在刺激期的占空比期间产生信号，以在占空比的一部分的治疗水平上提供具有强度的神经刺激治疗。 在各种实施例中，实现斜坡上升协议以开始占空比，实现斜降协议以结束占空比，或者实现了升温协议和斜降协议两者。 加速协议包括在占空比开始时到神经刺激治疗的非零第一亚阈值水平上升到治疗水平。 斜坡协议包括在占空比结束时将神经刺激治疗的强度从治疗强度水平向下降至非零秒次阈值水平。

    SYSTEMS AND METHODS FOR PROVIDING NEURAL STIMULATION TRANSITIONS
    3.
    发明申请
    SYSTEMS AND METHODS FOR PROVIDING NEURAL STIMULATION TRANSITIONS 有权
    用于提供神经刺激转换的系统和方法

    公开(公告)号：US20120310304A1

    公开(公告)日：2012-12-06

    申请号：US13587654

    申请日：2012-08-16

    申请人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfayesus

    发明人： Marina V. Brockway ,  Paul A. Haefner ,  Anthony V. Caparso ,  Wondimeneh Tesfayesus

    IPC分类号： A61N1/08

    CPC分类号： A61N1/36114 ,  A61N1/36117

    摘要： A method embodiment comprises generating a neural stimulation signal for a neural stimulation therapy. The signal is generated during a duty cycle of a stimulation period to provide the neural stimulation therapy with an intensity at a therapy level for a portion of the duty cycle. In various embodiments, a ramp up protocol is implemented to begin the duty cycle, a ramp down protocol is implemented to end the duty cycle, or both the ramp up protocol and the ramp down protocol are implemented. The ramp up protocol includes ramping up the intensity from a non-zero first subthreshold level for the neural stimulation therapy at the beginning of the duty cycle to the therapy level. The ramp down protocol includes ramping down the intensity from the therapy intensity level to a non-zero second subthreshold level for the neural stimulation therapy at the end of the duty cycle.

    摘要翻译： 方法实施例包括产生用于神经刺激治疗的神经刺激信号。 在刺激期的占空比期间产生信号，以在占空比的一部分的治疗水平上提供具有强度的神经刺激治疗。 在各种实施例中，实现斜坡上升协议以开始占空比，实现斜降协议以结束占空比，或者实现升温协议和斜降协议两者。 加速协议包括在占空比开始时到神经刺激治疗的非零第一亚阈值水平上升到治疗水平。 斜坡协议包括在占空比结束时将神经刺激治疗的强度从治疗强度水平向下降至非零秒次阈值水平。

    Screening Devices and Methods for Obstructive Sleep Apnea Therapy
    4.
    发明申请
    Screening Devices and Methods for Obstructive Sleep Apnea Therapy 有权
    阻塞性睡眠呼吸暂停治疗的筛查装置和方法

    公开(公告)号：US20140188185A1

    公开(公告)日：2014-07-03

    申请号：US13205315

    申请日：2011-08-08

    申请人： Wondimeneh Tesfayesus ,  Stephen L. Bolea ,  Peter R. Eastwood ,  David R. Hillman

    发明人： Wondimeneh Tesfayesus ,  Stephen L. Bolea ,  Peter R. Eastwood ,  David R. Hillman

    IPC分类号： A61N1/36

    CPC分类号： A61B5/0826 ,  A61B1/233 ,  A61B1/267 ,  A61B5/4552 ,  A61N1/0519 ,  A61N1/0551 ,  A61N1/3601 ,  A61N1/3611 ,  A61N1/36139

    摘要： Devices and methods for treating obstructive sleep apnea by first performing an assessment of the patient that involves observing the patient's upper airway during a tongue protrusion maneuver. The assessment may, for example, be done using endoscopy to observe the upper airway while the patient is awake in the supine position. An adequate response of the upper airway during the tongue protrusion maneuver is indicative of likely therapeutic success with hypoglossal nerve stimulation, and may be used for making clinical decisions. The principles of the present invention may be applied to other therapeutic interventions for OSA involving the upper airway.

    摘要翻译： 通过首先对患者的评估进行治疗阻塞性睡眠呼吸暂停的装置和方法，其涉及在舌突出动作期间观察患者的上呼吸道。 例如，可以使用内窥镜检查来观察患者在仰卧位时醒来时观察上呼吸道的评估。 在舌突出动作期间上呼吸道的充分反应表明舌下神经刺激可能具有治疗成功的作用，并可用于进行临床决策。 本发明的原理可以应用于涉及上呼吸道的OSA的其它治疗干预。

    DEVICES AND METHODS FOR SLEEP APNEA TREATMENT
    10.
    发明申请
    DEVICES AND METHODS FOR SLEEP APNEA TREATMENT 有权
    睡眠APNEA治疗的装置和方法

    公开(公告)号：US20130085546A1

    公开(公告)日：2013-04-04

    申请号：US13633670

    申请日：2012-10-02

    申请人： Stephen Bolea ,  Wondimeneh Tesfayesus ,  John Beck ,  Thomas Hoegh ,  Robert Atkinson ,  Sidney Hauschild

    发明人： Stephen Bolea ,  Wondimeneh Tesfayesus ,  John Beck ,  Thomas Hoegh ,  Robert Atkinson ,  Sidney Hauschild

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3611 ,  A61B2017/248 ,  A61F5/566 ,  A61N1/3601

    摘要： Devices and methods for improving the coupling between the soft palate and the genioglossus. This may be accomplished, for example, but shortening or stiffening the palatoglossal arch. Improved coupling between the soft palate and the genioglossus may be beneficial to a patient suffering from obstructive sleep apnea (OSA) as a stand-alone procedure, or in combination procedures and devices that cause anterior displacement of the tongue such as hypoglossal nerve stimulation, genioglossus advancement surgery, mandibular advancement surgery, mandibular advancement (oral) appliances, etc.

    摘要翻译： 用于改善软腭和颏舌肌之间的联系的装置和方法。 例如，这可以实现，但缩短或加强腭弓。 软腭和颏舌之间的改善的耦合可能对于患有作为独立手术的阻塞性睡眠呼吸暂停（OSA）的患者或者引起舌头前移位的组合手术和装置如舌下神经刺激，颏舌us 下颌前移手术，下颌前移（口腔）器具等。