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11.发明申请公开(公告)号：US20110038899A1
公开(公告)日：2011-02-17
申请号：US12933701
申请日：2009-03-27
IPC分类号： A61K9/00 , A61K31/5513 , A61K38/00 , A61K31/7052 , A61K31/573 , A61K31/565 , A61K31/436 , A61K31/337 , A61K38/12
摘要： Pharmaceutical solutions containing hydrophobic or lipophilic therapeutic agents and methods for producing the same are provided. Pharmaceutical solutions of the invention are produced by dissolving the therapeutic agent in one or more tocopherols or tocotrienols and one or more alcohols or glycols. These solutions are used to produce pharmaceutical compositions.
摘要翻译： 提供了含有疏水性或亲脂性治疗剂的药物溶液及其制备方法。 通过将治疗剂溶解在一种或多种生育酚或生育三烯酚和一种或多种醇或二醇中来制备本发明的药物溶液。 这些溶液用于制备药物组合物。
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12.发明申请BI-FUNCTIONAL CO-POLYMER USE FOR OPTHALMIC AND OTHER TOPICAL AND LOCAL APPLICATIONS 有权双功能聚合物用于非对称和其他局部和本地应用公开(公告)号：US20100226963A1
公开(公告)日：2010-09-09
申请号：US12708329
申请日：2010-02-18
CPC分类号： A61K31/785 , A61K9/0019 , A61K9/0043 , A61K9/0048 , A61K9/0051 , A61K9/0073 , A61K9/5031 , A61K9/5146 , A61K31/045 , A61K31/7036 , A61K31/74 , A61K31/765 , A61K35/02 , A61K45/06 , A61K47/34 , G02C7/04
摘要： The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
摘要翻译： 本发明涉及一种共聚物，其是可用于改变生物表面的润湿性和表面特性的接枝或嵌段共聚物。 使用这些制剂和涂层以改变受试者的润湿性和空间稳定性以及润滑生物表面的方法，例如治疗干眼综合征，以及防止不需要的蛋白质的粘附，例如用于治疗隐形眼镜 不容忍，被提供。
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公开(公告)号：US20090258865A1
公开(公告)日：2009-10-15
申请号：US12413439
申请日：2009-03-27
申请人： Steve Cartt , David Medeiros , Gary Thomas Gwozdz , Andrew Loxley , Mark Mitchnick , David F. Hale
发明人： Steve Cartt , David Medeiros , Gary Thomas Gwozdz , Andrew Loxley , Mark Mitchnick , David F. Hale
IPC分类号： A61K31/5513
CPC分类号： A61K31/355 , A61K9/0043 , A61K9/008 , A61K31/5513
摘要： The invention relates to pharmaceutical compositions comprising one or more benzodiazepine drugs for nasal administration, methods for producing and for using such compositions.
摘要翻译： 本发明涉及包含一种或多种用于鼻内给药的苯并二氮类药物的药物组合物，用于制备和使用这些组合物的方法。
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公开(公告)号：US20130065886A1
公开(公告)日：2013-03-14
申请号：US13495942
申请日：2012-06-13
申请人： Steve Cartt , David Medeiros , Garry Thomas Gwozdz , Andrew Loxley , Mark Mitchnick , David Hale , Edward T. Maggio
发明人： Steve Cartt , David Medeiros , Garry Thomas Gwozdz , Andrew Loxley , Mark Mitchnick , David Hale , Edward T. Maggio
IPC分类号： A61K31/5513 , A61P21/02 , A61P25/00 , A61P25/08 , A61P21/00 , A61P25/30 , A61P25/22 , A61P25/20
CPC分类号： A61K9/0043 , A61K9/008 , A61K9/08 , A61K31/355 , A61K31/5513 , A61K45/06 , A61K47/10 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions comprising one or more benzodiazepine drugs for nasal administration, methods for producing and for using such compositions.
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公开(公告)号：US07419527B2
公开(公告)日：2008-09-02
申请号：US10434397
申请日：2003-05-08
申请人： Garry Gwozdz , Mark Mitchnick , David Fairhurst
发明人： Garry Gwozdz , Mark Mitchnick , David Fairhurst
CPC分类号： B22F1/007 , B22F1/0059 , B22F2998/00 , C04B35/62821 , C04B35/62823 , C04B35/62834
摘要： Novel powders or particles are formed by associating them with relatively small proportions of hydrolysable liquid material. The resulting particle/liquid mass is placed in a mold and sintered under conditions of heat and pressure that enables at least some of the hydrolysable liquid to react within the sintered mass. The sintered mass displays a controllable range of properties such as increased density, increased tensile strength, and improved natural polish finish. The hydrolysable liquid may partially hydrolyze and/or react with the powders and particles, but the liquid is not completely (not 100%) reduced to an inorganic oxide prior to introduction to the mold and performance of the sintering process.
摘要翻译： 通过将它们与相对小比例的可水解液体材料缔合而形成新的粉末或颗粒。 将所得的颗粒/液体物质置于模具中并在热和压力条件下烧结，使至少一些可水解液体在烧结体内发生反应。 烧结体显示出可控范围的特性，例如增加的密度，增加的拉伸强度和改进的天然抛光光洁度。 可水解液体可能部分水解和/或与粉末和颗粒反应，但是在引入模具和执行烧结过程之前，液体不会完全（不是100％）还原成无机氧化物。
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16.发明申请DEVICES AND METHODS FOR ANALYSIS OF SAMPLES WITH DEPLETION OF ANALYTE CONTENT 审中-公开用于分析分析样品的装置和方法，分析分析内容公开(公告)号：US20090087925A1
公开(公告)日：2009-04-02
申请号：US11865555
申请日：2007-10-01
申请人： Peter Wagner , Frank Zaugg , Mark Mitchnick
发明人： Peter Wagner , Frank Zaugg , Mark Mitchnick
IPC分类号： G01N33/543 , B01J19/00 , C12M1/00 , G01N21/00 , G01N33/00
CPC分类号： G01N33/54366 , B01F5/061 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F2005/0621 , B01F2005/0636 , B01J2219/00605 , B01L3/502761 , B01L2200/148 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2400/0472 , B01L2400/086 , G01N33/56972 , G01N33/581 , G01N33/6869 , G01N2021/6439
摘要： A system and method for determining the presence and/or concentration of one or more analytes in a sample that comprises a fluid, the system comprising a solid substrate comprising a sample inlet or inlets and one or more analyte determination flow paths, each analyte determination flow path comprising a defined beginning and a defined terminus and comprising at least one capture zone containing a capture agent for an analyte, the capture agent or agents being immobilized along a portion of the flow path or paths, the flow path or paths being designed so that the one or more analytes are depleted from the sample and bound in a non-linear manner to the portion of the flow path or paths containing immobilized capture agent or agents, producing an analyte depletion end region for each analyte between the beginning and the terminus of the analyte determination flow path.
摘要翻译： 一种用于确定包含流体的样品中一种或多种分析物的存在和/或浓度的系统和方法，所述系统包括固体基质，其包含样品入口或入口以及一个或多个分析物确定流路径，每个分析物确定流程 路径，其包含限定的起始点和限定的末端，并且包含至少一个包含分析物的捕获剂的捕获区域，所述捕获剂或试剂沿所述流动路径或路径的一部分被固定，所述流动路径或路径被设计成使得 一个或多个分析物从样品中耗尽，并以非线性方式结合到包含固定化捕获剂或试剂的流动路径或路径的部分，从而在每个分析物的起始和终点之间产生分析物耗尽末端区域 分析物确定流路。
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公开(公告)号：US10166146B2
公开(公告)日：2019-01-01
申请号：US14200467
申请日：2014-03-07
申请人： Mark Mitchnick
发明人： Mark Mitchnick
摘要： A device for dispensing medication to the ear with a tympanic membrane sensor and medication dispenser which dispenses medication upon identification of the tympanic membrane by the sensor is provided. Also provided are methods for using the device to dispense medications to the ear.
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公开(公告)号：US20140257171A1
公开(公告)日：2014-09-11
申请号：US14200467
申请日：2014-03-07
申请人： Mark Mitchnick
发明人： Mark Mitchnick
CPC分类号： A61F11/00 , A61N5/062 , A61N2005/0605
摘要： A device for dispensing medication to the ear with a tympanic membrane sensor and medication dispenser which dispenses medication upon identification of the tympanic membrane by the sensor is provided. Also provided are methods for using the device to dispense medications to the ear.
摘要翻译： 提供了一种用于使用鼓膜传感器和药物分配器将药物分配到耳朵的装置，该装置在通过传感器识别鼓膜时分配药物。 还提供了使用该装置将药物分配给耳朵的方法。
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19.发明申请XANTHURENIC ACID DERIVATIVE PHARMACEUTICAL COMPOSITIONS AND METHODS RELATED THERETO 有权西兰酸衍生物药物组合物及其相关方法公开(公告)号：US20120028280A1
公开(公告)日：2012-02-02
申请号：US13269843
申请日：2011-10-10
IPC分类号： G01N33/53 , G01N33/50 , H01J49/00 , G01N27/447 , G01N33/566 , G01N30/00
CPC分类号： C07D215/48 , A61K31/341 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K31/635 , A61K31/675 , A61K31/706 , A61K45/06 , C07H17/02 , G01N33/5308 , G06K19/02 , G06K19/07749 , G06K19/0776 , A61K2300/00
摘要： The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
摘要翻译： 本发明涉及利尿药物组合物和方法，特别涉及式I的某些衍生物：或其前药或药学上可接受的盐; 和药学上可接受的载体。
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公开(公告)号：US20060217322A1
公开(公告)日：2006-09-28
申请号：US11323580
申请日：2005-12-29
IPC分类号： A61K31/7052 , A61K31/675 , A61K31/4709 , A61K31/4704
CPC分类号： C07D215/48 , A61K31/341 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K31/635 , A61K31/675 , A61K31/706 , A61K45/06 , C07H17/02 , G01N33/5308 , G06K19/02 , G06K19/07749 , G06K19/0776 , A61K2300/00
摘要： The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
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