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公开(公告)号：US07161679B2
公开(公告)日：2007-01-09
申请号：US10309994
申请日：2002-12-04
IPC分类号： G01B9/02
CPC分类号： G01J3/453
摘要： An interferometer spectrometer that has reduced alignment sensitivity is described herein. Parallelism of an output ray pair formed by a single input ray is not affected by variations in relative alignment of the components. In comparison to other compensated interferometer designs, lateral separation errors in the output ray pair due to optical component misalignment are reduced. The reduced alignment sensitivity may be accomplished by utilizing simple planar components that are common to both light paths. The reduced alignment sensitivity and simplicity in design provides a more compact and more robust interferometer, with reduced manufacturing costs associated therewith. An elliptical field of view light source that utilizes an array of collimator lenses is also described. The light source provides a more compact design than a single circular collimator lens of the same area, and is suitable for single channel or multi-channel use.
摘要翻译： 本文描述了具有降低的对准灵敏度的干涉仪光谱仪。 由单个输入光线形成的输出光线对的平行度不受组件相对对准的变化的影响。 与其他补偿干涉仪设计相比，减少了由于光学部件失准导致的输出光线对中的横向分离误差。 降低的对准灵敏度可以通过利用两个光路通用的简单平面部件来实现。 降低的对准灵敏度和设计简单性提供了更紧凑和更强大的干涉仪，同时降低了与之相关的制造成本。 还描述了利用准直透镜阵列的椭圆视场光源。 光源提供比同一区域的单个圆形准直透镜更紧凑的设计，并且适用于单通道或多通道使用。
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公开(公告)号：US06989901B2
公开(公告)日：2006-01-24
申请号：US10614267
申请日：2003-07-02
申请人： Russell E. Abbink
发明人： Russell E. Abbink
CPC分类号： G01J3/453
摘要： The present invention provides an improved interferometer design. Embodiments of the present invention provide a beam splitter, mounted with first and second reflective elements. An OPD element mounts relative to the other elements such that an optical path in the interferometer passes through the OPD element. The OPD element can be, for example, a plate comprising a refractive material mounted such that the thickness of the refractive material encountered by the optical path through the OPD element is variable. Various arrangements of components are described, and methods of constructing and methods of aligning such interferometers are also described.
摘要翻译： 本发明提供一种改进的干涉仪设计。 本发明的实施例提供一种安装有第一和第二反射元件的分束器。 OPD元件相对于其它元件安装，使得干涉仪中的光路通过OPD元件。 OPD元件可以是例如包括折射材料的板，其被安装成使得通过OPD元件的光路遇到的折射材料的厚度是可变的。 还描述了组件的各种布置，并且还描述了构造方法和对准这种干涉仪的方法。
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13.发明授权公开(公告)号：US06684099B2
公开(公告)日：2004-01-27
申请号：US10116271
申请日：2002-04-04
IPC分类号： A61B505
CPC分类号： A61B5/0059 , A61B5/6824
摘要： An optical sampling subsystem and method that reduces the effect of errors in an optical sampling subsystem when heterogeneously distributed samples are measured in the path of a spectrometer. The optical sampling subsystem is used to collect the non-uniformly distributed radiation exiting the heterogeneous sample and produce a uniform irradiance at its output. The output is then directed into the wavenumber (inverse of wavelength in centimeters) dispersive or modulating device of the spectrometer. The resulting spectra exhibit less spectral complexity arising from components of the sampling subsystem design and the heterogeneous sample, in particular, the effect of wavenumber shift is minimized. Improved quantitative predictions, qualitative analysis and calibration transfer are direct consequences of the reduced spectral complexity.
摘要翻译： 当在光谱仪的路径中测量非均匀分布的样本时，光采样子系统和方法可减少光采样子系统中误差的影响。 光采样子系统用于收集离散异质样品的非均匀分布的辐射，并在其输出端产生均匀的辐照度。 然后将输出引导到光谱仪的波数（以厘米为单位的波长的倒数）色散或调制装置。 所得到的光谱表现出较小的光谱复杂度，由采样子系统设计和异质样本的组成部分引起，特别是波数偏移的影响被最小化。 改进的定量预测，定性分析和校准转移是降低光谱复杂度的直接后果。
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公开(公告)号：US06504614B1
公开(公告)日：2003-01-07
申请号：US09415600
申请日：1999-10-08
IPC分类号： G01B902
CPC分类号： G01J3/453
摘要： An interferometer spectrometer that has reduced alignment sensitivity is described herein. Parallelism of an output ray pair formed by a single input ray is not affected by variations in relative alignment of the components. In comparison to other compensated interferometer designs, lateral separation errors in the output ray pair due to optical component misalignment are reduced. The reduced alignment sensitivity may be accomplished by utilizing simple planar components that are common to both light paths. The reduced alignment sensitivity and simplicity in design provides a more compact and more robust interferometer, with reduced manufacturing costs associated therewith. An elliptical field of view light source that utilizes an array of collimator lenses is also described. The light source provides a more compact design than a single circular collimator lens of the same area, and is suitable for single channel or multi-channel use.
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公开(公告)号：US20110184260A1
公开(公告)日：2011-07-28
申请号：US13036012
申请日：2011-02-28
IPC分类号： A61B5/1455
CPC分类号： G01N21/21 , A61B5/14532 , A61B5/14546 , A61B5/14558 , A61B5/7257 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0218 , G01J3/0262 , G01N21/49 , G01N2021/4792
摘要： The present invention provides methods and apparatuses for accurate noninvasive determination of tissue properties. Some embodiments of the present invention comprise an optical sampler having an illumination subsystem, adapted to communicate light having a first polarization to a tissue surface; a collection subsystem, adapted to collect light having a second polarization communicated from the tissue after interaction with the tissue; wherein the first polarization is different from the second polarization. The difference in the polarizations can discourage collection of light specularly reflected from the tissue surface, and can encourage preferential collection of light that has interacted with a desired depth of penetration or path length distribution in the tissue. The different polarizations can, as examples, be linear polarizations with an angle between, or elliptical polarizations of different handedness.
摘要翻译： 本发明提供用于精确无创确定组织性质的方法和装置。 本发明的一些实施例包括具有照明子系统的光学采样器，适于将具有第一偏振光的光传送到组织表面; 收集子系统，适于在与所述组织相互作用之后收集从所述组织传递的具有第二极化的光; 其中所述第一极化不同于所述第二极化。 极化的差异可以阻止从组织表面反射的光的收集，并且可以鼓励优先收集与组织中所需的穿透深度或路径长度分布相互作用的光。 作为示例，不同的极化可以是具有不同手性的角度或椭圆偏振之间的线性偏振。
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16.发明申请Methods and Apparatuses for Noninvasive Determinations of Analytes using Parallel Optical Paths 审中-公开使用平行光路无创测定分析物的方法和设备公开(公告)号：US20090018415A1
公开(公告)日：2009-01-15
申请号：US12239601
申请日：2008-09-26
IPC分类号： A61B5/00
CPC分类号： G01J3/02 , A61B5/14558 , G01J3/0208 , G01J3/0224 , G01J3/10 , G01J3/453 , G01N21/21 , G01N21/49 , G01N2021/4792
摘要： The present invention provides methods and apparatuses for accurate noninvasive determination of tissue properties. Some embodiments of the present invention comprise an optical sampler having an illumination subsystem, adapted to communicate light having a first polarization along a first path to a tissue surface; a collection subsystem, adapted to collect light having a second polarization communicated from the tissue along a second path after interaction with the tissue; wherein the first polarization is different from the second polarization; and wherein the first path and the second path are substantially parallel for at least of portion of each path.
摘要翻译： 本发明提供用于精确无创确定组织性质的方法和装置。 本发明的一些实施例包括具有照明子系统的光学采样器，其适于将沿着第一路径具有第一极化的光传送到组织表面; 收集子系统，适于在与所述组织相互作用之后收集沿着第二路径从所述组织传递的具有第二极化的光; 其中所述第一极化与所述第二极化不同; 并且其中所述第一路径和所述第二路径对于每条路径的至少部分基本平行。
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公开(公告)号：US07126682B2
公开(公告)日：2006-10-24
申请号：US09832631
申请日：2001-04-11
IPC分类号： G01J3/04
CPC分类号： G01J3/10 , G01J3/0218 , G01J3/12 , G01J3/32 , G01J2003/123 , G01J2003/1234 , G01N21/255
摘要： Spectroscopic system and spectrometers including an optical bandpass filter unit having a plurality of bandpass regions and a spatial encoding unit for encoding discrete frequencies of light passing through the optical filter. The incorporation of the encoding unit allows the spectrometer system to use a detector having one or a small number of elements, rather than using a more expensive detector array typically used with filter-based spectrometers. The system can also include an integrating chamber that collects the light that is not transmitted through the bandpass filter unit, and redirects this light to strike the filter unit again, resulting in a significant increase in the optical power passing through the filter. The integrating chamber maximizes the return of the reflected light to the filter assembly and minimizes optical losses. The integrating chamber may be an orthogonal design to preserve the optical geometric characteristics of the light entering the chamber.
摘要翻译： 光谱系统和光谱仪包括具有多个带通区的光学带通滤波器单元和用于编码通过滤光器的光的离散频率的空间编码单元。 编码单元的结合允许光谱仪系统使用具有一个或少量元件的检测器，而不是使用通常与基于滤光器的光谱仪一起使用的更昂贵的检测器阵列。 该系统还可以包括积分室，其收集不透过带通滤光器单元的光，并且重新定向该光以再次撞击过滤器单元，导致通过过滤器的光功率的显着增加。 积分室使反射光的返回最大化到滤光器组件，并使光损耗最小化。 积分室可以是正交设计，以保持进入室的光的光学几何特性。
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公开(公告)号：US06865408B1
公开(公告)日：2005-03-08
申请号：US10378237
申请日：2003-03-03
IPC分类号： A61B5/00 , G01J3/02 , G01J3/10 , G01N21/27 , G01N21/47 , G01N21/49 , G01N33/487 , G02B6/42 , G02B27/00
CPC分类号： G02B6/4298 , A61B5/0075 , A61B5/14532 , A61B5/1455 , G01J3/02 , G01J3/0216 , G01J3/0218 , G01J3/10 , G01N21/278 , G01N21/4785 , G01N21/49 , G01N2201/1293 , G02B6/4206
摘要： An apparatus and method for non-invasive measurement of glucose in human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes six subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The six subsystems include an illumination subsystem, a tissue sampling subsystem, a calibration maintenance subsystem, an FTIR spectrometer subsystem, a data acquisition subsystem, and a computing subsystem.
摘要翻译： 一种用于通过定量红外光谱对人体组织中葡萄糖进行非侵入性测量的临床相关水平的精确度和准确度的装置和方法。 该系统包括六个子系统，优化以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。 六个子系统包括照明子系统，组织采样子系统，校准维护子系统，FTIR光谱仪子系统，数据采集子系统和计算子系统。
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公开(公告)号：US06574490B2
公开(公告)日：2003-06-03
申请号：US09832585
申请日：2001-04-11
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , G01J3/02 , G01J3/0216 , G01J3/0218 , G01J3/10
摘要： An apparatus and method for non-invasive measurement of glucose in human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes six subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The six subsystems include an illumination subsystem, a tissue sampling subsystem, a calibration maintenance subsystem, an FTIR spectrometer subsystem, a data acquisition subsystem, and a computing subsystem.
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