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公开(公告)号：US4546084A
公开(公告)日：1985-10-08
申请号：US598114
申请日：1984-04-09
CPC分类号： C12P1/06 , Y10S435/825
摘要： A biologically pure culture of Actinomadura Sp. Strain H710-49 (ATCC 39144) is provided. The antibiotic designated BBM-1644 may be produced by fermentation of the subject culture.
摘要翻译： Actinomadura Sp。的生物纯文化。 提供了菌株H710-49（ATCC 39144）。 称为BBM-1644的抗生素可以通过培养受试者的发酵来生产。
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公开(公告)号：US4464467A
公开(公告)日：1984-08-07
申请号：US401469
申请日：1982-07-26
CPC分类号： C07D487/04 , C12P17/182 , C12R1/465 , Y10S435/886
摘要： A novel antitumor antibiotic designated herein as BBM-2040 is produced by fermentation of Streptomyces sp. strain J576-99 (ATCC 39143). BBM-2040, which may be recovered from the fermentation broth in either a desmethanol (BBM-2040B) or methanol-adduct (BBM-2040A) form, inhibits gram-positive and acid-fast bacteria and inhibits the growth of tumors such as P388 leukemia in mice.
摘要翻译： 本文命名为BBM-2040的新型抗肿瘤抗生素通过Streptomyces sp。 菌株J576-99（ATCC 39143）。 可以从脱甲醇（BBM-2040B）或甲醇加合物（BBM-2040A）形式的发酵液中回收的BBM-2040抑制革兰氏阳性和耐酸细菌并抑制肿瘤如P388的生长 白血病小鼠。
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公开(公告)号：US4341768A
公开(公告)日：1982-07-27
申请号：US250987
申请日：1981-04-03
IPC分类号： C12P21/04 , A61K38/00 , A61P31/04 , C07K1/20 , C07K7/60 , C07K7/62 , C07K14/195 , C07K14/41 , C12R1/09 , A61K37/00 , A61K35/00 , C07C103/52
CPC分类号： C12R1/09 , C07K7/62 , A61K38/00 , Y10S930/19 , Y10S930/27
摘要： A novel peptide antibiotic complex designated herein as Bu-2470 is produced by fermentation of Bacillus circulans strain G493-B6 (ATCC 31,805). Complex Bu-2470 may be separated into four bioactive peptide antibiotics designated as Bu-2470A, B.sub.1, B.sub.2a, and B.sub.2b. The complex and individual bioactive factors possess significant antimicrobial activity.
摘要翻译： 本文命名为Bu-2470的新型肽抗生素复合物是通过环状芽孢杆菌菌株G493-B6（ATCC 31,805）的发酵产生的。 复合物Bu-2470可以分成四种被称为Bu-2470A，B1，B2a和B2b的生物活性肽抗生素。 复杂和个体的生物活性因子具有显着的抗菌活性。
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公开(公告)号：US4260683A
公开(公告)日：1981-04-07
申请号：US103325
申请日：1979-12-14
IPC分类号： C12P19/44
摘要： A novel water-soluble basic antibiotic complex designated herein as Bu-2349 is produced by fermentation of Bu-2349-producing strains of the genus Bacillus. Complex Bu-2349 and its bioactive components designated as Bu-2349A and B are found to possess marked inhibitory activity against gram-positive and gram-negative bacteria including various types of aminoglycoside-resistant bacteria.
摘要翻译： 本文命名为Bu-2349的新型水溶性碱性抗生素复合物是通过发酵产芽孢杆菌属的Bu-2349产菌株产生的。 发现复合物Bu-2349及其被称为Bu-2349A和B的生物活性成分对革兰氏阳性和革兰氏阴性细菌具有显着的抑制活性，包括各种类型的氨基糖苷类抗性细菌。
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公开(公告)号：US4250170A
公开(公告)日：1981-02-10
申请号：US047455
申请日：1979-06-11
IPC分类号： C07H15/203 , C12P19/44 , A61K31/71 , C07H15/22
CPC分类号： C07H15/203 , C12P19/44 , C12R1/07
摘要： A novel water-soluble basic antibiotic complex designated herein as Bu-2349 is produced by fermentation of Bu-2349-producing strains of the genus Bacillus. Complex Bu-2349 and its bioactive components designated as Bu-2349A and B are found to possess marked inhibitory activity against gram-positive and gram-negative bacteria including various types of aminoglycoside-resistant bacteria.
摘要翻译： 本文命名为Bu-2349的新型水溶性碱性抗生素复合物是通过发酵产芽孢杆菌属的Bu-2349产菌株产生的。 发现复合物Bu-2349及其被称为Bu-2349A和B的生物活性成分对革兰氏阳性和革兰氏阴性细菌具有显着的抑制活性，包括各种类型的氨基糖苷类抗性细菌。
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公开(公告)号：US4912133A
公开(公告)日：1990-03-27
申请号：US165337
申请日：1988-03-07
申请人： Koko Sugawara , Masami Hatori , Hideo Kamei , Masataka Konishi , Toshikazu Oki , Koji Tomita
发明人： Koko Sugawara , Masami Hatori , Hideo Kamei , Masataka Konishi , Toshikazu Oki , Koji Tomita
IPC分类号： A61K31/335 , A61K31/336 , A61P35/00 , C07D303/36 , C12N1/20 , C12P17/02 , C12R1/55
CPC分类号： C12R1/55 , C07D303/36 , C12P17/02
摘要： A new antitumor antibiotic designated herein as BU-3862T is produced by fermentation of Streptomyces hygroscopicus ATCC 53709. BU-3862T and its diacetyl and dihydro derivatives inhibit the growth of tumors in experimental animals.
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17.发明授权
公开(公告)号：US4833079A
公开(公告)日：1989-05-23
申请号：US927203
申请日：1986-11-05
申请人： Hideo Kamei , Masaru Ohbayashi , Koji Tomita , Koko Sugawara , Masataka Konishi
发明人： Hideo Kamei , Masaru Ohbayashi , Koji Tomita , Koko Sugawara , Masataka Konishi
IPC分类号： C12P7/26
CPC分类号： C12P7/26 , Y10S435/886
摘要： The compound 3,7-dihydroxytropolone having the formula ##STR1## is produced by fermentation of Streptomyces tropolofaciens and is found to inhibit the growth of mammalian tumors.
摘要翻译： 具有式“IMAGE”的化合物3,7-二羟基托曲酮通过发酵链霉菌链霉菌（Streptomyces tropolofaciens）产生并被发现抑制哺乳动物肿瘤的生长。
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18.发明授权Biologically pure culture of the microorganism Streptomycas tropolofaciens used for producing 3,7-dihydroxytropolone and antitumor use 失效用于生产3,7-二羟托洛芬和抗肿瘤用途的微生物链霉菌Streptomycas的生物纯培养
公开(公告)号：US4883758A
公开(公告)日：1989-11-28
申请号：US294457
申请日：1989-01-06
申请人： Hideo Kamei , Masaru Ohbayashi , Koji Tomita , Koko Sugawara , Masataka Konishi
发明人： Hideo Kamei , Masaru Ohbayashi , Koji Tomita , Koko Sugawara , Masataka Konishi
IPC分类号： C12P7/26
CPC分类号： C12P7/26 , Y10S435/886
摘要： The compound 3,7-dihydroxytropolone having the formula ##STR1## is produced by fermentation of Streptomyces tropolofaciens and is found to inhibit the growth of mammalian tumors.
摘要翻译： 具有式“IMAGE”的化合物3,7-二羟基托曲酮通过发酵链霉菌链霉菌（Streptomyces tropolofaciens）产生并被发现抑制哺乳动物肿瘤的生长。
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公开(公告)号：US5093248A
公开(公告)日：1992-03-03
申请号：US438281
申请日：1989-11-13
申请人： Koko Sugawara , Masami Hatori , Hideo Kamei , Masataka Konishi , Toshikazu Oki , Koji Tomita
发明人： Koko Sugawara , Masami Hatori , Hideo Kamei , Masataka Konishi , Toshikazu Oki , Koji Tomita
IPC分类号： C07D303/36 , C12P17/02
CPC分类号： C12R1/55 , C07D303/36 , C12P17/02 , Y10S435/898
摘要： A new antitumor antibiotic designated herein as BU-3862T is produced by fermentation of Streptomyces hygroscopicus ATCC 53709. BU-3862T and its diacetyl and dihydro derivatives inhibit the growth of tumors in experimental animals.
摘要翻译： 本文称为BU-3862T的新型抗肿瘤抗生素通过发酵吸水链霉菌ATCC 53709产生.BB-3862T及其二乙酰基和二氢衍生物抑制实验动物中肿瘤的生长。
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公开(公告)号：US5114920A
公开(公告)日：1992-05-19
申请号：US244225
申请日：1988-09-14
申请人： Koko Sugawara , Yuji Nishiyama , Koji Tomita , Masataka Konishi , Toshikazu Oki
发明人： Koko Sugawara , Yuji Nishiyama , Koji Tomita , Masataka Konishi , Toshikazu Oki
摘要： New antibiotics designated BU-3292T A and B are provided which exhibit antimicrobial activity and also inhibit the growth of tumors in experimental animal systems. BU-3292T A is produced by fermentation of Elytrosporangium sp. nov. (ATCC 53784) while the BU-3292T B compound is obtained by oxidation of BU-3292T A.
摘要翻译： 提供了称为BU-3292T A和B的新抗生素，其具有抗微生物活性并且还抑制实验动物系统中肿瘤的生长。 BU-3292T A是通过发酵Elytrosporangium sp。 nov。 （ATCC 53784），而BU-3292T B化合物通过BU-3292T A的氧化获得。
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