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公开(公告)号：US11883443B2
公开(公告)日：2024-01-30
申请号：US14779116
申请日：2014-04-09
Applicant: Novozymes A/S
Inventor： David Drahos , Christian Munch , Lene Venke Kofod
IPC: A61K35/742 , A23K40/25 , C12N1/20 , A23K10/18 , A23K50/80 , A23K40/20 , A61K9/00 , A61K35/741 , C12R1/07 , C12R1/09 , C12R1/10 , C12R1/11 , C12R1/12 , C12R1/125
CPC classification number: A61K35/742 , A23K10/18 , A23K40/20 , A23K40/25 , A23K50/80 , A61K9/0056 , A61K35/741 , C12N1/20 , C12N1/205 , C12R2001/07 , C12R2001/09 , C12R2001/10 , C12R2001/11 , C12R2001/12 , C12R2001/125
Abstract: The present invention relates to compositions and methods for increasing the health of aquatic animals comprising one or more selected bacterial strains.
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2.发明授权
公开(公告)号：US5290695A
公开(公告)日：1994-03-01
申请号：US843812
申请日：1992-02-28
Applicant: Kiyoshi Morikawa , Hirofumi Miyazono , Hiroshi Maruyama , Keiichi Yoshida
Inventor： Kiyoshi Morikawa , Hirofumi Miyazono , Hiroshi Maruyama , Keiichi Yoshida
CPC classification number: C12R1/09 , C12N9/88 , Y10S435/835
Abstract: Disclosed are novel enzymes, heparitinase T-I, heparitinase T-II, heparitinase T-III and heparitinase T-IV, which degrade heparan sulfate and/or heparin, a process for producing thereof by cultivating a novel Bacillus circulans HpT 298 having an ability of producing these enzymes and a novel Bacillus circulans HpT 298.
Abstract translation: 公开了通过培养具有生产能力的新型环状芽孢杆菌HpT 298的新型酶，肝素酶，TI，肝素酶T-II，肝素三磷酸酶T-III和肝素三磷酸酶T-IV，其降解硫酸肝素和/或肝素 这些酶和新型环状芽孢杆菌HpT 298。
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公开(公告)号：US20190048426A1
公开(公告)日：2019-02-14
申请号：US16100394
申请日：2018-08-10
Applicant: Kent State University
Inventor： Oleg D. Lavrentovich , Chenhui Peng , Taras Turiv , Yubing Guo , Qi-Huo Wei
IPC: C12R1/125 , C09K19/54 , C12R1/07 , C12R1/08 , C12R1/085 , C12R1/09 , C12R1/10 , C12R1/11 , C12R1/12
Abstract: A method for controlling self-propelled particles includes providing the particles to a liquid crystalline medium having predesigned local ordering. The method may control at least one of: a local concentration, trajectory, and net flow of self-propelled particles.
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4.发明授权
公开(公告)号：US5405759A
公开(公告)日：1995-04-11
申请号：US154740
申请日：1993-11-18
Applicant: Kiyoshi Morikawa , Hirofumi Miyazono , Hiroshi Maruyama , Keiichi Yoshida
Inventor： Kiyoshi Morikawa , Hirofumi Miyazono , Hiroshi Maruyama , Keiichi Yoshida
CPC classification number: C12R1/09 , C12N9/88 , Y10S435/835
Abstract: Disclosed are novel enzymes, heparitinase T-I, heparitinase T-II, heparitinase T-III and heparitinase T-IV, which degrade heparan sulfate and/or heparin, a process for producing thereof by cultivating a novel Bacillus circulans HpT 298 having an ability of producing these enzymes and a novel Bacillus circulans HpT 298.
Abstract translation: 公开了通过培养具有生产能力的新型环状芽孢杆菌HpT 298的新型酶，肝素酶，TI，肝素酶T-II，肝素三磷酸酶T-III和肝素三磷酸酶T-IV，其降解硫酸肝素和/或肝素 这些酶和新型环状芽孢杆菌HpT 298。
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公开(公告)号：US4769329A
公开(公告)日：1988-09-06
申请号：US393630
申请日：1982-06-30
Applicant: Bryan Cooper , Werner Kuesters , Christoph Martin , Hardo Siegel
Inventor： Bryan Cooper , Werner Kuesters , Christoph Martin , Hardo Siegel
CPC classification number: C12P7/56 , C12N1/38 , Y10S435/835 , Y10S435/853 , Y10S435/856 , Y10S435/94
Abstract: A process for the preparation of optically pure D- or L-lactic acid by fermentation of an aqueous nutrient medium, which contains nitrogen, vitamins, aminoacids, sugars and trace elements, by means of a microorganism, at pH 4-6, wherein the nutrient medium contains brewers' yeast as the source of nitrogen, vitamins, aminoacids and trace elements.
Abstract translation: 一种通过在pH 4-6下通过微生物发酵包含氮，维生素，氨基酸，糖和微量元素的含水营养培养基来制备光学纯的D-或L-乳酸的方法，其中 营养培养基含有酿造酵母作为氮源，维生素，氨基酸和微量元素的来源。
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Patent Agency Ranking
公开(公告)号：US4477568A
公开(公告)日：1984-10-16
申请号：US419800
申请日：1982-09-20
Applicant: Hendrik Hokse , Frederik S. Kaper , Jacob T. Wijpkema
Inventor： Hendrik Hokse , Frederik S. Kaper , Jacob T. Wijpkema
CPC classification number: C12N9/1074 , C08B37/0012 , C12P19/18 , Y10S435/803 , Y10S435/813
Abstract: A process for producing cyclodextrin from starch in which an aqueous solun of starch is subjected to the action of an active cyclodextrin glycosyltransferase and the reaction mixture containing cyclodextrin, starch degradation products and active enzyme is continuously subjected to an ultrafiltration process to effect passage of the formed cyclodextrin through the membrane, while retaining substantially all of the other starch degradation products and active enzyme, thus permitting more cyclodextrin to be formed in the retentate, which will then pass the membrane, collecting the aqueous solution of cyclodextrin and recovering the cyclodextrin.
Abstract translation: 从淀粉生产环糊精的方法，其中淀粉水溶液经受活性环糊精糖基转移酶的作用，并且含有环糊精，淀粉降解产物和活性酶的反应混合物连续进行超滤过程，以使形成的 环糊精通过膜，同时保留基本上所有其他淀粉降解产物和活性酶，从而允许在滞留物中形成更多的环糊精，然后通过膜，收集环糊精的水溶液并回收环糊精。
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公开(公告)号：US20240294892A1
公开(公告)日：2024-09-05
申请号：US18007162
申请日：2020-07-28
Inventor： Yuan'an Wei , Xianwei Zeng , Zhilong Xie , Xinqiu Yang , Zijian Chen , Jingang Huan
CPC classification number: C12N9/2471 , C12N1/205 , C12P21/02 , C12R2001/09 , C12Y302/01023
Abstract: The present disclosure belongs to the technical field of biochemical engineering, and relates to a preparation method of β-galactosidase. The preparation method includes the following steps: step 1, seeding Bacillus circulans into a Luria-Bertani (LB) medium for culture and activation and then into a seed tank for culture to obtain a seed culture broth; step 2, introducing the seed culture broth into a fermentor containing a fermentation medium for fermentation to obtain a fermentation broth of B. circulans; and step 3, filtering or centrifuging the fermentation broth of B. circulans to remove cells to obtain a β-galactosidase liquid; the fermentation medium includes lactose, galactose, phytone, corn meal, yeast extract, a phosphate salt, a carbonate salt, and water. According to the method, fermentation time is short, production period is shortened, and specific activity of the resulting enzyme liquid is high. The present disclosure further provides a preparation method of an immobilized β-galactosidase without using a crosslinking agent. The resulting immobilized enzyme has excellent stability and can be continuously used for 264 hours or more, and costs for preparing galactose by using the immobilized enzyme is substantially reduced.
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8.发明授权Branched α-glucan, α-glucosyltransferase which forms the glucan, their preparation and uses 有权形成葡聚糖的分支α-葡聚糖，α-葡萄糖基转移酶，其制备和应用公开(公告)号：US09528134B2
公开(公告)日：2016-12-27
申请号：US14734607
申请日：2015-06-09
Applicant: Hayashibara Co., Ltd
Inventor： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keiji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
IPC: C12P19/04 , C12P19/18 , A21D2/18 , A23C9/13 , A23C9/154 , A23L1/09 , A23L1/19 , A23L1/20 , A23L1/305 , A23L2/39 , A61K8/73 , A61K31/716 , A61Q19/00 , C08B37/00 , C12N9/10 , C12R1/06 , C12R1/09
CPC classification number: A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
Abstract: The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
Abstract translation: 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构建的特征在于甲基化分析的支链葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上 葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链葡聚糖的新型± - 葡萄糖基转移酶，其制备方法及其用途。
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9.发明授权Branched alpha-glucan, alpha-glucosyltransferase which forms the glucan, their preparation and uses 有权分支的α-葡聚糖，形成葡聚糖的α-葡萄糖基转移酶，其制备和用途公开(公告)号：US09090923B2
公开(公告)日：2015-07-28
申请号：US14160749
申请日：2014-01-22
Applicant: Hayashibara Co., Ltd
Inventor： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
IPC: C12P19/18 , A21D2/18 , A23C9/13 , A23C9/154 , A23L1/09 , A23L1/19 , A23L1/20 , A23L1/305 , A23L2/39 , A61K8/73 , A61K31/716 , A61Q19/00 , C08B37/00 , C12N9/10 , C12P19/04 , C12R1/06 , C12R1/09
CPC classification number: A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
Abstract: The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitolis 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
Abstract translation: 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构成的特征在于甲基化分析的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）在部分甲基化的葡萄糖醇中的2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的总含量为60％以上 醋酸盐 （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡糖基转移酶，其制备方法及其用途。
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10.发明授权Enantiomer compositions of (1R,4S)-1-butyrylamino-4-(hydroxymethyl)-2-cyclopentene 失效（1R，4S）-1-丁酰氨基-4-（羟甲基）-2-环戊烯的对映体组成
公开(公告)号：US06137007A
公开(公告)日：2000-10-24
申请号：US373862
申请日：1999-08-13
Applicant: Christine Bernegger , Eva Maria Urban , Olwen Mary Birch , Knut Burgdorf , Frank Brux , Kay-Sara Etter , Pierre Bossard , Walter Brieden , Laurent Duc , John Gordon , Colm O'Murchu , Yves Guggisberg
Inventor： Christine Bernegger , Eva Maria Urban , Olwen Mary Birch , Knut Burgdorf , Frank Brux , Kay-Sara Etter , Pierre Bossard , Walter Brieden , Laurent Duc , John Gordon , Colm O'Murchu , Yves Guggisberg
IPC: C12P41/00 , C07C231/18 , C07C231/20 , C07C233/23 , C07C271/24 , C07D209/94 , C07D233/04 , C07D233/74 , C07D235/02 , C07D237/06 , C07D239/70 , C07D473/40 , C12P13/00 , C12P13/02 , C12P17/18 , C12R1/01 , C12R1/05 , C12R1/06 , C12R1/09 , C12R1/19 , C12R1/38 , C07C215/42
CPC classification number: C07C231/18 , C07C233/23 , C07C271/24 , C07D209/94 , C12P13/001 , C12P13/02 , C12P17/182 , C07B2200/07 , C07C2101/10
Abstract: A novel process for the preparation of (1S,4R)- or (1R,4S)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol of the formulae ##STR1## is described. This entails in the first stage (.+-.)-2-azabicyclo[2.2.1]hept-5-en-3-one of the formula ##STR2## being acylated to give a (.+-.)-2-azabicyclo[2.2.1]hept-5-en-3-one derivative of the general formula ##STR3## in which R.sup.1 denotes C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy, aryl or aryloxy, the latter being reduced in the second stage to give a cyclopentene derivative of the general formula ##STR4## in which R.sup.1 has the stated meaning, the latter then being converted in the third stage biotechnologically into the (1R,4S)- or (1S,4R)-1-amino-4-(hydroxymethyl)-2-cyclopentene of the formula ##STR5## the latter being converted in the fourth stage with N-(2-amino-4,6-dichloro-5-pyrimidinyl)formamide of the formula ##STR6## into the (1S,4R)- or (1R,4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentene-1-methanol of the formulae ##STR7## and the latter being cyclized in the fifth stage in a known manner to the final product of the formula I or II.
Abstract translation: 制备式（1S，4R） - 或（1R，4S）-4-（2-氨基-6-氯-9H-嘌呤-9-基）-2-环戊烯-1-甲醇的新方法， 被描述。 这需要在被酰化的式（+/-）-2-氮杂双环[2.2.1]庚-5-烯-3-酮的第一阶段中得到（+/-）-2-氮杂双环[2.2.1 ]庚-5-烯-3-酮衍生物，其中R 1表示C 1-4 - 烷基，C 1-4 - 烷氧基，芳基或芳氧基，后者在第二阶段中还原，得到 其中R 1具有所述含义的通式，后者在第三阶段中生物技术转化为（1R，4S） - 或（1S，4R）-1-氨基-4-（羟甲基）-2-环戊烯 式（1R，4S）-4 - （（1S，4R） - 或（1R，4S）-4 - 2-氨基-6-氯-5-甲酰氨基-4-嘧啶基）氨基] -2-环戊烯-1-甲醇，后者在第五阶段以已知方式环化为式I的最终产物 或II。
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