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公开(公告)号：US4912133A
公开(公告)日：1990-03-27
申请号：US165337
申请日：1988-03-07
申请人： Koko Sugawara , Masami Hatori , Hideo Kamei , Masataka Konishi , Toshikazu Oki , Koji Tomita
发明人： Koko Sugawara , Masami Hatori , Hideo Kamei , Masataka Konishi , Toshikazu Oki , Koji Tomita
IPC分类号： A61K31/335 , A61K31/336 , A61P35/00 , C07D303/36 , C12N1/20 , C12P17/02 , C12R1/55
CPC分类号： C12R1/55 , C07D303/36 , C12P17/02
摘要： A new antitumor antibiotic designated herein as BU-3862T is produced by fermentation of Streptomyces hygroscopicus ATCC 53709. BU-3862T and its diacetyl and dihydro derivatives inhibit the growth of tumors in experimental animals.
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公开(公告)号：US5093248A
公开(公告)日：1992-03-03
申请号：US438281
申请日：1989-11-13
申请人： Koko Sugawara , Masami Hatori , Hideo Kamei , Masataka Konishi , Toshikazu Oki , Koji Tomita
发明人： Koko Sugawara , Masami Hatori , Hideo Kamei , Masataka Konishi , Toshikazu Oki , Koji Tomita
IPC分类号： C07D303/36 , C12P17/02
CPC分类号： C12R1/55 , C07D303/36 , C12P17/02 , Y10S435/898
摘要： A new antitumor antibiotic designated herein as BU-3862T is produced by fermentation of Streptomyces hygroscopicus ATCC 53709. BU-3862T and its diacetyl and dihydro derivatives inhibit the growth of tumors in experimental animals.
摘要翻译： 本文称为BU-3862T的新型抗肿瘤抗生素通过发酵吸水链霉菌ATCC 53709产生.BB-3862T及其二乙酰基和二氢衍生物抑制实验动物中肿瘤的生长。
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公开(公告)号：US5114920A
公开(公告)日：1992-05-19
申请号：US244225
申请日：1988-09-14
申请人： Koko Sugawara , Yuji Nishiyama , Koji Tomita , Masataka Konishi , Toshikazu Oki
发明人： Koko Sugawara , Yuji Nishiyama , Koji Tomita , Masataka Konishi , Toshikazu Oki
摘要： New antibiotics designated BU-3292T A and B are provided which exhibit antimicrobial activity and also inhibit the growth of tumors in experimental animal systems. BU-3292T A is produced by fermentation of Elytrosporangium sp. nov. (ATCC 53784) while the BU-3292T B compound is obtained by oxidation of BU-3292T A.
摘要翻译： 提供了称为BU-3292T A和B的新抗生素，其具有抗微生物活性并且还抑制实验动物系统中肿瘤的生长。 BU-3292T A是通过发酵Elytrosporangium sp。 nov。 （ATCC 53784），而BU-3292T B化合物通过BU-3292T A的氧化获得。
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4.发明授权
公开(公告)号：US4833079A
公开(公告)日：1989-05-23
申请号：US927203
申请日：1986-11-05
申请人： Hideo Kamei , Masaru Ohbayashi , Koji Tomita , Koko Sugawara , Masataka Konishi
发明人： Hideo Kamei , Masaru Ohbayashi , Koji Tomita , Koko Sugawara , Masataka Konishi
IPC分类号： C12P7/26
CPC分类号： C12P7/26 , Y10S435/886
摘要： The compound 3,7-dihydroxytropolone having the formula ##STR1## is produced by fermentation of Streptomyces tropolofaciens and is found to inhibit the growth of mammalian tumors.
摘要翻译： 具有式“IMAGE”的化合物3,7-二羟基托曲酮通过发酵链霉菌链霉菌（Streptomyces tropolofaciens）产生并被发现抑制哺乳动物肿瘤的生长。
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5.发明授权Biologically pure culture of the microorganism Streptomycas tropolofaciens used for producing 3,7-dihydroxytropolone and antitumor use 失效用于生产3,7-二羟托洛芬和抗肿瘤用途的微生物链霉菌Streptomycas的生物纯培养
公开(公告)号：US4883758A
公开(公告)日：1989-11-28
申请号：US294457
申请日：1989-01-06
申请人： Hideo Kamei , Masaru Ohbayashi , Koji Tomita , Koko Sugawara , Masataka Konishi
发明人： Hideo Kamei , Masaru Ohbayashi , Koji Tomita , Koko Sugawara , Masataka Konishi
IPC分类号： C12P7/26
CPC分类号： C12P7/26 , Y10S435/886
摘要： The compound 3,7-dihydroxytropolone having the formula ##STR1## is produced by fermentation of Streptomyces tropolofaciens and is found to inhibit the growth of mammalian tumors.
摘要翻译： 具有式“IMAGE”的化合物3,7-二羟基托曲酮通过发酵链霉菌链霉菌（Streptomyces tropolofaciens）产生并被发现抑制哺乳动物肿瘤的生长。
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公开(公告)号：US4409210A
公开(公告)日：1983-10-11
申请号：US339355
申请日：1982-01-15
IPC分类号： C12N1/20 , A23K20/195 , A61K35/74 , A61K38/00 , A61P17/00 , A61P31/04 , C07K5/117 , C07K7/06 , C07K11/02 , C07K14/195 , C07K14/41 , C12P21/02 , C12P21/04 , C12R1/01 , A61K37/00 , C07C103/52
CPC分类号： C12R1/01 , C07K5/1024 , C07K7/06 , A61K38/00 , Y10S930/19 , Y10S930/27
摘要： A novel water-soluble peptide designated herein as Bu-2517 is produced by fermentation of Empedobacter sp. strain G393-B445 (ATCC 31962). The antibiotic exists in a cyclic depsipeptide structure and contains the amino acids D-serine, D-proline, L-proline, D-threo-.beta.-hydroxyaspartic acid, L-threo-.beta.-hydroxyaspartic acid, L-arginine and trans-L-3-hydroxyproline and the residue of the C.sub.14 fatty acid, 3-hydroxytetradecanoic acid. The Bu-2517 antibiotic inhibits the growth of a variety of aerobic and anaerobic gram-positive bacteria.
摘要翻译： 本文命名为Bu-2517的新型水溶性肽是通过Empedobacter sp。 菌株G393-B445（ATCC 31962）。 抗生素存在于环状肽末端结构中，含有D-丝氨酸，D-脯氨酸，L-脯氨酸，D-苏氨酸-β-羟基天冬氨酸，L-苏氨酸-β-羟基天冬氨酸，L-精氨酸和反式-L-氨基酸 3-羟基脯氨酸和C14脂肪酸的残基，3-羟基十四烷酸。 Bu-2517抗生素抑制各种需氧和厌氧革兰氏阳性菌的生长。
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公开(公告)号：US4533631A
公开(公告)日：1985-08-06
申请号：US478751
申请日：1983-03-25
CPC分类号： C12R1/01 , C07K7/06 , A61K38/00 , Y10S435/822 , Y10S930/19 , Y10S930/27
摘要： Disclosed is a process for preparation of the water-soluble peptide antibiotic designated Bu-2517 by fermentation of Empedobacter sp. strain G393-B445 (ATCC 31962).
摘要翻译： 本发明公开了通过Empedobacter sp的发酵制备名为Bu-2517的水溶性肽抗生素的方法。 菌株G393-B445（ATCC 31962）。
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公开(公告)号：US4518589A
公开(公告)日：1985-05-21
申请号：US538453
申请日：1983-10-03
IPC分类号： C12P19/46 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P35/00 , C07H17/04 , C12P19/60 , C12R1/01 , C12R1/04 , C12R1/465 , C12R1/52 , A61K31/71 , C07H15/24
摘要： A novel antibiotic complex designated BBM-2478 is produced by fermentation of an actinomycete strain J907-21 (ATCC 39417). The complex may be separated chromatographically into two bioactive components designated BBM-2478A and BBM-2478B. The BBM-2478A component displays both antibacterial and antitumor activity while the BBM-2478B component has antibacterial activity.
摘要翻译： 通过放线菌菌株J907-21（ATCC 39417）的发酵产生了称为BBM-2478的新型抗生素复合物。 该复合物可以色谱分离成两种生物活性成分，称为BBM-2478A和BBM-2478B。 BBM-2478A组分显示抗菌和抗肿瘤活性，而BBM-2478B组分具有抗菌活性。
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公开(公告)号：US5037836A
公开(公告)日：1991-08-06
申请号：US555887
申请日：1990-07-23
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , Y10S435/886
摘要： A novel antibiotic designated BU-4146T is produced by fermentation of Streptomyces amphibiosporus strain R310-104 (ATCC-53964). The antibiotic possesses both antifungal and antitumor activity.
摘要翻译： 命名为BU-4146T的新型抗生素通过发酵链霉菌（Streptomyces amphibiosporus）菌株R310-104（ATCC-53964）产生。 抗生素具有抗真菌和抗肿瘤活性。
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10.发明授权Process for preparing an antibiotic complex by culturing actinomyces strain ATCC 39417 失效通过培养放线菌菌株ATCC 39417制备抗生素复合物的方法
公开(公告)号：US4572895A
公开(公告)日：1986-02-25
申请号：US690283
申请日：1985-02-19
CPC分类号： C07H17/04 , C12P19/60 , C12R1/465 , Y10S435/822 , Y10S435/826
摘要： A novel antibiotic complex designated BBM-2478 is produced by fermentation of an actinomycete strain J907-21 (ATCC 39417). The complex may be separated chromatographically into two bioactive components designated BBM-2478A and BBM-2478B. The BBM-2478A component displays both antibacterial and antitumor activity while the BBM-2478B component has antibacterial activity.
摘要翻译： 通过放线菌菌株J907-21（ATCC 39417）的发酵产生了称为BBM-2478的新型抗生素复合物。 该复合物可以色谱分离成两种生物活性成分，称为BBM-2478A和BBM-2478B。 BBM-2478A组分显示抗菌和抗肿瘤活性，而BBM-2478B组分具有抗菌活性。
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