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    TISSUE ANCHORING ARTICLES
    11.
    发明申请
    TISSUE ANCHORING ARTICLES 有权

    公开(公告)号：US20220151940A1

    公开(公告)日：2022-05-19

    申请号：US17530585

    申请日：2021-11-19

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  David Dellal ,  Robert S. Langer

    IPC: A61K9/48 ,  A61J3/07 ,  A61K9/00 ,  A61B5/145 ,  A61B10/02 ,  A61M5/142 ,  A61M37/00 ,  A61N1/32 ,  A61N1/36 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61K38/28 ,  A61M5/158

    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

    Triggerable shape memory induction devices
    14.
    发明授权
    Triggerable shape memory induction devices 有权

    公开(公告)号：US10953208B2

    公开(公告)日：2021-03-23

    申请号：US15143230

    申请日：2016-04-29

    Applicant: Massachusetts Institute of Technology

    Inventor： Shiyi Zhang ,  Yida Zhao ,  Carlo Giovanni Traverso ,  Robert S. Langer

    IPC: A61M37/00 ,  A61L31/06 ,  A61L27/50 ,  A61L31/14 ,  A61L27/26 ,  A61L31/04 ,  A61L31/12 ,  A61L27/44

    Abstract: In accordance with the invention, compositions, devices, and related methods have been developed for medical-related and other applications. In some embodiments, the devices and compositions described herein comprise a triggerable shape memory polymer network. In certain embodiments, the polymer network comprises a covalently crosslinked polymeric material and a non-crosslinked polymeric material associated with the crosslinked polymeric material. In some cases, the polymer network has a first configuration (e.g., as polymerized), and a second configuration (e.g., upon heating and deformation), such that the polymer network can be triggered to recover the first configuration upon heating the polymeric material above a softening temperature of the polymeric material. In certain embodiments, the polymer network comprises a plurality of particles capable of increasing the temperature of the polymer network (e.g., above the softening temperature) in the presence of an external stimulus such as induction, radio frequency, or magnetic resonance, such that the polymer network changes configuration. The polymeric material may be molded into any suitable shape.

    SELF-RIGHTING SYSTEMS, METHODS, AND RELATED COMPONENTS
    15.
    发明申请
    SELF-RIGHTING SYSTEMS, METHODS, AND RELATED COMPONENTS 审中-公开

    公开(公告)号：US20200376192A1

    公开(公告)日：2020-12-03

    申请号：US16899644

    申请日：2020-06-12

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Robert S. Langer ,  Carlo Giovanni Traverso ,  Alex G. Abramson ,  Michael Williams ,  Jacob Wainer

    IPC: A61M5/142 ,  A61M37/00 ,  A61M5/158

    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

    RESIDENCE STRUCTURES AND RELATED METHODS
    19.
    发明申请
    RESIDENCE STRUCTURES AND RELATED METHODS 审中-公开

    公开(公告)号：US20190298652A1

    公开(公告)日：2019-10-03

    申请号：US16379727

    申请日：2019-04-09

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Lowell L. Wood, JR. ,  Philip A. Eckhoff

    IPC: A61K9/00 ,  A61K47/69 ,  C08G63/08 ,  C08G18/42 ,  C08G18/73 ,  A61K47/58 ,  A61M31/00 ,  A61K47/42 ,  A61K47/40 ,  A61K47/34 ,  A61K47/10 ,  C08L33/14 ,  C08L33/08 ,  C08L33/02 ,  A61K47/32 ,  A61K31/65 ,  A61K9/48 ,  A61K31/357 ,  A61K31/7048 ,  C08G83/00

    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

    RESIDENCE STRUCTURES AND RELATED METHODS
    20.
    发明申请
    RESIDENCE STRUCTURES AND RELATED METHODS 审中-公开

    公开(公告)号：US20190133936A1

    公开(公告)日：2019-05-09

    申请号：US16177704

    申请日：2018-11-01

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Lowell L. Wood, JR. ,  Philip A. Eckhoff

    IPC: A61K9/00 ,  A61K47/69 ,  A61K9/48 ,  C08L33/14 ,  C08L33/08 ,  C08L33/02 ,  C08G83/00 ,  C08G63/08 ,  C08G18/73 ,  C08G18/42 ,  A61M31/00 ,  A61K47/58 ,  A61K47/42 ,  A61K47/40 ,  A61K47/34 ,  A61K47/32 ,  A61K47/10 ,  A61K31/7048 ,  A61K31/65 ,  A61K31/357

    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

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