公开(公告)号：US20200147298A1

公开(公告)日：2020-05-14

申请号：US16613766

申请日：2018-05-17

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer ,  Jorrit Jeroen Water ,  Morten Revsgaard Frederiksen ,  Bo Uldall Kristiansen ,  Mikkel Oliver Jespersen ,  Mette Poulsen ,  Peter Herskind ,  Brian Jensen

IPC分类号： A61M5/142 ,  A61M37/00 ,  A61B10/02 ,  A61N1/36 ,  A61N1/32 ,  A61B5/145

摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

公开(公告)号：US20230050912A1

公开(公告)日：2023-02-16

申请号：US17826799

申请日：2022-05-27

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer ,  Jorrit Jeroen Water ,  Morten Revsgaard Frederiksen ,  Bo Uldall Kristiansen ,  Mikkel Oliver Jespersen ,  Mette Poulsen ,  Peter Herskind ,  Brian Jensen

IPC分类号： A61K9/48 ,  A61J3/07 ,  A61N1/36 ,  A61K9/00 ,  A61N1/32 ,  A61M5/32 ,  A61B5/145 ,  A61B10/02 ,  A61M5/20 ,  A61M31/00 ,  A61M5/142 ,  A61M5/158 ,  A61M37/00 ,  A61K38/28 ,  A61N1/05

摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

公开(公告)号：US20210361919A1

公开(公告)日：2021-11-25

申请号：US17055905

申请日：2019-05-17

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Alex G. Abramson ,  David Dellal ,  Christoph Winfried Johannes Steiger ,  Niclas Roxhed ,  Ester Caffarel Salvador ,  Vance Soares ,  Daniel Minahan ,  Morten Revsgaard Frederiksen

IPC分类号： A61M31/00 ,  A61M37/00

摘要： Articles for rapid release of components including, for example, quick release capsules, are generally provided. Advantageously, in some embodiments, the articles described herein may be configured to prevent fluid from contacting a component h contained therein (e.g., tissue interfacing component) or payload contained therein until a desired time, e.g., the time at which the component is configured to release from the article to a location internal to a subject (e.g., localize to a tissue wall in the subject). In some embodiments, the article comprises a first compartment and a second compartment not in fluid communication with the first compartment. In some embodiments, the first compartment and second compartment are fluidically isolated. For example, in some cases, the first compartment comprises a mechanism for releasing a component contained within the article and the second compartment comprises the component.

公开(公告)号：US12036324B2

公开(公告)日：2024-07-16

申请号：US17826799

申请日：2022-05-27

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer ,  Jorrit Jeroen Water ,  Morten Revsgaard Frederiksen ,  Bo Uldall Kristiansen ,  Mikkel Oliver Jespersen ,  Mette Poulsen ,  Peter Herskind ,  Brian Jensen

IPC分类号： A61K9/48 ,  A61B5/145 ,  A61B10/02 ,  A61J3/07 ,  A61K9/00 ,  A61K38/28 ,  A61M5/142 ,  A61M5/145 ,  A61M5/158 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61M37/00 ,  A61N1/32 ,  A61N1/36 ,  A61B10/06 ,  A61N1/05

CPC分类号： A61K9/4808 ,  A61B5/14503 ,  A61B5/14539 ,  A61B10/02 ,  A61J3/07 ,  A61K9/0002 ,  A61K9/0012 ,  A61K9/0021 ,  A61K9/0065 ,  A61K9/0092 ,  A61K9/4866 ,  A61K38/28 ,  A61M5/14276 ,  A61M5/1454 ,  A61M5/158 ,  A61M5/2033 ,  A61M5/329 ,  A61M5/3295 ,  A61M31/002 ,  A61M37/0015 ,  A61M37/0069 ,  A61N1/325 ,  A61N1/36007 ,  A61B2010/0208 ,  A61B10/0233 ,  A61B10/06 ,  A61M2005/14284 ,  A61M2005/1581 ,  A61M2005/1585 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2205/0238 ,  A61M2205/21 ,  A61M2210/1053 ,  A61M2210/106 ,  A61N1/0509

摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

公开(公告)号：US11771829B2

公开(公告)日：2023-10-03

申请号：US16778152

申请日：2020-01-31

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Alex G. Abramson ,  Morten Revsgaard Frederiksen ,  Mikkel Oliver Jespersen ,  Brian Mouridsen ,  Jesper Windum ,  Mette Poulsen ,  Brian Jensen ,  Jorrit Jeroen Water ,  Mikkel Wennemoes Hvitfeld Ley ,  Xiaoya Lu ,  Andreas Vegge

IPC分类号： A61M5/20 ,  A61K9/00 ,  A61M5/30

CPC分类号： A61M5/2033 ,  A61K9/0024 ,  A61M5/30 ,  A61M2005/202 ,  A61M2202/0007 ,  A61M2202/30 ,  A61M2210/1042

摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article.

公开(公告)号：US11369574B2

公开(公告)日：2022-06-28

申请号：US16613766

申请日：2018-05-17

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer ,  Jorrit Jeroen Water ,  Morten Revsgaard Frederiksen ,  Bo Uldall Kristiansen ,  Mikkel Oliver Jespersen ,  Mette Poulsen ,  Peter Herskind ,  Brian Jensen

IPC分类号： A61K9/48 ,  A61J3/07 ,  A61K9/00 ,  A61M5/142 ,  A61M37/00 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61M5/158 ,  A61B5/145 ,  A61B10/02 ,  A61N1/32 ,  A61N1/36 ,  A61K38/28 ,  A61N1/05

摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

公开(公告)号：US20200246545A1

公开(公告)日：2020-08-06

申请号：US16778152

申请日：2020-01-31

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital Inc. ,  Novo Nordisk A/S

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Alex G. Abramson ,  Morten Revsgaard Frederiksen ,  Mikkel Oliver Jespersen ,  Brian Mouridsen ,  Jesper Windum ,  Mette Poulsen ,  Brian Jensen ,  Jorrit Jeroen Water ,  Mikkel Wennemoes Hvitfeld Ley ,  Xiaoya Lu

IPC分类号： A61M5/20 ,  A61M5/30 ,  A61K9/00

摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article.

公开(公告)号：US12031977B2

公开(公告)日：2024-07-09

申请号：US17118267

申请日：2020-12-10

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Yunhua Shi ,  Vance Soares ,  Daniel Reker

IPC分类号： G01N33/50

CPC分类号： G01N33/5088 ,  G01N33/5044

摘要： Methods and compositions for determining multiplex interactions between drugs and drug transporters using an intestinal tissue explant are provided.

公开(公告)号：US20240108241A1

公开(公告)日：2024-04-04

申请号：US18541818

申请日：2023-12-15

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  The General Hospital Corporation

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Malvika Verma ,  Feyisope Eweje ,  Christoph Winfried Johannes Steiger ,  Junwei Li ,  Nhi Phan ,  Hen-Wei Huang ,  Jacqueline Chu ,  John Ashraf Fou Salama

IPC分类号： A61B5/07 ,  A61B5/00

CPC分类号： A61B5/073 ,  A61B5/4845 ,  A61B2562/02 ,  A61B2562/162 ,  A61B2562/164

摘要： Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

公开(公告)号：US20230398067A1

公开(公告)日：2023-12-14

申请号：US18035969

申请日：2021-11-10

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Adam Wentworth ,  Xiaoyue Qi

IPC分类号： A61K9/00 ,  A61K38/46 ,  A61K47/24 ,  A61K38/48 ,  A61K38/44 ,  A61K38/47 ,  A61K38/28

CPC分类号： A61K9/0065 ,  A61K38/465 ,  A61K47/24 ,  A61K38/4826 ,  A61K38/443 ,  A61K38/47 ,  A61K38/28 ,  C12Y304/21004 ,  C12Y101/03004 ,  C12Y302/01108

摘要： Articles and methods related to the administration of biomolecules to subjects using metal-organic frameworks are generally described. In some embodiments, an article is described, the article comprising a substrate comprising an adhesive layer, a support layer disposed on at least a portion of the substrate, and an active material disposed on and/or in at least a portion of the support layer, wherein the active material comprises a composite comprising a metal-organic framework and a biomolecule. In certain embodiments, a method of treating a subject with a biomolecule is described, the method comprising administering an article to a subject.