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    Cancer associated antigens and uses therefor
    17.
    发明授权
    Cancer associated antigens and uses therefor 有权
    癌症相关抗原及其用途

    公开(公告)号：US06686147B1

    公开(公告)日：2004-02-03

    申请号：US09392714

    申请日：1999-09-09

    申请人： Matthew J. Scanlan ,  Ali Gure ,  Lloyd J. Old ,  Yao-Tseng Chen ,  Barbara Williamson

    发明人： Matthew J. Scanlan ,  Ali Gure ,  Lloyd J. Old ,  Yao-Tseng Chen ,  Barbara Williamson

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6886 ,  C12Q2600/156

    摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in testis cells using antisera from seminoma patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with a variety of cancers. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.

    摘要翻译： 已经通过使用来自精原细胞瘤患者的抗血清的睾丸细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。 本发明涉及在患有多种癌症的患者中表达的癌症相关抗原的核酸和编码多肽。 本发明尤其提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。 本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。 还提供了前述的片段，包括功能片段和变体。 另外提供了含有上述分子的试剂盒。 本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

    Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith
    18.
    发明授权
    Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith 有权
    通过测定与其相关的多种抗原来确定乳腺癌和黑素瘤的方法

    公开(公告)号：US06338947B1

    公开(公告)日：2002-01-15

    申请号：US09578378

    申请日：2000-05-25

    申请人： Ugur Sahin ,  Özlem Türeci ,  Yao-Tseng Chen ,  Lloyd J. Old ,  Michael Pfreundschuh

    发明人： Ugur Sahin ,  Özlem Türeci ,  Yao-Tseng Chen ,  Lloyd J. Old ,  Michael Pfreundschuh

    IPC分类号： G01N3353

    CPC分类号： G01N33/57415 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/106

    摘要： The invention relates to assays for determining breast cancer or melanoma. It has been found that the accuracy of such assays can be improved by assaying samples for three or more known tumor rejection antigen precursors. For breast cancer, the tumor rejection antigen precursors known as SCP-1, NY-ESO-1, and SSX-2 are assayed. For melanoma, SSX-2, NY-ESO-1, and MAGE-3 are assayed. Additional known tumor rejection antigen precursors can also be determined to confirm the assays. It is preferred to carry these out via polymerase chain reactions.

    摘要翻译： 本发明涉及用于确定乳腺癌或黑素瘤的测定法。 已经发现，通过测定三种或更多种已知的肿瘤排斥抗原前体的样品，可以提高这些测定的准确性。 对于乳腺癌，测定称为SCP-1，NY-ESO-1和SSX-2的肿瘤排斥抗原前体。 对于黑素瘤，测定SSX-2，NY-ESO-1和MAGE-3。 还可以确定另外已知的肿瘤排斥抗原前体以确认测定。 优选通过聚合酶链反应进行这些操作。