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11.发明授权State machine framework for programming closed-loop algorithms that control the delivery of therapy to a patient by an implantable medical device 有权用于编程闭环算法的状态机框架，其通过可植入医疗装置控制对患者的治疗递送公开(公告)号：US09079039B2
公开(公告)日：2015-07-14
申请号：US13934096
申请日：2013-07-02
Applicant: Medtronic, Inc.
Inventor： David L. Carlson , Benjamin P. Isaacson , David E. Linde
CPC classification number: A61N1/37264 , A61N1/3606 , A61N1/36139 , A61N1/37247
Abstract: This disclosure describes a state machine framework for programming closed-loop algorithms that control the delivery of therapy to a patient by an implantable medical device (IMD). The state machine framework may use one or more programmable state parameters to define at least part of a structure of a state machine that generates one or more therapy decisions based on one or more sensed states of the patient. The state machine framework may include a state machine runtime environment that executes on an IMD and that is configurable to implement a variety of different state machines depending on programmable state parameters that are received from an external device. The techniques of this disclosure may, in some cases, allow IMD developers and/or users to program, change, and/or download new closed-loop control policy algorithms during the lifespan of the IMD without requiring new firmware code to be downloaded onto the IMD.
Abstract translation: 本公开描述了用于编程闭环算法的状态机框架，其通过可植入医疗装置（IMD）控制对患者的治疗递送。 状态机框架可以使用一个或多个可编程状态参数来定义基于患者的一个或多个感测状态产生一个或多个治疗决定的状态机的结构的至少一部分。 状态机框架可以包括在IMD上执行并且可配置为根据从外部设备接收的可编程状态参数来实现各种不同状态机的状态机运行时环境。 在某些情况下，本公开的技术可以允许IMD开发者和/或用户在IMD的寿命期间对新的闭环控制策略算法进行编程，改变和/或下载，而不需要将新的固件代码下载到 IMD。
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公开(公告)号：US20240382759A1
公开(公告)日：2024-11-21
申请号：US18786300
申请日：2024-07-26
Applicant: Medtronic, Inc.
Inventor： Benjamin P. Isaacson , David E. Linde , Scott R. Stanslaski , Christopher L. Pulliam , Rene A. Molina , Abbey Beuning Holt Becker , David L. Carlson , Nicholas D. Buse , Duane L. Bourget , Thaddeus S. Brink
Abstract: An example method includes determining, by an implantable medical device (IMD), an electrode of a plurality of electrodes of a lead to be used to deliver electrical stimulation to a patient at a particular time; selecting, by the IMD and based on the determined electrode, a set of electrodes of the plurality of electrodes; and sensing, by the IMD and via the selected set of electrodes, electrical signals of the patient at the particular time.
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公开(公告)号：US20230321442A1
公开(公告)日：2023-10-12
申请号：US18178430
申请日：2023-03-03
Applicant: Medtronic, Inc.
Inventor： Benjamin P. Isaacson , Brett M. Nelson , Duane L. Bourget , Nicholas D. Buse , Laura A. Skarie , David E. Linde
CPC classification number: A61N1/36132 , A61N1/0551 , A61N1/37211
Abstract: A system to provide flexible stimulation pattern definition, delivery, and control to dynamically adjust a therapy regimen for electrical stimulation therapy based on patient needs. Firmware in an electrical stimulation delivery device that executes the therapy regimen may be implemented as a “player” of a series of instructions for the received stimulation patterns. The system may include a wearable device or an implantable device. An external computing device configured to program the electrical stimulation delivery device may include a stimulation pattern construct collection from which a clinician can select, assemble, and modify waveforms, bursts, pattern, sensing or other event triggers etc. to create a therapy regimen. The external computing device may transmit software that defines the selected regimen to the electrical stimulation delivery device memory, where the device “plays” the instructions to deliver electrical stimulation according to the therapy regimen.
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公开(公告)号：US20210121697A1
公开(公告)日：2021-04-29
申请号：US17062213
申请日：2020-10-02
Applicant: Medtronic, Inc.
Inventor： David E. Linde , Benjamin P. Isaacson , Nicholas D. Buse , Duane L. Bourget , Robert S. Raike , Jonathon E. Giftakis , Caleb C. Zarns , Thomas L. Chouinard
Abstract: A medical device or system of medical devices can be configured to detect an indicator of a symptom in a patient; in response to detecting the indicator of the symptom in the patient, deliver to the patient a first stimulation therapy; and in response to determining that the indicator of the symptom has been present for more than a threshold amount of time after beginning to deliver the first stimulation therapy a second stimulation therapy different than the first stimulation therapy.
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公开(公告)号：US10820819B2
公开(公告)日：2020-11-03
申请号：US16023508
申请日：2018-06-29
Applicant: Medtronic, Inc.
Inventor： Pedram Afshar , Timothy J. Denison , David E. Linde , Scott R. Stanslaski
Abstract: The disclosure describes a method and system or controlling symptoms of patients suffering from Parkinson's Disease. In some examples, one or more biomarkers indicative of a patient's present symptoms are determined. The biomarkers may be used to control therapy delivered to the patient in a closed-loop manner. In addition, biomarkers may be used as an indication of therapy effectiveness.
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Patent Agency Ranking
16.发明授权公开(公告)号：US09439150B2
公开(公告)日：2016-09-06
申请号：US13862227
申请日：2013-04-12
Applicant: Medtronic, Inc.
Inventor： David L. Carlson , Scott R. Stanslaski , Peng Cong , Timothy J. Denison , David E. Linde , Randy M. Jensen
CPC classification number: H04W52/0238 , A61B5/04004 , A61B5/04012 , A61B5/7203 , A61B5/7217 , A61B5/7221 , A61B5/7225 , A61B2560/0209 , G06F1/3203 , H04W52/0274 , H04W52/028 , Y02D70/00
Abstract: This disclosure describes techniques for controlling spectral aggressors in a sensing device that uses a low power sleep mode to manage the power consumed by the device. In some examples, the techniques for controlling spectral aggressors may include configuring one or more of an algorithm processing rate for a processor, a buffering rate for the processor, a sampling rate for an analog-to-digital converter, an execution unit processing rate for the processor, and an algorithm subdivision factor for the processor such that spectral interference caused by a sleep cycle rate of the processor occurs outside of one or more target frequency bands of a sampled signal. The techniques of this disclosure may be used to reduce noise in a sensing system that uses a low power sleep mode to manage the power consumed by the device.
Abstract translation: 本公开描述了用于控制感测装置中的光谱侵略者的技术，其使用低功率睡眠模式来管理由设备消耗的功率。 在一些示例中，用于控制频谱侵扰者的技术可以包括配置处理器的算法处理速率，处理器的缓冲速率，模数转换器的采样率，执行单元处理速率 处理器和用于处理器的算法细分因子，使得由处理器的睡眠周期速率引起的频谱干扰发生在采样信号的一个或多个目标频带之外。 本公开的技术可以用于降低使用低功率睡眠模式来管理设备消耗的功率的感测系统中的噪声。
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公开(公告)号：US12070605B2
公开(公告)日：2024-08-27
申请号：US17651374
申请日：2022-02-16
Applicant: Medtronic, Inc.
Inventor： Benjamin P. Isaacson , David E. Linde , Scott R. Stanslaski , Christopher L. Pulliam , Rene A. Molina , Abbey Beuning Holt Becker , David L. Carlson , Nicholas D. Buse , Duane L. Bourget , Thaddeus S. Brink
CPC classification number: A61N1/36175 , A61N1/0534 , A61N1/36135 , A61N1/36192 , A61N1/37235
Abstract: An example method includes determining, by an implantable medical device (IMD), an electrode of a plurality of electrodes of a lead to be used to deliver electrical stimulation to a patient at a particular time; selecting, by the IMD and based on the determined electrode, a set of electrodes of the plurality of electrodes; and sensing, by the IMD and via the selected set of electrodes, electrical signals of the patient at the particular time.
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公开(公告)号：US20230069981A1
公开(公告)日：2023-03-09
申请号：US17818246
申请日：2022-08-08
Applicant: Medtronic, Inc.
Inventor： Benjamin P. Isaacson , Scott R. Stanslaski , Abbey Beuning Holt Becker , Rene A. Molina , Caleb C. Zarns , David E. Linde , Nicholas D. Buse , Thaddeus S. Brink
IPC: A61N1/36
Abstract: An example system includes stimulation generation circuitry configured to deliver electrical stimulation to a patient; sensing circuitry configured to sense one or more biomarker signals; and processing circuitry configured to: cause delivery of electrical stimulation with the patient in a first patient state; receive a first instance of a biomarker signal in presence of the electrical stimulation with the patient in the first patient state; cause delivery of electrical stimulation with the patient in a second patient state; receive a second instance of the biomarker signal in presence of the electrical stimulation with the patient in the second patient state; determine whether a difference between the first instance of the biomarker signal and the second instance of the biomarker signal satisfies a threshold; select a therapy mode based on whether the difference satisfies the threshold; and cause delivery of electrical stimulation in accordance with the selected therapy mode.
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公开(公告)号：US20210322770A1
公开(公告)日：2021-10-21
申请号：US17364609
申请日：2021-06-30
Applicant: MEDTRONIC, INC.
Inventor： Jonathon E. Giftakis , Timothy J. Denison , Paul H. Stypulkowski , Scott R. Stanslaski , Robert S. Raike , Mae Eng , David E. Linde , Thomas Adamski
IPC: A61N1/36
Abstract: In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
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公开(公告)号：US20200179703A1
公开(公告)日：2020-06-11
申请号：US16213578
申请日：2018-12-07
Applicant: Medtronic, Inc.
Inventor： Duane L. Bourget , David E. Linde , Robert Devine , Benjamin P. Isaacson , Jeffrey Herron
Abstract: Devices, systems, and techniques are described for transitioning between different groups of electrical stimulation programs. For example, a system may control delivery of second electrical stimulation defined by one or more second programs of a second group of stimulation programs on a time-interleaved basis with first electrical stimulation defined by one or more first programs of the first group of stimulation programs. The system may change a first ratio of the one or more first programs used to define the first electrical stimulation to the one or more second programs used to define the second electrical stimulation delivered within a first period of time to a second ratio of the one or more first programs used to define the first electrical stimulation to the one or more second programs used to define the second electrical stimulation delivered within a second period of time.
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