公开(公告)号：US10321992B2

公开(公告)日：2019-06-18

申请号：US15012533

申请日：2016-02-01

Applicant: Medtronic, Inc.

Inventor： Jason Quill ,  Padraig Savage ,  Joshua Dwork ,  Kshitija Garde ,  Sarah Ahlberg ,  Igor Kovalsky

IPC: A61F2/24

Abstract: Prosthetic heart valve devices and associated methods for percutaneous or transcatheter heart valve replacement are disclosed herein. A heart valve prosthesis configured in accordance herewith includes a frame having a valve support and a plurality of support arms extending therefrom. The plurality of support arms may include a main support arm configured to extend from the valve support for capturing at least a portion of a valve leaflet of a native heart valve therebetween when the valve prosthesis is in an expanded configuration and deployed within the native heart valve. In addition, the plurality of support arms may include multiple supplemental support arms disposed about the circumference of the valve support that when deployed in the expanded configuration are configured to at least partially engage subannular tissue at the native heart valve.

公开(公告)号：US20170224480A1

公开(公告)日：2017-08-10

申请号：US15494923

申请日：2017-04-24

Applicant: Medtronic, Inc.

Inventor： Kshitija Garde ,  Joel Racchini ,  Paul Rothstein ,  Jeffrey Sandstrom

IPC: A61F2/24

Abstract: A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments. The segments may be orthogonal or oblique to the outer surface of the tubular stent.

公开(公告)号：US09675451B2

公开(公告)日：2017-06-13

申请号：US14242347

申请日：2014-04-01

Applicant: Medtronic, Inc.

Inventor： Kshitija Garde ,  Joel Racchini ,  Paul Rothstein ,  Jeffrey Sandstrom

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2220/005 ,  A61F2230/0013 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/0069

Abstract: A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments. The segments may be orthogonal or oblique to the outer surface of the tubular stent.

公开(公告)号：US08986375B2

公开(公告)日：2015-03-24

申请号：US13795066

申请日：2013-03-12

Applicant: Medtronic, Inc.

Inventor： Kshitija Garde ,  Philip Haarstad ,  Igor Kovalsky ,  Stephen Nash ,  Gianfranco Pellegrini ,  Finn Rinne ,  Matthew Rust ,  Jeffrey Sandstrom ,  Padraig Savage ,  William Steinberg

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2403 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2250/0069

Abstract: A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the stent which includes a plurality of self-expanding struts and an annular sealing membrane. Each strut has a first end coupled to a distal end of the stent and a second end not coupled to the stent. Each anti-paravalvular leakage component is moveable between a compressed configuration and a deployed configuration. In the compressed configuration, each strut extends distally away from the distal end of the stent. In the deployed configuration, each strut extends proximally away from the distal end of the stent. In an embodiment hereof, the deployed strut has a C-shape and is twisted such that the C-shape lies in a plane substantially along or tangential with the outer surface of the stent. In another embodiment hereof, the deployed strut is rolled-up and extends radially away from the outer surface of the stent.

Abstract translation: 经导管瓣膜假体包括可扩张的管状支架，支架内的假体瓣膜，以及耦合到环绕支架并包围多个自膨胀支柱和环形密封膜的抗瓣膜泄漏部件。 每个支柱具有联接到支架的远端的第一端和未联接到支架的第二端。 每个反paravalvular泄漏组件可在压缩配置和部署配置之间移动。 在压缩构型中，每个支柱远离支架远端延伸。 在展开的构造中，每个支柱向近端延伸远离支架的远端。 在本发明的一个实施例中，所展开的支柱具有C形并且被扭曲，使得C形位于与支架的外表面基本上沿或相切的平面中。 在本发明的另一个实施例中，部署的支柱被卷起并且从支架的外表面径向延伸。

公开(公告)号：US20140236287A1

公开(公告)日：2014-08-21

申请号：US13772676

申请日：2013-02-21

Applicant: MEDTRONIC, INC.

Inventor： Cynthia Clague ,  Scott Mosher ,  Marian Creaven ,  Declan Costello ,  Gavin Kenny ,  Michael Krivoruchko ,  Adam Shipley ,  Mark Torrianni ,  Kshitija Garde ,  Eric Richardson

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2250/0003 ,  A61F2250/0039 ,  A61F2250/0069 ,  A61F2310/00023

Abstract: A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.

Abstract translation: 防止瓣膜间泄漏的方法包括同时传送心脏瓣膜假体和环形密封部件。 在输送期间，密封部件从心脏瓣膜假体的第一位置移动到与心脏瓣膜假体的第一位置纵向间隔开的第二位置。 密封部件通过心脏瓣膜假体的轮廓外表面在第二位置处固定在心脏瓣膜假体周围。 密封部件可以是柔性环，或者可以是具有在圆柱形套筒上纵向延伸的多个肋的圆柱形柔性套管。 肋条用于展开密封部件，使得圆柱形套筒的至少一部分向外离开远离心脏瓣膜假体的外表面。

公开(公告)号：US20140222142A1

公开(公告)日：2014-08-07

申请号：US14175100

申请日：2014-02-07

Applicant: Medtronic, Inc.

Inventor： Igor Kovalsky ,  Cathleen Bergin ,  Marian Creaven ,  Joshua Dwork ,  Kshitija Garde ,  Daniel Glozman ,  Ilia Hariton ,  Pham Lo ,  Jason Quill ,  Jeffrey Sandstrom ,  Padraig Savage ,  Michael Schendel ,  Elizabeth Schotzko ,  Yossi Tuval ,  Nadav Yellin

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2457 ,  A61F2210/0004 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0036 ,  A61F2250/0071

Abstract: Heart valve prosthesis are disclosed that include a frame or support structure having an inflow portion, a valve-retaining tubular or central portion and a pair of support arms. The inflow portion radially extends from a first end of the valve-retaining tubular portion and the pair of support arms are circumferentially spaced apart and radially extend from an opposing second end of the valve-retaining tubular portion.

Abstract translation: 公开了包括具有流入部分，阀保持管状或中心部分和一对支撑臂的框架或支撑结构的心脏瓣膜假体。 流入部分从阀保持管状部分的第一端径向延伸，并且一对支撑臂沿圆周间隔开并且从阀保持管状部分的相对的第二端径向延伸。